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EC 2.7.11.15 Details
EC number
2.7.11.15
Accepted name
β-adrenergic-receptor kinase
Reaction
ATP + [β-adrenergic receptor] = ADP + phospho-[β-adrenergic receptor]
Other name(s)
ATP:β-adrenergic-receptor phosphotransferase,
[β-adrenergic-receptor] kinase,
β-adrenergic receptor-specific kinase,
β-AR kinase,
β-ARK,
β-ARK 1,
β-ARK 2,
β-receptor kinase,
GRK2,
GRK3,
β-adrenergic-receptor kinase (phosphorylating),
β2ARK,
βARK1,
β-adrenoceptor kinase,
β-adrenoceptor kinase 1,
β-adrenoceptor kinase 2,
ADRBK1,
BARK1,
adrenergic receptor kinase,
STK15
Systematic name
ATP:[β-adrenergic receptor] phosphotransferase
CAS registry number
102925-39-3
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
History
created 1989 as EC 2.7.1.126, transferred 2005 to EC 2.7.11.15
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