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Literature summary for 3.5.1.99 extracted from

  • Long, J.Z.; LaCava, M.; Jin, X.; Cravatt, B.F.
    An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase (2011), J. Lipid Res., 52, 337-344.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.99

Inhibitors

Inhibitors Comment Organism Structure
PF-3845 FAAH inhibitor, in vivo inhibition Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
anandamide + H2O Mus musculus i.e. arachidonoyl ethanolamide arachidonic acid + ethanolamine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein contains N-linked glycans Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
lung
-
 Mus musculus
-
additional information negligible activity in brown adipose tissue and heart Mus musculus
-
spleen
-
 Mus musculus
-
testis
-
 Mus musculus
-
white adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anandamide + H2O i.e. arachidonoyl ethanolamide Mus musculus arachidonic acid + ethanolamine
-
 ?

Synonyms

Synonyms Comment Organism
FA amide hydrolase
-
 Mus musculus
FAAH
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Mus musculus

General Information

General Information Comment Organism
malfunction tissue-specific changes in N-acyl ethanolamine congeners and N-acyl taurines metabolism caused by FAAH disruption in central and peripheral tissues, overview Mus musculus
physiological function fatty acid amide hydrolase is the principal enzyme responsible for anandamide hydrolysis in mammalian tissues and regulates amidated lipid transmitters, including the endocannabinoid anandamide and its N-acyl ethanolamine congeners and transient receptor potential channel agonists N-acyl taurines, in a tissue-specific manner, overview Mus musculus