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EC 2.7.11.34 Details
EC number
2.7.11.34
Accepted name
NEK6-subfamily protein kinase
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other name(s)
NEK6, NEK7, nekl-3
Comment
Requires Mg2+. NEK6 subfamily kinases are present in animals, though lost in insects, and include human NEK6 and NEK7 and C. elegans nekl-3. They are activated in mitosis by phosphorylation by NEK9 [1], and phosphorylate cytoskeletal proteins including EML4, KIF11A and KIF14 [4,2]. In C. elegans, nekl-3 is involved in clathrin-mediated endocytosis [5]. In peptide arrays, NEK6 prefers to phosphorylate Ser residues, with hydrophobic residues at -2 and +1 and charged residues at -1, -2 and +2 [3].
History
created 2022
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EC Tree
1 Oxidoreductases
2 Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.3 Carboxy- and carbamoyltransferases
2.1.4 Amidinotransferases
2.1.5 Methylenetransferases
2.2 Transferring aldehyde or ketonic groups
2.3 Acyltransferases
2.4 Glycosyltransferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.6 Transferring nitrogenous groups
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.3 Phosphotransferases with a nitrogenous group as acceptor
2.7.4 Phosphotransferases with a phosphate group as acceptor
2.7.5 Phosphotransferases with regeneration of donors, apparently catalysing intramolecular transfers (deleted sub-subclass)
2.7.6 Diphosphotransferases
2.7.7 Nucleotidyltransferases
2.7.8 Transferases for other substituted phosphate groups
2.7.9 Phosphotransferases with paired acceptors
2.7.10 Protein-tyrosine kinases
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase
2.7.11.3 dephospho-[reductase kinase] kinase
2.7.11.4 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase
2.7.11.5 [isocitrate dehydrogenase (NADP+)] kinase
2.7.11.6 [tyrosine 3-monooxygenase] kinase
2.7.11.7 myosin-heavy-chain kinase
2.7.11.8 Fas-activated serine/threonine kinase
2.7.11.9 Goodpasture-antigen-binding protein kinase
2.7.11.10 IκB kinase
2.7.11.11 cAMP-dependent protein kinase
2.7.11.12 cGMP-dependent protein kinase
2.7.11.13 protein kinase C
2.7.11.14 rhodopsin kinase
2.7.11.15 β-adrenergic-receptor kinase
2.7.11.16 G-protein-coupled receptor kinase
2.7.11.17 Ca2+/calmodulin-dependent protein kinase
2.7.11.18 myosin-light-chain kinase
2.7.11.19 phosphorylase kinase
2.7.11.20 elongation factor 2 kinase
2.7.11.21 polo kinase
2.7.11.22 cyclin-dependent kinase
2.7.11.23 [RNA-polymerase]-subunit kinase
2.7.11.24 mitogen-activated protein kinase
2.7.11.25 mitogen-activated protein kinase kinase kinase
2.7.11.26 tau-protein kinase
2.7.11.27 [acetyl-CoA carboxylase] kinase
2.7.11.28 tropomyosin kinase
2.7.11.29 low-density-lipoprotein receptor kinase
2.7.11.30 receptor protein serine/threonine kinase
2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
2.7.11.32 [pyruvate, phosphate dikinase] kinase
2.7.11.33 [pyruvate, water dikinase] kinase
2.7.11.34 NEK6-subfamily protein kinase
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.13 Protein-histidine kinases
2.7.14 Protein-arginine kinases
2.7.99 Other protein kinases
2.8 Transferring sulfur-containing groups
2.9 Transferring selenium-containing groups
2.10 Transferring molybdenum- or tungsten-containing groups
3 Hydrolases
4 Lyases
5 Isomerases
6 Ligases
7 Translocases