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Literature summary for 3.5.1.99 extracted from

  • Boger, D.L.; Sato, H.; Lerner, A.E.; Hedrick, M.P.; Fecik, R.A.; Miyauchi, H.; Wilkie, G.D.; Austin, B.J.; Patricelli, M.P.; Cravatt, B.F.
    Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide (2000), Proc. Natl. Acad. Sci. USA, 97, 5044-5049.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.99

Inhibitors

Inhibitors Comment Organism Structure
(10Z)-1,1,1-trifluorononadec-10-en-2-one
-
 Homo sapiens
(10Z)-1-bromononadec-10-en-2-one
-
 Homo sapiens
(10Z)-2-oxononadec-10-enamide
-
 Homo sapiens
(5Z,8Z,11Z,14Z)-1-pyridazin-3-ylicosa-5,8,11,14-tetraen-1-one
-
 Homo sapiens
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
 Homo sapiens
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
 Homo sapiens
(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
 Homo sapiens
(9E)-1-pyridazin-3-yloctadec-9-en-1-one
-
 Homo sapiens
(9E)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(1,3-benzothiazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(1,3-oxazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(1,3-thiazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(1-methyl-1H-benzimidazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(1-methyl-1H-imidazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(1-methyl-1H-tetrazol-5-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(1H-benzimidazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(1H-tetrazol-5-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(2-methyl-2H-tetrazol-5-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(4,5-dihydro-1,3-oxazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(4-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(5-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(6-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-(7-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-phenyloctadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-pyrazin-2-yloctadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-pyridazin-3-yloctadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-pyridin-2-yloctadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-pyrimidin-2-yloctadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-pyrimidin-4-yloctadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-yloctadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-[1,3]oxazolo[5,4-b]pyridin-2-yloctadec-9-en-1-one
-
 Homo sapiens
(9Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-yloctadec-9-en-1-one
-
 Homo sapiens
(9Z)-octadec-9-enal
-
 Homo sapiens
1-(1,3-benzoxazol-2-yl)octadecan-1-one
-
 Homo sapiens
1-pyridazin-3-yloctadecan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-4-phenylbutan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-5-phenylpentan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-6-phenylhexan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-7-phenylheptan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-8-phenyloctan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yl-9-phenylnonan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yldec-9-en-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yldec-9-yn-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yldecan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yldodecan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-ylethanone
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-ylheptan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-ylhexadecan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-ylhexan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-yn-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadecan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yloctan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-ylpentan-1-one
-
 Homo sapiens
1-[1,3]oxazolo[4,5-b]pyridin-2-yltetradecan-1-one
-
 Homo sapiens
ethyl (10Z)-2-oxononadec-10-enoate
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-
plasma membrane
-
 Rattus norvegicus 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
FAAH
-
 Homo sapiens
FAAH
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000014
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-yn-1-one
-
 Homo sapiens
0.00000015
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yldec-9-en-1-one
-
 Homo sapiens
0.00000018
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yldec-9-yn-1-one
-
 Homo sapiens
0.0000002
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yl-6-phenylhexan-1-one
-
 Homo sapiens
0.00000028
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yl-7-phenylheptan-1-one
-
 Homo sapiens
0.0000003
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yl-5-phenylpentan-1-one
-
 Homo sapiens
0.00000039
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yl-8-phenyloctan-1-one
-
 Homo sapiens
0.00000052
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yl-9-phenylnonan-1-one
-
 Homo sapiens
0.00000057
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yldodecan-1-one
-
 Homo sapiens
0.00000069
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yloctan-1-one
-
 Homo sapiens
0.00000075
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yldecan-1-one
-
 Homo sapiens
0.000001
-
 (5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
 Homo sapiens
0.0000017
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yltetradecan-1-one
-
 Homo sapiens
0.0000019
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-ylhexadecan-1-one
-
 Homo sapiens
0.000002
-
 (5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
 Homo sapiens
0.0000021
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-ylheptan-1-one
-
 Homo sapiens
0.0000023
-
 (9Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one
-
 Homo sapiens
0.0000032
-
 (9E)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one
-
 Homo sapiens
0.0000037
-
 (9Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-yloctadec-9-en-1-one
-
 Homo sapiens
0.0000069
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yl-4-phenylbutan-1-one
-
 Homo sapiens
0.0000072
-
 (9Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-yloctadec-9-en-1-one
-
 Homo sapiens
0.000011
-
 (9Z)-1-[1,3]oxazolo[5,4-b]pyridin-2-yloctadec-9-en-1-one
-
 Homo sapiens
0.000011
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadecan-1-one
-
 Homo sapiens
0.000015
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-ylhexan-1-one
-
 Homo sapiens
0.000017
-
 (9Z)-1-(1,3-oxazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
0.000018
-
 (5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one
-
 Homo sapiens
0.000047
-
 (5Z,8Z,11Z,14Z)-1-pyridazin-3-ylicosa-5,8,11,14-tetraen-1-one
-
 Homo sapiens
0.00005
-
 1-[1,3]oxazolo[4,5-b]pyridin-2-ylpentan-1-one
-
 Homo sapiens
0.000065
-
 (9Z)-1-(2-methyl-2H-tetrazol-5-yl)octadec-9-en-1-one
-
 Homo sapiens
0.000082
-
 (10Z)-1,1,1-trifluorononadec-10-en-2-one
-
 Homo sapiens
0.00011
-
 (9Z)-1-pyrimidin-4-yloctadec-9-en-1-one
-
 Homo sapiens
0.00013
-
 (9Z)-1-pyridazin-3-yloctadec-9-en-1-one
-
 Homo sapiens
0.00015
-
 (9E)-1-pyridazin-3-yloctadec-9-en-1-one
-
 Homo sapiens
0.00037
-
 (9Z)-1-(1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
0.0005
-
 ethyl (10Z)-2-oxononadec-10-enoate
-
 Homo sapiens
0.00054
-
 (9Z)-1-pyrazin-2-yloctadec-9-en-1-one
-
 Homo sapiens
0.0007
-
 1-pyridazin-3-yloctadecan-1-one
-
 Homo sapiens
0.0009
-
 (10Z)-2-oxononadec-10-enamide
-
 Homo sapiens
0.001
-
 (10Z)-1-bromononadec-10-en-2-one
-
 Homo sapiens
0.0024
-
 1-(1,3-benzoxazol-2-yl)octadecan-1-one
-
 Homo sapiens
0.0025
-
 (9Z)-1-pyrimidin-2-yloctadec-9-en-1-one
-
 Homo sapiens
0.0037
-
 (9Z)-1-(1-methyl-1H-tetrazol-5-yl)octadec-9-en-1-one
-
 Homo sapiens
0.0045
-
 (9Z)-1-(4,5-dihydro-1,3-oxazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens
0.0085
-
 (9Z)-octadec-9-enal
-
 Homo sapiens
0.0098
-
 (9Z)-1-(1H-tetrazol-5-yl)octadec-9-en-1-one
-
 Homo sapiens
0.013
-
 (9Z)-1-(7-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one
-
 Homo sapiens