3.4.21.5: thrombin
This is an abbreviated version!
For detailed information about thrombin, go to the full flat file.
Word Map on EC 3.4.21.5
-
3.4.21.5
-
platelet
-
anticoagulant
-
heparin
-
thrombosis
-
bleeding
-
endothelial
-
artery
-
thromboplastin
-
collagen
-
agonist
-
thromboembolism
-
coronary
-
procoagulant
-
adp
-
antithrombotic
-
venous
-
fibrinolysis
-
thrombus
-
hemorrhage
-
hemostatic
-
hirudin
-
plasminogen
-
antiplatelet
-
thrombomodulin
-
protease-activated
-
arachidonic
-
plasmin
-
thromboxane
-
intravascular
-
viii
-
d-dimers
-
atrial
-
thrombocytopenia
-
aspirin
-
aptamer
-
hypercoagulability
-
willebrand
-
warfarin
-
percutaneous
-
p-selectin
-
rivaroxaban
-
platelet-rich
-
unfractionated
-
coagulopathy
-
prothrombotic
-
embolism
-
haemostasis
-
diagnostics
-
analysis
-
hemophilia
-
biotechnology
-
thrombolytic
-
nutrition
-
synthesis
-
clopidogrel
-
medicine
- 3.4.21.5
- platelet
-
anticoagulant
- heparin
- thrombosis
- bleeding
- endothelial
- artery
- thromboplastin
- collagen
- agonist
- thromboembolism
- coronary
-
procoagulant
- adp
-
antithrombotic
- venous
-
fibrinolysis
- thrombus
- hemorrhage
-
hemostatic
- hirudin
- plasminogen
-
antiplatelet
- thrombomodulin
-
protease-activated
-
arachidonic
- plasmin
-
thromboxane
-
intravascular
- viii
-
d-dimers
- atrial
- thrombocytopenia
- aspirin
- aptamer
- hypercoagulability
- willebrand
- warfarin
-
percutaneous
-
p-selectin
- rivaroxaban
-
platelet-rich
-
unfractionated
- coagulopathy
-
prothrombotic
- embolism
-
haemostasis
- diagnostics
- analysis
- hemophilia
- biotechnology
-
thrombolytic
- nutrition
- synthesis
- clopidogrel
- medicine
Reaction
selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B =
Synonyms
activated factor II, alpha-thrombin, alphaTh, beta-thrombin, blood-coagulation factor II, activated, blood-coagulation factor IIa, clotting factor IIa, EC 3.4.4.13, factor IIa, fibrinogenase, thrombase, thrombin, E, thrombin-C, thrombofort, TLE2, topical, tropostasin
ECTree
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IC50 Value
IC50 Value on EC 3.4.21.5 - thrombin
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0.4
(2S)-1-(1,3-benzodioxol-5-ylacetyl)-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.4
(2S)-1-(cyclohexylacetyl)-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.4
(2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]-N-methylpyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.12
(2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]-N-propylpyrrolidine-2-carboxamide
Homo sapiens
-
at 37°C
0.4
(2S)-1-[(2R)-2-amino-3-(1,3-benzodioxol-5-yl)propanoyl]-N-methylpyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.4
(2S)-1-[(2R)-2-amino-3-(1,3-benzodioxol-5-yl)propanoyl]-N-propylpyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.013
(2S)-1-[(2R)-2-amino-3-(4-chlorophenyl)propanoyl]-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide
Homo sapiens
-
at 37°C
0.21
(2S)-1-[(2R)-2-amino-3-(4-chlorophenyl)propanoyl]-N-propylpyrrolidine-2-carboxamide
Homo sapiens
-
at 37°C
0.4
(2S)-1-[(2R)-2-amino-3-cyclohexylpropanoyl]-N-methylpyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.4
(2S)-1-[(2R)-2-cyclohexyl-2-hydroxyacetyl]-N-(2-methoxyethyl)pyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.4
(2S)-1-[3-(4-chlorophenyl)propanoyl]-N-(2-methoxyethyl)pyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.4
(2S)-1-[3-(4-chlorophenyl)propanoyl]-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.4
(2S)-1-[3-(4-chlorophenyl)propanoyl]-N-propylpyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.23
1-(2-amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid isobutyl-amide
Homo sapiens
-
at 37°C
0.17
1-(2-cyclohexyl-2-phenylmethanesulfonylamino-acetyl)-pyrrolidine-2-carboxylic acid methylamide
Homo sapiens
-
at 37°C
0.4
1-[(2R)-2-amino-2-cyclohexylacetyl]-N-(2-methoxyethyl)-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.02
1-[(2R)-2-amino-2-cyclohexylacetyl]-N-(cyclohexylmethyl)-L-prolinamide
Homo sapiens
-
at 37°C
0.0042
1-[(2R)-2-amino-2-cyclohexylacetyl]-N-(thiophen-2-ylmethyl)-L-prolinamide
Homo sapiens
-
at 37°C
0.4
1-[(2R)-2-amino-4,4-diphenylbutanoyl]-N-(2-methoxyethyl)-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.4
1-[(2R)-2-amino-4,4-diphenylbutanoyl]-N-propyl-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.049
1-[(9-hydroxy-9H-fluoren-9-yl)acetyl]-N-(thiophen-2-ylmethyl)-L-prolinamide
Homo sapiens
-
at 37°C
0.4
3-(1,3-benzodioxol-5-yl)-D-alanyl-N-(2-methoxyethyl)-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.4
3-(9-hydroxy-9H-fluoren-9-yl)-D-alanyl-N-(2-methoxyethyl)-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.4
3-(9-hydroxy-9H-fluoren-9-yl)-D-alanyl-N-methyl-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.4
3-cyclohexyl-D-alanyl-N-(2-methoxyethyl)-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.4
4-chloro-D-phenylalanyl-N-(2-methoxyethyl)-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37°C
0.0016
beta-phenyl-D-phenylalanyl-N-(thiophen-2-ylmethyl)-L-prolinamide
Homo sapiens
-
at 37°C
0.00429
glycosaminoglycan AD4, glycosaminoglycan AD9, glycosaminoglycan AE11
Bos taurus
-
IC50 above 0.00429 mM
-
0.052
kaempferol 3-O-(2'',4''-di-(E)-p-coumaroyl)-rhamnoside
Bos taurus
-
pH and temperature not specified in the publication
0.083
kaempferol 3-O-(2''-p-coumaroyl)-rhamnoside
Bos taurus
-
pH and temperature not specified in the publication
0.307
N-(4-carbamimidoylbenzyl)-2-(1-[[(4-chloro-2-methoxyphenyl)sulfonyl]amino]-4-methyl-2-oxo-1,2-dihydropyridin-3-yl)acetamide
Homo sapiens
-
-
0.092
N-(4-carbamimidoylbenzyl)-2-(1-[[2-(2,5-dimethylphenyl)ethyl]amino]-4-methyl-2-oxo-1,2-dihydropyridin-3-yl)acetamide
Homo sapiens
-
-
0.023
N-(4-carbamimidoylbenzyl)-2-(4-methyl-1-[[2-(2-methylphenyl)ethyl]amino]-2-oxo-1,2-dihydropyridin-3-yl)acetamide
Homo sapiens
-
-
0.091
N-(4-carbamimidoylbenzyl)-2-[4-methyl-2-oxo-1-[(2-phenylethyl)amino]-1,2-dihydropyridin-3-yl]acetamide
Homo sapiens
-
-
0.0000002
thrombin inhibitor from Naja haje
Bos taurus
-
in 10 mM imidazole buffer (pH 7.4), at 37°C
-
0.0000454
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.0000778
DV23
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.0000129
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.000102
DV23K10R
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.0000075
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.0000101
DV24
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.0000482
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.000141
DV24H12A
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.0000014
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.0000017
DV24K10RY
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.0000046
DV24K10RY
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.0000078
DV24K10RY
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.000007
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.000012
DV24K10RYphos
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.0000087
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.0000124
DV24Yphos
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.0000017
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.000002
DV24Ysulf
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.0000162
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.000177
EP21
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.0000131
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.000173
EP25
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.0000135
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.000124
EP25A22E
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.0000726
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.000102
hirulog-1
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.0000109
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.0000117
MH18
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.000328
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.000343
MH18H12A
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.0000012
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.0000013
MH18Ysulf
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.0000115
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.0000123
MH22
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.0000136
Homo sapiens
-
pH and temperature not specified in the publication, after no preincubation time
0.0000156
MH22A22E
Homo sapiens
-
pH and temperature not specified in the publication, after 20 min preincubation
0.00000825
Homo sapiens
-
synthetic molecule, pH and temperature not specified in the publication, after no preincubation time
0.0000104
variegin
Homo sapiens
-
synthetic molecule, pH and temperature not specified in the publication, after 20 min preincubation