Information on EC 2.7.11.16 - G-protein-coupled receptor kinase

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EC Tree 2 Transferases 2.7 Transferring phosphorus-containing groups 2.7.11 Protein-serine/threonine kinases 2.7.11.16 G-protein-coupled receptor kinase

IUBMB Comments

Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.15, β-adrenergic-receptor kinase).

The enzyme appears in viruses and cellular organisms

2.7.11.16
desensitization
hypertension
g-proteins
gpcrs
beta-adrenergic
rhodopsin
beta-arrestins
agonist-dependent
natriuresis
agonist-occupied
agonist-mediated
medicine
diagnostics

Reaction Schemes

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ATP

[G-protein-coupled receptor]

ADP

[G-protein-coupled receptor] phosphate

ATP

[G protein-coupled receptor]

ADP

[G protein-coupled receptor]phosphate

Synonyms
g-protein-coupled receptor kinase, g protein-coupled receptor kinase 5, g protein-coupled receptor kinase 4, g protein-coupled receptor kinase 6, grk4gamma, g-protein-coupled receptor kinase 5, g-protein-coupled receptor kinase 6, grk-6, g-protein coupled receptor kinase 5, g protein-coupled receptor kinase grk6, more