EC Number   |
Application |
Reference |
|---|
    2.7.1.35 | agriculture |
plants lacking enzyme activity display chlorosis and reduced plant size, and hypersensitivity to NaCl and sucrose. Mutant has higher level of pyridoxine, pyridoxamine, and pyridoxal 5'-phosphate. Mutant shows higher activity of pyridoxine/pyridoxamine 5'-phosphate oxidase as well as of the vitamin B6 de novo pathway enzyme Pdx1 and increased total vitamin B6 levels |
694710 |
| 2.7.1.35 | drug development |
in silico analysis of the human and parasite PdxK structure reveals significant differences in the active site region thus highlighting the potential of the parasite PdxK as an antileishmanial drug target |
-, 759342 |
| 2.7.1.35 | medicine |
ingestion of 4'-O-methylpyridoxine, i.e. ginkgotoxin, triggers epileptic convulsions and other neuronal symptoms. 4'-O-Methylpyridoxine is an competitive inhibitor of pyridoxal kinase and leads to temporarily reduced pyridoxal phosphate formation in vitro and possibly in vivo |
673580 |
| 2.7.1.35 | medicine |
potential target for drugs |
662440 |
| 2.7.1.35 | synthesis |
production of cadaverine (1,5-diaminopentane) can be done by fermentation or direct bioconversion and plays an important role as a building block of polyamides. Lysine decarboxylase (CadA) transforms L-lysine to cadaverine and pyridoxal 5'-phosphate (PLP) can increase the conversion rate and yield as a cofactor. Biotransformation of cadaverine using whole Escherichia coli cells that overexpress lysine decarboxylase has many merits, such as the rapid conversion of L-lysine to cadaverine, possible application of high concentration reactions up to the molar level, production of less byproduct, and potential reuse of the enzyme by immobilization. But the supply of PLP, an essential cofactor of lysine decarboxylase, is the major bottleneck in this system. Among various PLP systems examined, pyridoxal kinase (PdxY) shows the highest conversion of PL to PLP, resulting in more than 60 % conversion of L-lysine to cadaverine with lysine decarboxylase. Method evaluation and optimization. Interconversion of interconvertion of pyridoxal and pyridoxamine has to be controlled |
759126 |
