Protein Variants | Comment | Organism |
---|---|---|
additional information | fusion of the N-terminal acidic extension, residues 1-75, of heparin cofactor II to alpha1-proteinase inhibitor M358R to the enzyme specifically increases the rate of thrombin inhibition by 6fold, the mutant is termed HAPI M358R, maximal enhancement of alpha1-PI M358R activity requires the acidic residues between HCII residues 55 and 75, because no enhancement is observed either by fusion of residues 1-54 alone or by fusion of a mutated HCII acidic extension in which all Glu and Asp residues between positions 55 and 75 are neutralized by mutation, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
heparin cofactor II | HCII, i.e. alpha1-antitrypsin, a serpin cofactor, contains a unique N-terminal extension that binds thrombin exosite 1, the mutant M358R is more active in inhibition of thrombin than the wild-type protein, maximal enhancement of alpha1-PI M358R activity requires the acidic residues between HCII residues 55 and 75 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
alpha-thrombin | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Homo sapiens |