3.4.21.5: thrombin

This is an abbreviated version!
For detailed information about thrombin, go to the full flat file.

Word Map on EC 3.4.21.5

3.4.21.5

platelet

anticoagulant

heparin

thrombosis

bleeding

endothelial

artery

thromboplastin

collagen

agonist

thromboembolism

coronary

procoagulant

adp

antithrombotic

venous

fibrinolysis

thrombus

hemorrhage

hemostatic

hirudin

plasminogen

antiplatelet

thrombomodulin

protease-activated

arachidonic

plasmin

thromboxane

intravascular

viii

d-dimers

atrial

thrombocytopenia

aspirin

aptamer

hypercoagulability

willebrand

warfarin

percutaneous

p-selectin

rivaroxaban

platelet-rich

unfractionated

coagulopathy

prothrombotic

embolism

haemostasis

diagnostics

analysis

hemophilia

biotechnology

thrombolytic

nutrition

synthesis

clopidogrel

medicine

Reaction

selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B =

Synonyms

activated factor II, alpha-thrombin, alphaTh, beta-thrombin, blood-coagulation factor II, activated, blood-coagulation factor IIa, clotting factor IIa, EC 3.4.4.13, factor IIa, fibrinogenase, thrombase, thrombin, E, thrombin-C, thrombofort, TLE2, topical, tropostasin

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.5 thrombin

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Results	in table
20	Activating Compound
1007	AA Sequence
51	Application
1	CAS Registry Number
14	Cloned(Commentary)
1	Cofactor
31	Crystallization (Commentary)
28522	Disease/ Diagnostics
6	Expression
43	General Information
2	General Stability
99	IC50 Value
461	Inhibitors
19	kcat/KM [mM/s]
134	Ki Value [mM]
108	KM Value [mM]
11	Localization
27	Metals/Ions
18	Molecular Weight [Da]
116	Natural Substrates/ Products (Substrates)
233	Organism
1062	PDB ID
20	pH Optimum
1	pH Range
1	pH Stability
17	Posttranslational Modification
155	Protein Variants
22	Purification (Commentary)
11	Reaction
1	Reaction Type
233	Reference
1	Renatured (Commentary)
102	Source Tissue
7	Specific Activity [micromol/min/mg]
5	Storage Stability
299	Substrates and Products (Substrate)
12	Subunits
62	Synonyms
19	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
97	Turnover Number [1/s]

KI Value

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KI Value on EC 3.4.21.5 - thrombin

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0.00015

(1R)-2-[(2S)-2-[(3-chlorobenzyl)carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethanaminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00043

(1R)-2-[(2S)-2-[(3-chlorobenzyl)carbamoyl]pyrrolidin-1-yl]-1-cyclopentyl-2-oxoethanaminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00018

(2R)-1-[(2S)-2-[(3-chlorobenzyl)carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-aminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00681

(2R)-1-[(2S)-2-[(3-chlorobenzyl)carbamoyl]pyrrolidin-1-yl]-1-oxobutan-2-aminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.033

(2R)-1-[(2S)-2-[(3-chlorobenzyl)carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-aminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00092

(2R)-1-[(2S)-2-[(3-chlorobenzyl)carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-aminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.0001

(2R)-1-[(2S)-2-[(3-chlorobenzyl)carbamoyl]pyrrolidin-1-yl]-3-cyclohexyl-1-oxopropan-2-aminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00254

(2R)-1-[(2S)-2-[(3-chlorobenzyl)carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-aminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00041

(2R)-1-[(2S)-2-[(3-chlorobenzyl)carbamoyl]pyrrolidin-1-yl]-4,4-dimethyl-1-oxopentan-2-aminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00054

(2R)-1-[(2S)-2-[(3-chlorobenzyl)carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-aminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

1.46

(2S)-1-acetyl-N-(3-chlorobenzyl)pyrrolidine-2-carboxamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.322

(2S)-1-butanoyl-N-(3-chlorobenzyl)pyrrolidine-2-carboxamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.0068

(2S)-1-[(2R)-2-aminobutanoyl]-N-(3-chlorobenzyl)pyrrolidine-2-carboxamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% dimethyl sulfoxide, 0.1% (w/v) PEG 8000, at 25 °C

0.00018

(2S)-1-[(2R)-2-aminobutanoyl]-N-(4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% dimethyl sulfoxide, 0.1% (w/v) PEG 8000, at 25 °C

0.155 - 0.484

(2S)-N-(3-chlorobenzyl)-1-(3-methylbutanoyl)pyrrolidine-2-carboxamide

show

0.0943

(2S)-N-(3-chlorobenzyl)-1-(3-phenylpropanoyl)pyrrolidine-2-carboxamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.109

(2S)-N-(3-chlorobenzyl)-1-(4-methylpentanoyl)pyrrolidine-2-carboxamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.0724

(2S)-N-(3-chlorobenzyl)-1-(cyclopentylacetyl)pyrrolidine-2-carboxamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.444

(2S)-N-(3-chlorobenzyl)-1-propanoylpyrrolidine-2-carboxamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00175

(E)-2-(3-aminophenyl)-N-(3-[[1-(1-benzothiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl]methoxy]phenyl)ethenesulfonamide

-

pH and temperature not specified in the publication

0.0392

(E)-2-(3-chlorophenyl)-N-(3-[[1-(pyridin-3-ylmethyl)-1H-1,2,3-triazol-4-yl]methoxy]phenyl)ethenesulfonamide

-

pH and temperature not specified in the publication

0.0625

(E)-2-(3-nitrophenyl)-N-(3-[[1-(pyridin-3-ylmethyl)-1H-1,2,3-triazol-4-yl]methoxy]phenyl)ethenesulfonamide

-

pH and temperature not specified in the publication

0.00543

(E)-N-(3-[[1-(1,3-benzothiazol-2-ylmethyl)-1H-1,2,3-triazol-4-yl]methoxy]phenyl)-2-(3-chlorophenyl)ethenesulfonamide

-

pH and temperature not specified in the publication

0.0046

(E)-N-(3-[[1-(1,3-benzothiazol-2-ylmethyl)-1H-1,2,3-triazol-4-yl]methoxy]phenyl)-2-(3-nitrophenyl)ethenesulfonamide

-

pH and temperature not specified in the publication

0.00088

(E)-N-(3-[[1-(1-benzothiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl]methoxy]phenyl)-2-(3-chlorophenyl)ethenesulfonamide

-

pH and temperature not specified in the publication

0.00227

(E)-N-(3-[[1-(1-benzothiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl]methoxy]phenyl)-2-(3-fluorophenyl)ethenesulfonamide

-

pH and temperature not specified in the publication

0.00171

(E)-N-(3-[[1-(1-benzothiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl]methoxy]phenyl)-2-(3-nitrophenyl)ethenesulfonamide

-

pH and temperature not specified in the publication

0.00197

(E)-N-(3-[[1-(1-benzothiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl]methoxy]phenyl)-2-[3-(trifluoromethyl)phenyl]ethenesulfonamide

-

pH and temperature not specified in the publication

0.00689

(E)-N-(3-[[1-(1H-indol-2-ylmethyl)-1H-1,2,3-triazol-4-yl]methoxy]phenyl)-2-(3-nitrophenyl)ethenesulfonamide

-

pH and temperature not specified in the publication

0.0137

(E)-N-(3-[[1-(3-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy]phenyl)-2-(3-chlorophenyl)ethenesulfonamide

-

pH and temperature not specified in the publication

0.00891

(E)-N-[3-[(1-benzyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl]-2-(3-chlorophenyl)ethenesulfonamide

-

pH and temperature not specified in the publication

0.0052

(E)-N-[3-[2-(3-chlorobenzyl)-2H-tetrazol-5-yl]phenyl]-2-(3-methylphenyl)ethenesulfonamide

-

pH and temperature not specified in the publication

0.000037

1-[N-[2-(amidino-N'-methylaminooxy)ethyl]amino]carbonylmethyl-6-methyl-3-(2-[4-methylphenyl]ethylamino)pyrazinone

-

-

0.0000017

1-[N-[2-(amidinoaminooxy)ethyl]amino]carbonylmethyl-6-chloro-3-[2,2-difluoro-2-phenylethylamino]pyrazinone

-

-

0.0000023

1-[N-[2-(amidinoaminooxy)ethyl]amino]carbonylmethyl-6-cyano-3-[2,2-difluoro-2-phenylethylamino]pyrazinone

-

-

0.0000068

1-[N-[2-(amidinoaminooxy)ethyl]amino]carbonylmethyl-6-methyl-3-(2,2-diphenylethylamino)pyrazinone

-

-

0.000015

1-[N-[2-(amidinoaminooxy)ethyl]amino]carbonylmethyl-6-methyl-3-(2-[2,4-difluorophenyl]ethylamino)pyrazinone

-

-

0.000047

1-[N-[2-(amidinoaminooxy)ethyl]amino]carbonylmethyl-6-methyl-3-(2-[3,4-difluorophenyl]ethylamino)pyrazinone

-

-

0.000047

1-[N-[2-(amidinoaminooxy)ethyl]amino]carbonylmethyl-6-methyl-3-(2-[4-trifluoromethylphenyl]ethylamino)pyrazinone

-

-

0.000044

1-[N-[2-(amidinoaminooxy)ethyl]amino]carbonylmethyl-6-methyl-3-(2-[5-indanyl]ethylamino)pyrazinone

-

-

0.00012

1-[N-[2-(amidinoaminooxy)ethyl]amino]carbonylmethyl-6-methyl-3-(3,4-dimethoxyphenylethylamino)pyrazinone

-

-

0.000066

1-[N-[2-(amidinoaminooxy)ethyl]amino]carbonylmethyl-6-methyl-3-(4-ethylphenethylamino)pyrazinone

-

-

0.000013

1-[N-[2-(amidinoaminooxy)ethyl]amino]carbonylmethyl-6-methyl-3-(4-fluorophenethylamino)pyrazinone

-

-

0.000011

1-[N-[2-(amidinoaminooxy)ethyl]amino]carbonylmethyl-6-methyl-3-(4-methoxyphenethylamino)pyrazinone

-

-

0.0000013

1-[N-[2-(amidinoaminooxy)ethyl]amino]carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone

-

-

0.000012

1-[N-[2-(amidinoaminooxy)ethyl]amino]carbonylmethyl-6-methyl-3-[2-(1-naphthalene)ethyl]aminopyrazinone

-

-

0.00808

2-[(2S)-2-[(3-chlorobenzyl)carbamoyl]pyrrolidin-1-yl]-2-oxoethanaminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.0000026

3-(benzyl(2-(4-carbamimidoylbenzyl)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino)-3-oxopropanoic acid

-

-

0.0000065

3-(benzyl(2-(4-carbamimidoylbenzyl)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino)-4-oxobutanoic acid

-

-

0.00062

4-amidinophenylpyruvate

-

0.1

4-nitrophenyl 2-propyl methylphosphonate

-

IC50 above 0.1 mM, at pH 7.0 in 0.05 M phosphate buffer and 0.15 M NaCl at 25°C

0.00094

amino[4-([[1-(3,3-dimethylbutanoyl)-L-prolyl]amino]methyl)phenyl]methaniminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00117

amino[4-([[1-(3-cyclohexylpropanoyl)-L-prolyl]amino]methyl)phenyl]methaniminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00118

amino[4-([[1-(3-cyclopentylpropanoyl)-L-prolyl]amino]methyl)phenyl]methaniminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00381

amino[4-([[1-(3-methylbutanoyl)-L-prolyl]amino]methyl)phenyl]methaniminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00075

amino[4-([[1-(3-phenylpropanoyl)-L-prolyl]amino]methyl)phenyl]methaniminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00128

amino[4-([[1-(4-methylpentanoyl)-L-prolyl]amino]methyl)phenyl]methaniminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00361

amino[4-([[1-(cyclohexylacetyl)-L-prolyl]amino]methyl)phenyl]methaniminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00164

amino[4-([[1-(cyclopentylacetyl)-L-prolyl]amino]methyl)phenyl]methaniminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.0057

amino[4-[([[(2S)-1-butanoylpyrrolidin-2-yl]carbonyl]amino)methyl]phenyl]methaniminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.039

amino[4-[([[(2S)-1-propanoylpyrrolidin-2-yl]carbonyl]amino)methyl]phenyl]methaniminium chloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.0000014

antithrombin III

-

pH 7.4, 37°C

-

0.0000064

argatroban

-

pH 7.4, 37°C

98

Aspartame

-

pH 7.4, 37°C

0.0003

benzamidine

-

0.000047

beta-phenyl-D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% dimethyl sulfoxide, 0.1% (w/v) PEG 8000, at 25 °C

0.0000001

beta-phenyl-D-phenylalanyl-N-(4-carbamimidoylbenzyl)-L-prolinamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% dimethyl sulfoxide, 0.1% (w/v) PEG 8000, at 25 °C

0.00000175

bivalirudin

-

pH 7.4, 37°C

0.000003

CH-248

-

pH 7.4, 25°C

0.00018

D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% dimethyl sulfoxide, 0.1% (w/v) PEG 8000, at 25 °C

0.000004

D-phenylalanyl-N-(4-carbamimidoylbenzyl)-L-prolinamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% dimethyl sulfoxide, 0.1% (w/v) PEG 8000, at 25 °C

0.0000045

dabigatran

-

-

0.0000000000493

dipetalogastin II

-

pH 8.0, 37°C

-

0.000000000446

dipetarudin

-

pH 8.0, 37°C

-

0.0000022

DV23

-

pH and temperature not specified in the publication, after no preincubation time

0.0000006

DV23K10R

-

pH and temperature not specified in the publication, after no preincubation time

0.00000031

DV24

-

pH and temperature not specified in the publication, after no preincubation time

0.0000032

DV24H12A

-

pH and temperature not specified in the publication, after no preincubation time

0.00000004 - 0.00000026

DV24K10RY

show

0.00000033

DV24Yphos

-

pH and temperature not specified in the publication, after no preincubation time

0.00000006

DV24Ysulf

-

pH and temperature not specified in the publication, after no preincubation time

0.00000032

EP21

-

pH and temperature not specified in the publication, after no preincubation time

0.00000037

EP25

-

pH and temperature not specified in the publication, after no preincubation time

0.00000031

EP25A22E

-

pH and temperature not specified in the publication, after no preincubation time

0.0000036

ethyl 2-(benzyl(2-(4-carbamimidoylbenzyl)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino)-2-oxoacetate

-

-

0.0088

glycoprotein Ibalpha(1-282) peptide

-

pH 8.0, 25°C

-

0.054

glycoprotein Ibalpha(268-282) peptide

-

pH 8.0, 25°C

-

0.027

GPRP

-

pH 7.4, 37°C

0.000025

HD22

-

pH 8.0, 25°C

-

0.00265

heparin

-

pH 7.4, 37°C

0.000000000237

Hirudin

-

pH 8.0, 37°C

-

0.0015

hirugen

-

pH 7.4, 37°C

-

0.0000023

hirulog-1

-

pH and temperature not specified in the publication, after no preincubation time

0.000000000125

inhibitor from Dipetalogaster maximus

-

pH 8.0, 25°C

-

0.0000043

inogatran

-

pH 7.4, 25°C

0.000024

L-Phe-L-Pro-L-Arg-chloromethylketone

-

at pH 7.0 in 0.05 M phosphate buffer and 0.15 M NaCl at 25°C

0.0000013

melagatran

-

pH 7.4, 25°C

0.0000149

MH18

-

pH and temperature not specified in the publication, after no preincubation time

0.000329

MH18H12A

-

pH and temperature not specified in the publication, after no preincubation time

0.00000125

MH18Ysulf

-

pH and temperature not specified in the publication, after no preincubation time

0.0000141

MH22

-

pH and temperature not specified in the publication, after no preincubation time

0.0000151

MH22A22E

-

pH and temperature not specified in the publication, after no preincubation time

0.0297

N-(3-chlorobenzyl)-1-(3-cyclohexylpropanoyl)-L-prolinamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.0929

N-(3-chlorobenzyl)-1-(3-cyclopentylpropanoyl)-L-prolinamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.0345

N-(3-chlorobenzyl)-1-(cyclohexylacetyl)-L-prolinamide

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00000066 - 0.0000021

N-alpha-(2-naphthylsulfonyl-glycyl)-4-amidinophenylalanine-piperidine

show

0.000023

N-[4-[amino(iminio)methyl]benzyl]-1-[(2R)-2-ammonio-2-cyclohexylacetyl]-L-prolinamide dichloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00015

N-[4-[amino(iminio)methyl]benzyl]-1-[(2R)-2-ammonio-3,3-dimethylbutanoyl]-L-prolinamide dichloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00007

N-[4-[amino(iminio)methyl]benzyl]-1-[(2R)-2-ammonio-3-methylbutanoyl]-L-prolinamide dichloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.000004

N-[4-[amino(iminio)methyl]benzyl]-1-[(2R)-2-ammonio-3-phenylpropanoyl]-L-prolinamide dichloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.000011

N-[4-[amino(iminio)methyl]benzyl]-1-[(2R)-2-ammonio-4,4-dimethylpentanoyl]-L-prolinamide dichloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00002

N-[4-[amino(iminio)methyl]benzyl]-1-[(2R)-2-ammonio-4-methylpentanoyl]-L-prolinamide dichloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00018

N-[4-[amino(iminio)methyl]benzyl]-1-[(2R)-2-ammoniobutanoyl]-L-prolinamide dichloride

-

in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.1

paraoxon

-

IC50 above 0.1 mM, at pH 7.0 in 0.05 M phosphate buffer and 0.15 M NaCl at 25°C

0.0000208

Phe-Pro-Arg-chloromethyl ketone

-

pH 7.4, 37°C

0.00000000000014

RWJ-50353

-

-

0.0000000000011

RWJ-51438

-

-

0.0000728

thrombin inhibitor from Naja haje

-

in 10 mM imidazole buffer (pH 7.4), at 37°C

-

0.00001

Toggle-25 t

-

pH 7.4, 37°C

-

0.00000032

variegin

-

synthetic molecule, pH and temperature not specified in the publication, after no preincubation time

0.0561

[4-[([[(2S)-1-acetylpyrrolidin-2-yl]carbonyl]amino)methyl]phenyl](amino)methaniminium chloride

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in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

0.00142

[amino(4-[[([(2S)-1-[(2R)-2-ammoniopropanoyl]pyrrolidin-2-yl]carbonyl)amino]methyl]phenyl)methylidene]ammonium dichloride

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in 50 mM Tris-HCl, pH 7.4, 154 mM NaCl, 5% (v/v) DMSO, 0.1% (w/v) PEG 8000, at 25°C

additional information

additional information

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Release 2023.1 (January 2023)