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Information on EC 2.7.1.35 - pyridoxal kinase
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2.7.1.35 pyridoxal kinaseIUBMB Comments
Pyridoxine, pyridoxamine and various derivatives can also act as acceptors.
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Word Map
- 2.7.1.35
- 5'-phosphate
-
vitamers
- pyridoxal-5'-phosphate
-
plp-dependent
-
4-pyridoxic
- ribokinase
- agriculture
- synthesis
- drug development
- medicine
The enzyme appears in viruses and cellular organisms
Synonyms
pyridoxal kinase, pyridoxine kinase, pl kinase, ldpdxk, pyridoxal phosphokinase, stplk, hpl kinase, epl kinase 1, pn kinase, epl kinase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ePL kinase
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two different forms encoded by genes PdxK and PdxY yielding kinase 1 and kinase 2, low activity of kinase 2 suggests that this kinase originally has another substrate but can also utilize pyridoxal
kinase (phosphorylating), pyridoxal
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kinase, pyridoxal (phosphorylating)
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LdPdxK
PdxK
PL kinase
PLK
Plk1
PM kinase
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PN kinase
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PN/PL/PM kinase
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pyridoxal 5-phosphate-kinase
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pyridoxal kinase
pyridoxal kinase PKL
pyridoxal kinase-like protein SOS4
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pyridoxal phosphokinase
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pyridoxamine kinase
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pyridoxine kinase
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pyridoxine/pyridoxal/pyridoxamine kinase
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-
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SAV0580
Sos4
vitamin B6 kinase
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PL kinase
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PLK
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pyridoxal kinase
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-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + pyridoxal = ADP + pyridoxal 5'-phosphate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:pyridoxal 5'-phosphotransferase
Pyridoxine, pyridoxamine and various derivatives can also act as acceptors.
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CAS REGISTRY NUMBER
COMMENTARY
9026-42-0
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 4'-O-methylpyridoxine
ADP + 4'-O-methylpyridoxine 5'-phosphate
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-5-phosphomethyl-2-methylpyrimidine
ATP + methyl (1S)-1-[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
ADP + methyl (1S)-1-[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate 5'-phosphate
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-
-
?
ATP + methyl N-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl]histidinate
ADP + methyl N-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl]histidinate 5'-phosphate
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-
-
?
ATP + methyl N-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl]tryptophanate
ADP + methyl N-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl]tryptophanate 5'-phosphate
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-
-
?
methyl (1S)-1-[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylate + ATP
methyl (1S)-1-[3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl]-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylate + ADP
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very probably: methyl (1S)-1-[3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl]-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylate is an inhibitor of Plasmodium falciparum ornithine decarboxylase
-
?
methyl N-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl]histidinate + ATP
methyl N-([3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl]methyl)histidinate + ADP
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methyl N-([3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl]methyl)histidinate is an inhibitor of Plasmodium falciparum ornithine decarboxylase: IC50 = 0.058 mM
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?
methyl N-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl]tryptophanate + ATP
methyl N-([3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl]methyl)tryptophanate + ADP
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methyl N-([3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl]methyl)tryptophanate is an inhibitor of Plasmodium falciparum ornithine decarboxylase: IC50 = 0.064 mM
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?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-5-phosphomethyl-2-methylpyrimidine
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?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-5-phosphomethyl-2-methylpyrimidine
reaction of EC 2.7.1.49
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?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-5-phosphomethyl-2-methylpyrimidine
reaction of EC 2.7.1.49
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?
ATP + 4-deoxypyridoxine
ADP + 4-deoxypyridoxine 5'-phosphate
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-
-
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?
ATP + 4-deoxypyridoxine
ADP + 4-deoxypyridoxine 5'-phosphate
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-
-
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?
ATP + ginkgotoxin
?
ginkgotoxin (from leaves of Ginkgo biloba) acts as pseudo-substrate for pyridoxal kinase with a Km value of 0.0297 mM
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?
ATP + ginkgotoxin
?
ginkgotoxin (from leaves of Ginkgo biloba) acts as pseudo-substrate for pyridoxal kinase with a Km value of 0.0297 mM
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?
ATP + omega-methylpyridoxal
ADP + omega-methylpyridoxal 5'-phosphate
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-
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?
ATP + omega-methylpyridoxal
ADP + omega-methylpyridoxal 5'-phosphate
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-
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?
ATP + omega-methylpyridoxal
ADP + omega-methylpyridoxal 5'-phosphate
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-
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?
ATP + omega-methylpyridoxal
ADP + omega-methylpyridoxal 5'-phosphate
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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the SOS4 gene encodes a pyridoxal kinase that functions upstream of ethylene and auxin in root hair development, SOS4 is required for the initiation and tip growth of root hairs
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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generates the active form of vitamin B6, which serves as cofactor for many enzymes
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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the pdxY gene encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis. The pyridoxal kinase PdxY and the pyridoxine/pyridoxal/pyridoxamine kinase PdxK are the only physiologically important B6 vitamer kinases in Escherichia coli and their function is confined to the pyridoxal 5'-phosphate salvage pathway
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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generates the active form of vitamin B6, which serves as cofactor for many enzymes
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
generates the active form of vitamin B6, which serves as cofactor for many enzymes
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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generates the active form of vitamin B6, which serves as cofactor for many enzymes, increased enzyme activity detected 12-24 h after ischemia, pyridoxal 5'-phosphate essential for the synthesis of some neurotransmitters
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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key enzyme in transformation of vitamin B6 to pyridoxal 5'-phosphate. Pyridoxal 5'-phosphate is the crucial cofactor required by numerous enzymes involved in the metabolism of amino acids and the synthesis of many neurotransmitters
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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generates the active form of vitamin B6, which serves as cofactor for many enzymes
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
generates the active form of vitamin B6, which serves as cofactor for many enzymes
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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generates the active form of vitamin B6, which serves as cofactor for many enzymes
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
preferred substrate
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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important enzyme involved in bioactivation of vitamin B6
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?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
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generates the active form of vitamin B6, which serves as cofactor for many enzymes, interaction of pyridoxal kinase with pyridoxal 5'-phosphate dependent enzymes seems to be important for providing sufficient amounts of enzyme cofactor
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?
ATP + pyridoxamine
ADP + pyridoxamine 5'-phosphate
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?
ATP + pyridoxamine
ADP + pyridoxamine 5'-phosphate
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33% of the activity with pyridoxal
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?
ATP + pyridoxamine
ADP + pyridoxamine 5'-phosphate
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?
ATP + pyridoxamine
ADP + pyridoxamine 5'-phosphate
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not a substrate of the purified enzyme
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?
ATP + pyridoxamine
ADP + pyridoxamine 5'-phosphate
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study of substrate-enzyme interaction between immobilized pyridoxamine and recombinant porcine pyridoxal kinase using surface plasmon resonance biosensor
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?
ATP + pyridoxine
ADP + pyridoxine 5'-phosphate
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?
ATP + pyridoxine
ADP + pyridoxine 5'-phosphate
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40% of the activity with pyridoxal
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?
ATP + pyridoxine
ADP + pyridoxine 5'-phosphate
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-
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?
ATP + pyridoxine
ADP + pyridoxine 5'-phosphate
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46% of the activity with pyridoxal
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?
ATP + pyridoxine
ADP + pyridoxine 5'-phosphate