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Information on EC 2.7.11.14 - rhodopsin kinase

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IUBMB Comments
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, beta-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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ATP
+
rhodopsin
=
ADP
+
phosphorhodopsin
+
=
+
Synonyms
cone-specific kinase GRK7, G protein receptor kinase 1, G protein-coupled receptor kinase, G protein-coupled receptor kinase 1, G protein-coupled receptor kinase GRK7, G-protein coupled protein kinase 7a, G-protein coupled protein kinase 7b, G-protein coupled receptor kinase, G-protein coupled receptor kinase 1, G-protein receptor kinase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + rhodopsin = ADP + phosphorhodopsin
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