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Information on EC 1.13.11.60 - linoleate 8R-lipoxygenase

for references in articles please use BRENDA:EC1.13.11.60

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IUBMB Comments

The enzyme contains heme [1,4]. The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, which is subsequently isomerized by the C-terminal P450 heme thiolate domain to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.5, 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase) . The bifunctional enzyme from Gaeumannomyces graminis also catalyses the oxidation of linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, but its second domain isomerizes it to (7S,8S,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.6, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase) .

The enzyme appears in viruses and cellular organisms

Synonyms
linoleate diol synthase, 7,8-lds, 5,8-lds, 8r-dioxygenase, 8r-dox, 7,8-linoleate diol synthase, dioxygenase-cytochrome p450, 8(r)-dioxygenase, 8r-dox-5,8-lds, 8-dox, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
linoleate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS