Information on EC 2.7.11.30 - receptor protein serine/threonine kinase

Word Map on EC 2.7.11.30
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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.11.30
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RECOMMENDED NAME
GeneOntology No.
receptor protein serine/threonine kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Phosphorylation
SYSTEMATIC NAME
IUBMB Comments
ATP:[receptor-protein] phosphotransferase
The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].
CAS REGISTRY NUMBER
COMMENTARY hide
146702-86-5
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152060-53-2
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154907-75-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1141388 A+, 1141727 A+, 1225462 A+, 1225474 A+, 1225476 A+, 1225477 A+, 1225479 A+, 1225498 A+, 1225505 A+, 1225507 A+, 1225517 A+, 1225518 A+, 1225552 A+, 1225572 A+, 1225588 A+, 1225589 A+, 1225599 A+, 1343802 A+, 1351664 A+, 1353026 A+, 1354040 A+, 1650826 A+, 1671024 A+, 1716038 A+, 1747658 A+, 1842339 A+, 1846075 A+, 1925742 A+, 1939082 A+, 1946695 A+, 1946830 A+, 1946850 A+, 1946902 A+, 1946980 A+, 2076085 A+, 2076101 A+, 2076112 A+, 2076129 A+, 2076162 A+, 2076167 A+, 2076207 A+, 2076236 A+, 2076249 A+, 2076250 A+, 2076263 A+, 2076266 A+, 2076308 A+, 2076330 A+, 2076342 A+, 2076353 A+, 2076356 A+, 2076378 A+, 2076391 A+, 2076417 A+, 2076430 A+, 2076437 A+, 2076440 A+, 2076457 A+, 2076462 A+, 2076476 A+, 2076487 A+, 2172418 A+, 2317031 A+, 2324204 A+, 2327525 A+, 2328946 A+, 2334538 A+, 2390131 A+, 2390137 A+, 2390150 A+, 2390246 A+, 2390261 A+, 2390295 A+, 2390299 A+, 2390307 A+, 2390308 A+, 2390325 A+, 2390328 A+, 2390361 A+, 2390363 A+, 2415594 A+, 2539958 A+, 2569636 A+, 2777368 A+, 2779033 A+, 2894808 A+, 2930851 A+, 2943958 A+, 2979361 A+, 2981479 A+, 2981894 A+, 3014140 A+, 3103314 A+, 3103351 A+, 3103386 A+, 3103387 A+, 3103408 A+, 3103415 A+, 3103452 A+, 3103464 A+, 3103496 A+, 3103517 A+, 3103523 A+, 3103524 A+, 3103528 A+, 3103550 A+, 3103590 A+, 3103612 A+, 3103619 A+, 3103675 A+, 3103676 A+, 3103677 A+, 3103690 A+, 3103695 A+, 3103700 A+, 3103704 A+, 3103720 A+, 3103724 A+, 3103728 A+, 3103763 A+, 3103767 A+, 3103776 A+, 3103780 A+, 3103816 A+, 3103823 A+, 3103829 A+, 3103843 A+, 692159 A+, 771537 A+, 1225542 A++, 1225560 A++, 1225562 A++, 1225563 A++, 1225591 A++, 2076347 A++, 2076366 A++, 2334928 A++, 2335753 A++, 2390229 A++, 2390232 A++, 2390324 A++, 2390331 A++, 2390341 A++, 2390349 A++, 2390351 A++, 2950112 A++, 2981038 A++, 2981383 A++, 3103555 A++, 3103621 A++, 3103622 A++, 3103714 A++, 3103753 A++, 1225551 A++, 1932422 A++, 2076297 A++, 2076322 A++, 2076472 A++, 2390217 A++, 2390243 A++, 2390244 A++, 2698385 A++, 2777936 A++, 2870981 A++, 2950524 A++, 2957132 A++, 2973343 A++, 2974897 A++, 2979503 A++, 2980514 A++, 3102141 A++, 3103549 A++, 3103758 A++, 3103810 A++, 693932 A++, 1225482 A+++, 1225520 A+++, 1225525 A+++, 1225526 A+++, 1225565 A+++, 1225594 A+++, 1225597 A+++, 1225605 A+++, 1225607 A+++, 1225573 A++++, 1225579 A++++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1129946 A+, 1138137 A+, 1141262 A+, 1141539 A+, 1179444 A+, 1188227 A+, 1225403 A+, 1225406 A+, 1225420 A+, 1225442 A+, 1225448 A+, 1225451 A+, 1225453 A+, 1225460 A+, 1225491 A+, 1225501 A+, 1225527 A+, 1225546 A+, 1225575 A+, 1225576 A+, 1225577 A+, 1225600 A+, 1307723 A+, 1352827 A+, 1361291 A+, 1413760 A+, 1418652 A+, 1441307 A+, 1466026 A+, 1613230 A+, 1745638 A+, 1946510 A+, 1946577 A+, 1946604 A+, 1946732 A+, 1946754 A+, 1946866 A+, 1947611 A+, 1948047 A+, 2076061 A+, 2076070 A+, 2076087 A+, 2076096 A+, 2076099 A+, 2076126 A+, 2076133 A+, 2076144 A+, 2076151 A+, 2076165 A+, 2076166 A+, 2076192 A+, 2076205 A+, 2076216 A+, 2076218 A+, 2076257 A+, 2076283 A+, 2076300 A+, 2076306 A+, 2076312 A+, 2076335 A+, 2076343 A+, 2076385 A+, 2076403 A+, 2076446 A+, 2076488 A+, 2321569 A+, 2328161 A+, 2334307 A+, 2345462 A+, 2390083 A+, 2390104 A+, 2390111 A+, 2390121 A+, 2390124 A+, 2390133 A+, 2390160 A+, 2390169 A+, 2390198 A+, 2390275 A+, 2390308 A+, 2390319 A+, 2390359 A+, 2390367 A+, 2489450 A+, 2772926 A+, 2864887 A+, 2931551 A+, 2958189 A+, 2969467 A+, 2978820 A+, 3103280 A+, 3103309 A+, 3103320 A+, 3103323 A+, 3103362 A+, 3103443 A+, 3103489 A+, 3103495 A+, 3103525 A+, 3103543 A+, 3103596 A+, 3103751 A+, 703244 A+, 792384 A+, 1225531 A++, 1475328 A++, 2076269 A++, 2076471 A++, 3103499 A++, 3103669 A++, 2076427 A++, 2195239 A++, 2390282 A++, 2950112 A++, 1141163 A+++, 1225414 A+++, 1225418 A+++, 1225419 A+++, 1225446 A+++, 1225454 A+++, 1225457 A+++, 1225473 A+++, 1225493 A+++, 1225547 A+++, 1225570 A+++, 1225611 A+++, 819222 A+++, 1225519 A++++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
shrimp
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
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activin receptor-like-kinase 1 is a receptor for ligands of the transforming growth factor-beta family
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + KKVLTQMGSPSIRCS(P)SV(P)S
ADP + ?
show the reaction diagram
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Smad3-derived peptide substrate
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-
?
ATP + KKVLTQMGSPSIRCS(P)SVA
ADP + ?
show the reaction diagram
-
Smad3-derived peptide substrate
-
-
?
ATP + KKVLTQMGSPSIRCS(P)SVS
ADP + ?
show the reaction diagram
-
Smad3-derived peptide substrate
-
-
?
ATP + KMGSPSVRCS(P)SMS
ADP + ?
show the reaction diagram
TGF-beta-induced phosphorylation by TbetaRI receptor kinase of the Smad2-derived, phosphorylated peptide substrate containing Ser465 phosphorylation site, poor activity with nonphosphorylated peptide substrate
-
-
?
ATP + KVLTQMGSPSIRCS(P)SVS
ADP + ?
show the reaction diagram
-
Smad3-derived peptide substrate
-
-
?
ATP + KVLTQMGSPSIRCSSV(P)S
ADP + ?
show the reaction diagram
-
Smad3-derived peptide substrate
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-
?
ATP + KVLTQMGSPSVRCS(P)SMS
ADP + ?
show the reaction diagram
-
Smad2-derived peptide substrate
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-
?
ATP + KVLTQMGSPSVRCSSMS
ADP + ?
show the reaction diagram
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Smad2-derived peptide substrate
-
-
?
ATP + KVLTQMGSPSVRCSSMS(P)S
ADP + ?
show the reaction diagram
-
Smad2-derived peptide substrate
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-
?
ATP + Smad
ADP + phosphorylated Smad
show the reaction diagram
ATP + Smad1
ADP + phosphorylated Smad1
show the reaction diagram
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phosphorylation by ALK1
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-
?
ATP + Smad2
ADP + phosphorylated Smad2
show the reaction diagram
ATP + Smad3
ADP + phosphorylated Smad3
show the reaction diagram
ATP + Smad5
ADP + phosphorylated Smad5
show the reaction diagram
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phosphorylation by ALK1
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-
?
ATP + [actividin receptor]
ADP + [actividin receptor] phosphate
show the reaction diagram
ATP + [TGF-beta receptor II]
ADP + [TGF-beta receptor II] phosphate
show the reaction diagram
ATP + [TGF-beta receptor I]
ADP + [TGF-beta receptor I] phosphate
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + Smad
ADP + phosphorylated Smad
show the reaction diagram
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involved in ALK5 activation of p38 MAPK signaling and of GADDbeta45 and BGN expression induced by TGF-beta
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-
?
ATP + Smad1
ADP + phosphorylated Smad1
show the reaction diagram
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phosphorylation by ALK1
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-
?
ATP + Smad2
ADP + phosphorylated Smad2
show the reaction diagram
ATP + Smad3
ADP + phosphorylated Smad3
show the reaction diagram
ATP + Smad5
ADP + phosphorylated Smad5
show the reaction diagram
-
phosphorylation by ALK1
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-
?
ATP + [actividin receptor]
ADP + [actividin receptor] phosphate
show the reaction diagram
ATP + [TGF-beta receptor II]
ADP + [TGF-beta receptor II] phosphate
show the reaction diagram
-
regulation and metabolism, overview
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?
ATP + [TGF-beta receptor I]
ADP + [TGF-beta receptor I] phosphate
show the reaction diagram
additional information
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-(1,3-benzodioxol-5-yl)-2-(6-ethylpyridin-2-yl)ethanone
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1-(1,3-benzodioxol-5-yl)-2-(6-methylpyridin-2-yl)ethanone
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1-(1,3-benzodioxol-5-yl)-2-bromo-2-(6-ethylpyridin-2-yl)ethanone
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1-(1,3-benzodioxol-5-yl)-2-bromo-2-(6-methylpyridin-2-yl)ethanone
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1-(1,3-benzodioxol-5-yl)-2-bromo-2-pyridin-2-ylethanone
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1-(1,3-benzodioxol-5-yl)-2-pyridin-2-ylethanone
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2,6-lutidine
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i.e. 2,6-dimethylpyridine
2-(6-ethylpyridin-2-yl)-1-quinoxalin-6-ylethanone
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2-(6-methylpyridin-2-yl)-1-quinoxalin-6-ylethanone
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2-bromo-2-(6-ethylpyridin-2-yl)-1-quinoxalin-6-ylethanone
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2-bromo-2-(6-methylpyridin-2-yl)-1-quinoxalin-6-ylethanone
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2-bromo-2-pyridin-2-yl-1-quinoxalin-6-ylethanone
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2-picoline
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2-pyridin-2-yl-1-quinoxalin-6-ylethanone
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3-((4-(6-methylpyridin-2-yl)-5-(quinolin-6-yl)-1H-imidazol-2-yl)methyl)benzamide
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IN-1233, inhibitor specifically inhibits TGF-beta signaling via ALK-5 by acting as a competitive inhibitor of the ATP-binding site, inhibition of activin receptor-like kinase-5 signaling in vivo with the selective small-molecule inhibitor prevents pulmonary arterial hypertension, right ventricular hypertrophy, and vascular remodeling after monocrotaline injection and inhibits the progression of established pulmonary arterial hypertension in this model
3-([[4-(1,3-benzodioxol-5-yl)-5-(6-ethylpyridin-2-yl)-1,3-thiazol-2-yl]amino]methyl)benzamide
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3-([[4-(1,3-benzodioxol-5-yl)-5-(6-ethylpyridin-2-yl)-1,3-thiazol-2-yl]amino]methyl)benzonitrile
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3-([[4-(1,3-benzodioxol-5-yl)-5-(6-methylpyridin-2-yl)-1,3-thiazol-2-yl]amino]methyl)benzamide
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3-([[4-(1,3-benzodioxol-5-yl)-5-(6-methylpyridin-2-yl)-1,3-thiazol-2-yl]amino]methyl)benzonitrile
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3-([[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1,3-thiazol-2-yl]amino]methyl)benzamide
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3-([[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1,3-thiazol-2-yl]amino]methyl)benzonitrile
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3-([[5-(6-ethylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-yl]amino]methyl)benzonitrile
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3-([[5-(6-methylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-yl]amino]methyl)benzonitrile
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3-[[(5-pyridin-2-yl-4-quinoxalin-6-yl-1,3-thiazol-2-yl)amino]methyl]benzamide
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3-[[(5-pyridin-2-yl-4-quinoxalin-6-yl-1,3-thiazol-2-yl)amino]methyl]benzonitrile
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3-[[5-(6-ethylpyridin-2-yl)-4-(quinoxalin-6-yl)thiazol-2-ylamino]methyl]benzamide
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3-[[5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)thiazol-2-ylamino]methyl]benzamide
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4(quinolin-4-yl)-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole derivatives
4-(1,3-benzodioxol-5-yl)-5-(6-ethylpyridin-2-yl)-1,3-thiazol-2-amine
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4-(1,3-benzodioxol-5-yl)-5-(6-methylpyridin-2-yl)-1,3-thiazol-2-amine
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4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1,3-thiazol-2-amine
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4-([[4-(1,3-benzodioxol-5-yl)-5-(6-ethylpyridin-2-yl)-1,3-thiazol-2-yl]amino]methyl)benzonitrile
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4-([[4-(1,3-benzodioxol-5-yl)-5-(6-methylpyridin-2-yl)-1,3-thiazol-2-yl]amino]methyl)benzonitrile
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4-([[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1,3-thiazol-2-yl]amino]methyl)benzonitrile
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4-([[5-(6-ethylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-yl]amino]methyl)benzamide
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4-([[5-(6-ethylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-yl]amino]methyl)benzonitrile
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4-([[5-(6-methylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-yl]amino]methyl)benzamide
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4-([[5-(6-methylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-yl]amino]methyl)benzonitrile
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4-phenyl substituted pyrazole inhibitors
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inhibitory potency of 4-phenyl substituted pyrazole derivatives, IC50 of 30-555 nM, overview
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4-phenyl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole derivatives
4-[[(5-pyridin-2-yl-4-quinoxalin-6-yl-1,3-thiazol-2-yl)amino]methyl]benzamide
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4-[[(5-pyridin-2-yl-4-quinoxalin-6-yl-1,3-thiazol-2-yl)amino]methyl]benzonitrile
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5-(6-ethylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-amine
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5-(6-methylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-amine
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5-pyridin-2-yl-4-quinoxalin-6-yl-1,3-thiazol-2-amine
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6-ethyl-2-methylpyridine
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i.e. 2-ethyl-6-methylpyridine
calphostin C
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LY2109761
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TGF-beta receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-beta1 in myelo-monocytic leukaemic cells, it LY2109761 enhanced apoptosis only in the presence of exogenously added TGF-beta1
LY2157299
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inhibits Smad3 and Smad3 phosphorylation and antagonizes TGF-beta receptor I kinase activity in vivo in human cancer cells implanted into nude mice, pharmacokinetic model, overview
LY364947
LY566578
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competitive to ATP, noncompetitive to the peptide substrate, IC50 is 70 nM, mechanism
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LY580276
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PD98059
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PEG10
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ancient retroviral/retrotransposon element intergrated as a single copy gene in to human chromosome 7q21, encodes two splicing varaiants PEG10-RF1 and PEG10-RF1/2, gag- and gag-pol-like proteins that interact with TGF-beta family proteins, DNA and amino acid sequence deteramination and analysis of PEG10-RF1, PEG10-RF1 inhibits ALK1 and ALK5 signaling by direct interaction, overview
Rapamycin
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SB-431542
SB-505124
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SB-525334
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SB203580
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SD-208
Smad7
inhibits induction of receptor activation/signaling by GDF-9 in vivo
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additional information
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
actividin
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actividin A
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required for activity in a complex formed with ALK4 and ActRIIB or ActRII, identification of the functional binding site
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actividin B
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required for activity in a complex formed with ALK4 and ActRIIB or ActRII, identification of the functional binding site
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ALK5
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is important for ALK1/TGF-beta signaling
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growth differentiation factor-9
i.e. GDF-9, interacts with bone morphogenetic protein type II receptor, and activates type I actividin receptor-like kinase 5, ALK5, GDF-9 belongs to the TGF-beta family, no stimulation of receptors ALK1, ALK2, ALK3, and ALKA6 by GDF-9
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SARA protein
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i.e. Smad anchor for receptor activation protein, binding site for co-modulator Smad4, modulates self-association of partially phosphorylated Smad2 preventing premature release of monophosphorylated substrate, interaction with Smad2 via the Smad2 MH2 domain
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TGF-beta
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TGF-beta 3
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binds and activates ALK5
-
additional information
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increased D-glucose and palmitate concentrations increase the ALK7 enzyme expression in INS-1 cells
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0057 - 0.0088
ATP
0.26
KKVLTQMGSPSIRCS(P)SVS
-
pH 7.5, 30C, recombinant wild-type ALK5
0.331
KVLTQMGSPSVRCS(P)SMS
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pH 7.5, 30C, recombinant wild-type ALK5
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000028
LY364947
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pH 7.5, 30C, recombinant mutant T204D ALK5, inhibition of autophosphorylation
0.000038
LY566578
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pH 7.5, 30C, recombinant mutant T204D ALK5, inhibition of autophosphorylation
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0.000037
LY580276
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pH 7.5, 30C, recombinant mutant T204D ALK5, inhibition of autophosphorylation
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000034
3-((4-(6-methylpyridin-2-yl)-5-(quinolin-6-yl)-1H-imidazol-2-yl)methyl)benzamide
Rattus norvegicus
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-
0.00005 - 0.0051
4(quinolin-4-yl)-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole derivatives
0.00003 - 0.000555
4-phenyl substituted pyrazole inhibitors
Homo sapiens
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inhibitory potency of 4-phenyl substituted pyrazole derivatives, IC50 of 30-555 nM, overview
-
0.000005 - 0.02
4-phenyl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole derivatives
0.000031 - 0.000175
LY364947
0.00007
LY566578
Homo sapiens
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competitive to ATP, noncompetitive to the peptide substrate, IC50 is 70 nM, mechanism
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0.00058
LY580276
Homo sapiens
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competitive to ATP, noncompetitive to the peptide substrate, IC50 is 580 nM, mechanism
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
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assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22
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assay at
22 - 30
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assay at
25
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assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
e.g. on the dorsal surface of male parasites, and on the dorsal and ventral surfaces of female parasites
Manually annotated by BRENDA team
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from patients of German origin with tentative diagnosis of hereditary hemorrhagic telangiectasia
Manually annotated by BRENDA team
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CD34+ and stromal cells
Manually annotated by BRENDA team
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anaplastic carcinoma lung cell
Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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ALK2, nontransforming ventricular, misexpression of LAK2 in endocardial cells
Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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hepatoma cell line
Manually annotated by BRENDA team
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a myeloid leukemic cell line
Manually annotated by BRENDA team
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bone marrow stromal cells
Manually annotated by BRENDA team
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pancreatic Smad4 null cell line, expression of Smad2 and Smad3
Manually annotated by BRENDA team
surface, primary expression of type II receptor serine/threonine kinase, SmRK2
Manually annotated by BRENDA team
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an ovarian surface epithelial cell line
Manually annotated by BRENDA team
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an ovarian surface epithelial cell line
Manually annotated by BRENDA team
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hematopoietic cells
Manually annotated by BRENDA team
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a myeloid leukemic cell line
Manually annotated by BRENDA team
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breast carcinoma cell line, derived from malignant pleural effusions
Manually annotated by BRENDA team
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breast carcinoma cell line, derived from malignant pleural effusions
Manually annotated by BRENDA team
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breast Smad4 null cell line, expression of Smad2 and Smad3
Manually annotated by BRENDA team
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enbryonic fibroblast cell line
Manually annotated by BRENDA team
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osteosarcoma cell line
Manually annotated by BRENDA team
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a myelo-monocytic leukemic cell line
Manually annotated by BRENDA team
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carcinoma breast cell
Manually annotated by BRENDA team
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fibroblast cell line
Manually annotated by BRENDA team
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an ovarian cancer cell line
Manually annotated by BRENDA team
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primary cell culture, immunohistochemic analysis for ALK6 detection
Manually annotated by BRENDA team
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a myelo-monocytic leukemic cell line
Manually annotated by BRENDA team
-
a myelo-monocytic leukemic cell line
Manually annotated by BRENDA team
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diverse VACO cell lines, Smad4 null cell lines, expression analysis of Smad2, overview
Manually annotated by BRENDA team
additional information
PDB
SCOP
CATH
ORGANISM
UNIPROT