Application | Comment | Organism |
---|---|---|
medicine | enzyme is a target for development of inhibitors in antithrombotic therapy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dipetalogastin II | strong inhibitor, fron the assassin bug Dipetalogaster maximus | Homo sapiens | |
dipetarudin | cloning and purification of the chimeric inhibitor composed of the N-terminal head structure of dipetalogastin II and the exosite 1 blcking segment of hirudin, connected through a five glycine linker, MW 7560 | Homo sapiens | |
Hirudin | blocks exosite 1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B | serine protease | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O | i.e. S2238, synthetic chromogenic substrate | Homo sapiens | D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-thrombin | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000000000493 | - |
dipetalogastin II | pH 8.0, 37°C | Homo sapiens | |
0.000000000237 | - |
Hirudin | pH 8.0, 37°C | Homo sapiens | |
0.000000000446 | - |
dipetarudin | pH 8.0, 37°C | Homo sapiens |