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ATP + 11-cis-retinal-rhodopsin
ADP + 11-cis-retinal-phosphorhodopsin
-
-
-
-
?
ATP + 13-cis-retinal-rhodopsin
ADP + 13-cis-retinal-phosphorhodopsin
-
-
-
-
?
ATP + 338-SKTETSQVAPA-348
?
ATP + 9-cis-retinal-rhodopsin
ADP + 9-cis-retinal-phosphorhodopsin
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
ATP + Ac-RRRAAAAASAAA-NH2
ADP + Ac-RRRAAAAApSAAA-NH2
-
synthetic peptide substrate
-
-
?
ATP + arrestin
ADP + phospho-arrestin
ATP + arrestin
ADP + phosphoarrestin
ATP + beta-adrenergic receptor
ADP + phospho-beta-adrenergic receptor
-
phosphorylates rhodopsin better than betaAR
-
-
?
ATP + cone opsin
ADP + phosphorylated cone opsin
light-dependent phosphorylation
-
-
?
ATP + DDEASTTVSKTETSQVARRR
?
-
synthetic peptide C, very poor substrate
-
-
?
ATP + M cone opsin
ADP + phosphorylated M cone opsin
ATP + M opsin
ADP + phosphorylated m opsin
ATP + opsin
ADP + phosphoopsin
ATP + peptide
ADP + phosphopeptide
ATP + protein
ADP + phosphoprotein
autophosphorylation
-
-
?
ATP + rhodopsin
ADP + phospho-rhodopsin
-
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
ATP + rhodopsin
ADP + phosphorylated rhodopsin
ATP + rhodopsin 1
ADP + phosphorhodopsin 1
-
-
-
-
?
ATP + rhodopsin TM5
ADP + phosphorhodopsin TM5
-
-
-
?
ATP + RRREEEEESAAA
ADP + RRREEEEE-(P)SAAA
-
synthetic peptide substrate
-
-
?
ATP + S cone opsin
ADP + phosphorylated S cone opsin
ATP + S opsin
ADP + phosphorylated S opsin
ATPgammaS + rhodopsin
?
-
ATPgammaS is a good substrate, 2-3 mol phosphate/mol rhodopsin
-
-
?
GTP + rhodopsin
GDP + phosphorhodopsin
additional information
?
-
ATP + 338-SKTETSQVAPA-348

?
-
peptide containing the last 11 amino acids of the C-terminal of bovine rhodopsin
-
-
?
ATP + 338-SKTETSQVAPA-348
?
-
phosphorylated at Ser-343, about 11% of the rate with rhodopsin, photoactivated rhodopsin-dependent, soluble active kinase catalyzes photoactivated rhodopsin-independent peptide phosphorylation
-
-
?
ATP + 338-SKTETSQVAPA-348
?
-
peptide containing the last 11 amino acids of the C-terminal of bovine rhodopsin
-
-
?
ATP + 338-SKTETSQVAPA-348
?
-
only in the presence of photoactivated rhodopsin, which activates RK for peptide phosphorylation, also activated by metarhodopsin III, but not by opsin, up to 60% of the rate with photoactivated rhodopsin, light-dependent phosphorylation
-
-
?
ATP + a protein

ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
the phosphorylase kinase phosphorylates proteins and proteolytic fragments thereof, phosphorylation of multiple residues in the substrate sequence
-
-
?
ATP + arrestin

ADP + phospho-arrestin
-
-
-
-
?
ATP + arrestin
ADP + phospho-arrestin
-
the enzyme interacts with the squid visual arrestin, arrestin binding to photoactivated rhodopsin is a key mechanism of desensitization, overview
-
-
?
ATP + arrestin

ADP + phosphoarrestin
-
phosphorylation of arrestin in the presence of Ca2+, Ca2+ may facilitate arrestin-binding to RK
-
-
?
ATP + arrestin
ADP + phosphoarrestin
-
phosphorylation of arrestin in the presence of Ca2+, occurs only after photoactivation in vivo, dual role of RK in the inactivation of the squid visual system
-
-
?
ATP + M cone opsin

ADP + phosphorylated M cone opsin
-
light-dependent, multi-site phosphorylation
-
-
?
ATP + M cone opsin
ADP + phosphorylated M cone opsin
-
light-dependent, multi-site phosphorylation
-
-
?
ATP + M opsin

ADP + phosphorylated m opsin
-
M opsin binds to cone arrestin during cone phototransduction in the retina
-
-
?
ATP + M opsin
ADP + phosphorylated m opsin
-
M opsin binds to cone arrestin during cone phototransduction in the retina
-
-
?
ATP + opsin

ADP + phosphoopsin
-
-
-
?
ATP + opsin
ADP + phosphoopsin
the enzyme is involved in the opsin deactivation process, GRK subtypes play a role in phosphorylating non-visual opsins in the particular extraretinal tissues
-
-
?
ATP + peptide

ADP + phosphopeptide
-
-
-
-
?
ATP + peptide
ADP + phosphopeptide
-
corresponding to the C-terminus and loop 5-6 of opsin, poor substrates, phosphorylates serine and threonine residues in each peptide
-
-
?
ATP + peptide
ADP + phosphopeptide
-
acid-rich peptides, RK prefers acid residues localized to the C-terminal side of the serine
-
-
?
ATP + peptide
ADP + phosphopeptide
-
acidic peptides, stimulated by photolyzed rhodopsin, K-491 of RK participates in substrate binding
-
-
?
ATP + peptide
ADP + phosphopeptide
-
containing sites phosphorylated in rhodopsin
-
-
?
ATP + peptide
ADP + phosphopeptide
-
monophosphorylated
-
-
?
ATP + peptide
ADP + phosphopeptide
-
less amount of phosphoryl group incorporation than of rhodopsin
-
-
?
ATP + peptide
ADP + phosphopeptide
low catalytic efficiency of RK toward a peptide containing its major autophosphorylation site
-
-
?
ATP + rhodopsin

ADP + phosphorhodopsin
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
-
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
the autophosphorylation region of RK is involved in binding of ATP to the catalytic site and may regulate selectivity of the site of phosphorylation
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
regulation of GRK1
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
domain structure, catalytic domain of 270 amino acids in the center of the sequence
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates multiple serine and threonine residues in the C-terminal region of opsin peptide in the sequence 334-343, incorporation of up to 7 phosphates, rate of incorporation of the first phosphates is slower than the rate of formation of more highly phosphorylated species
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates rhodopsin in the disc-membrane
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates rhodopsin in the disc-membrane
-
ir
ATP + rhodopsin
ADP + phosphorhodopsin
highly specific for rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
highly specific for rhodopsin
-
ir
ATP + rhodopsin
ADP + phosphorhodopsin
-
highly specific for rhodopsin
-
ir
ATP + rhodopsin
ADP + phosphorhodopsin
-
specificity of ATP-binding site
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
specificity of ATP-binding site
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
recombinant RK expressed in SF9 cells catalyzes high-gain phosphorylation in which photoactivation of one rhodopsin molecule causes incorporation of up to several hundred phosphates into the total rhodopsin pool
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
recombinant RK expressed in SF9 cells catalyzes high-gain phosphorylation in which photoactivation of one rhodopsin molecule causes incorporation of up to several hundred phosphates into the total rhodopsin pool
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
the interaction of RK-ATP complex with photoactivated rhodopsin leads to the formation, presumably due to the reorganization of the protein structure, of a soluble active kinase species which reverts to the inactive resting state in a time-dependent fashion, the active kinase catalyzes a photoactivated rhodopsin-independent peptide phosphorylation and dark-phosphorylation of rhodopsin, two-step model for enzyme activation and catalysis
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
fully bleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
catalyzes multisite phosphorylation of purified rhodopsin in phospholipid vesicles
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
incorporation of 1.8 mol phosphate/mol of RK
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
only phosphorylates C-terminal sites of rhodopsin, role of the cytoplasmic loops and C-terminal region of rhodopsin in binding and activating enzyme, V-VI loop is crucial for kinase binding, truncated forms of rhodopsin as substrates
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
light-dependent phosphorylation
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
light-dependent phosphorylation
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
light-dependent phosphorylation
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
light-dependent phosphorylation
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
light-dependent phosphorylation
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
light-dependent phosphorylation
-
ir
ATP + rhodopsin
ADP + phosphorhodopsin
-
light-dependent phosphorylation
-
ir
ATP + rhodopsin
ADP + phosphorhodopsin
-
preferred substrate: ATP
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
preferred substrate: ATP
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
preferred substrate: ATP
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
preferred substrate: ATP
-
ir
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates bovine rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates bovine rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates bovine rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates bovine rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates bovine rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates bovine rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates bovine rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates bovine rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates bovine rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates bovine rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates bovine rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates bovine rhodopsin
-
ir
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates bovine rhodopsin
-
ir
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates rhodopsin solubilized in dodecyl maltoside
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
highly specific for photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
highly specific for photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
highly specific for photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
highly specific for photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
highly specific for photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
highly specific for photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
highly specific for photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
highly specific for photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
highly specific for photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
highly specific for photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
highly specific for photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
highly specific for photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
highly specific for photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
preferred substrate: photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
preferred substrate: photobleached rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
preferred substrate: light-activated form of rhodopsin, i.e. metarhodopsin II
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
preferred substrate: light-activated form of rhodopsin, i.e. metarhodopsin II
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
preferred substrate: light-activated form of rhodopsin, i.e. metarhodopsin II
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
preferred substrate: light-activated form of rhodopsin, i.e. metarhodopsin II
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
RK normally exists in an inactive resting state and is only activated following interaction with photoactivated rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
RK normally exists in an inactive resting state and is only activated following interaction with photoactivated rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
blocking of SH- and amino-groups of rhodopsin by chemical modification does not affect phosphorylation, except for succinylated rhodopsin, the binding or recognition site of enzyme contains multiple regions of rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
5-6 mol phosphate/mol rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
RK binds to the cytoplasmic loops of photolyzed rhodopsin, forming a stable complex, and then phosphorylating it at the C-terminus, phosphorylation at different sites, including Ser-334, Ser-338 and Ser342, may play different roles in phototransduction
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
incorporation of 5-7 phosphate groups/mol rhodopsin
-
ir
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates rhodopsin from cattle, rabbit, pig, alligator, best substrate: bovine rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylation sites of photolyzed rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylation sites of photolyzed rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
rhodopsin with multiphosphorylation sites
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
rhodopsin with multiphosphorylation sites
-
ir
ATP + rhodopsin
ADP + phosphorhodopsin
-
effect of bovine rhodopsin mutants with disulfide cross-links between different cytoplasmic regions on the possibility to serve as substrate, only substrate is a rhodopsin mutant containing a disulfide cross-link between Cys-65 and Cys-316
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
substrates: R135K, R135Q, R135A and R135L mutants of bovine rhodopsin, R135A is phosphorylated even in the absence of 11-cis-retinal
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
catalyzes the transfer of the terminal gamma phosphate group of ATP to the opsin protein
-
ir
ATP + rhodopsin
ADP + phosphorhodopsin
high-gain phosphorylation of rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
high-gain phosphorylation of rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
high-gain phosphorylation of rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
high-gain phosphorylation of rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
high-gain phosphorylation of rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
high-gain phosphorylation of rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
phosphorylates serine and threonine residues in the carboxy-terminal region of opsin peptide
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates serine and threonine residues in the carboxy-terminal region of opsin peptide
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylates serine and threonine residues in the carboxy-terminal region of opsin peptide
-
ir
ATP + rhodopsin
ADP + phosphorhodopsin
domain structure
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
domain structure
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
domain structure
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
domain structure
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
phosphorylation of enzyme may represent one of the control mechanisms for rhodopsin phosphorylation
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
specific and Ca2+-dependent recoverin/RK interaction may play an important role in photoreceptor light adaptation
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
RK partially terminates the biochemical events that follow photon absorption
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
deactivation of photoexcited rhodopsin by its phosphorylation by RK, in vivo, since ATP is present, RK exists in an autophosphorylated state
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
major regulatory mechanism for the control of photorhodopsin transduction pathway
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
light-dependent initiating of deactivation of rhodopsin
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
involved in a mechanism for quenching or terminating the visual signal involving the interaction of metarhodopsin II with RK and arrestin, phosphorylation of light-activated rhodopsin by RK is the key step in the signal-termination reaction
-
?
ATP + rhodopsin
ADP + phosphorhodopsin
-
involved in a mechanism for quenching or terminating the visual signal involving the interaction of metarhodopsin II with RK a