EC Explorer
[browse EC tree] - [search]
EC 2.7.11.13 Details
EC number
2.7.11.13
Accepted name
protein kinase C
Reaction
ATP + a protein = ADP + a phosphoprotein
Other name(s)
calcium-dependent protein kinase C,
calcium-independent protein kinase C,
calcium/phospholipid dependent protein kinase,
cPKCα,
cPKCβ,
cPKCγ,
nPKCδ,
nPKCε,
nPKC,
nPKC,
PKC,
PKCα,
PKCβ,
PKCγ,
PKCδ,
PKCε,
PKCζ,
Pkc1p,
protein kinase Cε,
STK24
Systematic name
ATP:protein phosphotransferase (diacylglycerol-dependent)
Comment
A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters.
History
created 2005 (EC 2.7.1.37 part-incorporated 2005)
EC Tree