Reference on EC 1.3.98.1 - dihydroorotate dehydrogenase (fumarate)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Taylor, W.H.; Taylor, M.L.; Eames, D.F.
Two functionally different dihydroorotic dehydrogenases in bacteria
J. Bacteriol.
91
2251-2256
1966
Pseudomonas sp.
Manually annotated by BRENDA team
Taylor, W.H.; Taylor, C.D.; Taylor, M.L.
Biosynthetic dihydroorotate dehydrogenase from Lactobacillus bulgaricus: partial characterization of the enzyme
J. Bacteriol.
119
98-105
1974
Lactobacillus delbrueckii subsp. bulgaricus
Manually annotated by BRENDA team
Pascal, R.A.; Le Trang, N.; Cerami, A.; Walsh, C.
Purification and properties of dihydroorotate oxidase from Crithidia fasciculata and Trypanosoma brucei
Biochemistry
22
171-178
1983
Crithidia fasciculata, Trypanosoma brucei brucei, Trypanosoma brucei brucei EATRO 110
Manually annotated by BRENDA team
Taylor, M.L.; Taylor, D.F.; Eames, W.H.
Biosynthetic dihydroorotate dehydrogenase from Lactobacillus bulgaricus
J. Bacteriol.
105
1015-1027
1971
Lactobacillus delbrueckii subsp. bulgaricus
Manually annotated by BRENDA team
Pascal, R.A.; Walsh, C.T.
Mechanistic studies with deuterated dihydroorotates on the dihydroorotate oxidase from Crithidia fasciculata
Biochemistry
23
2745-2752
1984
Crithidia fasciculata
Manually annotated by BRENDA team
Bjornberg, O.; Jordan, D.B.; Palfey, B.A.; Jensen, K.F.
Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis
Arch. Biochem. Biophys.
391
286-294
2001
Escherichia coli, Lactococcus lactis
Manually annotated by BRENDA team
Rowland, P.; Bjornberg, O.; Nielsen, F.S.; Jensen, K.F.; Larsen, S.
The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymic function
Protein Sci.
7
1269-1279
1998
Lactococcus lactis
Manually annotated by BRENDA team
Nielsen, F.S.; Rowland, P.; Larsen, S.; Jensen, K.F.
Purification and characterization of dihydroorotate dehydrogenase A from Lactococcus lactis, crystallization and preliminary X-ray diffraction studies of the enzyme
Protein Sci.
5
852-856
1996
Lactococcus lactis
Manually annotated by BRENDA team
Jordan, D.B.; Bisaha, J.J.; Picollelli, M.A.
Catalytic properties of dihydroorotate dehydrogenase from Saccharomyces cerevisiae: studies on pH, alternate substrates, and inhibitors
Arch. Biochem. Biophys.
378
84-92
2000
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Forman, H.J.; Kennedy, J.
Purification of the primary dihydroorotate dehydrogenase (oxidase) from rat liver mitochondria
Prep. Biochem.
7
345-355
1977
Rattus norvegicus
Manually annotated by BRENDA team
Sierra Pagan, M.L.; Zimmermann, B.H.
Cloning and expression of the dihydroorotate dehydrogenase from Toxoplasma gondii
Biochim. Biophys. Acta
1637
178-181
2003
Toxoplasma gondii (Q8MXD1)
Manually annotated by BRENDA team
Sorensen, G.; Dandanell, G.
A new type of dihydroorotate dehydrogenase, type 1S, from the thermoacidophilic archaeon Sulfolobus solfataricus
Extremophiles
6
245-251
2002
Saccharolobus solfataricus
Manually annotated by BRENDA team
Norager, S.; Arent, S.; Bjornberg, O.; Ottosen, M.; Lo Leggio, L.; Jensen, K.F.; Larsen, S.
Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J. Biol. Chem.
278
28812-28822
2003
Lactococcus lactis
Manually annotated by BRENDA team
Baldwin, J.; Michnoff, C.H.; Malmquist, N.A.; White, J.; Roth, M.G.; Rathod, P.K.; Phillips, M.A.
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
J. Biol. Chem.
280
21847-21853
2005
Plasmodium falciparum
Manually annotated by BRENDA team
Haque, T.S.; Tadesse, S.; Marcinkeviciene, J.; Rogers, M.J.; Sizemore, C.; Kopcho, L.M.; Amsler, K.; Ecret, L.D.; Zhan, D.L.; Hobbs, F.; Slee, A.; Trainor, G.L.; Stern, A.M.; Copeland, R.A.; Combs, A.P.
Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase
J. Med. Chem.
45
4669-4678
2002
Helicobacter pylori
Manually annotated by BRENDA team
Takashima, E.; Inaoka, D.K.; Osanai, A.; Nara, T.; Odaka, M.; Aoki, T.; Inaka, K.; Harada, S.; Kita, K.
Characterization of the dihydroorotate dehydrogenase as a soluble fumarate reductase in Trypanosoma cruzi
Mol. Biochem. Parasitol.
122
189-200
2002
Trypanosoma cruzi
Manually annotated by BRENDA team
Loffler, M.; Klein, A.; Hayek-Ouassini, M.; Knecht, W.; Konrad, L.
Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells
Nucleosides Nucleotides Nucleic Acids
23
1281-1285
2004
Mus musculus
Manually annotated by BRENDA team
Nara, T.; Kamei, Y.; Tsubouchi, A.; Annoura, T.; Hirota, K.; Iizumi, K.; Dohmoto, Y.; Ono, T.; Aoki, T.
Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells
Parasitol. Int.
54
59-64
2005
Trypanosoma cruzi
Manually annotated by BRENDA team
Ottosen, M.B.; Bjornberg, O.; Norager, S.; Larsen, S.; Palfey, B.A.; Jensen, K.F.
The dimeric dihydroorotate dehydrogenase A from Lactococcus lactis dissociates reversibly into inactive monomers
Protein Sci.
11
2575-2583
2002
Lactococcus lactis
Manually annotated by BRENDA team
Norager, S.; Jensen, K.F.; Bjornberg, O.; Larsen, S.
E. coli dihydroorotate dehydrogenase reveals structural and functional distinctions between different classes of dihydroorotate dehydrogenases
Structure
10
1211-1223
2002
Escherichia coli
Manually annotated by BRENDA team
Vorisek, J.; Technikova, Z.; Schwippel, J.; Benoist, P.
Enzymatic activities of Ura2 and Ura1 proteins (aspartate carbamoyltransferase and dihydro-orotate dehydrogenase) are present in both isolated membranes and cytoplasm of Saccharomyces cerevisiae
Yeast
19
449-457
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hurt, D.E.; Widom, J.; Clardy, J.
Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor
Acta Crystallogr. Sect. D
62
312-323
2006
Plasmodium falciparum, Plasmodium falciparum (Q08210)
Manually annotated by BRENDA team
Inaoka, D.K.; Takashima, E.; Osanai, A.; Shimizu, H.; Nara, T.; Aoki, T.; Harada, S.; Kita, K.
Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate
Acta Crystallogr. Sect. F
61
875-878
2005
Trypanosoma cruzi (Q4D3W2), Trypanosoma cruzi
Manually annotated by BRENDA team
Cordeiro, A.T.; Feliciano, P.R.; Nonato, M.C.
Crystallization and preliminary X-ray diffraction analysis of Leishmania major dihydroorotate dehydrogenase
Acta Crystallogr. Sect. F
62
1049-1051
2006
Leishmania major
Manually annotated by BRENDA team
Annoura, T.; Nara, T.; Makiuchi, T.; Hashimoto, T.; Aoki, T.
The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions
J. Mol. Evol.
60
113-127
2005
Euglena gracilis, Euglena gracilis (Q75XR0), Neobodo saliens, Neobodo saliens (Q6F4D1), Parabodo caudatus (Q6F4D0), Trypanosoma cruzi
Manually annotated by BRENDA team
Sariego, I.; Annoura, T.; Nara, T.; Hashimoto, M.; Tsubouchi, A.; Iizumi, K.; Makiuchi, T.; Murata, E.; Kita, K.; Aoki, T.
Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms
Parasitol. Int.
55
11-16
2006
Trypanosoma cruzi (Q4D3W2), Trypanosoma cruzi (Q4DEJ0), Trypanosoma cruzi (Q4DGV2), Trypanosoma cruzi
Manually annotated by BRENDA team
Shi, J.; Dertouzos, J.; Gafni, A.; Steel, D.; Palfey, B.A.
Single-molecule kinetics reveals signatures of half-sites reactivity in dihydroorotate dehydrogenase A catalysis
Proc. Natl. Acad. Sci. USA
103
5775-5780
2006
Lactococcus lactis
Manually annotated by BRENDA team
Feliciano, P.R.; Cordeiro, A.T.; Costa-Filho, A.J.; Nonato, M.C.
Cloning, expression, purification, and characterization of Leishmania major dihydroorotate dehydrogenase
Protein Expr. Purif.
48
98-103
2006
Leishmania major
Manually annotated by BRENDA team
Annoura, T.; Sariego, I.; Nara, T.; Makiuchi, T.; Fujimura, T.; Taka, H.; Mineki, R.; Murayama, K.; Aoki, T.
Dihydroorotate dehydrogenase arises from novel fused gene product with aspartate carbamoyltransferase in Bodo saliens
Biochem. Biophys. Res. Commun.
358
253-258
2007
Neobodo saliens
Manually annotated by BRENDA team
Pinheiro, M.P.; Iulek, J.; Cristina Nonato, M.
Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase from Y strain
Biochem. Biophys. Res. Commun.
369
812-817
2008
Trypanosoma cruzi, Trypanosoma cruzi Y
Manually annotated by BRENDA team
Fagan, R.L.; Jensen, K.F.; Bjoernberg, O.; Palfey, B.A.
Mechanism of flavin reduction in the class 1A dihydroorotate dehydrogenase from Lactococcus lactis
Biochemistry
46
4028-4036
2007
Lactococcus lactis
Manually annotated by BRENDA team
Wolfe, A.E.; Thymark, M.; Gattis, S.G.; Fagan, R.L.; Hu, Y.C.; Johansson, E.; Arent, S.; Larsen, S.; Palfey, B.A.
Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis
Biochemistry
46
5741-5753
2007
Lactococcus lactis
Manually annotated by BRENDA team
Zameitat, E.; Pierik, A.J.; Zocher, K.; Loeffler, M.
Dihydroorotate dehydrogenase from Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues
FEMS Yeast Res.
7
897-904
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Arakaki, T.L.; Buckner, F.S.; Gillespie, J.R.; Malmquist, N.A.; Phillips, M.A.; Kalyuzhniy, O.; Luft, J.R.; Detitta, G.T.; Verlinde, C.L.; Van Voorhis, W.C.; Hol, W.G.; Merritt, E.A.
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
Mol. Microbiol.
68
37-50
2008
Trypanosoma brucei
Manually annotated by BRENDA team
Inaoka, D.; Sakamoto, K.; Shimizu, H.; Shiba, T.; Kurisu, G.; Nara, T.; Aoki, T.; Kita, K.; Harada, S.
Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: Atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction
Biochemistry
47
10881-10891
2008
Trypanosoma cruzi (Q4D3W2), Trypanosoma cruzi
Manually annotated by BRENDA team
Pawlik, A.; Herczynska, M.; Kurzawski, M.; Safranow, K.; Dziedziejko, V.; Drozdzik, M.
The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide
Pharmacogenomics
10
303-309
2009
Homo sapiens
Manually annotated by BRENDA team
Cheleski, J.; Wiggers, H.J.; Citadini, A.P.; da Costa Filho, A.J.; Nonato, M.C.; Montanari, C.A.
Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry
Anal. Biochem.
399
13-22
2010
Trypanosoma cruzi
Manually annotated by BRENDA team
Cheleski, J.; Rocha, J.R.; Pinheiro, M.P.; Wiggers, H.J.; da Silva, A.B.; Nonato, M.C.; Montanari, C.A.
Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery
Eur. J. Med. Chem.
45
5899-5909
2010
Trypanosoma cruzi (Q4D3W2), Trypanosoma cruzi
Manually annotated by BRENDA team
Liu, Y.; Gao, Z.Q.; Liu, C.P.; Xu, J.H.; Li, L.F.; Ji, C.N.; Su, X.D.; Dong, Y.H.
Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans
Acta Crystallogr. Sect. F
67
182-187
2011
Streptococcus mutans (Q8DVA1), Streptococcus mutans
Manually annotated by BRENDA team
McDonald, C.A.; Palfey, B.A.
Substrate binding and reactivity are not linked: grafting a proton-transfer network into a Class 1A dihydroorotate dehydrogenase
Biochemistry
50
2714-2716
2011
Lactococcus lactis
Manually annotated by BRENDA team
Cordeiro, A.T.; Feliciano, P.R.; Pinheiro, M.P.; Nonato, M.C.
Crystal structure of dihydroorotate dehydrogenase from Leishmania major
Biochimie
94
1739-1748
2012
Leishmania major
Manually annotated by BRENDA team
Ke, H.; Morrisey, J.M.; Ganesan, S.M.; Painter, H.J.; Mather, M.W.; Vaidya, A.B.
Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function
Eukaryot. Cell
10
1053-1061
2011
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ganesan, S.M.; Morrisey, J.M.; Ke, H.; Painter, H.J.; Laroiya, K.; Phillips, M.A.; Rathod, P.K.; Mather, M.W.; Vaidya, A.B.
Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection
Mol. Biochem. Parasitol.
177
29-34
2011
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Reis, R.A.; Ferreira, P.; Medina, M.; Nonato, M.C.
The mechanistic study of Leishmania major dihydro-orotate dehydrogenase based on steady- and pre-steady-state kinetic analysis
Biochem. J.
473
651-660
2016
Leishmania major
Manually annotated by BRENDA team
Silva, N.d.e..F.; Lameira, J.; Alves, C.N.; Marti, S.
Computational study of the mechanism of half-reactions in class 1A dihydroorotate dehydrogenase from Trypanosoma cruzi
Phys. Chem. Chem. Phys.
15
18863-18871
2013
Trypanosoma cruzi (Q4D3W2), Trypanosoma cruzi, Trypanosoma cruzi CL Brener (Q4D3W2)
Manually annotated by BRENDA team