Cloned (Comment) | Organism |
---|---|
transient expression of wild-type and mutant enzymes in COS-7 cells, and in Min-6 and Hep-G2 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
T194D | site-directed mutagenesis of ALK7 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calphostin C | - |
Homo sapiens | |
additional information | LY294002 completely abolishes the ALK7 mutant T194D/Smad3-induced synergistic effect by inhibiting interaction between the Smad3-Linker and PDX-1 | Homo sapiens | |
PD98059 | - |
Homo sapiens | |
Rapamycin | - |
Homo sapiens | |
SB203580 | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [actividin receptor] | Homo sapiens | activins regulate pancreatic development, differentiation and insulin secretion, insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells, SBE and A/GG elements of the human insulin promoter are involved in the regulation of the ALK7 signal, regulation, overview | ADP + [actividin receptor] phosphate | - |
? | |
additional information | Homo sapiens | ALK7 is a receptor for nodal and activin AB and B, overview. The insulin promoter is activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1, PDX-1, in the ALK7 pathway, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreatic beta cell | and beta cell lines | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [actividin receptor] | - |
Homo sapiens | ADP + [actividin receptor] phosphate | - |
? | |
ATP + [actividin receptor] | activins regulate pancreatic development, differentiation and insulin secretion, insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells, SBE and A/GG elements of the human insulin promoter are involved in the regulation of the ALK7 signal, regulation, overview | Homo sapiens | ADP + [actividin receptor] phosphate | - |
? | |
additional information | ALK7 is a receptor for nodal and activin AB and B, overview. The insulin promoter is activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1, PDX-1, in the ALK7 pathway, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
activin receptor-like kinase 7 | - |
Homo sapiens |
ALK7 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |