Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-imidazolidone-4-carboxylate + ATP + H2O
2-imidazolidone + ADP + phosphate
2-imidazoline-4-carboxylate + ATP + H2O
2-imidazoline-4-carboxylate + ADP + phosphate
-
does not undergo ring cleavage, but stimulates formation of inorganic phosphate from ATP
-
-
?
2-imidazolinone-4-carboxylate + H2O
?
-
-
-
-
?
2-oxo-5,5-dimethylthiazolidine-4-carboxylate + H2O
?
-
-
-
-
?
2-piperidone-6-carboxylate + ATP + H2O
2-aminoadipate + phosphate + ADP
2-thiazolinone-4-carboxylate + H2O
?
-
-
-
-
?
3-methyl-5-oxoproline + H2O
2-amino-3-methylpentanedioic acid
-
-
-
-
?
3-oxy-5-oxoproline + H2O
3-oxyglutamate + phosphate
4-methyl-5-oxoproline + H2O
2-amino-4-methylpentanedioic acid
-
-
-
-
?
4-oxy-5-oxoproline + H2O
4-oxyglutamate + phosphate
5'-p-fluorosulfonylbenzoyladenosine + H2O
?
-
-
-
-
?
5'-p-fluorosulfonylbenzoylinosine + H2O
?
-
-
-
-
?
5-oxo-L-proline + ATP + 2 H2O
L-glutamate + phosphate + ADP
-
assay at pH 7.2, 5 mM substrate, 4°C, 20 min
-
-
?
5-oxo-L-proline + ATP + H2O
L-glutamate + ADP + phosphate
assay at 30°C, pH 9.5, reaction stopped by 20 microl acetic acid and heating for 5 min at 100°C
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
alpha-hydroxyglutarate lactone + H2O
?
-
-
-
-
?
ATP + 5-oxo-L-proline + 2 H2O
ADP + phosphate + L-glutamate
-
-
-
?
DL-2-oxo-3,3-dimethylthiazolidine-4-carboxylate + H2O
?
-
-
-
-
?
DL-cis-2-oxo-5-methyloxazolidine-4-carboxylate + H2O
DL-threonine + ADP + phosphate
-
-
-
-
?
L-2-iminothiazolidine-4-carboxylate + H2O
L-cystine
-
-
-
-
?
L-2-oxooxazolidine-4-carboxylate + H2O + ATP
L-serine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
L-dihydroorotate + H2O
?
-
do not undergo ring cleavage, but stimulates formation of inorganic phosphate from ATP
-
-
?
L-trans-2-oxo-5-methyloxazolidine-4-carboxylate + H2O
L-threonine + ADP + phosphate
-
-
-
-
?
XTP + H2O
?
-
less than 5% of the activity observed with ATP
-
-
?
additional information
?
-
2-imidazolidone-4-carboxylate + ATP + H2O
2-imidazolidone + ADP + phosphate
-
-
-
-
?
2-imidazolidone-4-carboxylate + ATP + H2O
2-imidazolidone + ADP + phosphate
-
promotes enzymatic hydrolysis of ATP but is not itself hydrolyzed
-
-
?
2-piperidone-6-carboxylate + ATP + H2O
2-aminoadipate + phosphate + ADP
-
-
-
-
?
2-piperidone-6-carboxylate + ATP + H2O
2-aminoadipate + phosphate + ADP
-
-
-
?
3-oxy-5-oxoproline + H2O
3-oxyglutamate + phosphate
-
-
-
-
?
3-oxy-5-oxoproline + H2O
3-oxyglutamate + phosphate
-
-
-
?
4-oxy-5-oxoproline + H2O
4-oxyglutamate + phosphate
-
-
-
-
?
4-oxy-5-oxoproline + H2O
4-oxyglutamate + phosphate
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
component F8 + component beta5
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
209370, 209371, 209373, 209374, 209375, 209376, 209377, 209378, 209379, 209380, 209381, 209382, 209383, 209384, 209385, 209386, 209387 -
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
ir
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
conversion essentially irreversible, very slow reversal can be shown by measurement of ATP formation in presence of high glutamate concentrations
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
conversion essentially irreversible, very slow reversal can be shown by measurement of ATP formation in presence of high glutamate concentrations
-
-
ir
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
Rattus norvegicus Wistar albino
-
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
ATP is required
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
ATP + H2O
?
-
-
-
-
?
CTP + H2O
?
-
less than 5% of the activity observed with ATP
-
-
?
CTP + H2O
?
-
less than 5% of the activity observed with ATP
-
-
?
dATP + H2O
?
-
-
-
-
?
GTP + H2O
?
-
less than 5% of the activity observed with ATP
-
-
?
GTP + H2O
?
-
less than 5% of the activity observed with ATP
-
-
?
ITP + H2O
?
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
-
-
-
-
?
MgATP2- + H2O
?
-
-
-
-
-
MgATP2- + H2O
?
-
component beta5
-
-
?
MgATP2- + H2O
?
-
-
-
-
-
MgATP2- + H2O
?
-
-
-
-
?
MgATP2- + H2O
?
-
-
-
-
-
UTP + H2O
?
-
less than 5% of the activity observed with ATP
-
-
?
UTP + H2O
?
-
less than 5% of the activity observed with ATP
-
-
?
additional information
?
-
-
CTP, TTP and UTP are no substrates
-
-
-
additional information
?
-
-
CTP, TTP and UTP are no substrates
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
no activity observed with 5-oxo-D-proline
-
-
-
additional information
?
-
-
no activity observed with 5-oxo-D-proline
-
-
-
additional information
?
-
-
no activity observed with 5-oxo-D-proline
-
-
-
additional information
?
-
-
L-thioproline is no substrate
-
-
-
additional information
?
-
-
5-oxo-D-proline, 2-pyrrolidone-4-carboxylate, N-methyl-5-oxo-L-proline and N-acetyl-L-alanine are no substrates
-
-
-
additional information
?
-
-
L-proline, 2-pyrrolidone, N-methyl-5-oxo-L-proline, DL-piperidine-2-carboxylic acid and cyclohexanone-3-carboxylic acid are no substrates
-
-
-
additional information
?
-
-
L-proline, 2-pyrrolidone, N-methyl-5-oxo-L-proline, DL-piperidine-2-carboxylic acid and cyclohexanone-3-carboxylic acid are no substrates
-
-
-
additional information
?
-
-
CTP and UTP are poor substrates
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
ATP + 5-oxo-L-proline + 2 H2O
ADP + phosphate + L-glutamate
O14841
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
209370, 209373, 209375, 209376, 209378, 209379, 209380, 209381, 209382, 209383, 209384, 209385, 209386, 209387 -
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
P97608
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
conversion essentially irreversible, very slow reversal can be shown by measurement of ATP formation in presence of high glutamate concentrations
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
conversion essentially irreversible, very slow reversal can be shown by measurement of ATP formation in presence of high glutamate concentrations
-
-
ir
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
Rattus norvegicus Wistar albino
-
-
-
-
-
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5-oxoprolinase (atp-hydrolysing) deficiency
5-Oxoprolinase deficiency associated with severe psychomotor developmental delay, failure to thrive, microcephaly and microcytic anaemia.
5-oxoprolinase (atp-hydrolysing) deficiency
5-Oxoprolinase deficiency: report of the first human OPLAH mutation.
5-oxoprolinase (atp-hydrolysing) deficiency
5-Oxoprolinuria associated with 5-oxoprolinase deficiency; further evidence that this is a benign disorder.
5-oxoprolinase (atp-hydrolysing) deficiency
5-oxoprolinuria due to hereditary 5-oxoprolinase deficiency in two brothers--a new inborn error of the gamma-glutamyl cycle.
5-oxoprolinase (atp-hydrolysing) deficiency
5-Oxoprolinuria in Heterozygous Patients for 5-Oxoprolinase (OPLAH) Missense Changes.
5-oxoprolinase (atp-hydrolysing) deficiency
5-Oxoprolinuria in patients with and without defects in the gamma-glutamyl cycle.
5-oxoprolinase (atp-hydrolysing) deficiency
A newborn infant with generalized glutathione synthetase deficiency.
5-oxoprolinase (atp-hydrolysing) deficiency
Clinical, biochemical, and molecular characterization of patients with glutathione synthetase deficiency.
5-oxoprolinase (atp-hydrolysing) deficiency
Coma, metabolic acidosis, and methemoglobinemia in a patient with acetaminophen toxicity.
5-oxoprolinase (atp-hydrolysing) deficiency
Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies.
5-oxoprolinase (atp-hydrolysing) deficiency
Growth failure, encephalopathy, and endocrine dysfunctions in two siblings, one with 5-oxoprolinase deficiency.
5-oxoprolinase (atp-hydrolysing) deficiency
Inborn errors in the metabolism of glutathione.
5-oxoprolinase (atp-hydrolysing) deficiency
New insights into the genetics of 5-oxoprolinase deficiency and further evidence that it is a benign biochemical condition.
5-oxoprolinase (atp-hydrolysing) deficiency
Patients with genetic defects in the gamma-glutamyl cycle.
5-oxoprolinase (atp-hydrolysing) deficiency
Pyroglutamic acid-induced metabolic acidosis: a case report.
5-oxoprolinase (atp-hydrolysing) deficiency
[5-Oxoprolinase deficiency]
Acidosis
Transient 5-oxoprolinuria (pyroglutamic aciduria) with systemic acidosis in an adult receiving antibiotic therapy.
Anemia
5-Oxoprolinase deficiency associated with severe psychomotor developmental delay, failure to thrive, microcephaly and microcytic anaemia.
Anemia, Hemolytic
Patients with genetic defects in the gamma-glutamyl cycle.
Brain Diseases
Growth failure, encephalopathy, and endocrine dysfunctions in two siblings, one with 5-oxoprolinase deficiency.
Breast Neoplasms
Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model.
Drug-Related Side Effects and Adverse Reactions
Potential for selective modulation of glutathione in cancer chemotherapy.
gamma-glutamyltransferase deficiency
Patients with genetic defects in the gamma-glutamyl cycle.
glutathione synthase deficiency
5-Oxoprolinuria in patients with and without defects in the gamma-glutamyl cycle.
glutathione synthase deficiency
A newborn infant with generalized glutathione synthetase deficiency.
glutathione synthase deficiency
Clinical, biochemical, and molecular characterization of patients with glutathione synthetase deficiency.
glutathione synthase deficiency
Patients with genetic defects in the gamma-glutamyl cycle.
glutathione synthase deficiency
Pyroglutamic aciduria (5-oxoprolinuria) without glutathione synthetase deficiency and with decreased pyroglutamate hydrolase activity.
Malnutrition
Pyroglutamic acid-induced metabolic acidosis: a case report.
membrane dipeptidase deficiency
Inborn errors in the metabolism of glutathione.
Microcephaly
5-Oxoprolinase deficiency associated with severe psychomotor developmental delay, failure to thrive, microcephaly and microcytic anaemia.
Neoplasms
Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues.
Neoplasms
Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathione.
Neoplasms
Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model.
Neoplasms
Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.
Neoplasms
Modulation of glutathione by a cysteine pro-drug enhances in vivo tumor response.
Neoplasms
Selective glutathione repletion with oral oxothiazolidine carboxylate (OTZ) in the radiated tumor-bearing rat.
Neoplasms
Sensitization effect of L-2-oxothiazolidine-4-carboxylate on tumor cells to melphalan and the role of 5-oxo-L-prolinase in glutathione modulation in tumor cells.
Sepsis
Pyroglutamic acid-induced metabolic acidosis: a case report.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Hsu, T.; Meister, A.
Metabolism in vivo of 5-oxo-L-proline and its inhibition by analogs of 5-oxo-L-proline
Methods Enzymol.
113
468-471
1985
Mus musculus, Mus musculus NCS, Rattus norvegicus
brenda
Seddon, A.P.; Li, L.; Meister, A.
5-Oxo-L-prolinase from Pseudomonas putida
Methods Enzymol.
113
451-458
1985
Pseudomonas putida, Pseudomonas putida ALA, Rattus norvegicus
brenda
Meister, A.; Griffith, O.W.; Williamson, J.M.
5-Oxo-L-Prolinase from rat kidney
Methods Enzymol.
113
445-451
1985
Rattus norvegicus
brenda
Seddon, A.P.; Li, L.; Meister, A.
Resolution of 5-oxo-L-prolinase into a 5-oxo-L-proline-dependent ATPase and a coupling protein
J. Biol. Chem.
259
8091-8094
1984
Pseudomonas putida, Rattus norvegicus
brenda
Williamson, J.M.; Meister, A.
New substrates of 5-oxo-L-prolinase
J. Biol. Chem.
257
12039-12042
1982
Mus musculus, Rattus norvegicus
brenda
Williamson, J.M.; Meister, A.
Effect of sulfhydryl group modification on the activities of 5-oxo-L-prolinase
J. Biol. Chem.
257
9161-9172
1982
Rattus norvegicus
brenda
Griffith, O.W.; Meister, A.
Interaction of 5-oxo-L-prolinase with nucleoside triphosphates. Evidence suggesting substrate-dependent conformational change
J. Biol. Chem.
257
4392-4397
1982
Rattus norvegicus
brenda
Griffith, O.W.; Meister, A.
5-Oxo-L-prolinase (L-pyroglutamate hydrolase). Studies of the chemical mechanism
J. Biol. Chem.
256
9981-9985
1981
Rattus norvegicus
brenda
Tsui, E.; Yeung, A.
Development of gamma-glutamylcysteine synthetase and oxoprolinase in rat kidney
Experientia
35
1293-1295
1979
Rattus norvegicus, Rattus norvegicus Wistar albino
brenda
Mazelis, M.; Creveling, R.G.
5-Oxoprolinase (L-pyroglutamate hydrolase) in higher plants
Plant Physiol.
62
798-801
1978
Brassica oleracea, Brassica rapa, Cucurbita pepo, Daucus carota, Pisum sativum, Pseudomonas sp., Raphanus sativus, Rattus norvegicus, Solanum tuberosum, Spinacia oleracea, Triticum aestivum
brenda
Griffith, O.W.; Meister, A.
Dependence of energy coupling on nucleotide base structure in the reaction catalyzed by 5-oxo-L-prolinase
Biochem. Biophys. Res. Commun.
70
759-765
1976
Rattus norvegicus
brenda
Van Der Werf, P.; Griffith, O.W.; Meister, A.
5-Oxo-L-prolinase (L-pyroglutamate hydrolase) purification and catalytic properties
J. Biol. Chem.
250
6686-6692
1975
Bos taurus, Canis lupus familiaris, Felis catus, Mus musculus, Oryctolagus cuniculus, Ovis aries, Rattus norvegicus, Rattus norvegicus Sprague-Dawley, Sus scrofa
brenda
Wendel, A.; Flugge, U.J.
5-Oxoprolinase from rat kidney, I assay, purification, and determination of kinetic parameters
Hoppe-Seyler's Z. Physiol. Chem.
356
873-880
1975
Mus musculus, Rattus norvegicus
brenda
Wendel, A.; Flugge, U.J.; Jenke, H.S.
5-Oxoprolinase from rat kidney, II molecular weight determinations
Hoppe-Seyler's Z. Physiol. Chem.
356
881-885
1975
Rattus norvegicus
brenda
Van Der Werf, P.; Stephani, R.A.; Meister, A.
Accumulation of 5-oxoproline in mouse tissues after inhibition of 5-oxoprolinase and administration of amino acids: Evidence for function of the gamma-glutamyl cycle
Proc. Natl. Acad. Sci. USA
71
1026-1029
1974
Homo sapiens, Mus musculus, Pseudomonas sp., Rattus norvegicus
brenda
Van Der Werf, P.; Meister, A.
Isolation of 5-oxoprolinase from a prokaryote
Biochem. Biophys. Res. Commun.
56
90-96
1974
Mus musculus, Pseudomonas sp., Rattus norvegicus
brenda
Van Der Werf, P.; Stephani, R.A.; Orlowski, M.; Meister, A.
Inhibition of 5-oxoprolinase by 2-imidazolidone-4-carboxylic acid
Proc. Natl. Acad. Sci. USA
70
759-761
1973
Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Van Der Werf, P.; Orlowski, M.; Meister, A.
Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the gamma-glutamyl cycle
Proc. Natl. Acad. Sci. USA
68
2982-2985
1971
Homo sapiens, Ovis aries, Rattus norvegicus, Sus scrofa
brenda
Ye, G.J.; Breslow, E.; Meister, A.
The amino acid sequence of rat kidney 5-oxo-L-prolinase determined by cDNA cloning
J. Biol. Chem.
271
32293-32300
1996
Pseudomonas putida, Rattus norvegicus (P97608)
brenda
Srivenugopal, K.S.; Ali-Osman, F.
Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues
Cancer Lett.
117
105-111
1997
Homo sapiens
brenda
Chen, X.; Schecter, R.L.; Griffith, O.W.; Hayward, M.A.; Alpert, L.C.; Batist, G.
Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: A potential new target for biochemical modulation of glutathione
Clin. Cancer Res.
4
131-138
1998
Homo sapiens, Rattus norvegicus
brenda
Chen, X.; Batist, G.
Sensitization effect of L-2-oxothiazolidine-4-carboxylate on tumor cells to melphalan and the role of 5-oxo-L-prolinase in glutathione modulation in tumor cells
Biochem. Pharmacol.
56
743-749
1998
Homo sapiens
brenda
Jaeger, M.; Weber, P.; Wolf, S.
Immunohistochemical localization of 5-oxo-L-prolinase, an enzyme of the gamma-glutamyl cycle, in porcine brain microvessels
FEBS Lett.
445
215-217
1999
Sus scrofa
brenda
Weber, P.; Jaeger, M.; Bangsow, T.; Knell, G.; Piechaczek, K.; Koch, J.; Wolf, S.
Kinetic parameters and tissue distribution of 5-oxo-L-prolinase determined by a fluorimetric assay
J. Biochem. Biophys. Methods
38
71-82
1999
Rattus norvegicus, Sus scrofa
brenda
Mochizuki, K.
Purification and characterization of 5-oxo-L-prolinase from Paecilomyces varioti F-1, an ATP-dependent hydrolase active with L-2-oxothiazolidine-4-carboxylic acid
Arch. Microbiol.
172
182-185
1999
Alcaligenes sp., Alcaligenes sp. F-137, Paecilomyces variotii, Paecilomyces variotii F-1, Pseudomonas putida, Rattus norvegicus
brenda
Watanabe, T.; Abe, K.; Ishikawa, H.; Iijima, Y.
Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery
Biol. Pharm. Bull.
27
288-294
2004
Bos taurus, Bos taurus (Q75WB5)
brenda
Ruijter, G.J.; Mourad-Baars, P.E.; Ristoff, E.; Onkenhout, W.; Poorthuis, B.J.
Persistent 5-oxoprolinuria with normal glutathione synthase and 5-oxoprolinase activities
J. Inherit. Metab. Dis.
29
587
2006
Homo sapiens
brenda
Ohkama-Ohtsu, N.; Oikawa, A.; Zhao, P.; Xiang, C.; Saito, K.; Oliver, D.J.
A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis
Plant Physiol.
148
1603-1613
2008
Arabidopsis thaliana (Q9FIZ7)
brenda
Kaufmann, Y.; Todorova, V.K.; Luo, S.; Klimberg, V.S.
Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model
Nutr. Cancer
60
518-525
2008
Rattus norvegicus
brenda
Kumar, A.; Bachhawat, A.K.
A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?
J. Biosci.
35
21-25
2010
Homo sapiens
brenda
Kumar, A.; Bachhawat, A.K.
OXP1/YKL215c encodes an ATP-dependent 5-oxoprolinase in Saccharomyces cerevisiae: functional characterization, domain structure and identification of actin-like ATP-binding motifs in eukaryotic 5-oxoprolinases
FEMS Yeast Res.
10
394-401
2010
Saccharomyces cerevisiae (P28273), Saccharomyces cerevisiae
brenda
Almaghlouth, I.; Mohamed, J.; Al-Amoudi, M.; Al-Ahaidib, L.; Al-Odaib, A.; Alkuraya, F.
5-Oxoprolinase deficiency: report of the first human OPLAH mutation
Clin. Genet.
82
193-196
2012
Homo sapiens, Homo sapiens (O14841)
brenda
Calpena, E.; Deshpande, A.A.; Yap, S.; Kumar, A.; Manning, N.J.; Bachhawat, A.K.; Espinos, C.
New insights into the genetics of 5-oxoprolinase deficiency and further evidence that it is a benign biochemical condition
Eur. J. Pediatr.
174
407-411
2015
Homo sapiens, Homo sapiens (O14841)
brenda
HOME
login
history
all enzymes
BRENDA home
History
Enzyme Nomenclature
New: Word Map on EC 3.5.2.9
COMMENTARY
3.5.2.9-RECOMMENDED NAME
----REACTION TYPE
top
Information
