Information on EC 2.7.11.30 - receptor protein serine/threonine kinase

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The expected taxonomic range for this enzyme is: Bilateria

EC NUMBER
COMMENTARY
2.7.11.30
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RECOMMENDED NAME
GeneOntology No.
receptor protein serine/threonine kinase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
show the reaction diagram
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-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:[receptor-protein] phosphotransferase
The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
activin receptor-like kinase 1
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activin receptor-like kinase 1
P37023
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activin receptor-like kinase 1
-
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activin receptor-like kinase 1 gene
P37023
-
activin receptor-like kinase 2
-
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activin receptor-like kinase 5
-
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activin receptor-like kinase 5
-
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activin receptor-like kinase 5
-
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activin receptor-like kinase 5
-
-
activin receptor-like kinase 6
-
-
activin receptor-like kinase 7
-
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activin receptor-like kinase 7
Q8NER5
-
activin receptor-like kinase 7
-
-
activin receptor-like kinase-5
-
-
activin receptor-like kinase-7
-
-
activin receptor-like-kinase 1
-
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activin-like kinase receptor 1
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activin-like kinase receptor 4
-
-
ACTR-IC
Q8NER5
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ACVRL1
P37023
-
ACVRL1
-
-
ALK1
P37023
-
ALK4
-
-
ALK5
-
-
alk5 kinase
P36897
-
ALK6
-
-
ALK7
Q8NER5
-
BMP type I receptor
-
-
BMP type II receptor
-
-
BMP type II receptor
-
-
BMPR-II
-
-
BMPR2
P37023
-
BMPRII
-
-
bone morphogenetic protein receptor II gene
P37023
-
bone morphogenetic protein type II receptor
-
-
bone morphogenetic protein type II receptor
-
-
ESK2
-
-
-
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MIS type II receptor
-
-
-
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MRII
-
-
-
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receptor serine/threonine kinase
Q6GZL5
-
RSTK
Q6GZL5
-
serine/threonine receptor kinase
-
-
Serine/threonine-protein kinase receptor R1
-
-
-
-
Serine/threonine-protein kinase receptor R4
-
-
-
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Serine/threonine-protein kinase receptor R5
-
-
-
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Serine/threonine-protein kinase receptor R6
-
-
-
-
SKR1
-
-
-
-
SKR2
-
-
-
-
SKR3
-
-
-
-
SKR4
-
-
-
-
SKR5
-
-
-
-
SKR6
-
-
-
-
SmRK2
Q6GZL5
-
TbetaKI
-
-
TbetaR-I
-
-
TbetaR-I
-
-
TbetaR-II
-
-
TbetaRI
-
-
TbetaRI
-
-
TbetaRI kinase
-
-
TbetaRI receptor kinase
-
-
TbetaRII
-
-
TBRI
P36897
-
TGF-beta receptor
-
-
TGF-beta receptor
-
-
TGF-beta receptor
-
-
TGF-beta receptor 1
Q8NER5
-
TGF-beta receptor I
-
-
TGF-beta receptor I
-
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TGF-beta receptor I kinase
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TGF-beta receptor I kinase
P36897
-
TGF-beta receptor II
-
-
TGF-beta receptor II kinase
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-
TGF-beta receptor kinase
-
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TGF-beta type I receptor
-
-
-
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TGF-beta type I receptor
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TGF-beta type I receptor kinase
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TGF-beta type I receptor kinase
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TGF-beta type I receptor kinase
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TGF-beta type II receptor
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-
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TGF-beta type-I receptor
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TGFbetaRI/II kinase
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transforming growth factor beta type-I receptor
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transforming growth factor-beta receptor
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transforming growth factor-beta receptor
-
-
transforming growth factor-beta receptor
-
-
transforming growth factor-beta receptor 1
Q8NER5
-
transforming growth factor-beta receptor I
-
-
transforming growth factor-beta receptor I
-
-
transforming growth factor-beta receptor II
-
-
transforming growth factor-beta type 1 receptor kinase
-
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transforming growth factor-beta type I receptor
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transforming growth factor-beta type I receptor kinase
-
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transforming growth factor-beta type1 receptor kinase
-
-
TRKI
-
-
TSK-7L
-
-
-
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type I receptor kinase
-
-
type I receptor TGF-beta kinase
-
-
type I serine/threonine kinase
-
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type II receptor serine/threonine kinase
Q6GZL5
-
MISRII
-
-
-
-
additional information
-
ALK7 is a type I serine/threonine kinase receptor belonging to the TGF-beta family of proteins
additional information
-
the enzyme belongs to the TGF-beta superfamily of enzymes
additional information
Q6GZL5
the RSTK belong to the TGF-beta family of receptor serine/threonine kinases
CAS REGISTRY NUMBER
COMMENTARY
146702-86-5
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152060-53-2
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154907-75-2
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
ALK4 is a type I transmembrane serine/threonine kinase receptor
-
-
Manually annotated by BRENDA team
gene ACVRIC, activin receptor type 1C precursor, four GenBank entries; several isoforms by alternative splicing
SwissProt
Manually annotated by BRENDA team
wild-type and endoglin +/- mice
-
-
Manually annotated by BRENDA team
Booroola ewes
-
-
Manually annotated by BRENDA team
female Sprague-Dawley rats
SwissProt
Manually annotated by BRENDA team
male sprague-dawley rats
-
-
Manually annotated by BRENDA team
3 isozymes
SwissProt
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM