Information on EC 6.1.1.19 - Arginine-tRNA ligase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
6.1.1.19
-
RECOMMENDED NAME
GeneOntology No.
Arginine-tRNA ligase
PATHWAY
KEGG Link
MetaCyc Link
Aminoacyl-tRNA biosynthesis
-
tRNA charging
-
SYSTEMATIC NAME
IUBMB Comments
L-Arginine:tRNAArg ligase (AMP-forming)
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Arg-tRNA synthetase
O59147
-
Arginine translase
-
-
-
-
Arginine--tRNA ligase
-
-
-
-
Arginine-tRNA synthetase
-
-
-
-
Arginyl transfer ribonucleic acid synthetase
-
-
-
-
Arginyl-transfer RNA synthetase
-
-
-
-
Arginyl-tRNA synthetase
-
-
-
-
Arginyl-tRNA synthetase
Q19825
-
Arginyl-tRNA synthetase
B2G3G6
-
Arginyl-tRNA synthetase
-
-
Arginyl-tRNA synthetase
B6ETP1
-
Arginyl-tRNA synthetase
-
-
Arginyl-tRNA synthetase
-
-
Arginyl-tRNA synthetase
Q5Y930
-
Arginyl-tRNA synthetase
Oenococcus oeni IOEB 8406
Q5Y930
-
-
arginyl–tRNA synthetase
-
-
arginyl–tRNA synthetase
Escherichia coli MRE600
-
-
-
arginyl–tRNA synthetase
-
-
ArgRS
-
-
-
-
ArgRS
Escherichia coli MRE600
-
-
-
ArgRS
O59147
-
ArgS2
Q5Y930
-
ArgS2
Oenococcus oeni IOEB 8406
Q5Y930
-
-
RARS2
-
-
Synthetase, arginyl-transfer ribonucleate
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
37205-35-9
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
gene argS
UniProt
Manually annotated by BRENDA team
2 mutant enzymes with reduced affinity for Arg, a mutant with reduced affinity for arginine-tRNAArg and reduced aminoacylation in vivo for two of the five isoaccepting species of tRNAArg
-
-
Manually annotated by BRENDA team
strain AB1132 and NP2, two enzyme forms
-
-
Manually annotated by BRENDA team
strain B
-
-
Manually annotated by BRENDA team
strain K12
-
-
Manually annotated by BRENDA team
strain K12; strain K12 mutant argS MA5002
-
-
Manually annotated by BRENDA team
strain MRE600
-
-
Manually annotated by BRENDA team
Escherichia coli AB1132
strain AB1132 and NP2, two enzyme forms
-
-
Manually annotated by BRENDA team
Escherichia coli K12
strain K12
-
-
Manually annotated by BRENDA team
Escherichia coli K12
strain K12; strain K12 mutant argS MA5002
-
-
Manually annotated by BRENDA team
Escherichia coli MRE600
strain MRE600
-
-
Manually annotated by BRENDA team
Geobacillus stearothermophilus NCA 1518
strain NCA 1518
-
-
Manually annotated by BRENDA team
strain SN2
-
-
Manually annotated by BRENDA team
Mycobacterium smegmatis SN2
strain SN2
-
-
Manually annotated by BRENDA team
strain IOEB 8406
TrEMBL
Manually annotated by BRENDA team
Oenococcus oeni IOEB 8406
strain IOEB 8406
TrEMBL
Manually annotated by BRENDA team
enzyme exists as a high MW component of the multienzyme aminoacyl-tRNA synthetase complex and a low MW free enzyme
-
-
Manually annotated by BRENDA team
enzyme exists as a 72000 MW component of the multienzyme aminoacyl-tRNA synthetase complex or as 60000 MW free enzyme form
-
-
Manually annotated by BRENDA team
Saccharomyces carlsbergensis 836
strain 836
-
-
Manually annotated by BRENDA team
Saccharomyces carlsbergensis C836
strain C836
-
-
Manually annotated by BRENDA team
IC50 VALUE [mM]
IC50 VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.5
9.5
B2G3G6, -
activity range, pH-profile, overview
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
35
-
-
35°C: about 50% of maximal activity, 70°C: rapid drop of activity above
additional information
-
-
Arg and tRNA show synergistic protection at Arg concentrations of 0.1 mM or more, the presence of ATP is absolutely required to induce synergistic protection at lower Arg concentrations; tRNA protects from heat inactivation above 1 mg/ml
PDB
SCOP
CATH
ORGANISM
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Escherichia coli (strain K12)
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)