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2-imidazolidone-4-carboxylate + ATP + H2O
2-imidazolidone + ADP + phosphate
2-imidazoline-4-carboxylate + ATP + H2O
2-imidazoline-4-carboxylate + ADP + phosphate
-
does not undergo ring cleavage, but stimulates formation of inorganic phosphate from ATP
-
-
?
2-imidazolinone-4-carboxylate + H2O
?
-
-
-
-
?
2-oxo-5,5-dimethylthiazolidine-4-carboxylate + H2O
?
-
-
-
-
?
2-piperidone-6-carboxylate + ATP + H2O
2-aminoadipate + phosphate + ADP
2-thiazolinone-4-carboxylate + H2O
?
-
-
-
-
?
3-methyl-5-oxoproline + H2O
2-amino-3-methylpentanedioic acid
-
-
-
-
?
3-oxy-5-oxoproline + H2O
3-oxyglutamate + phosphate
4-methyl-5-oxoproline + H2O
2-amino-4-methylpentanedioic acid
-
-
-
-
?
4-oxy-5-oxoproline + H2O
4-oxyglutamate + phosphate
5'-p-fluorosulfonylbenzoyladenosine + H2O
?
-
-
-
-
?
5'-p-fluorosulfonylbenzoylinosine + H2O
?
-
-
-
-
?
5-oxo-L-proline + ATP + 2 H2O
L-glutamate + phosphate + ADP
-
assay at pH 7.2, 5 mM substrate, 4°C, 20 min
-
-
?
5-oxo-L-proline + ATP + H2O
L-glutamate + ADP + phosphate
assay at 30°C, pH 9.5, reaction stopped by 20 microl acetic acid and heating for 5 min at 100°C
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
alpha-hydroxyglutarate lactone + H2O
?
-
-
-
-
?
ATP + 5-oxo-L-proline + 2 H2O
ADP + phosphate + L-glutamate
-
-
-
?
DL-2-oxo-3,3-dimethylthiazolidine-4-carboxylate + H2O
?
-
-
-
-
?
DL-cis-2-oxo-5-methyloxazolidine-4-carboxylate + H2O
DL-threonine + ADP + phosphate
-
-
-
-
?
L-2-iminothiazolidine-4-carboxylate + H2O
L-cystine
-
-
-
-
?
L-2-oxooxazolidine-4-carboxylate + H2O + ATP
L-serine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
L-dihydroorotate + H2O
?
-
do not undergo ring cleavage, but stimulates formation of inorganic phosphate from ATP
-
-
?
L-trans-2-oxo-5-methyloxazolidine-4-carboxylate + H2O
L-threonine + ADP + phosphate
-
-
-
-
?
XTP + H2O
?
-
less than 5% of the activity observed with ATP
-
-
?
additional information
?
-
2-imidazolidone-4-carboxylate + ATP + H2O

2-imidazolidone + ADP + phosphate
-
-
-
-
?
2-imidazolidone-4-carboxylate + ATP + H2O
2-imidazolidone + ADP + phosphate
-
promotes enzymatic hydrolysis of ATP but is not itself hydrolyzed
-
-
?
2-piperidone-6-carboxylate + ATP + H2O

2-aminoadipate + phosphate + ADP
-
-
-
-
?
2-piperidone-6-carboxylate + ATP + H2O
2-aminoadipate + phosphate + ADP
-
-
-
?
3-oxy-5-oxoproline + H2O

3-oxyglutamate + phosphate
-
-
-
-
?
3-oxy-5-oxoproline + H2O
3-oxyglutamate + phosphate
-
-
-
?
4-oxy-5-oxoproline + H2O

4-oxyglutamate + phosphate
-
-
-
-
?
4-oxy-5-oxoproline + H2O
4-oxyglutamate + phosphate
-
-
-
?
5-oxo-L-proline + H2O + ATP

L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
component F8 + component beta5
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
209370, 209371, 209373, 209374, 209375, 209376, 209377, 209378, 209379, 209380, 209381, 209382, 209383, 209384, 209385, 209386, 209387 -
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
ir
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
conversion essentially irreversible, very slow reversal can be shown by measurement of ATP formation in presence of high glutamate concentrations
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
conversion essentially irreversible, very slow reversal can be shown by measurement of ATP formation in presence of high glutamate concentrations
-
-
ir
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
ATP is required
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
ATP + H2O

?
-
-
-
-
?
CTP + H2O

?
-
less than 5% of the activity observed with ATP
-
-
?
CTP + H2O
?
-
less than 5% of the activity observed with ATP
-
-
?
dATP + H2O

?
-
-
-
-
?
GTP + H2O

?
-
less than 5% of the activity observed with ATP
-
-
?
GTP + H2O
?
-
less than 5% of the activity observed with ATP
-
-
?
ITP + H2O

?
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP

L-cysteine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
-
-
-
-
?
MgATP2- + H2O

?
-
-
-
-
-
MgATP2- + H2O
?
-
component beta5
-
-
?
MgATP2- + H2O
?
-
-
-
-
-
MgATP2- + H2O
?
-
-
-
-
?
MgATP2- + H2O
?
-
-
-
-
-
UTP + H2O

?
-
less than 5% of the activity observed with ATP
-
-
?
UTP + H2O
?
-
less than 5% of the activity observed with ATP
-
-
?
additional information

?
-
-
CTP, TTP and UTP are no substrates
-
-
-
additional information
?
-
-
CTP, TTP and UTP are no substrates
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
no activity observed with 5-oxo-D-proline
-
-
-
additional information
?
-
-
no activity observed with 5-oxo-D-proline
-
-
-
additional information
?
-
-
no activity observed with 5-oxo-D-proline
-
-
-
additional information
?
-
-
L-thioproline is no substrate
-
-
-
additional information
?
-
-
5-oxo-D-proline, 2-pyrrolidone-4-carboxylate, N-methyl-5-oxo-L-proline and N-acetyl-L-alanine are no substrates
-
-
-
additional information
?
-
-
L-proline, 2-pyrrolidone, N-methyl-5-oxo-L-proline, DL-piperidine-2-carboxylic acid and cyclohexanone-3-carboxylic acid are no substrates
-
-
-
additional information
?
-
-
L-proline, 2-pyrrolidone, N-methyl-5-oxo-L-proline, DL-piperidine-2-carboxylic acid and cyclohexanone-3-carboxylic acid are no substrates
-
-
-
additional information
?
-
-
CTP and UTP are poor substrates
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
ATP + 5-oxo-L-proline + 2 H2O
ADP + phosphate + L-glutamate
O14841
-
-
-
?
5-oxo-L-proline + H2O + ATP

L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
209370, 209373, 209375, 209376, 209378, 209379, 209380, 209381, 209382, 209383, 209384, 209385, 209386, 209387 -
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
P97608
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
conversion essentially irreversible, very slow reversal can be shown by measurement of ATP formation in presence of high glutamate concentrations
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
conversion essentially irreversible, very slow reversal can be shown by measurement of ATP formation in presence of high glutamate concentrations
-
-
ir
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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5-oxoprolinase (atp-hydrolysing) deficiency
5-Oxoprolinase deficiency associated with severe psychomotor developmental delay, failure to thrive, microcephaly and microcytic anaemia.
5-oxoprolinase (atp-hydrolysing) deficiency
5-Oxoprolinase deficiency: report of the first human OPLAH mutation.
5-oxoprolinase (atp-hydrolysing) deficiency
5-Oxoprolinuria associated with 5-oxoprolinase deficiency; further evidence that this is a benign disorder.
5-oxoprolinase (atp-hydrolysing) deficiency
5-oxoprolinuria due to hereditary 5-oxoprolinase deficiency in two brothers--a new inborn error of the gamma-glutamyl cycle.
5-oxoprolinase (atp-hydrolysing) deficiency
5-Oxoprolinuria in Heterozygous Patients for 5-Oxoprolinase (OPLAH) Missense Changes.
5-oxoprolinase (atp-hydrolysing) deficiency
5-Oxoprolinuria in patients with and without defects in the gamma-glutamyl cycle.
5-oxoprolinase (atp-hydrolysing) deficiency
A newborn infant with generalized glutathione synthetase deficiency.
5-oxoprolinase (atp-hydrolysing) deficiency
Clinical, biochemical, and molecular characterization of patients with glutathione synthetase deficiency.
5-oxoprolinase (atp-hydrolysing) deficiency
Coma, metabolic acidosis, and methemoglobinemia in a patient with acetaminophen toxicity.
5-oxoprolinase (atp-hydrolysing) deficiency
Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies.
5-oxoprolinase (atp-hydrolysing) deficiency
Growth failure, encephalopathy, and endocrine dysfunctions in two siblings, one with 5-oxoprolinase deficiency.
5-oxoprolinase (atp-hydrolysing) deficiency
Inborn errors in the metabolism of glutathione.
5-oxoprolinase (atp-hydrolysing) deficiency
New insights into the genetics of 5-oxoprolinase deficiency and further evidence that it is a benign biochemical condition.
5-oxoprolinase (atp-hydrolysing) deficiency
Patients with genetic defects in the gamma-glutamyl cycle.
5-oxoprolinase (atp-hydrolysing) deficiency
Pyroglutamic acid-induced metabolic acidosis: a case report.
5-oxoprolinase (atp-hydrolysing) deficiency
Unravelling 5-oxoprolinuria (pyroglutamic aciduria) due to bi-allelic OPLAH mutations: 20 new mutations in 14 families.
5-oxoprolinase (atp-hydrolysing) deficiency
[5-Oxoprolinase deficiency]
Acidosis
Transient 5-oxoprolinuria (pyroglutamic aciduria) with systemic acidosis in an adult receiving antibiotic therapy.
Anemia
5-Oxoprolinase deficiency associated with severe psychomotor developmental delay, failure to thrive, microcephaly and microcytic anaemia.
Anemia, Hemolytic
Patients with genetic defects in the gamma-glutamyl cycle.
Anemia, Hemolytic
Unravelling 5-oxoprolinuria (pyroglutamic aciduria) due to bi-allelic OPLAH mutations: 20 new mutations in 14 families.
Brain Diseases
Growth failure, encephalopathy, and endocrine dysfunctions in two siblings, one with 5-oxoprolinase deficiency.
Breast Neoplasms
Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model.
Drug-Related Side Effects and Adverse Reactions
Potential for selective modulation of glutathione in cancer chemotherapy.
gamma-glutamyltransferase deficiency
Patients with genetic defects in the gamma-glutamyl cycle.
glutathione synthase deficiency
5-Oxoprolinuria in patients with and without defects in the gamma-glutamyl cycle.
glutathione synthase deficiency
A newborn infant with generalized glutathione synthetase deficiency.
glutathione synthase deficiency
Clinical, biochemical, and molecular characterization of patients with glutathione synthetase deficiency.
glutathione synthase deficiency
Patients with genetic defects in the gamma-glutamyl cycle.
glutathione synthase deficiency
Pyroglutamic aciduria (5-oxoprolinuria) without glutathione synthetase deficiency and with decreased pyroglutamate hydrolase activity.
glutathione synthase deficiency
Unravelling 5-oxoprolinuria (pyroglutamic aciduria) due to bi-allelic OPLAH mutations: 20 new mutations in 14 families.
Malnutrition
Pyroglutamic acid-induced metabolic acidosis: a case report.
membrane dipeptidase deficiency
Inborn errors in the metabolism of glutathione.
Microcephaly
5-Oxoprolinase deficiency associated with severe psychomotor developmental delay, failure to thrive, microcephaly and microcytic anaemia.
Neoplasms
Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues.
Neoplasms
Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathione.
Neoplasms
Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model.
Neoplasms
Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.
Neoplasms
Modulation of glutathione by a cysteine pro-drug enhances in vivo tumor response.
Neoplasms
Selective glutathione repletion with oral oxothiazolidine carboxylate (OTZ) in the radiated tumor-bearing rat.
Neoplasms
Sensitization effect of L-2-oxothiazolidine-4-carboxylate on tumor cells to melphalan and the role of 5-oxo-L-prolinase in glutathione modulation in tumor cells.
Sepsis
Pyroglutamic acid-induced metabolic acidosis: a case report.
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Hsu, T.; Meister, A.
Metabolism in vivo of 5-oxo-L-proline and its inhibition by analogs of 5-oxo-L-proline
Methods Enzymol.
113
468-471
1985
Mus musculus, Mus musculus NCS, Rattus norvegicus
brenda
Seddon, A.P.; Li, L.; Meister, A.
5-Oxo-L-prolinase from Pseudomonas putida
Methods Enzymol.
113
451-458
1985
Pseudomonas putida, Pseudomonas putida ALA, Rattus norvegicus
brenda
Meister, A.; Griffith, O.W.; Williamson, J.M.
5-Oxo-L-Prolinase from rat kidney
Methods Enzymol.
113
445-451
1985
Rattus norvegicus
brenda
Seddon, A.P.; Li, L.; Meister, A.
Resolution of 5-oxo-L-prolinase into a 5-oxo-L-proline-dependent ATPase and a coupling protein
J. Biol. Chem.
259
8091-8094
1984
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