Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(3'-deoxy-5'-O-triphenylmethyl-beta-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)-phenyl)-thiourea | - |
Homo sapiens | |
1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | - |
Homo sapiens | |
3'-(1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | - |
Homo sapiens | |
3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | - |
Homo sapiens | |
3'-(4-butyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | - |
Homo sapiens | |
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridine | - |
Homo sapiens | |
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | - |
Homo sapiens | |
3'-(4-cyclopentylmethyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | - |
Homo sapiens | |
3'-(5-(4-chlorophenyl)-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | - |
Homo sapiens | |
3'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',3'-dideoxy-3,4-dihydrothymidine | - |
Homo sapiens | |
3'-deoxy-3'-(4-(3,4-dichlorophenyl)-1,2,3-triazol-1-yl)-beta-D-thymidine | - |
Homo sapiens | |
3'-deoxy-3'-(4-phenyl-1,2,3-triazol-1-yl)-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridine | - |
Homo sapiens | |
3'-deoxy-3'-(4-phenyl-1,2,3-triazol-1-yl)-beta-D-thymidine | - |
Homo sapiens | |
3'-deoxy-3'-(4-pyridin-2-yl-1,2,3-triazol-1-yl)-beta-D-thymidine | - |
Homo sapiens | |
3'-deoxy-3'-(5-phenyl-1,2,3-triazol-1-yl)-beta-D-thymidine | - |
Homo sapiens | |
3'-hexanoylamino-3'-deoxythymidine | very potent inhibitor of thymidine kinase 2 | Homo sapiens | |
5-(E)-(2-bromovinyl)uridine | - |
Homo sapiens | |
5-[(E)-2-bromoethenyl]-2'-O-octanoyluridine | - |
Homo sapiens | |
N-methyl-4-[{[8-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)octyl]oxy}(diphenyl)methyl]benzamide | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + thymidine | - |
Homo sapiens | ADP + dTMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thymidine kinase 2 | - |
Homo sapiens |
TK-2 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0104 | - |
5-(E)-(2-bromovinyl)uridine | thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000036 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridine | |
0.000042 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 3'-deoxy-3'-(4-(3,4-dichlorophenyl)-1,2,3-triazol-1-yl)-beta-D-thymidine | |
0.000046 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | |
0.00015 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 3'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',3'-dideoxy-3,4-dihydrothymidine | |
0.00015 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 3'-(4-cyclopentylmethyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | |
0.00023 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 3'-(4-butyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | |
0.00025 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 3'-deoxy-3'-(4-phenyl-1,2,3-triazol-1-yl)-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridine | |
0.0003 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | |
0.00032 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 3'-deoxy-3'-(4-phenyl-1,2,3-triazol-1-yl)-beta-D-thymidine | |
0.0011 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 3'-deoxy-3'-(5-phenyl-1,2,3-triazol-1-yl)-beta-D-thymidine | |
0.0013 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 3'-deoxy-3'-(4-pyridin-2-yl-1,2,3-triazol-1-yl)-beta-D-thymidine | |
0.0015 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | |
0.004 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 3'-(5-(4-chlorophenyl)-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | |
0.0047 | - |
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 3'-(1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | |
0.5 | - |
IC50 above 0.5 mM, thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C | Homo sapiens | 1-(3'-deoxy-5'-O-triphenylmethyl-beta-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)-phenyl)-thiourea |