Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.1.99 extracted from

  • Muccioli, G.G.; Xu, C.; Odah, E.; Cudaback, E.; Cisneros, J.A.; Lambert, D.M.; Lopez Rodriguez, M.L.; Bajjalieh, S.; Stella, N.
    Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells (2007), J. Neurosci., 27, 2883-2889.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1,1-biphenyl-3-yl-carbamic acid cyclohexyl ester i.e. URB602 Mus musculus
methyl arachidonyl fluorophosphonate
-
Mus musculus
additional information the microglial-specific isozyme is not inhibited by URB597, i.e. 3'-carbamoyl-biphenyl-3-ylcyclohexylcarbamate, and inhibitors of cyclooxygenases, lipooxygenases, and diacylglycerol lipases, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-arachidonoylglycerol + H2O Mus musculus FAAH is responsible for approximately one-half of the 2-arachidonoylglycerol hydrolysis occurring in BV-2 cell homogenate ?
-
?
anandamide + H2O Mus musculus anandamide hydrolysis in BV-2 cells is entirely attributable to FAAH ethanolamine + arachidonic acid
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BV-2 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-arachidonoylglycerol + H2O FAAH is responsible for approximately one-half of the 2-arachidonoylglycerol hydrolysis occurring in BV-2 cell homogenate Mus musculus ?
-
?
anandamide + H2O anandamide hydrolysis in BV-2 cells is entirely attributable to FAAH Mus musculus ethanolamine + arachidonic acid
-
?

Synonyms

Synonyms Comment Organism
FAAH
-
Mus musculus