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Information on EC 1.12.7.2 - ferredoxin hydrogenase
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1.12.7.2 ferredoxin hydrogenaseIUBMB Comments
Contains iron-sulfur clusters. The enzymes from some sources contains nickel. Can use molecular hydrogen for the reduction of a variety of substances.
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Word Map
- 1.12.7.2
- hydrogenases
- alcaligenes
- eutrophus
- pasteurianum
- viologen
- desulfovibrio
-
n2-fixing
- nife-hydrogenases
-
h2-dependent
- hoxefuyh
-
o2-tolerant
-
hupls
-
hydrogen-oxidizing
-
nad-reducing
- fructosovorans
-
oxygen-tolerant
-
h2-oxidizing
- biotechnology
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
membrane-bound hydrogenase, hydrogenase i, bidirectional hydrogenase, hydrogenlyase, fe-fe hydrogenase, [fefe] hydrogenase hyda1, c-mbh, ddhydab, ferredoxin-dependent [fefe]-hydrogenase, mbh hydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
bidirectional hydrogenase
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C-MBH
engineered minimal catalytically active 4-subunit subcomplex of respiratory membrane-bound hydrogenase
EC 1.12.1.1
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formerly
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EC 1.12.7.1
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formerly
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EC 1.18.3.1
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formerly
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EC 1.18.99.1
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formerly
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EC 1.98.1.1
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formerly
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Ech hydrogenase
energy-converting hydrogenase
Fe hydrogenlyase
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ferredoxin-dependent [FeFe] hydrogenase
H2 oxidizing hydrogenase
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H2 producing hydrogenase [ambiguous]
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HYD1
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HYD2
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hydA
HydA1
HydA2
hydrogen-lyase [ambiguous]
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hydrogenase (ferredoxin)
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hydrogenase I
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hydrogenase II
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hydrogenlyase
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hydrogenlyase [ambiguous]
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MBH hydrogenase
MbhJKLN
engineered minimal catalytically active 4-subunit subcomplex of respiratory membrane-bound hydrogenase, MbhJKLN
MDH
membrane-bound hydrogenase
NiFe hydrogenase
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uptake hydrogenase [ambiguous]
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[FeFe] hydrogenase
[FeFe]-hydrogenase
[Ni-Fe] hydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
H2 + oxidized ferredoxin = reduced ferredoxin + 2 H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
hydrogen:ferredoxin oxidoreductase
Contains iron-sulfur clusters. The enzymes from some sources contains nickel. Can use molecular hydrogen for the reduction of a variety of substances.
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CAS REGISTRY NUMBER
COMMENTARY
9080-02-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
H+ + reduced benzyl viologen
H2 + oxidized benzyl viologen
-
58.8% relative activity, purified enzyme
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-
?
H2 + 2 oxidized ferredoxin
2 reduced ferredoxin + 2 H+
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-
-
?
H2 + oxidized benzyl viologen
reduced benzyl viologen + H+
-
wild-type enzyme catalysed the reduction of benzylviologen at fourfold higher rates than the reduction of ferredoxin
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-
?
H2 + oxidized CAC3527 ferredoxin
H+ + reduced CAC3527 ferredoxin
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mutant CAC3527 ferredoxin displays an almost 8fold lower reduction potential than wild type ferredoxin
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-
r
H2 + oxidized ferredoxin CAC0587
H+ + reduced ferredoxin CAC0587
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ferredoxin CAC0587 is the standard major ferredoxin
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r
H2 + oxidized ferredoxin Pet F
reduced ferredoxin Pet F + H+
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-
-
-
?
H2 + oxidized flavodoxin CAC0587
H+ + reduced flavodoxin CAC0587
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flavodoxin CAC0587 is the standard major flavodoxin
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-
r
(SeO3)2- + H2 + ?
Se + H2O + ?
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methyl viologen and benzyl viologen as electron acceptors
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-
?
(SeO3)2- + H2 + ?
Se + H2O + ?
-
methyl viologen and benzyl viologen as electron acceptors
-
-
?
(TeO3)2- + H2 + ?
Te + H2O + ?
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methyl viologen as electron acceptor
-
-
?
(TeO3)2- + H2 + ?
Te + H2O + ?
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methyl viologen as electron acceptor
-
-
?
2 H+ + reduced ferredoxin
H2 + oxidized ferredoxin
-
-
-
-
?
2 H+ + reduced ferredoxin
H2 + oxidized ferredoxin
-
the exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation
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-
?
2 H+ + reduced polyferredoxin
H2 + oxidized polyferredoxin
-
-
-
-
?
2 H+ + reduced polyferredoxin
H2 + oxidized polyferredoxin
-
the exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation
-
-
?
2 H+ + reduced polyferredoxin
H2 + oxidized polyferredoxin
-
the exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation
-
-
?
2 H+ + reduced polyferredoxin
H2 + oxidized polyferredoxin
-
the exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation
-
-
?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
-
-
-
-
?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
-
-
-
-
r
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
-
reaction is proposed to be coupled to energy conservation
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-
?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
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-
?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
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-
?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
Chlorococcum submarinum
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hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
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-
?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
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-
?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
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-
?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
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?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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94.3% relative activity, purified enzyme
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-
?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
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?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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the exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation
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?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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Ech hydrogenase acts as primary proton pump in a ferredoxin-dependent electron transport system. Ech hydrogenase is necessary to generate an electrochemical ion gradient when ferredoxin is the only reducing equivalent and heterodisulfide is absent
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?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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Ech hydrogenase acts as primary proton pump in a ferredoxin-dependent electron transport system. Ech hydrogenase is necessary to generate an electrochemical ion gradient when ferredoxin is the only reducing equivalent and heterodisulfide is absent
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?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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Mbh function as a redox-driven ion pump coupling the reduction of protons with electrons derived from the oxidation of a low-potential ferredoxin to the generation of a H+ motive force
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?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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the exergonic reaction is coupled to energy conservation by means of electron-transport phosphorylation
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?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
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?
H+ + reduced ferredoxin
H2 + oxidized ferredoxin
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hydrogen production is light-dependent, since the [FeFe] hydrogenase is coupled to the photosynthetic electron transport chain via ferredoxin
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?
H+ + reduced methyl viologen
H2 + oxidized methyl viologen
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r
H+ + reduced methyl viologen
H2 + oxidized methyl viologen
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-
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?
H+ + reduced methyl viologen
H2 + oxidized methyl viologen
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-
-
-
?
H+ + reduced methyl viologen
H2 + oxidized methyl viologen
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-
-
-
?
H+ + reduced methyl viologen
H2 + oxidized methyl viologen
Clostridium acetobutylicum NBRC 13948
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-
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?
H+ + reduced methyl viologen
H2 + oxidized methyl viologen
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-
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r
H+ + reduced methyl viologen
H2 + oxidized methyl viologen
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r
H+ + reduced methyl viologen
H2 + oxidized methyl viologen
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100% relative activity, purified enzyme
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?
H+ + reduced methyl viologen
H2 + oxidized methyl viologen
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-
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?
H2 + electron acceptor
H+ + reduced electron acceptor
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ferricyanide as electron acceptor
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r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methylene blue as electron acceptor
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r
H2 + electron acceptor
H+ + reduced electron acceptor
-
ferricyanide as electron acceptor
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r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methylene blue as electron acceptor
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-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
sulfonatopropyl viologen, sodium metatungstate and sodium silicotungstate as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
sulfonatopropyl viologen, sodium metatungstate and sodium silicotungstate as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methylene blue as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methylene blue as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
FAD and FMN as electron acceptors
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
FAD, FMN or riboflavin as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
benzyl viologen as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
benzyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
dichlorophenol indophenol as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methylene blue as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methylene blue as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
FAD, FMN or riboflavin as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
benzyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methylene blue as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
benzyl viologen as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
dichlorophenol indophenol as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methylene blue as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
FAD and FMN as electron acceptors
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
dichlorophenol indophenol as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methylene blue as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
benzyl viologen as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methylene blue as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
?
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
benzyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
benzyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methylene blue as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
cytochrome b as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
phenosafranine as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
benzyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
Methanosarcina barkeri MS / DSM 800
-
methylene blue as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
Methanosarcina barkeri MS / DSM 800
-
cytochrome b as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
Methanosarcina barkeri MS / DSM 800
-
methyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
Methanosarcina barkeri MS / DSM 800
-
phenosafranine as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
Methanosarcina barkeri MS / DSM 800
-
benzyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methylene blue as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
benzyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
NADP+ as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
cytochrome b as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
benzyl viologen as electron acceptor
-
-
r
H2 + electron acceptor
H+ + reduced electron acceptor
-
methyl viologen as electron acceptor
-
-
r
H2 + ferredoxin + oxidized metronidazole
H+ + ferredoxin + reduced metronidazole
-
-
-
-
?
H2 + ferredoxin + oxidized metronidazole
H+ + ferredoxin + reduced metronidazole
-
-
-
-
?
H2 + oxidized benzyl viologen
H+ + reduced benzyl viologen
-
-
-
-
r
H2 + oxidized benzyl viologen
H+ + reduced benzyl viologen
-
-
-
-
r
H2 + oxidized ferredoxin
H+ + reduced ferredoxin
-
-
-
r
H2 + oxidized ferredoxin
H+ + reduced ferredoxin
-
-
-
r
H2 + oxidized ferredoxin
H+ + reduced ferredoxin
-
2[4Fe4S] ferredoxin
-
-
r
H2 + oxidized ferredoxin
H+ + reduced ferredoxin
-
under anoxic conditions
-
-
r
H2 + oxidized ferredoxin
H+ + reduced ferredoxin
-
ferredoxin links the enzyme to photosynthesis
-
r
H2 + oxidized ferredoxin
H+ + reduced ferredoxin