Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.35 extracted from

  • Ramos, R.J.; Albersen, M.; Vringer, E.; Bosma, M.; Zwakenberg, S.; Zwartkruis, F.; Jans, J.J.M.; Verhoeven-Duif, N.M.
    Discovery of pyridoxal reductase activity as part of human vitamin B6 metabolism (2019), Biochim. Biophys. Acta, 1863, 1088-1097 .
    View publication on PubMed
Search for more literature for 2.7.1.35

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pyridoxal Homo sapiens
-
 ADP + pyridoxal 5'-phosphate
-
 ir
ATP + pyridoxamine Homo sapiens
-
 ADP + pyridoxamine 5'-phosphate
-
 ir
ATP + pyridoxine Homo sapiens
-
 ADP + pyridoxine 5'-phosphate
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens O00764
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyridoxal
-
 Homo sapiens ADP + pyridoxal 5'-phosphate
-
 ir
ATP + pyridoxamine
-
 Homo sapiens ADP + pyridoxamine 5'-phosphate
-
 ir
ATP + pyridoxine
-
 Homo sapiens ADP + pyridoxine 5'-phosphate
-
 ir
additional information pyridoxal kinase catalyzes the forward reactions with pyridoxal, pyridoxamine, and pyridoxine, while pyridoxal phosphotase (PL phosphatase, PDXP, EC 3.1.3.74) catalyzes the reverse reaction of dephophorylation Homo sapiens ?
-
-

Synonyms

Synonyms Comment Organism
PdxK
-
 Homo sapiens
PL kinase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function vitamin B6 enters the cells after hydrolysis of the phosphorylated forms by the membrane-bound tissue non-specific alkaline phosphatase (TNSALP, EC 3.1.3.1). Once inside the cells, pyridoxal kinase (PL kinase, PDXK, EC 2.7.1.35) phosphorylates the hydroxymethyl group of PL, PN and PM to their respective 5'-phosphate forms Homo sapiens