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Literature summary for 1.3.98.1 extracted from
- The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions (2005), J. Mol. Evol., 60, 113-127.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | an ancient common ancestor of Euglenozoa had a mitochondrial DHOD whose descendant exists in Euglena gracilis | Euglena gracilis |
| additional information | Bodo saliens has an ACT/DHOD gene fusion encoding aspartate carbamoyltransferase, the second enzyme of the de novo pyrimidine pathway, and DHOD | Neobodo saliens |
| additional information | the cytosolic DHOD gene acquired may have contributed to adaptation to anaerobiosis in the kinetoplastid lineage and further contributes to the subsequent establishment of parasitism in a trypanosomatid ancestor | Trypanosoma cruzi |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Euglena gracilis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | DHOD-knockout Trypanosoma cruzi do not express the enzyme protein and can not survive even in the presence of pyrimidine nucleosides, suggesting a vital role of fumarate reductase activity in the regulation of cellular redox balance | Trypanosoma cruzi |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Trypanosoma cruzi | 5829 | - |
| cytosol | - |
Neobodo saliens | 5829 | - |
| cytosol | - |
Parabodo caudatus | 5829 | - |
| mitochondrion | - |
Euglena gracilis | 5739 | - |
| mitochondrion | - |
Trypanosoma cruzi | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Euglena gracilis | - |
- |
- |
| Euglena gracilis | Q75XR0 | - |
- |
| Neobodo saliens | - |
- |
- |
| Neobodo saliens | Q6F4D1 | - |
- |
| Parabodo caudatus | Q6F4D0 | - |
- |
| Trypanosoma cruzi | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydroorotate + fumarate | - |
Euglena gracilis | orotate + ? | - |
? |  |
| dihydroorotate + fumarate | - |
Trypanosoma cruzi | orotate + ? | - |
? | |
| dihydroorotate + fumarate | - |
Neobodo saliens | orotate + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACT/DHOD | - |
Neobodo saliens |
| ACT/DHOD | gene fusion encoding aspartate carbamoyltransferase and dihyroorotate dehydrogenase | Neobodo saliens |
| DHOD | - |
Euglena gracilis |
| DHOD | - |
Trypanosoma cruzi |
| DHOD | - |
Neobodo saliens |
| DHOD | - |
Parabodo caudatus |
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Release 2023.1 (January 2023)
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