Literature summary for 3.5.1.99 extracted from

Quistad, G.B.; Sparks, S.E.; Casida, J.E.
Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides (2001), Toxicol. Appl. Pharmacol., 173, 48-55.

Inhibitors

Inhibitors	Comment	Organism
chlorpyrifos oxon	-	Mus musculus
DFP	-	Mus musculus
dodecyl-benzodioxaphosphorin oxide	-	Mus musculus
ethyl octylphosphonofluoridate	-	Mus musculus
methyl arachidonyl phosphonofluoridate	-	Mus musculus
additional information	organophosphorus compound-induced FAAH inhibition and the associated anandamide accumulation may lead to reduced limb mobility as a secondary neurotoxic effect	Mus musculus
O-octyl-benzodioxaphosphorin oxide	-	Mus musculus
octyl-benzodioxaphosphorin oxide	-	Mus musculus
oleyl-benzodioxaphosphorin oxide	-	Mus musculus
paraoxon	-	Mus musculus
phenyl-benzodioxaphosphorin oxide	-	Mus musculus
profenofos	-	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
anandamide + H2O	Mus musculus	fatty acid amide hydrolase is a modulator of endogenous signaling compounds affecting sleep (oleamide) and analgesia (anandamide)	ethanolamine + arachidonic acid	-	?
oleamide + H2O	Mus musculus	fatty acid amide hydrolase is a modulator of endogenous signaling compounds affecting sleep (oleamide) and analgesia (anandamide)	oleic acid + NH3	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
liver	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
anandamide + H2O	-	Mus musculus	ethanolamine + arachidonic acid	-	?
anandamide + H2O	fatty acid amide hydrolase is a modulator of endogenous signaling compounds affecting sleep (oleamide) and analgesia (anandamide)	Mus musculus	ethanolamine + arachidonic acid	-	?
oleamide + H2O	-	Mus musculus	oleic acid + NH3	-	?
oleamide + H2O	fatty acid amide hydrolase is a modulator of endogenous signaling compounds affecting sleep (oleamide) and analgesia (anandamide)	Mus musculus	oleic acid + NH3	-	?

Synonyms

Synonyms	Comment	Organism
FAAH	-	Mus musculus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.0000001	-	25°C, pH 9.0, brain enzyme	Mus musculus	methyl arachidonyl phosphonofluoridate
0.00000018	-	25°C, pH 9.0, liver enzyme	Mus musculus	oleyl-benzodioxaphosphorin oxide
0.0000006	-	25°C, pH 9.0, brain enzyme	Mus musculus	ethyl octylphosphonofluoridate
0.00000067	-	25°C, pH 9.0, brain enzyme	Mus musculus	oleyl-benzodioxaphosphorin oxide
0.0000009	-	25°C, pH 9.0, liver enzyme	Mus musculus	dodecyl-benzodioxaphosphorin oxide
0.0000011	-	25°C, pH 9.0, liver enzyme	Mus musculus	ethyl octylphosphonofluoridate
0.000005	-	25°C, pH 9.0, brain enzyme	Mus musculus	dodecyl-benzodioxaphosphorin oxide
0.000007	-	25°C, pH 9.0, liver enzyme	Mus musculus	octyl-benzodioxaphosphorin oxide
0.0000081	-	25°C, pH 9.0, brain enzyme	Mus musculus	octyl-benzodioxaphosphorin oxide
0.000024	-	25°C, pH 9.0, liver enzyme	Mus musculus	O-octyl-benzodioxaphosphorin oxide
0.00004	-	25°C, pH 9.0, brain enzyme	Mus musculus	chlorpyrifos oxon
0.000056	-	25°C, pH 9.0, liver enzyme	Mus musculus	chlorpyrifos oxon
0.000073	-	25°C, pH 9.0, brain enzyme	Mus musculus	O-octyl-benzodioxaphosphorin oxide
0.000082	-	25°C, pH 9.0, liver enzyme	Mus musculus	methyl arachidonyl phosphonofluoridate
0.00015	-	25°C, pH 9.0, liver enzyme	Mus musculus	profenofos
0.00027	-	25°C, pH 9.0, brain enzyme	Mus musculus	profenofos
0.00054	-	25°C, pH 9.0, brain enzyme	Mus musculus	paraoxon
0.00077	-	25°C, pH 9.0, liver enzyme	Mus musculus	paraoxon
0.0089	-	25°C, pH 9.0, liver enzyme	Mus musculus	phenyl-benzodioxaphosphorin oxide
0.011	-	25°C, pH 9.0, brain enzyme	Mus musculus	phenyl-benzodioxaphosphorin oxide
0.029	-	25°C, pH 9.0, liver enzyme	Mus musculus	DFP
0.048	-	25°C, pH 9.0, brain enzyme	Mus musculus	DFP