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ATP + [EML4]-(L-serine/L-threonine)
ADP + [EML4]-(L-serine/L-threonine) phosphate
ATP + [Kif14]-(L-serine/L-threonine)
ADP + [Kif14]-(L-serine/L-threonine) phosphate
ATP + [Mklp2]-(L-serine/L-threonine)
ADP + [Mklp2]-(L-serine/L-threonine) phosphate
ATP + [EML4]-(L-serine/L-threonine)
ADP + [EML4]-(L-serine/L-threonine) phosphate
Substrates: the mitotic kinase NEK6 phosphorylates the EML4 N-terminal domain at Ser144
Products: -
?
ATP + [EML4]-(L-serine/L-threonine)
ADP + [EML4]-(L-serine/L-threonine) phosphate
Substrates: the mitotic kinase NEK7 phosphorylates the EML4 N-terminal domain at Ser146
Products: -
?
ATP + [Kif14]-(L-serine/L-threonine)
ADP + [Kif14]-(L-serine/L-threonine) phosphate
Substrates: Nek7 phosphorylates Kif14, allowing the kinesin to localize citron kinase to the cleavage furrow in anaphase and contribute to proper midbody formation in cytokinesis
Products: -
?
ATP + [Kif14]-(L-serine/L-threonine)
ADP + [Kif14]-(L-serine/L-threonine) phosphate
Substrates: -
Products: -
?
ATP + [Mklp2]-(L-serine/L-threonine)
ADP + [Mklp2]-(L-serine/L-threonine) phosphate
Substrates: Nek6 phosphorylates Mklp2 at Ser244, inhibiting its bundling activity until anaphase onset
Products: -
?
ATP + [Mklp2]-(L-serine/L-threonine)
ADP + [Mklp2]-(L-serine/L-threonine) phosphate
Substrates: -
Products: -
?
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ATP + [EML4]-(L-serine/L-threonine)
ADP + [EML4]-(L-serine/L-threonine) phosphate
ATP + [Kif14]-(L-serine/L-threonine)
ADP + [Kif14]-(L-serine/L-threonine) phosphate
Substrates: Nek7 phosphorylates Kif14, allowing the kinesin to localize citron kinase to the cleavage furrow in anaphase and contribute to proper midbody formation in cytokinesis
Products: -
?
ATP + [Mklp2]-(L-serine/L-threonine)
ADP + [Mklp2]-(L-serine/L-threonine) phosphate
Substrates: Nek6 phosphorylates Mklp2 at Ser244, inhibiting its bundling activity until anaphase onset
Products: -
?
ATP + [EML4]-(L-serine/L-threonine)
ADP + [EML4]-(L-serine/L-threonine) phosphate
Substrates: the mitotic kinase NEK6 phosphorylates the EML4 N-terminal domain at Ser144
Products: -
?
ATP + [EML4]-(L-serine/L-threonine)
ADP + [EML4]-(L-serine/L-threonine) phosphate
Substrates: the mitotic kinase NEK7 phosphorylates the EML4 N-terminal domain at Ser146
Products: -
?
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malfunction
loss of NEKL-3 activity leads to penetrant larval molting defects and to the abnormal localization of trafficking markers in arrested larvae. Loss of NEKL-3 results in a strong reduction in clathrin exchange. Mammalian NEK6 and NEK7 can partially rescue endocytosis and molting defects in nekl-3 mutant worms
malfunction
depletion of the enzyme in cells leads to increased EML4 binding to microtubules in mitosis
physiological function
MLT proteins functionally cooperate with the conserved NIMA kinase family members NEKL-2/NEK8 and NEKL-3/NEK6/NEK7 to promote cuticle shedding. The NEKL-MLT network regulates early steps in clathrin-mediated endocytosis at the apical surface of hyp7
physiological function
NEKL-3 is involved in clathrin-mediated endocytosis
physiological function
Nercc1/Nek9 and Nek6 represent a novel cascade of mitotic NIMA family protein kinases whose combined function is important for mitotic progression
physiological function
a bifurcation in a signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14. A Nek9, Nek6, and Mklp2 signaling module controls the timely localization and bundling activity of Mklp2 at the anaphase central spindle. A separate Nek9, Nek7, and Kif14 signaling module is required for the recruitment of the Rho-interacting kinase citron to the anaphase midzone
physiological function
constitutive activation of NEK6 reduces EML4 association with interphase microtubules
physiological function
the phosphorylation-site motifs for the mitotic kinases Nek6, Nek7 and Nek9 are essentially identical to that of their upstream activator Plk1, suggesting that Nek6/7/9 function as phosphomotif amplifiers of Plk1 signaling
physiological function
constitutive activation of NEK7 reduces EML4 association with interphase microtubules
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Kooij, B.; Creixell, P.; Vlimmeren, A.; Joughin, B.; Miller, C.; Haider, N.; Simpson, C.; Linding, R.; Stambolic, V.; Turk, B.; Yaffe, M.
Comprehensive substrate specificity profiling of the human nek kinome reveals unexpected signaling outputs
eLife
8
e44635
2019
Homo sapiens (Q9HC98), Homo sapiens (Q8TDX7)
brenda
Lazetic, V.; Fay, D.S.
Conserved Ankyrin Repeat Proteins and their NIMA Kinase partners regulate extracellular matrix remodeling and intracellular trafficking in Caenorhabditis elegans
Genetics
205
273-293
2017
Caenorhabditis elegans (G5EFM9), Caenorhabditis elegans
brenda
Belham, C.; Roig, J.; Caldwell, J.; Aoyama, Y.; Kemp, B.; Comb, M.; Avruch, J.
A mitotic cascade of NIMA family kinases Nercc1/Nek9 activates the Nek6 and Nek7 kinases
J. Biol. Chem.
278
34897-34909
2003
Homo sapiens (Q9HC98), Homo sapiens (Q8TDX7)
brenda
Cullati, S.; Kabeche, L.; Kettenbach, A.; Gerber, S.
A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase
J. Cell Biol.
216
2339-2354
2017
Homo sapiens (Q9HC98), Homo sapiens (Q8TDX7)
brenda
Joseph, B.B.; Wang, Y.; Edeen, P.; Lazetic, V.; Grant, B.D.; Fay, D.S.
Control of clathrin-mediated endocytosis by NIMA family kinases
PLoS Genet.
16
e1008633
2020
Caenorhabditis elegans (G5EFM9), Caenorhabditis elegans
brenda
Adib, R.; Montgomery, J.; Atherton, J.; ORegan, L.; Richards, M.; Straatman, K.; Roth, D.; Straube, A.; Bayliss, R.; Moores, C.; Fry, A.
Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression
Sci. Signal.
12
eaaw2939
2019
Homo sapiens (Q9HC98), Homo sapiens (Q8TDX7)
brenda
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