Literature summary for 2.7.11.30 extracted from

Lux, A.; Beil, C.; Majety, M.; Barron, S.; Gallione, C.J.; Kuhn, H.M.; Berg, J.N.; Kioschis, P.; Marchuk, D.A.; Hafner, M.
Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1 (2005), J. Biol. Chem., 280, 8482-8493.

Search for more literature for 2.7.11.30

Activating Compound

Activating Compound	Comment	Organism	Structure
TGF-beta 3	binds and activates ALK5	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
co-expression and co-localization of ALK1 mutant Q201D and cytoplasmic PEG10-RF1 mutant YFP in COS-1 cells, expression of ALK1 and ALK5 with PEG10-RF1 in a two-hydrid system in Saccharomyces cerevisiae, overview	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
Q201D	constitutively active ALK1 mutant	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
PEG10	ancient retroviral/retrotransposon element intergrated as a single copy gene in to human chromosome 7q21, encodes two splicing varaiants PEG10-RF1 and PEG10-RF1/2, gag- and gag-pol-like proteins that interact with TGF-beta family proteins, DNA and amino acid sequence deteramination and analysis of PEG10-RF1, PEG10-RF1 inhibits ALK1 and ALK5 signaling by direct interaction, overview	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	with a cytoplasmic domain	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
placenta	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
activin receptor-like kinase 1	-	Homo sapiens
activin receptor-like kinase 5	-	Homo sapiens
ALK1	-	Homo sapiens
ALK5	-	Homo sapiens
TGF-beta type I receptor	-	Homo sapiens
transforming growth factor-beta receptor	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)