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Literature summary for 3.5.2.9 extracted from

  • Chen, X.; Schecter, R.L.; Griffith, O.W.; Hayward, M.A.; Alpert, L.C.; Batist, G.
    Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: A potential new target for biochemical modulation of glutathione (1998), Clin. Cancer Res., 4, 131-138.
    View publication on PubMed
Search for more literature for 3.5.2.9

Application

Application Comment Organism
medicine potenial implications for carcinogenesis and cancer chemotherapy Homo sapiens
medicine animal model for the human condition 5-oxoprolinuria, an inborn deficiency of renal 5-oxoprolinase activity Homo sapiens
medicine animal model for the human condition 5-oxoprolinuria, an inborn deficiency of renal 5-oxoprolinase activity Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
cytoplasm
-
 Rattus norvegicus 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
140000
-
 2 * 140000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-oxo-L-proline + H2O + ATP Homo sapiens
-
 L-glutamate + ADP + phosphate
-
 ?
5-oxo-L-proline + H2O + ATP Rattus norvegicus
-
 L-glutamate + ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Rattus norvegicus
-
 rat
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
blood peripheral mononuclear cells Homo sapiens
-
kidney
-
 Homo sapiens
-
kidney
-
 Rattus norvegicus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
lung
-
 Homo sapiens
-
lung
-
 Rattus norvegicus
-
stomach
-
 Homo sapiens
-

Storage Stability

Storage Stability Organism
-80°C, no activity lost for up to 1 week Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-oxo-L-proline + H2O + ATP
-
 Homo sapiens L-glutamate + ADP + phosphate
-
 ?
5-oxo-L-proline + H2O + ATP
-
 Rattus norvegicus L-glutamate + ADP + phosphate
-
 ?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
-
 Homo sapiens L-cysteine + ADP + phosphate
-
 ?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
-
 Rattus norvegicus L-cysteine + ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 140000, SDS-PAGE Rattus norvegicus