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show all sequences of 1.13.11.60

Discovery of a novel linoleate dioxygenase of Fusarium oxysporum and linoleate diol synthase of Colletotrichum graminicola

Sooman, L.; Oliw, E.H.; Lipids 50, 1243-1252 (2015)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene GLRG_10013, phylogenetic analysis
Colletotrichum graminicola
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
linoleate
Colletotrichum graminicola
-
(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate
-
-
r
additional information
Colletotrichum graminicola
the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
?
-
-
-
additional information
Colletotrichum graminicola M1.001
the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
?
-
-
-
additional information
Colletotrichum graminicola M1.001 / M2 / FGSC 10212
the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
?
-
-
-
oleate + O2
Colletotrichum graminicola
-
(9Z)-7,8-dihydroxyoctadeca-9-enoic acid
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Colletotrichum graminicola
E3QVI1
-
-
Colletotrichum graminicola M1.001
E3QVI1
-
-
Colletotrichum graminicola M1.001 / M2 / FGSC 10212
E3QVI1
-
-
Fusarium oxysporum
F9FU71
-
-
Fusarium oxysporum Fo5176
F9FU71
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R)-8-hydro(pero)xy-(9Z,12Z)-octadecadienoate + O2
-
743200
Colletotrichum graminicola
(8R,11R)-8,11-dihydro(pero)xy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydro(pero)xy-(9Z,12Z)-octadecadienoate
-
-
-
?
(R)-8-hydro(pero)xy-(9Z,12Z)-octadecadienoate + O2
-
743200
Colletotrichum graminicola M1.001
(8R,11R)-8,11-dihydro(pero)xy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydro(pero)xy-(9Z,12Z)-octadecadienoate
-
-
-
?
(R)-8-hydro(pero)xy-(9Z,12Z)-octadecadienoate + O2
-
743200
Colletotrichum graminicola M1.001 / M2 / FGSC 10212
(8R,11R)-8,11-dihydro(pero)xy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydro(pero)xy-(9Z,12Z)-octadecadienoate
-
-
-
?
alpha-linolenic acid + O2
-
743200
Colletotrichum graminicola
?
-
-
-
?
alpha-linolenic acid + O2
-
743200
Colletotrichum graminicola M1.001
?
-
-
-
?
alpha-linolenic acid + O2
-
743200
Colletotrichum graminicola M1.001 / M2 / FGSC 10212
?
-
-
-
?
arachidonic acid + O2
-
743200
Fusarium oxysporum
(R)-10-hydroxyarachidonic acid
-
-
-
?
arachidonic acid + O2
-
743200
Fusarium oxysporum Fo5176
(R)-10-hydroxyarachidonic acid
-
-
-
?
docosapentaenoic acid + O2
-
743200
Fusarium oxysporum
(R)-10-hydroperoxy-docosapentaenoic acid
-
-
-
?
docosapentaenoic acid + O2
-
743200
Fusarium oxysporum Fo5176
(R)-10-hydroperoxy-docosapentaenoic acid
-
-
-
?
gamma-linolenic acid + O2
-
743200
Fusarium oxysporum
(R)-8-hydroxy-gamma-linolenic acid
-
-
-
?
gamma-linolenic acid + O2
-
743200
Fusarium oxysporum Fo5176
(R)-8-hydroxy-gamma-linolenic acid
-
-
-
?
linoleate
-
743200
Colletotrichum graminicola
(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate
-
-
-
r
linoleate + O2
-
743200
Colletotrichum graminicola
(R)-8-hydro(pero)xy-(9Z,12Z)-octadecadienoate + (8R,11R)-8,11-dihydro(pero)xy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydro(pero)xy-(9Z,12Z)-octadecadienoate
-
-
-
?
linoleate + O2
-
743200
Fusarium oxysporum
(R)-8-hydroperoxy-(9Z,12Z)octadecadienoic acid
-
-
-
?
linoleate + O2
-
743200
Fusarium oxysporum Fo5176
(R)-8-hydroperoxy-(9Z,12Z)octadecadienoic acid
-
-
-
?
additional information
enzyme metabolizes fatty acids to hydroperoxides with broad substrate specificity. Products show R configuration at the (n-10) positions. Fatty acids of the n-3 series are oxidized less efficiently and often to hydroperoxides with an R configuration at both (n-10) and (n-7) positions
743200
Fusarium oxysporum
?
-
-
-
-
additional information
enzyme oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases, but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
743200
Colletotrichum graminicola
?
-
-
-
-
additional information
no substrate: gamma-linolenoate
743200
Colletotrichum graminicola
?
-
-
-
-
additional information
the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
743200
Colletotrichum graminicola
?
-
-
-
-
additional information
enzyme oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases, but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
743200
Colletotrichum graminicola M1.001
?
-
-
-
-
additional information
no substrate: gamma-linolenoate
743200
Colletotrichum graminicola M1.001
?
-
-
-
-
additional information
the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
743200
Colletotrichum graminicola M1.001
?
-
-
-
-
additional information
enzyme oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases, but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
743200
Colletotrichum graminicola M1.001 / M2 / FGSC 10212
?
-
-
-
-
additional information
no substrate: gamma-linolenoate
743200
Colletotrichum graminicola M1.001 / M2 / FGSC 10212
?
-
-
-
-
additional information
the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
743200
Colletotrichum graminicola M1.001 / M2 / FGSC 10212
?
-
-
-
-
additional information
enzyme metabolizes fatty acids to hydroperoxides with broad substrate specificity. Products show R configuration at the (n-10) positions. Fatty acids of the n-3 series are oxidized less efficiently and often to hydroperoxides with an R configuration at both (n-10) and (n-7) positions
743200
Fusarium oxysporum Fo5176
?
-
-
-
-
oleate + O2
-
743200
Colletotrichum graminicola
8-hydroperoxyoctadecamonoenoate + 7,8-dihydroxyoctadecamonoenoate
-
-
-
?
oleate + O2
-
743200
Colletotrichum graminicola
(9Z)-7,8-dihydroxyoctadeca-9-enoic acid
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
-
-
assay at
Colletotrichum graminicola
-
-
assay at
Fusarium oxysporum
Temperature Range [°C]
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
additional information
-
incubation at room temperature augments the non-enzymatic formation of epoxy alcohols
Colletotrichum graminicola
additional information
-
incubation at room temperature augments the non-enzymatic formation of epoxy alcohols
Fusarium oxysporum
Cloned(Commentary) (protein specific)
Commentary
Organism
gene GLRG_10013, phylogenetic analysis
Colletotrichum graminicola
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
linoleate
Colletotrichum graminicola
-
(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate
-
-
r
additional information
Colletotrichum graminicola
the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
?
-
-
-
additional information
Colletotrichum graminicola M1.001
the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
?
-
-
-
additional information
Colletotrichum graminicola M1.001 / M2 / FGSC 10212
the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
?
-
-
-
oleate + O2
Colletotrichum graminicola
-
(9Z)-7,8-dihydroxyoctadeca-9-enoic acid
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R)-8-hydro(pero)xy-(9Z,12Z)-octadecadienoate + O2
-
743200
Colletotrichum graminicola
(8R,11R)-8,11-dihydro(pero)xy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydro(pero)xy-(9Z,12Z)-octadecadienoate
-
-
-
?
(R)-8-hydro(pero)xy-(9Z,12Z)-octadecadienoate + O2
-
743200
Colletotrichum graminicola M1.001
(8R,11R)-8,11-dihydro(pero)xy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydro(pero)xy-(9Z,12Z)-octadecadienoate
-
-
-
?
(R)-8-hydro(pero)xy-(9Z,12Z)-octadecadienoate + O2
-
743200
Colletotrichum graminicola M1.001 / M2 / FGSC 10212
(8R,11R)-8,11-dihydro(pero)xy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydro(pero)xy-(9Z,12Z)-octadecadienoate
-
-
-
?
alpha-linolenic acid + O2
-
743200
Colletotrichum graminicola
?
-
-
-
?
alpha-linolenic acid + O2
-
743200
Colletotrichum graminicola M1.001
?
-
-
-
?
alpha-linolenic acid + O2
-
743200
Colletotrichum graminicola M1.001 / M2 / FGSC 10212
?
-
-
-
?
arachidonic acid + O2
-
743200
Fusarium oxysporum
(R)-10-hydroxyarachidonic acid
-
-
-
?
arachidonic acid + O2
-
743200
Fusarium oxysporum Fo5176
(R)-10-hydroxyarachidonic acid
-
-
-
?
docosapentaenoic acid + O2
-
743200
Fusarium oxysporum
(R)-10-hydroperoxy-docosapentaenoic acid
-
-
-
?
docosapentaenoic acid + O2
-
743200
Fusarium oxysporum Fo5176
(R)-10-hydroperoxy-docosapentaenoic acid
-
-
-
?
gamma-linolenic acid + O2
-
743200
Fusarium oxysporum
(R)-8-hydroxy-gamma-linolenic acid
-
-
-
?
gamma-linolenic acid + O2
-
743200
Fusarium oxysporum Fo5176
(R)-8-hydroxy-gamma-linolenic acid
-
-
-
?
linoleate
-
743200
Colletotrichum graminicola
(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate
-
-
-
r
linoleate + O2
-
743200
Colletotrichum graminicola
(R)-8-hydro(pero)xy-(9Z,12Z)-octadecadienoate + (8R,11R)-8,11-dihydro(pero)xy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydro(pero)xy-(9Z,12Z)-octadecadienoate
-
-
-
?
linoleate + O2
-
743200
Fusarium oxysporum
(R)-8-hydroperoxy-(9Z,12Z)octadecadienoic acid
-
-
-
?
linoleate + O2
-
743200
Fusarium oxysporum Fo5176
(R)-8-hydroperoxy-(9Z,12Z)octadecadienoic acid
-
-
-
?
additional information
enzyme metabolizes fatty acids to hydroperoxides with broad substrate specificity. Products show R configuration at the (n-10) positions. Fatty acids of the n-3 series are oxidized less efficiently and often to hydroperoxides with an R configuration at both (n-10) and (n-7) positions
743200
Fusarium oxysporum
?
-
-
-
-
additional information
enzyme oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases, but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
743200
Colletotrichum graminicola
?
-
-
-
-
additional information
no substrate: gamma-linolenoate
743200
Colletotrichum graminicola
?
-
-
-
-
additional information
the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
743200
Colletotrichum graminicola
?
-
-
-
-
additional information
enzyme oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases, but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
743200
Colletotrichum graminicola M1.001
?
-
-
-
-
additional information
no substrate: gamma-linolenoate
743200
Colletotrichum graminicola M1.001
?
-
-
-
-
additional information
the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
743200
Colletotrichum graminicola M1.001
?
-
-
-
-
additional information
enzyme oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases, but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
743200
Colletotrichum graminicola M1.001 / M2 / FGSC 10212
?
-
-
-
-
additional information
no substrate: gamma-linolenoate
743200
Colletotrichum graminicola M1.001 / M2 / FGSC 10212
?
-
-
-
-
additional information
the dioxygenase-cytochrome P450 homologue oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid
743200
Colletotrichum graminicola M1.001 / M2 / FGSC 10212
?
-
-
-
-
additional information
enzyme metabolizes fatty acids to hydroperoxides with broad substrate specificity. Products show R configuration at the (n-10) positions. Fatty acids of the n-3 series are oxidized less efficiently and often to hydroperoxides with an R configuration at both (n-10) and (n-7) positions
743200
Fusarium oxysporum Fo5176
?
-
-
-
-
oleate + O2
-
743200
Colletotrichum graminicola
8-hydroperoxyoctadecamonoenoate + 7,8-dihydroxyoctadecamonoenoate
-
-
-
?
oleate + O2
-
743200
Colletotrichum graminicola
(9Z)-7,8-dihydroxyoctadeca-9-enoic acid
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
-
-
assay at
Colletotrichum graminicola
-
-
assay at
Fusarium oxysporum
Temperature Range [°C] (protein specific)
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
additional information
-
incubation at room temperature augments the non-enzymatic formation of epoxy alcohols
Colletotrichum graminicola
additional information
-
incubation at room temperature augments the non-enzymatic formation of epoxy alcohols
Fusarium oxysporum
General Information
General Information
Commentary
Organism
evolution
homologue dioxygenase-cytochrome P450 (DOX-CYP) is a fusion protein of the animal heme peroxidase (cyclooxygenase) superfamily. Phylogenetic tree of fungal fusion enzymes with homology to the animal heme peroxidase and CYP superfamilies, overview
Colletotrichum graminicola
metabolism
fungal oxylipins can be formed by two subfamilies of cyclooxygenase-related DOX. The enzymatic activities of the DOX-CYP homologue of Colletotrichum graminicola and the DOX homologue of Fusarium oxysporum. The former oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid. The latter metabolizes fatty acids to hydroperoxides with broad substrate specificity. It oxidizes 20:4n-6 and 18:2n-6 to hydroperoxides with an R configuration at the (n-10) positions, and other n-6 fatty acids in the same way
Colletotrichum graminicola
General Information (protein specific)
General Information
Commentary
Organism
evolution
homologue dioxygenase-cytochrome P450 (DOX-CYP) is a fusion protein of the animal heme peroxidase (cyclooxygenase) superfamily. Phylogenetic tree of fungal fusion enzymes with homology to the animal heme peroxidase and CYP superfamilies, overview
Colletotrichum graminicola
metabolism
fungal oxylipins can be formed by two subfamilies of cyclooxygenase-related DOX. The enzymatic activities of the DOX-CYP homologue of Colletotrichum graminicola and the DOX homologue of Fusarium oxysporum. The former oxidizes oleic and linoleic acids in analogy with 7,8-linoleate diol synthases (LDSs), but with the additional biosynthesis of 8,11-dihydroxylinoleic acid. The latter metabolizes fatty acids to hydroperoxides with broad substrate specificity. It oxidizes 20:4n-6 and 18:2n-6 to hydroperoxides with an R configuration at the (n-10) positions, and other n-6 fatty acids in the same way
Colletotrichum graminicola
Other publictions for EC 1.13.11.60
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741712
Seo
Characterization of a recombi ...
Colletotrichum gloeosporioides, Colletotrichum gloeosporioides KACC 40961
Appl. Microbiol. Biotechnol.
100
3087-3099
2016
1
-
1
-
11
-
-
17
-
-
1
1
1
5
-
-
1
-
-
1
8
-
25
3
2
-
1
18
3
-
-
-
-
-
-
1
-
1
-
-
11
-
-
-
-
17
-
-
1
1
1
-
-
1
-
1
8
-
25
3
2
-
1
18
3
-
-
-
-
-
-
-
20
20
742730
Seo
Production of 7,8-dihydroxy u ...
Colletotrichum gloeosporioides, Colletotrichum gloeosporioides KACC 40961
J. Agric. Food Chem.
64
8555-8562
2016
1
1
1
-
1
-
-
-
-
-
-
2
-
6
-
-
1
-
-
1
-
-
14
-
1
-
-
-
1
-
-
-
-
-
-
1
1
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
1
-
1
-
-
14
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
743200
Sooman
Discovery of a novel linoleat ...
Colletotrichum graminicola, Colletotrichum graminicola M1.001, Colletotrichum graminicola M1.001 / M2 / FGSC 10212, Fusarium oxysporum, Fusarium oxysporum Fo5176
Lipids
50
1243-1252
2015
-
-
1
-
-
-
-
-
-
-
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