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3.4.21.5: thrombin

This is an abbreviated version!
For detailed information about thrombin, go to the full flat file.

Word Map on EC 3.4.21.5

Reaction

selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B =

Synonyms

activated factor II, alpha-thrombin, alphaTh, beta-thrombin, blood-coagulation factor II, activated, blood-coagulation factor IIa, clotting factor IIa, EC 3.4.4.13, factor IIa, fibrinogenase, thrombase, thrombin, E, thrombin-C, thrombofort, TLE2, topical, tropostasin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.5 thrombin

KCat KM Value

KCat KM Value on EC 3.4.21.5 - thrombin

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
8800 - 51000
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide
900 - 1900
di-L-Glu-L-Pro-L-Arg-4-nitroanilide
1000
Fc-[RFSRPQL]-PEG
-
-
3 - 7.43
fibrinogen
-
3 - 7.43
protease-activated receptor 1
-
3 - 7.43
Protein kinase C
-
14300 - 22700
tosyl-Gly-Pro-Arg-4-nitroanilide