Information on EC 3.5.1.99 - fatty acid amide hydrolase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY hide
3.5.1.99
-
RECOMMENDED NAME
GeneOntology No.
fatty acid amide hydrolase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
anandamide + H2O = arachidonic acid + ethanolamine
show the reaction diagram
oleamide + H2O = oleic acid + NH3
show the reaction diagram
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
anandamide degradation
-
-
SYSTEMATIC NAME
IUBMB Comments
fatty acylamide amidohydrolase
Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia.
CAS REGISTRY NUMBER
COMMENTARY hide
153301-19-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Mus musculus C57BL/6J
-
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague–Dawley
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(11Z)-eicosenamide + H2O
(11Z)-eicosenoic acid + NH3
show the reaction diagram
-
105% of the activity with oleamide
-
-
?
(12Z)-octadecenamide + H2O
(12Z)-octadecenoic acid + NH3
show the reaction diagram
-
92% of the activity with oleamide
-
-
?
(13Z)-eicosenamide + H2O
(13Z)-eicosenoic acid + NH3
show the reaction diagram
-
103% of the activity with oleamide
-
-
?
(13Z)-octadecenamide + H2O
(13Z)-octadecenoic acid + NH3
show the reaction diagram
-
82% of the activity with oleamide
-
-
?
(15Z)-octadecenamide + H2O
(15Z)-octadecenoic acid + NH3
show the reaction diagram
-
90% of the activity with oleamide
-
-
?
(5Z)-eicosenamide + H2O
(5Z)-eicosenoic acid + NH3
show the reaction diagram
-
116% of the activity with oleamide
-
-
?
(5Z,8Z,11Z,14Z)-N-(2-fluoroethyl)icosa-5,8,11,14-tetraenamide + H2O
?
show the reaction diagram
-
hydrolysis rate is 1.3fold higher than the rate of anandamide hydrolysis
-
-
?
(5Z,8Z,11Z,14Z)-N-(2-hydroxy-1,1-dimethylethyl)icosa-5,8,11,14-tetraenamide + H2O
?
show the reaction diagram
-
hydrolyzed at 4.3% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-(2-methylpropyl)icosa-5,8,11,14-tetraenamide + H2O
?
show the reaction diagram
-
hydrolyzed at 2% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-(3-hydroxyphenyl)icosa-5,8,11,14-tetraenamide + H2O
?
show the reaction diagram
-
hydrolysis rate is 1.5fold higher than the rate of anandamide hydrolysis
-
-
?
(5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide + H2O
?
show the reaction diagram
-
hydrolyzed at 16% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-tert-butylicosa-5,8,11,14-tetraenamide + H2O
?
show the reaction diagram
-
hydrolyzed at 1.8% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-[(1S)-1-methylpropyl]icosa-5,8,11,14-tetraenamide + H2O
?
show the reaction diagram
-
hydrolyzed at 6.3% the rate of anandamide
-
-
?
(5Z,8Z,11Z,14Z)-N-[(2R)-2-hydroxypropyl]icosa-5,8,11,14-tetraenamide + H2O
?
show the reaction diagram
-
hydrolysis rate is 1.2fold higher than the rate of anandamide hydrolysis
-
-
?
(5Z,8Z,11Z,14Z)-N-[(2S)-2-hydroxypropyl]icosa-5,8,11,14-tetraenamide + H2O
?
show the reaction diagram
-
hydrolyzed at 21% the rate of anandamide
-
-
?
(6Z)-octadecenamide + H2O
(6Z)-octadecenoic acid + NH3
show the reaction diagram
-
91% of the activity with oleamide
-
-
?
(7Z)-octadecenamide + H2O
(7Z)-octadecenoic acid + NH3
show the reaction diagram
-
109% of the activity with oleamide
-
-
?
(8Z)-eicosenamide + H2O
(8Z)-eicosenoic acid + NH3
show the reaction diagram
-
112% of the activity with oleamide
-
-
?
(9E)-octadecenamide + H2O
(9E)-octadecenoic acid + NH3
show the reaction diagram
-
52% of the activity with oleamide
-
-
?
(9Z)-N-(2-hydroxyethyl)octadec-9-enamide + H2O
?
show the reaction diagram
-
hydrolyzed at 61% the rate of anandamide
-
-
?
(9Z)-N-ethyloctadec-9-enamide + H2O
oleic acid + ethanolamine
show the reaction diagram
-
-
-
-
?
(9Z)-tetradec-9-enamide + H2O
myristoleic acid + NH3
show the reaction diagram
-
86% of the activity with oleamide
-
-
?
(9Z,12Z)-N-(2-hydroxyethyl)octadeca-9,12-dienamide + H2O
?
show the reaction diagram
-
hydrolyzed at 75% the rate of anandamide
-
-
?
(9Z,12Z)-N-[(1R)-2-hydroxy-1-methylethyl]octadeca-9,12-dienamide + H2O
?
show the reaction diagram
-
hydrolyzed at 20.5% the rate of anandamide
-
-
?
(9Z,12Z)-octadeca-9,12-dienamide + H2O
(9Z,12Z)-octadeca-9,12-dienoate + NH3
show the reaction diagram
-
104% of the activity with oleamide
-
-
?
(R)-alpha-methanandamide + H2O
?
show the reaction diagram
-
2.4% of the activity with anandamide
-
-
?
(R)-beta-methanandamide + H2O
?
show the reaction diagram
-
121% of the activity with anandamide
-
-
?
(S)-alpha-methanandamide + H2O
?
show the reaction diagram
-
23% of the activity with anandamide
-
-
?
(S)-beta-methanandamide + H2O
?
show the reaction diagram
-
21% of the activity with anandamide
-
-
?
1-arachidonoylglycerol + H2O
?
show the reaction diagram
-
-
-
-
?
11,14,17-eicosatrienamide + H2O
11,14,17-eicosatrienoic acid + NH3
show the reaction diagram
-
140% of the activity with oleamide
-
-
?
11,14-eicosadienamide + H2O
? + NH3
show the reaction diagram
-
127% of the activity with oleamide
-
-
?
2,2-dimethyloleamide + H2O
2,2-dimethyloleic acid + NH3
show the reaction diagram
-
3% of the activity with oleamide
-
-
?
2-arachidonoylglycerol + H2O
?
show the reaction diagram
2-methyloleamide + H2O
2-methyloleic acid + NH3
show the reaction diagram
-
7% of the activity with oleamide
-
-
?
2-oleoylglycerol + H2O
?
show the reaction diagram
-
-
-
-
?
8,11,14-eicosatrienamide + H2O
8,11,14-eicosatrienoic acid + NH3
show the reaction diagram
-
138% of the activity with oleamide
-
-
?
all-trans-anandamide + H2O
ethanolamine + arachidonic acid
show the reaction diagram
-
all-trans-anandamide is an equally good substrate for rabbit platelet FAAH compared to anandamide
-
-
?
alpha-linolenamide + H2O
? + NH3
show the reaction diagram
-
138% of the activity with oleamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
show the reaction diagram
anandamide + H2O
ethanolamine + arachidonic acid
show the reaction diagram
arachidonamide + H2O
arachidonic acid + NH3
show the reaction diagram
arachidonoyl 7-amido-4-methylcoumarin + H2O
arachidonic acid + 7-amino-4-methylcoumarin
show the reaction diagram
arachidonoyl ethanolamide + H2O
arachidonic acid + ethanolamine
show the reaction diagram
-
-
-
-
?
arachidonoyl ethanolamide + H2O
oleic acid + ethanolamine
show the reaction diagram
-
-
-
-
?
arachidonoyl p-nitroanilide + H2O
arachidonate + p-nitroaniline
show the reaction diagram
-
-
-
-
?
arachidonyl-7-amino-4-methylcoumarin amide + H2O
arachidonic acid + 7-amino-4-methylcoumarin
show the reaction diagram
beta-arachidonoylglycerol + H2O
?
show the reaction diagram
-
hydrolysis is 2.5fold higher than the rate of anandamide hydrolysis
-
-
?
decanoyl 7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
decanoyl p-nitroanilide + H2O
decanoate + p-nitroaniline
show the reaction diagram
-
-
-
-
?
dodecanoamide + H2O
dodecanoic acid + NH3
show the reaction diagram
-
74% of the activity with oleamide
-
-
?
erucamide + H2O
? + NH3
show the reaction diagram
-
83% of the activity with oleamide
-
-
?
heptanoyl p-nitroanilide + H2O
heptanoate + p-nitroaniline
show the reaction diagram
-
-
-
-
?
lauroyl p-nitroanilide + H2O
laurate + p-nitroaniline
show the reaction diagram
-
-
-
-
?
linoelaidamide + H2O
(9E,12E)-octadeca-9,12-dienoic acid + NH3
show the reaction diagram
-
54% of the activity with oleamide
-
-
?
myristic amide + H2O
myristic acid + NH3
show the reaction diagram
myristoyl p-nitroanilide + H2O
myristate + p-nitroaniline
show the reaction diagram
-
-
-
-
?
N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide + H2O
4-pyren-1-ylbutanoic acid + ?
show the reaction diagram
-
-
-
-
?
N-(2-hydroxyethyl)linoleoylamide + H2O
?
show the reaction diagram
-
-
-
-
?
N-(2-hydroxyethyl)octadecanamide + H2O
?
show the reaction diagram
-
hydrolyzed at 15.0% the rate of anandamide
-
-
?
N-(4-hydroxy-2-methylphenyl) arachidonoyl amide + H2O
4-amino-m-cresol + NH3
show the reaction diagram
-
the rate of metabolism of VDM11 is about 15–20% of that for anandamide
-
-
?
N-(o-hydroxyphenyl)arachidonamide + H2O
?
show the reaction diagram
-
-
-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
show the reaction diagram
N-oleoylethanolamine + H2O
oleic acid + ethanolamine
show the reaction diagram
N-oleoyltaurine + H2O
taurine + oleic acid
show the reaction diagram
4% of the activity with anandamide
-
-
?
N-palmitoyl ethanolamine + H2O
palmitic acid + ethanolamine
show the reaction diagram
-
-
-
-
?
N-palmitoylethanolamine + H2O
palmitic acid + ethanolamine
show the reaction diagram
nervonamide + H2O
? + NH3
show the reaction diagram
-
82% of the activity with oleamide
-
-
?
nonanoyl p-nitroanilide + H2O
nonanoate + p-nitroaniline
show the reaction diagram
-
-
-
-
?
octanoyl p-nitroanilide + H2O
octanoate + p-nitroaniline
show the reaction diagram
-
-
-
-
?
oleamide + H2O
oleic acid + NH3
show the reaction diagram
oleoyl ethanolamide + H2O
arachidonic acid + ethanolamine
show the reaction diagram
-
-
-
-
?
oleoyl ethanolamide + H2O
oleic acid + ethanolamine
show the reaction diagram
-
-
-
-
?
oleoyl methyl amide + H2O
?
show the reaction diagram
-
-
-
-
?
oleoyl methyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
oleoyl methyl ester + H2O
oleic acid + methanol
show the reaction diagram
-
-
-
-
?
oleoyl p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
oleoyl p-nitroanilide + H2O
oleate + p-nitroaniline
show the reaction diagram
-
-
-
-
?
palmitic amide + H2O
palmitic acid + NH3
show the reaction diagram
palmitoamide + H2O
palmitoic acid + NH3
show the reaction diagram
-
72% of the activity with oleamide
-
-
?
palmitoleamide + H2O
palmitoleic acid + NH3
show the reaction diagram
-
79% of the activity with oleamide
-
-
?
palmitoyl p-nitroanilide + H2O
palmitate + p-nitroaniline
show the reaction diagram
-
-
-
-
?
palmitoylethanolamide + H2O
palmitic acid + ethanolamine
show the reaction diagram
-
substrate of FAAH and FAAH-2, the latter shows lower activity than FAAH
-
-
?
stearamide + H2O
stearic acid + NH3
show the reaction diagram
-
69% of the activity with oleamide
-
-
?
stearic amide + H2O
stearic acid + NH3
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(9Z)-N-ethyloctadec-9-enamide + H2O
oleic acid + ethanolamine
show the reaction diagram
-
-
-
-
?
2-arachidonoylglycerol + H2O
?
show the reaction diagram
-
FAAH is responsible for approximately one-half of the 2-arachidonoylglycerol hydrolysis occurring in BV-2 cell homogenate
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
show the reaction diagram
anandamide + H2O
ethanolamine + arachidonic acid
show the reaction diagram
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
show the reaction diagram
N-oleoylethanolamine + H2O
oleic acid + ethanolamine
show the reaction diagram
-
-
-
-
?
N-palmitoyl ethanolamine + H2O
palmitic acid + ethanolamine
show the reaction diagram
-
-
-
-
?
N-palmitoylethanolamine + H2O
palmitic acid + ethanolamine
show the reaction diagram
-
-
-
-
?
oleamide + H2O
oleic acid + NH3
show the reaction diagram
palmitoylethanolamide + H2O
palmitic acid + ethanolamine
show the reaction diagram
-
substrate of FAAH and FAAH-2, the latter shows lower activity than FAAH
-
-
?
additional information
?
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1-benzhydryltriazol-4-yl)methyl N-cyclohexylcarbamate
-
73% inhibition at 0.1 mM
(1-benzothiophen-6-ylamino)([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)methanone
-
-
(1-benzylpiperidin-4-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
(1-benzyltriazol-4-yl)methyl N-cyclohexylcarbamate
-
-
(1-phenethyltriazol-4-yl)methyl N-cyclohexylcarbamate
-
-
(1-phenyltriazol-4-yl)methyl N-cyclohexylcarbamate
-
-
(10Z)-1,1,1-trifluorononadec-10-en-2-one
-
-
(10Z)-1-bromononadec-10-en-2-one
-
-
(10Z)-2-oxononadec-10-enamide
-
-
(1H-benzo[d][1,2,3]triazol-1-yl)(4-(3-phenoxybenzyl)-piperazin-1-yl)-methanone
-
-
(1H-benzo[d][1,2,3]triazol-1-yl)(4-(4-phenoxybenzyl)-piperazin-1-yl)-methanone hydrochloride
-
-
(1H-imidazol-1-yl)(4-(3-phenoxybenzyl)piperazin-1-yl)methanone
-
-
(1H-imidazol-1-yl)(4-(4-phenoxy-benzyl)-piperazin-1-yl)-methanone hydrochloride
-
-
(2R)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
(2S)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
(3-phenylphenyl)methyl N-cyclohexylcarbamate
-
65% inhibition at 0.1 mM
(3H-[1,2,3]triazol[4,5-b]pyridin-3-yl)(4-(3-phenoxybenzyl)-piperazin-1-yl)-methanone
-
-
(3R,4R)-4-acetoxy-3-((10R)-(t-butyldimethylsilyloxy)-ethyl)-azetidin-2-one
-
-
(4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)-piperidin-1-yl)(1H-1,2,4-triazol-1-yl)methanone
-
-
(4-benzhydrylpiperazin-1-yl)(4-phenyl-1H-imidazol-1-yl)methanone
-
62% activity remaining at 0.01 mM
(4-benzylpiperazin-1-yl)[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
(4-phenylpiperazin-1-yl)(1H-1,2,4-triazol-1-yl)methanone
-
-
(5-iodo-1,3-oxazol-2-yl)[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
-
(5-iodo-1,3-oxazol-2-yl)[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
-
(5E)-5-(4-methoxybenzylidene)-3-[1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indol-5-yl]-1,3-thiazolidine-2,4-dione
-
-
(5Z,8Z,11Z,14Z)-1-pyridazin-3-ylicosa-5,8,11,14-tetraen-1-one
-
-
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
-
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
-
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
-
(5Z,8Z,11Z,14Z)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)icosa-5,8,11,14-tetraenamide
-
-
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
-
i.e. (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide or N-arachidonoylethanolamine, competitive
(5Z,8Z,11Z,14Z)-N-[(2R)-tetrahydrofuran-2-ylmethyl]icosa-5,8,11,14-tetraenamide
-
-
(5Z,8Z,11Z,14Z)-N-[(2S)-tetrahydrofuran-2-ylmethyl]icosa-5,8,11,14-tetraenamide
-
-
(6aR,10aR)-3-(1,1-dimethylheptyl)-9-(hydroxymethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
-
-
(6E,9E,12E,15E)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one
-
-
(9E)-1-pyridazin-3-yloctadec-9-en-1-one
-
-
(9E)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-(1,3-benzothiazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1,3-oxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1,3-thiazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1-methyl-1H-benzimidazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1-methyl-1H-imidazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1-methyl-1H-tetrazol-5-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1H-benzimidazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(1H-tetrazol-5-yl)octadec-9-en-1-one
-
-
(9Z)-1-(2-methyl-2H-tetrazol-5-yl)octadec-9-en-1-one
-
-
(9Z)-1-(4,5-dihydro-1,3-oxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(4-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(5-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(6-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-(7-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
(9Z)-1-phenyloctadec-9-en-1-one
-
-
(9Z)-1-pyrazin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-pyridazin-3-yloctadec-9-en-1-one
-
-
(9Z)-1-pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-pyrimidin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-pyrimidin-4-yloctadec-9-en-1-one
-
-
(9Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-[1,3]oxazolo[5,4-b]pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-yloctadec-9-en-1-one
-
-
(9Z)-octadec-9-enal
-
-
(benzyl-1,2,4-triazol-3-yl)methyl N-cyclohexylcarbamate
-
-
-
(dodecylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
-
-
(phenylamino)[[(4-phenylcyclohexylidene)amino]oxy]methanone
-
-
(phenylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
-
-
(phenylamino)[[(E)-[1-[4-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
-
-
(R,S)-ibuprofen
-
-
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl 2-(biphenyl-4-yl)acetate
-
-
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl 3-(1H-indol-3-yl)propanoate
-
-
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl biphenyl-4-carboxylate
-
-
(S)-(4-oxo-1-pent-4-enoylazetidin-2-yl)methyl-4-phenylbutanoate
-
-
([(E)-[1-(2,2'-bithiophen-5-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
-
-
([(E)-[1-(4-cyclohexylphenyl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(diphenylamino)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(phenylamino)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(piperidin-1-yl)methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(4-fluorophenyl)amino]methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(4-methoxyphenyl)amino]methanone
-
-
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(5-phenylpentyl)amino]methanone
-
-
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(dimethylamino)methanone
-
-
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone
-
-
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(phenylamino)methanone
-
-
1,1'-(5,5'-bi-1,3-oxazole-2,2'-diyl)bis(7-phenylheptan-1-one)
-
-
1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
-
-
-
1,1-biphenyl-3-yl-carbamic acid cyclohexyl ester
-
i.e. URB602
1,3-benzodioxol-5-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
1,3-oxazol-2-yl[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]methanone
-
-
1,3-oxazol-2-yl[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]methanone
-
-
1,3-oxazol-2-yl[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
-
1,3-oxazol-2-yl[(3R)-7-phenyl-3,4-dihydro-2H-chromen-3-yl]methanone
-
-
1,3-oxazol-2-yl[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]methanone
-
-
1,3-oxazol-2-yl[(3S)-7-phenyl-3,4-dihydro-2H-chromen-3-yl]methanone
-
-
1-(1,3-benzoxazol-2-yl)octadecan-1-one
-
-
1-(1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(1-phenyl-1,2,4-triazol-3-yl)methyl N-cyclohexylcarbamate
-
70% inhibition at 0.1 mM
-
1-(2-oxo-3-[4-[4-(trifluoromethyl)phenoxy]phenoxy]propyl)-1H-indole-5-carboxylic acid
-
21% inhibition at 0.01 mM
1-(2-oxo-3-[[4'-(propan-2-yl)biphenyl-4-yl]oxy]propyl)-1H-indole-5-carboxylic acid
-
-
1-(4-octylphenoxy)-3-[5-(1H-tetrazol-5-yl)-1H-indol-1-yl]propan-2-one
-
-
1-(5-acetyl-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-bromo-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-chloro-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-fluoro-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-furan-2-yl-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-iodo-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-(5-methyl-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
-
-
1-oxazolo[4,5-b]pyridin-2-yl-9-octadecyn-1-one
-
-
1-pyridazin-3-yloctadecan-1-one
-
-
1-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl (benzyloxy)acetate
-
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl 3-(1H-indol-3-yl)propanoate
-
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl 4-(pyridin-2-yl)butanoate
-
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl 4-(pyridin-4-yl)butanoate
-
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl biphenyl-4-carboxylate
-
-
1-[(3S)-2-oxo-1-(pent-4-enoyl)azetidin-3-yl]ethyl biphenyl-4-ylacetate
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-4-phenylbutan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-5-phenylpentan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-6-phenylhexan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-7-phenylheptan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-8-phenyloctan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-9-phenylnonan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yldec-9-en-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yldec-9-yn-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yldecan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yldodecan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylethanone
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylheptan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylhexadecan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylhexan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-yn-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadecan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yloctan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-ylpentan-1-one
-
-
1-[1,3]oxazolo[4,5-b]pyridin-2-yltetradecan-1-one
-
-
1-[1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indol-5-yl]-1H-benzimidazole-7-carboxylic acid
-
-
1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid
-
-
1-[2-oxo-3-[4-(2-phenoxyethoxy)phenoxy]propyl]-1H-indole-5-carboxylic acid
-
-
1-[2-oxo-3-[4-(2-phenylpropan-2-yl)phenoxy]propyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(4-benzylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indazole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid
1-[3-(biphenyl-2-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(biphenyl-3-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-(biphenyl-4-yloxy)-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3'-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-methoxybiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(3-methylbiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
39% inhibition at 0.01 mM
1-[3-[(4'-chlorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
1-[3-[(4'-fluorobiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(4'-methoxybiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[(4'-methylbiphenyl-4-yl)oxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(4-fluorophenyl)phenoxy]-2-oxopropyl]indazole-5-carboxylic acid
-
-
1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(heptyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(hexyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(nonyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[3-[4-(octyloxy)phenoxy]-2-oxopropyl]-1H-indole-5-carboxylic acid
-
-
1-[4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidin-1-yl]-3,3,3-trifluoro-2-(trifluoromethyl)propan-1-one
-
-
1-[5-(2,4-dimethoxypyrimidin-5-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2,6-dimethoxypyrimidin-4-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(2-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-benzyl-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one
-
-
1-[5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one
-
-
1-[5-(3-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(3-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-aminopyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-fluoropyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-methoxypyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(4-nitropyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(5-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(6-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(methylsulfanyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(morpholin-4-ylcarbonyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1-[5-(morpholin-4-ylcarbonyl)-1H-indol-1-yl]-3-(4-octylphenoxy)propan-2-one
-
-
1-[5-[(4-methylpiperazin-1-yl)carbonyl]-1,3-oxazol-2-yl]-7-phenylheptan-1-one
-
-
1H-benzotriazol-1-yl[4-(diphenylmethyl)piperazin-1-yl]methanone
-
-
2,2,2-trichloroethyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate
-
-
2,2-dimethyl-1,3-dioxolan-4-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
2-(1-benzyltriazol-4-yl)ethyl N-cyclohexylcarbamate
-
-
2-(1-phenyltriazol-4-yl)ethyl N-cyclohexylcarbamate
-
-
2-(2-fluorobiphenyl-4-yl)-N-(2-(3-methylpyridin-2-ylamino)-2-oxoethyl)propanamide
-
-
2-(2-fluorobiphenyl-4-yl)-N-(3-methylpyridin-2-yl)propanamide
-
mode of inhibition, overview. Flu-AM1 does not inhibit the enzyme from brain in vivo
-
2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
2-(6-methoxynaphthalen-2-yl)-N-(3-methylpyridin-2-yl)propanamide
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carbaldehyde
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carbonitrile
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxylic acid
-
-
2-(methylamino)-2-oxoethyl [2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl]carbamate
2-iodobenzylarachidonoylamide
-
-
2-iodobenzyllinoleoylamide
-
-
2-iodophenethylarachidonoylamide
-
-
2-iodophenethyllinoleoylamide
-
-
2-methoxyphenethylarachidonoylamide
-
-
2-methoxyphenethyllinoleoylamide
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylic acid
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carbonitrile
-
-
2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carboxylic acid
-
-
2H-benzotriazol-2-yl(4-phenylpiperazin-1-yl)methanone
-
-
2H-benzotriazol-2-yl[4-(diphenylmethyl)piperazin-1-yl]methanone
-
-
3'-carbamoyl-biphenyl-3-yl-cyclohexylcarbamate
-
-
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate
-
-
3'-[(1E)-N-[(phenylcarbamoyl)oxy]ethanimidoyl]biphenyl-3-carboxamide
-
-
3-iodobenzylarachidonoylamide
-
-
3-iodobenzyllinoleoylamide
-
-
3-iodophenethylarachidonoylamide
-
-
3-iodophenethyllinoleoylamide
-
-
3-methoxyphenethylarachidonoylamide
-
-
3-methoxyphenethyllinoleoylamide
-
-
3-phenylpropane-1-sulfonyl fluoride
-
-
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N,N-diethylazetidine-1-carboxamide
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-ethyl-N-(2-hydroxyethyl)azetidine-1-carboxamide
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-(2-phenylethyl)azetidine-1-carboxamide
3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methyl-N-phenylazetidine-1-carboxamide
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid
-
-
3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile
-
-
4-(3-phenoxybenzyl)-N-(4-methoxyphenyl)piperazine-1-carboxamide
-
-
4-(3-phenoxybenzyl)-N-(4-nitrophenyl)piperazine-1-carboxamide
-
-
4-(3-phenoxybenzyl)-N-phenylpiperazine-1-carboxamide
-
-
4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide
4-(4-benzyloxyphenoxy)butanesulfonyl fluoride
-
-
4-(acetylamino)phenyl (4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetate
-
-
4-(acetylamino)phenyl 2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoate
-
competitive, also able to inhibit the FAAH activity in rat basophilic leukemia cells as assessed by measuring either the hydrolysis of anandamide, the FAAH-dependent cellular accumulation of anandamide, or the FAAH-dependent recycling of tritium to the cellmembranes
4-(acetylamino)phenyl 2-[[2-(trifluoromethyl)pyridin-4-yl]amino]pyridine-3-carboxylate
-
-
4-(acetylamino)phenyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoate
-
-
4-(acetylamino)phenyl 2-[[3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylate
-
-
4-(acetylamino)phenyl 2-{[2-(trifluoromethyl)pyridin-4-yl]amino}benzoate
-
-
4-(acetylamino)phenyl 3-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoate
-
-
4-(acetylamino)phenyl 3-methyl-4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 3-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 4-([[2-(trifluoromethyl)pyridin-4-yl]amino]methyl)benzoate
-
-
4-(acetylamino)phenyl 4-chloro-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 5-chloro-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl 5-methyl-2-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoate
-
-
4-(acetylamino)phenyl N-(3-methyl-4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoyl)glycinate
-
-
4-(acetylamino)phenyl N-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]benzoyl)glycinate
-
-
4-(acetylamino)phenyl N-[(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)acetyl]glycinate
-
-
4-(acetylamino)phenyl N-[2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoyl]glycinate
-
-
4-(benzyloxy)phenyl butylcarbamate
-
-
4-benzhydryl-N-(4-(trifluoromethyl)phenyl)piperazine-1-carboxamide
-
86% activity remaining at 0.01 mM
4-benzhydryl-N-(4-butylphenyl)piperazine-1-carboxamide
-
84% activity remaining at 0.01 mM
4-benzhydryl-N-(4-methoxyphenyl)piperazine-1-carboxamide
-
89% activity remaining at 0.01 mM
4-benzhydryl-N-(4-nitrophenyl)piperazine-1-carboxamide
-
84% activity remaining at 0.01 mM
4-benzhydryl-N-(pyridin-2-yl)piperazine-1-carboxamide
-
87% activity remaining at 0.01 mM
4-benzhydryl-N-(pyridin-3-yl)piperazine-1-carboxamide
-
87% activity remaining at 0.01 mM
4-benzhydryl-N-phenylpiperazine-1-carboxamide
-
88% activity remaining at 0.01 mM
4-iodobenzylarachidonoylamide
-
-
4-iodobenzyllinoleoylamide
-
-
4-iodophenethylarachidonoylamide
-
-
4-iodophenethyllinoleoylamide
-
-
4-methoxyphenethylarachidonoylamide
-
-
4-methoxyphenethyllinoleoylamide
-
-
4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
-
-
4-nitrophenyl 4-(diphenylmethyl)piperazine-1-carboxylate
-
-
4-nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate
-
-
4-nitrophenyl 4-[bis(4-fluorophenyl)methyl]piperazine-1-carboxylate
-
-
4-nitrophenyl-4-(4-phenoxy-benzyl)-piperazine-1-carboxylate
-
-
4-nitrophenyl-4-(bis(benzo[d][1,3]dioxol-5-yl)methyl)piperidine-1-carboxylate
-
-
4-phenylbutane-1-sulfonyl fluoride
-
-
4-[2-(2,4-difluorophenyl)pyridin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[2-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide
-
-
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide
-
-
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid
-
-
4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile
-
-
4-[3-(4-chlorophenoxy)benzyl]-N-(pyridin-3-yl)piperazine-1-carboxamide
4-[3-[4-(decyloxy)phenoxy]-2-oxopropoxy]benzoic acid
-
-
4-[4-(2,3-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)piperazine-1-carboxamide
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(2,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(3,4-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[4-(3,5-difluorophenyl)pyrimidin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[6-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
4-[6-(2,4-difluorophenyl)pyrimidin-4-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
5-(4-benzyloxyphenyl)pentanesulfonyl fluoride
-
-
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-morpholin-4-yl-1H-pyrazole-3-carboxamide
-
-
5-(4-hydroxyphenyl)pentanesulfonyl fluoride
5-phenylpentane-1-sulfonyl fluoride
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]furan-2-carboxylic acid
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyrimidine-2,4(1H,3H)-dione
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-carboxylic acid
-
-
5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-sulfonamide
-
-
6-bromo-N-(2-fluorophenyl)-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidine]-1'-carboxamide
6-hydroxybiphenyl-3-yl cyclohexylcarbamate
6-phenylhexane-1-sulfonyl fluoride
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxamide
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxamide
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylic acid
-
-
6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyrimidine-2,4(1H,3H)-dione
-
-
7-(2-benzyloxyphenyl)heptanesulfonyl fluoride
-
-
7-(2-hydroxyphenyl)heptanesulfonyl fluoride
-
-
7-(3-benzyloxyphenyl)heptanesulfonyl fluoride
-
-
7-(3-hydroxyphenyl)heptanesulfonyl fluoride
-
-
7-(4-benzyloxyphenyl)heptane-1-sulfonic acid methyl ester
-
-
7-(4-benzyloxyphenyl)heptanesulfonyl fluoride
-
-
7-(4-hydroxyphenyl)heptanesulfonyl fluoride
-
-
7-phenyl-1-(5-phenyl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
7-phenyl-1-(5-pyrimidin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyrimidin-4-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-pyrimidin-5-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-(5-thiophen-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
-
7-phenyl-1-[5-(1H-tetrazol-5-yl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(piperidin-1-ylcarbonyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one
7-phenyl-1-[5-(thiomorpholin-4-ylcarbonyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(trifluoroacetyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[2-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[3-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[4-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenyl-1-[5-[4-(trifluoromethyl)pyridin-2-yl]-1,3-oxazol-2-yl]heptan-1-one
-
-
7-phenylheptane-1-sulfonyl fluoride
-
-
8-phenyloctane-1-sulfonyl fluoride
-
-
azepan-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
azetidin-1-yl[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl]methanone
benzol
-
-
benzyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)-piperidine-1-carboxylate
-
-
biphenyl-3-yl cyclohexylcarbamate
CF3-OH
chlorpyrifos oxon
-
-
cis-anandamide
-
inhibits hydrolysis of anandamide
cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester
-
i.e. URB597, attenuates the development of lipopolysaccharide-induced paw edema and reverses lipopolysaccharide-induced hyperalgesia through the respective CB2 and CB1 mechanisms of action. The inhibition is not affected by capsazepine, a transient receptor potential vanilloid type 1 antagonist
decyl benzodioxaphosphorin oxide
-
-
diazoxon
-
-
dichlorvos
-
-
diisopropyl fluorophosphate
-
-
dodecyl benzodioxaphosphorin oxide
-
-
dodecyl sulfonyl fluoride
-
-
dodecyl-benzodioxaphosphorin oxide
-
-
ethoxy oleoyl fluorophosphonate
-
irreversible inhibitor, exclusively modifies FAAH at S241
ethyl (10Z)-2-oxononadec-10-enoate
-
-
ethyl 4-(1H-1,2,4-triazol-1-ylcarbonyl)piperazine-1-carboxylate
-
-
ethyl 4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-ylcarbonyl)piperazine-1-carboxylate
-
-
ethyl octylphosphonofluoridate
-
-
flurbiprofen
-
-
heptyl benzodioxaphosphorin oxide
-
-
hexadecyl sulfonylfluoride
Ibuprofen
-
-
isopropyl dodecylfluorophosphate
-
-
JP104
-
-
methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-ylphosphonofluoridate
-
-
methyl 2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxylate
-
-
methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate
-
-
methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carboxylate
-
-
methyl 3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate
-
-
methyl 4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate
-
-
methyl 5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]furan-2-carboxylate
-
-
methyl 5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-carboxylate
-
-
methyl 6-(2-[[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-(2-[[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-(2-[[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-(2-[[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl]carbonyl]-1,3-oxazol-5-yl)pyridine-2-carboxylate
-
-
methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate
-
-
methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate
-
-
methyl arachidonoyl fluorophosphonate
methyl arachidonyl fluorophosphonate
methyl arachidonyl phosphonofluoridate
-
-
methyl arachidonylfluoroposphate
-
-
methyl octylphosphonofluoridate
-
-
N,N-dibenzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
N,N-dimethyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
-
-
N,N-dimethyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
-
-
N,N-dimethyl-2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
N-(2-hydroxyethyl)linoleoylamide
-
competitive versus anadamide
N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
N-(3-methylpyridin-2-yl)-2-(4'-isobutylphenyl)propionamide
-
i.e. Ibu-am5
N-(4-hydroxy-2-methylphenyl) arachidonoyl amide
-
i.e. VDM11, inhibits the metabolism of anandamide by rat brain FAAH. Inhibition may at least in part be a consequence of the compound acting as an alternative substrate
N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
-
i.e. AM404, a bioactive N-acylphenolamine, derived from paracetamol, competitve inhibition
N-(4-hydroxyphenyl)arachidonylamide
-
i.e. AM404, inhibits the metabolism of anandamide by rat brain FAAH
N-(phenylcarbamoyl)-3'-[(1E)-N-[(phenylcarbamoyl)oxy]ethanimidoyl]biphenyl-3-carboxamide
-
-
N-(pyridazin-3-yl)-4-(3-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzylidene)piperidine-1-carboxamide
N-(pyridin-3-yl)-4-(3-[[5-(trifluoromethyl)pyridin-2-yl]oxy]benzyl)piperidine-1-carboxamide
-
-
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-(2-hydroxyethyl)azetidine-1-carboxamide
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-[2-(dimethylamino)ethyl]azetidine-1-carboxamide
N-benzyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
N-benzyl-3-[(R)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
N-benzyl-3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]-N-methylazetidine-1-carboxamide
N-methyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-carboxamide
-
-
N-methyl-1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-indole-5-sulfonamide
-
-
N-methyl-2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide
-
-
N-n-heptyl benzodioxaphosphorin oxide
-
-
N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
N-phenyl-4-(3-phenyl-4,5-dihydro-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
-
-
N-tert-butyl-3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidine-1-carboxamide
N-[4-(4-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
naproxen
-
38% inhibition at 0.1 mM
O-n-octyl benzodioxaphosphorin oxide
-
-
O-octyl-benzodioxaphosphorin oxide
-
-
octyl sulfonyl fluoride
-
-
octyl-benzodioxaphosphorin oxide
-
-
OL-135
oleoyl ethylamide
oleoyl oxazolopyridine
oleyl-benzodioxaphosphorin oxide
-
-
oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
oxiran-2-ylmethyl (9Z)-hexadec-9-enoate
-
-
oxiran-2-ylmethyl (9Z)-octadec-9-enoate
-
-
oxiran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
-
-
oxiran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
-
-
oxiran-2-ylmethyl 1,1'-biphenyl-2-carboxylate
-
-
oxiran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
-
-
oxiran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
-
-
oxiran-2-ylmethyl benzoate
-
-
palmitoyl ethanolamide
Paraoxon
-
-
PF-3845
phenyl-benzodioxaphosphorin oxide
-
-
phenylmethane sulfonyl fluoride
-
irreversible inhibition
piperidin-1-yl[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
-
-
profenofos
-
-
S-heptyl benzodioxaphosphorin oxide
-
-
S-nonyl benzodioxaphosphorin oxide
-
-
S-pentyl benzodioxaphosphorin oxide
-
-
stearyl benzodioxaphosphorin oxide
-
-
tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z)-hexadec-9-enoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z)-octadec-9-enoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z)-octadeca-9,12-dienoate
-
-
tetrahydro-2H-pyran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
-
-
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-2-carboxylate
-
-
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-3-carboxylate
-
-
tetrahydro-2H-pyran-2-ylmethyl 1,1'-biphenyl-4-carboxylate
-
-
tetrahydro-2H-pyran-2-ylmethyl benzoate
-
-
tetrahydro-2H-pyran-4-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
trans-anandamide
-
inhibits hydrolysis of anandamide
URB532
-
-
URB597
VER-156084
[(2R)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
-
[(2S)-4-oxo-1-(pent-4-enoyl)azetidin-2-yl]methyl (benzyloxy)acetate
-
-
[(2S)-4-oxo-1-(pent-4-enoyl)azetidin-2-yl]methyl 4-(pyridin-2-yl)butanoate
-
-
[(2S)-4-oxo-1-(pent-4-enoyl)azetidin-2-yl]methyl 4-(pyridin-4-yl)butanoate
-
-
[(2S)-6-phenoxy-3,4-dihydro-2H-chromen-2-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
-
[(3R)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl](1,3-oxazol-2-yl)methanone
-
-
[(3R)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
-
[(3R)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
-
[(3R)-7-phenyl-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
-
[(3S)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl](1,3-oxazol-2-yl)methanone
-
-
[(3S)-7-(benzyloxy)-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
-
[(3S)-7-phenoxy-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
-
[(3S)-7-phenyl-3,4-dihydro-2H-chromen-3-yl][5-(pyridin-2-yl)-1,3-oxazol-2-yl]methanone
-
-
[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
-
-
[1-(2-naphthylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
-
-
[1-(m-tolylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
-
-
[1-(o-tolylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
-
-
[1-(p-tolylmethyl)triazol-4-yl]methyl N-cyclohexylcarbamate
-
-
[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(2-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(2-cyanophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
-
[1-[(2-fluoro-3-methoxy-phenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
-
[1-[(2-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
-
-
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(3,5-difluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3,5-dimethoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3-cyanophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
-
[1-[(3-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(3-methoxyphenyl)methyl]triazol-4-yl]methyl N-[[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl]carbamate
[1-[(4-chlorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
-
[1-[(4-cyanophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
-
[1-[(4-fluorophenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
-
[1-[(4-methoxyphenyl)methyl]triazol-4-yl]methyl N-cyclohexylcarbamate
-
-
[3-[(2-chlorophenyl)(4-chlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)(3,4-dichlorophenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)(3-methoxyphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)(phenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(3-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](1,3-dihydro-2H-isoindol-2-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-hydroxypiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](2-methylpiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3,4-dihydroisoquinolin-2(1H)-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-hydroxypyrrolidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](3-methylpiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4,4-difluoropiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-fluoropiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-hydroxypiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperazin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](4-methylpiperidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](morpholin-4-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
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-
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](pyrrolidin-1-yl)methanone
[3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
[3-[(4-chlorophenyl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(6-chloropyridin-3-yl)(2-methylphenyl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[(S)-(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[1,3-benzodioxol-5-yl(2-chloropyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[3-[phenyl(pyridin-3-yl)methoxy]azetidin-1-yl](piperidin-1-yl)methanone
[4-(3-phenoxybenzyl)piperazin-1-yl](1H-1,2,4-triazol-1-yl)methanone
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-
[4-(diphenylmethyl)piperazin-1-yl](1H-1,2,4-triazol-1-yl)methanone
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-
[4-(diphenylmethyl)piperazin-1-yl](1H-imidazol-1-yl)methanone
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-
[4-[bis(1,3-benzodioxol-5-yl)methyl]piperidin-1-yl](1H-1,2,4-triazol-1-yl)methanone
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[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl](1H-1,2,4-triazol-1-yl)methanone
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-
[[(E)-[1-[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]ethylidene]amino]oxy](naphthalen-1-ylamino)methanone
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-
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
33
(R)-alpha-methanandamide
-
pH 7.4, 37°C
7.94
(S)-alpha-methanandamide
-
pH 7.4, 37°C
0.0018 - 2.78
anandamide
2.34
arachidonamide
-
pH 7.4, 37°C
0.06
arachidonoyl p-nitroanilide
-
pH 9.0, wild-type enzyme
0.057
decanoyl p-nitroanilide
-
pH 9.0, wild-type enzyme
0.41
heptanoyl p-nitroanilide
-
pH 9.0, wild-type enzyme
0.065
lauroyl p-nitroanilide
-
pH 9.0, wild-type enzyme
0.069 - 0.099
myristoyl p-nitroanilide
7.31
N-(o-hydroxyphenyl)arachidonamide
-
pH 7.4, 37°C
0.057 - 0.57
nonanoyl p-nitroanilide
0.22
octanoyl p-nitroanilide
-
pH 9.0, wild-type enzyme
0.007 - 0.037
oleamide
0.009 - 0.041
oleoyl methyl amide
0.022 - 0.063
oleoyl methyl ester
0.012 - 0.126
oleoyl p-nitroanilide
0.074
palmitoyl p-nitroanilide
-
pH 9.0, wild-type enzyme
additional information
additional information
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.48
arachidonoyl p-nitroanilide
Rattus norvegicus
-
pH 9.0, wild-type enzyme
0.56
decanoyl p-nitroanilide
Rattus norvegicus
-
pH 9.0, wild-type enzyme
0.46
heptanoyl p-nitroanilide
0.13 - 0.29
myristoyl p-nitroanilide
0.2 - 0.6
nonanoyl p-nitroanilide
0.73
octanoyl p-nitroanilide
Rattus norvegicus
-
pH 9.0, wild-type enzyme
0.00026 - 20
oleamide
0.0001 - 1.9
oleoyl methyl amide
0.0002 - 0.17
oleoyl methyl ester
0.00052 - 2.8
oleoyl p-nitroanilide
0.27
palmitoyl p-nitroanilide
Rattus norvegicus
-
pH 9.0, wild-type enzyme
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000082
(10Z)-1,1,1-trifluorononadec-10-en-2-one
-
-
0.001
(10Z)-1-bromononadec-10-en-2-one
-
-
0.0009
(10Z)-2-oxononadec-10-enamide
-
-
0.000047
(5Z,8Z,11Z,14Z)-1-pyridazin-3-ylicosa-5,8,11,14-tetraen-1-one
-
-
0.000001
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
-
0.000002
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
-
0.000018
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
-
0.00015
(9E)-1-pyridazin-3-yloctadec-9-en-1-one
-
-
0.0000032
(9E)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one
-
-
0.00037
(9Z)-1-(1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
0.000017
(9Z)-1-(1,3-oxazol-2-yl)octadec-9-en-1-one
-
-
0.0037
(9Z)-1-(1-methyl-1H-tetrazol-5-yl)octadec-9-en-1-one
-
-
0.0098
(9Z)-1-(1H-tetrazol-5-yl)octadec-9-en-1-one
-
-
0.000065
(9Z)-1-(2-methyl-2H-tetrazol-5-yl)octadec-9-en-1-one
-
-
0.0045
(9Z)-1-(4,5-dihydro-1,3-oxazol-2-yl)octadec-9-en-1-one
-
-
0.013
(9Z)-1-(7-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
-
0.00054
(9Z)-1-pyrazin-2-yloctadec-9-en-1-one
-
-
0.00013
(9Z)-1-pyridazin-3-yloctadec-9-en-1-one
-
-
0.0025
(9Z)-1-pyrimidin-2-yloctadec-9-en-1-one
-
-
0.00011
(9Z)-1-pyrimidin-4-yloctadec-9-en-1-one
-
-
0.0000023
(9Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one
-
-
0.0000072
(9Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-yloctadec-9-en-1-one
-
-
0.000011
(9Z)-1-[1,3]oxazolo[5,4-b]pyridin-2-yloctadec-9-en-1-one
-
-
0.0000037
(9Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-yloctadec-9-en-1-one
-
-
0.0085
(9Z)-octadec-9-enal
-
-
0.000038
(phenylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone
-
pH 8.4, 37°C
0.0035
1,1'-(5,5'-bi-1,3-oxazole-2,2'-diyl)bis(7-phenylheptan-1-one)
-
-
0.0024
1-(1,3-benzoxazol-2-yl)octadecan-1-one
-
-
0.000048
1-(1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
0.000002
1-(5-acetyl-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
0.000003
1-(5-bromo-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
0.000005
1-(5-chloro-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
0.00003
1-(5-fluoro-1,3-oxazol-2-yl)-7-phenylheptan-1-one
-
-
0.000012
1-(5-furan-2-yl-1,3-oxazol-2-yl)-7-phenylheptan-1-one