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Literature summary for 2.7.11.30 extracted from
- Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent (2003), J. Biol. Chem., 278, 11721-11728.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| TGF-beta | binds and activates the TGF-beta receptor, treatment of cells with TGF-beta increaes the production of matrix proteins | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Rattus norvegicus | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Smad2 | Rattus norvegicus | TGF-beta-mediated activation of Smad2 by the TGF-beta receptor | ADP + phosphorylated Smad2 | - |
? |  |
| ATP + Smad3 | Rattus norvegicus | TGF-beta-mediated activation of Smad3 by the TGF-beta receptor | ADP + phosphorylated Smad3 | - |
? | |
| additional information | Rattus norvegicus | TGF-beta mediates activation of Smad2 and Smad3 in a differentiated way dependent on the developmental and activationstages of the cells, regulation, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatic stellate cell | primary, differential TGF-beta-mediated activation of Smad2 and Smad3 in activated and non-activated cells, overview | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Smad2 | TGF-beta-mediated activation of Smad2 by the TGF-beta receptor | Rattus norvegicus | ADP + phosphorylated Smad2 | - |
? | |
| ATP + Smad2 | phosphorylation by the TGF-beta receptor | Rattus norvegicus | ADP + phosphorylated Smad2 | - |
? | |
| ATP + Smad3 | TGF-beta-mediated activation of Smad3 by the TGF-beta receptor | Rattus norvegicus | ADP + phosphorylated Smad3 | - |
? | |
| ATP + Smad3 | phosphorylation by the TGF-beta receptor | Rattus norvegicus | ADP + phosphorylated Smad3 | - |
? | |
| additional information | TGF-beta mediates activation of Smad2 and Smad3 in a differentiated way dependent on the developmental and activationstages of the cells, regulation, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TGF-beta receptor | - |
Rattus norvegicus |
| transforming growth factor-beta receptor | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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