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Literature summary for 2.7.11.30 extracted from

  • Xu, Y.; Tabe, Y.; Jin, L.; Watt, J.; McQueen, T.; Ohsaka, A.; Andreeff, M.; Konopleva, M.
    TGF-beta receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-beta1 in myelo-monocytic leukaemic cells co-cultured with stromal cells (2008), Br. J. Haematol., 142, 192-201.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
LY2109761 TGF-beta receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-beta1 in myelo-monocytic leukaemic cells, it LY2109761 enhanced apoptosis only in the presence of exogenously added TGF-beta1 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [TGF-beta receptor II] Homo sapiens regulation and metabolism, overview ADP + [TGF-beta receptor II] phosphate
-
 ?
additional information Homo sapiens TGF-beta receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-beta1 in myelo-monocytic leukaemic cells, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell a myeloid leukemic cell line Homo sapiens
-
KG-1 cell a myeloid leukemic cell line Homo sapiens
-
MOLM-13 cell a myelo-monocytic leukemic cell line Homo sapiens
-
myelomonocytic leukemia cell
-
 Homo sapiens
-
THP-1 cell a myelo-monocytic leukemic cell line Homo sapiens
-
U-937 cell a myelo-monocytic leukemic cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [TGF-beta receptor II]
-
 Homo sapiens ADP + [TGF-beta receptor II] phosphate
-
 ?
ATP + [TGF-beta receptor II] regulation and metabolism, overview Homo sapiens ADP + [TGF-beta receptor II] phosphate
-
 ?
additional information TGF-beta receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-beta1 in myelo-monocytic leukaemic cells, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TGF-beta receptor II kinase
-
 Homo sapiens
TGFbetaRI/II kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens