Reference on EC 2.7.1.21 - thymidine kinase and Organism(s) Homo sapiens and UniProt Accession P04183
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sherley, J.L.; Kelly, T.J.
Human cytosolic thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells
J. Biol. Chem.
263
375-382
1988
Homo sapiens
Cheng, Y.C.
Thymidine kinase from blast cells of myelocytic leukemia
Methods Enzymol.
51
365-371
1978
Homo sapiens
Bone, R.; Cheng, Y.C.; Wolfenden, R.
Inhibition of thymidine kinase by P1-(adenosine-5)-P5-(thymidine-5)-pentaphosphate
J. Biol. Chem.
261
5731-5735
1986
Homo sapiens
Kit, S.
Thymidine kinase
Microbiol. Sci.
2
369-375
1985
Gallus gallus, Cytomegalovirus, Homo sapiens, Betapolyomavirus macacae
Gan, T.E.; Brumley, J.L.; van der Weyden, M.B.
Human thymidine kinase. Purification and properties of the cytosolic enzyme of placenta
J. Biol. Chem.
258
7000-7004
1983
Homo sapiens
Ellims, P.H.; van der Weyden, M.B.
Kinetic mechanism and inhibition of human liver thymidine kinase
Biochim. Biophys. Acta
660
238-242
1981
Homo sapiens
Ellims, P.H.; van der Weyden, M.B.
Human liver thymidine kinase. Purification and some properties of the enzyme
J. Biol. Chem.
255
11290-11295
1980
Homo sapiens
Lee, L.S.; Cheng, Y.C.
Human deoxythymidine kinase. I. Purification and general properties of the cytoplasmic and mitochondrial isozymes derived from blast cells of acute myelocytic leukemia
J. Biol. Chem.
251
2600-2604
1976
Homo sapiens
Kit, S.; Leung, W.C.; Trkula, D.
Properties of mitochondrial thymidine kinases of parental and enzyme-deficient HeLa cells
Arch. Biochem. Biophys.
158
503-513
1973
Homo sapiens
Taylor, A.T.; Stafford, M.A.; Jones, O.W.
Properties of thymidine kinase partially purified from human fetal and adult tissue
J. Biol. Chem.
247
1930-1935
1972
Homo sapiens
Wang, L.; Saada, A.; Eriksson, S.
Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy
J. Biol. Chem.
278
6963-6968
2003
Homo sapiens (O00142), Homo sapiens
Zhang, F.; Shao, X.; Li, H.; Robison, J.G.; Murray, B.K.; O'Neill, K.L.
A monoclonal antibody specific for human thymidine kinase 1
Hybridoma
20
25-34
2001
Homo sapiens
Berenstein, D.; Christensen, J.F.; Kristensen, T.; Hofbauer, R.; Munch-Petersen, B.
Valine, not methionine, is amino acid 106 in human cytosolic thymidine kinase (TK1). Impact on oligomerization, stability, and kinetic properties
J. Biol. Chem.
275
32187-32192
2000
Homo sapiens
Wang, L.; Munch-Petersen, B.; Herrstrom Sjoberg, A.; Hellman, U.; Bergman, T.; Jornvall, H.; Eriksson, S.
Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates
FEBS Lett.
443
170-174
1999
Homo sapiens (O00142), Homo sapiens
Li, C.L.; Lu, C.Y.; Ke, P.Y.; Chang, Z.F.
Perturbation of ATP-induced tetramerization of human cytosolic thymidine kinase by substitution of serine-13 with aspartic acid at the mitotic phosphorylation site
Biochem. Biophys. Res. Commun.
313
587-593
2004
Homo sapiens
Barroso, J.F.; Elholm, M.; Flatmark, T.
Tight binding of deoxyribonucleotide triphosphates to human thymidine kinase 2 expressed in Escherichia coli. Purification and partial characterization of its dimeric and tetrameric forms
Biochemistry
42
15158-15169
2003
Homo sapiens (O00142), Homo sapiens
Barroso, J.F.; Carvalho, R.N.; Flatmark, T.
Kinetic analysis and ligand-induced conformational changes in dimeric and tetrameric forms of human thymidine kinase 2
Biochemistry
44
4886-4896
2005
Homo sapiens
Frederiksen, H.; Berenstein, D.; Munch-Petersen, B.
Effect of valine 106 on structure-function relation of cytosolic human thymidine kinase. Kinetic properties and oligomerization pattern of nine substitution mutants of V106
Eur. J. Biochem.
271
2248-2256
2004
Homo sapiens
Birringer, M.S.; Claus, M.T.; Folkers, G.; Kloer, D.P.; Schulz, G.E.; Scapozza, L.
Structure of a type II thymidine kinase with bound dTTP
FEBS Lett.
579
1376-1382
2005
Leishmania major, Vaccinia virus (O57203), Homo sapiens (P04183), Homo sapiens, Mycoplasma pneumoniae (P75070)
Welin, M.; Kosinska, U.; Mikkelsen, N.E.; Carnrot, C.; Zhu, C.; Wang, L.; Eriksson, S.; Munch-Petersen, B.; Eklund, H.
Structures of thymidine kinase 1 of human and mycoplasmic origin
Proc. Natl. Acad. Sci. USA
101
17970-17975
2004
Ureaplasma urealyticum, Homo sapiens (P04183), Homo sapiens
Votava, T.; Topolcan, O.; Holubec, L.; Cerna, Z.; Sasek, L.; Finek, J.; Kormunda, S.
Changes of serum thymidine kinase in children with acute leukemia
Anticancer Res.
27
1925-1928
2007
Homo sapiens
Perez-Perez, M.J.; Hernandez, A.I.; Priego, E.M.; Rodriguez-Barrios, F.; Gago, F.; Camarasa, M.J.; Balzarini, J.
Mitochondrial thymidine kinase inhibitors
Curr. Top. Med. Chem.
5
1205-1219
2005
Human alphaherpesvirus 1, Homo sapiens (O00142), Homo sapiens (P04183)
Sandrini, M.P.; Clausen, A.R.; Munch-Petersen, B.; Piskur, J.
Thymidine kinase diversity in bacteria
Nucleosides Nucleotides Nucleic Acids
25
1153-1158
2006
Bacillus cereus, Bacillus subtilis, Clostridium perfringens, Escherichia coli, Listeria monocytogenes, Staphylococcus aureus, Xanthomonas campestris, Streptomyces coelicolor (O50519), Gallus gallus (P04047), Homo sapiens (P04183), Mus musculus (P04184), Yersinia enterocolitica (Q0H7D6), Solanum lycopersicum (Q71F77), Salmonella enterica subsp. enterica serovar Typhi (Q8XFQ8), Clostridium acetobutylicum (Q97F65), Arabidopsis thaliana (Q9FN47), Arabidopsis thaliana (Q9S750), Ureaplasma parvum (Q9PPP5), Deinococcus radiodurans (Q9RSY5)
Zhu, C.; Harlow, L.S.; Berenstein, D.; Munch-Petersen, S.; Munch-Petersen, B.
Effect of C-terminal of human cytosolic thymidine kinase (TK1) on in vitro stability and enzymatic properties
Nucleosides Nucleotides Nucleic Acids
25
1185-1188
2006
Homo sapiens
Perez-Perez, M.J.; Priego, E.M.; Hernandez, A.I.; Familiar, O.; Camarasa, M.J.; Negri, A.; Gago, F.; Balzarini, J.
Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future
Med. Res. Rev.
28
797-820
2008
Homo sapiens
Leyton, J.; Smith, G.; Lees, M.; Perumal, M.; Nguyen, Q.D.; Aigbirhio, F.I.; Golovko, O.; He, Q.; Workman, P.; Aboagye, E.O.
Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901
Mol. Cancer Ther.
7
3112-3121
2008
Homo sapiens
Balzarini, J.; Van Daele, I.; Negri, A.; Solaroli, N.; Karlsson, A.; Liekens, S.; Gago, F.; Van Calenbergh, S.
Human mitochondrial thymidine kinase is selectively inhibited by 3-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity
Mol. Pharmacol.
75
1127-1136
2009
Homo sapiens, Human alphaherpesvirus 1 (P03176), Human alphaherpesvirus 1
Lin, J.; Roy, V.; Wang, L.; You, L.; Agrofoglio, L.A.; Deville-Bonne, D.; McBrayer, T.R.; Coats, S.J.; Schinazi, R.F.; Eriksson, S.
3-(1,2,3-Triazol-1-yl)-3-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations
Bioorg. Med. Chem.
18
3261-3269
2010
Homo sapiens (P04183), Homo sapiens, Ureaplasma parvum (Q9PPP5), Ureaplasma parvum
Agarwal, H.K.; McElroy, C.A.; Sjuvarsson, E.; Eriksson, S.; Darby, M.V.; Tjarks, W.
Synthesis of N3-substituted carboranyl thymidine bioconjugates and their evaluation as substrates of recombinant human thymidine kinase 1
Eur. J. Med. Chem.
60
456-468
2013
Homo sapiens
Skovgaard, T.; Uhlin, U.; Munch-Petersen, B.
Comparative active-site mutation study of human and Caenorhabditis elegans thymidine kinase 1
FEBS J.
279
1777-1787
2012
Caenorhabditis elegans, Homo sapiens (P04183), Homo sapiens
Mutahir, Z.; Clausen, A.R.; Andersson, K.M.; Wisen, S.M.; Munch-Petersen, B.; Piskur, J.
Thymidine kinase 1 regulatory fine-tuning through tetramer formation
FEBS J.
280
1531-1541
2013
Anolis carolinensis (C3VAL3), Caenorhabditis elegans (G5EEZ5), Gallus gallus (P04047), Homo sapiens (P04183), Homo sapiens, Rattus norvegicus (P27158), Bacillus cereus (Q0H0H6), Dictyostelium discoideum (Q27564), Xenopus tropicalis (Q5I0A2), Danio rerio (Q803Y1), Arabidopsis thaliana (Q9S750 and Q9FN47)
Chen, Y.L.; Eriksson, S.; Chang, Z.F.
Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage
J. Biol. Chem.
285
27327-27335
2010
Homo sapiens
Van Poecke, S.; Negri, A.; Gago, F.; Van Daele, I.; Solaroli, N.; Karlsson, A.; Balzarini, J.; Van Calenbergh, S.
3-[4-Aryl-(1,2,3-triazol-1-yl)]-3-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase
J. Med. Chem.
53
2902-2912
2010
Homo sapiens
Sun, R.; Eriksson, S.; Wang, L.
Identification and characterization of mitochondrial factors modulating thymidine kinase 2 activity
Nucleosides Nucleotides Nucleic Acids
29
382-385
2010
Homo sapiens, Rattus norvegicus
Van Poecke, S.; Negri, A.; Janssens, J.; Solaroli, N.; Karlsson, A.; Gago, F.; Balzarini, J.; Van Calenbergh, S.
Synthesis, modeling and evaluation of 3-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors
Org. Biomol. Chem.
9
892-901
2011
Homo sapiens
Jagarlamudi, K.; Hansson, L.; Eriksson, S.
Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and blood donors: Implications of using serum TK1 as a biomarker
BMC Cancer
15
66
2015
Homo sapiens (P04183), Homo sapiens
Szantho, E.; Bhattoa, H.P.; Csoban, M.; Antal-Szalmas, P.; Ujfalusi, A.; Kappelmayer, J.; Hevessy, Z.
Serum thymidine kinase activity: analytical performance, age-related reference ranges and validation in chronic lymphocytic leukemia
PLoS ONE
9
e91647
2014
Homo sapiens
Zhang, S.Y.; Lin, B.D.; Li, B.R.
Evaluation of the diagnostic value of alpha-L-fucosidase, alpha-fetoprotein and thymidine kinase 1 with ROC and logistic regression for hepatocellular carcinoma
FEBS open bio
5
240-244
2015
Homo sapiens (P04183), Homo sapiens
Okamura, S.; Osaki, T.; Nishimura, K.; Ohsaki, H.; Shintani, M.; Matsuoka, H.; Maeda, K.; Shiogama, K.; Itoh, T.; Kamoshida, S.
Thymidine kinase-1/CD31 double immunostaining for identifying activated tumor vessels
Biotech. Histochem.
94
60-64
2019
Homo sapiens (P04183)
Cabel, L.; Rosenblum, D.; Lerebours, F.; Brain, E.; Loirat, D.; Bergqvist, M.; Cottu, P.; Donnadieu, A.; Bethune, A.; Kiavue, N.; Rodrigues, M.; Pierga, J.; Tanguy, M.; Bidard, F.
Plasma thymidine kinase 1 activity and outcome of ER+ HER2- metastatic breast cancer patients treated with palbociclib and endocrine therapy
Breast Cancer Res.
22
98
2020
Homo sapiens (P04183), Homo sapiens
Sun, R.; Eriksson, S.; Wang, L.
The expression and activity of thymidine kinase 1 and deoxycytidine kinase are modulated by hydrogen peroxide and nucleoside analogs
Nucleosides Nucleotides Nucleic Acids
39
1347-1358
2020
Homo sapiens (P04183)
Larsson, A.M.; Bendahl, P.O.; Aaltonen, K.; Jansson, S.; Forsare, C.; Bergqvist, M.; Jorgensen, C.L.T.; Ryden, L.
Serial evaluation of serum thymidine kinase activity is prognostic in women with newly diagnosed metastatic breast cancer
Sci. Rep.
10
4484
2020
Homo sapiens (P04183), Homo sapiens
