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Information on EC 2.6.1.5 - tyrosine transaminase
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EC Tree
2.6.1.5 tyrosine transaminaseIUBMB Comments
A pyridoxal-phosphate protein. L-Phenylalanine can act instead of L-tyrosine. The mitochondrial enzyme may be identical with EC 2.6.1.1 (aspartate transaminase). The three isoenzymic forms are interconverted by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain). The enzyme can also catalyse the final step in the methionine-salvage pathway of Klebsiella pneumoniae .
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Word Map
- 2.6.1.5
- glucocorticoid
- dexamethasone
- hepatoma
- hepatocytes
- steroid
- albumin
- glucagon
- hydrocortisone
- fetal
-
liver-specific
- corticosterone
-
adrenalectomized
-
carboxykinase
- phosphoenolpyruvate
- glycogen
- alpha-fetoprotein
- ornithine
- tyrosinemia
- oxygenase
- camp
- pyridoxal
-
transamination
- glucose-6-phosphatase
-
dibutyryl
-
antiglucocorticoids
-
pyrrolase
- cortisol
-
glucocorticoid-induced
- actinomycin
-
morris
-
dexamethasone-induced
-
gluconeogenic
-
bt2camp
-
glucocorticoid-responsive
-
reuber
-
rosmarinic
-
hepatocyte-specific
- dex
- methylprednisolone
- pepck
-
superinduction
-
glucocorticoid-dependent
- triamcinolone
- homogentisate
-
acetonide
- p-hydroxyphenylpyruvate
-
palmoplantar
-
amino-transferase
-
hepatocyte-like
- medicine
-
hyperkeratosis
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
tyrosine aminotransferase, tyrosine transaminase, tatase, tyrat, tyrosine-alpha-ketoglutarate transaminase, l-tyrosine:2-oxoglutarate aminotransferase, phenylalanine aminotransferase, phenylalanine transaminase, at5g53970, l-tyrosine aminotransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
aminotransferase, tyrosine
-
-
-
-
glutamic phenylpyruvic aminotransferase
-
-
-
-
glutamic-hydroxyphenylpyruvic transaminase
-
-
-
-
L-phenylalanine 2-oxoglutarate aminotransferase
-
-
-
-
L-tyrosine aminotransferase
-
-
-
-
L-tyrosine-2-oxoglutarate aminotransferase
-
-
-
-
phenylalanine aminotransferase
-
-
-
-
phenylalanine transaminase
-
-
-
-
phenylalanine-alpha-ketoglutarate transaminase
-
-
-
-
phenylpyruvate transaminase
-
-
-
-
phenylpyruvic acid transaminase
-
-
-
-
TAT
TAT1
TAT2
TATase
TyrAT
tyrosine aminotransferase
tyrosine-2-ketoglutarate aminotransferase
-
-
-
-
tyrosine-2-oxoglutarate aminotransferase
-
-
-
-
tyrosine-alpha-ketoglutarate aminotransferase
-
-
-
-
tyrosine-alpha-ketoglutarate transaminase
-
-
-
-
additional information
-
the mitochondrial enzyme may be identical with EC 2.6.1.1 and with EC 2.6.1.57
tyrosine aminotransferase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
amino group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
Biosynthesis of secondary metabolites, Cysteine and methionine metabolism, Isoquinoline alkaloid biosynthesis, Novobiocin biosynthesis, Phenylalanine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Tropane, piperidine and pyridine alkaloid biosynthesis, Tyrosine metabolism, Ubiquinone and other terpenoid-quinone biosynthesis
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(S)-reticuline biosynthesis, (S)-reticuline biosynthesis, (S)-reticuline biosynthesis, (S)-reticuline biosynthesis, Isoquinoline alkaloid biosynthesis, Isoquinoline alkaloid biosynthesis, Isoquinoline alkaloid biosynthesis, Isoquinoline alkaloid biosynthesis, Isoquinoline alkaloid biosynthesis, Isoquinoline alkaloid biosynthesis, Phenylalanine, tyrosine and tryptophan biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
L-tyrosine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. L-Phenylalanine can act instead of L-tyrosine. The mitochondrial enzyme may be identical with EC 2.6.1.1 (aspartate transaminase). The three isoenzymic forms are interconverted by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain). The enzyme can also catalyse the final step in the methionine-salvage pathway of Klebsiella pneumoniae [8].
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CAS REGISTRY NUMBER
COMMENTARY
9014-55-5
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2-aminophenyl)alanine + 2-oxoglutarate
3-(4-aminophenyl)-2-oxopropanoate + L-glutamate
-
10% of the activity that with L-tyrosine
-
?
(3-fluorophenyl)alanine + 2-oxoglutarate
3-(3-fluorophenyl)-2-oxopropanoate + L-glutamate
-
4% of the activity that with L-tyrosine
-
?
(4-chlorophenyl)alanine + 2-oxoglutarate
3-(3-chlorophenyl)-2-oxopropanoate + L-glutamate
-
17% of the activity with L-tyrosine
-
?
(4-fluorophenyl)alanine + 2-oxoglutarate
3-(4-fluorophenyl)-2-oxopropanoate + L-glutamate
-
7.9% of the activity that with L-tyrosine
-
?
(R)-3-amino-5-methyl-hexanoic acid + 2-oxoglutarate
?
relative activity: 48%
-
-
?
(S)-beta-phenylalanine + 2-oxoglutarate
3-oxo-3-phenylpropionic acid + L-glutamate
relative activity: 100%
-
-
?
(S)-beta-phenylalanine + pyruvate
3-oxo-3-phenylpropionic acid + L-alanine
the activity of VpAT with pyruvate is 85% of that with alpha-ketoglutarate as the amino acceptor
-
-
?
2-oxoglutarate + L-phenylalanine
L-glutamate + phenylpyruvate
-
-
-
?
3,4-dihydroxyphenylalanine + 2-oxoglutarate
3-(3,4-dihydroxyphenyl)-2-oxopropanoate + L-glutamate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
L-tyrosine + 2-oxoglutarate
-
-
-
r
3-aminotyrosine + 2-oxoglutarate
3-(3-amino-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
16% of the activity than with L-tyrosine
-
?
3-methoxytyrosine + 2-oxoglutarate
3-(3-methoxy-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
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22% of the activity with L-tyrosine
-
?
4-hydroxyphenylpyruvate + L-aspartate
L-tyrosine + oxaloacetate
-
35% of the activity with L-glutamate
-
r
4-hydroxyphenylpyruvate + L-phenylalanine
L-glutamate + phenylpyruvate
-
-
-
?
L-ethionine + 2-oxoglutarate
4-ethylsulfanyl-2-oxobutanoate + L-glutamate
-
17% of the activity than with L-tyrosine
-
?
L-glutamine + 2-oxoglutarate
5-amino-2,5-dioxopentanoic acid + L-glutamate
-
-
-
r
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + L-glutamate
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
r
L-serine + 2-oxoglutarate
3-hydroxy-2-oxopropanoic acid + L-glutamate
-
-
-
r
L-tryptophan + oxaloacetate
3-(1H-indol-3-yl)-2-oxopropanoate + L-glycine
-
-
-
-
?
L-tyrosine + 2-oxohexanoate
3-(4-hydroxyphenyl)-2-oxopropanoate + (2S)-2-aminohexanoate
-
-
-
-
?
L-tyrosine + 2-oxopentanoate
3-(4-hydroxyphenyl)-2-oxopropanoate + (2S)-2-aminopentanoate
relative activity compared to 2-oxoglutarate: 3%
-
-
?
L-tyrosine + oxaloacetate
?
relative activity compared to 2-oxoglutarate: 75%
-
-
?
L-tyrosine + prephenate
?
relative activity compared to 2-oxoglutarate: 23%
-
-
?
L-tyrosine + pyruvate
?
relative activity compared to 2-oxoglutarate: 40%
-
-
?
oxaloacetate + L-glutamate
L-aspartate + 2-oxoglutarate
-
-
-
r
phenylpyruvate + L-glutamate
2-oxoglutarate + L-phenylalanine
-
-
-
r
rac-2-fluoro-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 15%
-
-
?
rac-2-methyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 5%
-
-
?
rac-3-bromo-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 53%
-
-
?
rac-3-chloro-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 56%
-
-
?
rac-3-fluoro-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 48%
-
-
?
rac-3-methyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 54%
-
-
?
rac-4-bromo-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 62%
-
-
?
rac-4-ethyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 134%
-
-
?
rac-4-fluoro-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 87%
-
-
?
rac-4-iso-propyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 61%
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-
?
rac-4-methyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 100%
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-
?
rac-4-nitro-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 32%
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-
?
rac-4-nitro-hydroxy-phenylalanine + 2-oxoglutarate
?
relative activity: 61%
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-
?
rac-4-propyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 126%
-
-
?
rac-4-trifluoromethyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 73%
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-
?
rac-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 100%
-
-
?
3,4-dihydroxyphenylalanine + 2-oxoglutarate
3-(3,4-dihydroxyphenyl)-2-oxopropanoate + L-glutamate
-
-
-
?
3,4-dihydroxyphenylalanine + 2-oxoglutarate
3-(3,4-dihydroxyphenyl)-2-oxopropanoate + L-glutamate
-
85% of the activity than with L-tyrosine
-
?
3-iodotyrosine + 2-oxoglutarate
3-(4-hydroxy-3-iodophenyl)-2-oxopropanoate + L-glutamate
-
as effective as L-tyrosine
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?
3-iodotyrosine + 2-oxoglutarate
3-(4-hydroxy-3-iodophenyl)-2-oxopropanoate + L-glutamate
-
84% of the activity than with L-tyrosine
-
?
4-hydroxyphenylpyruvate + L-glutamate
L-tyrosine + 2-oxoglutarate
-
-
-
r
4-hydroxyphenylpyruvate + L-glutamate
L-tyrosine + 2-oxoglutarate
favoured direction of reaction for isoform TAT2
-
-
r
L-asparagine + 2-oxoglutarate
2-oxosuccinamate + L-glutamate
-
-
-
r
L-asparagine + 2-oxoglutarate
2-oxosuccinamate + L-glutamate
-
15% of the activity with L-tyrosine
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
isoenzymes TAT-2 and TAT-3, best substrate for isoenzyme TAT-3
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
higher activity than with L-tyrosine
-
?
L-cysteine + 2-oxoglutarate
3-mercapto-2-oxopropanoate + L-glutamate
-
-
-
r
L-cysteine + 2-oxoglutarate
3-mercapto-2-oxopropanoate + L-glutamate
-
higher activity than with L-tyrosine
-
?
L-glutamate + 4-hydroxyphenylpyruvate
2-oxoglutarate + L-tyrosine
-
-
-
-
r
L-glutamate + 4-hydroxyphenylpyruvate
2-oxoglutarate + L-tyrosine
-
-
-
?
L-glutamate + phenylpyruvate
2-oxoglutarate + L-phenylalanine
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
20% of the activity than with L-tyrosine
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropanoate + L-glutamate
-
-
-
r
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropanoate + L-glutamate
-
-
-
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropanoate + L-glutamate
-
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
lower activity than with L-tyrosine
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
higher rate than with L-tyrosine
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
no activity
-
?
L-tryptophan + 2-oxoglutarate
3-(1H-indol-3-yl)-2-oxopropanoate + L-glutamate
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-(1H-indol-3-yl)-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-(1H-indol-3-yl)-2-oxopropanoate + L-glutamate
-
-
-
-
r
L-tryptophan + pyruvate
3-(1H-indol-3-yl)-2-oxopropanoate + L-alanine
-
-
-
r
L-tryptophan + pyruvate
3-(1H-indol-3-yl)-2-oxopropanoate + L-alanine
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
best substrate
-
-
r
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
highly specific for: L-tyrosine
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
isoenzymes TAT-1, TAT-2 and TAT-3 show a pronounced preference for L-tyrosine over other aromatic amino acids
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
isoenzyme TAT-1: oxaloacetate and 2-oxoglutarate utilized equally well as amino acceptor, isoenzyme TAT-2: oxaloacetate is most effective, isoenzyme TAT-3: 2-oxoglutarate is most effective
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
first step in tyrosine pathway leading to the formation of rosmarinic acid (alpha-O-caffeoyl-3,4-dihydroxyphenyllactic acid)
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
best substrate and favoured direction of reaction for isoform TAT1
-
-
r
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
r
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
specific for 2-oxoglutarate as the amino group acceptor
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate