Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ALK5 | is important for ALK1/TGF-beta signaling | Mus musculus | |
TGF-beta | activates the type II and type I membrane receptors, e.g. ALK1 and ALK5 | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression of ALK1 and ALK5 in 293T cells, Hep-G2 cells, and in COS-7 cells using the adenovirus transfection system | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of ALK5 expression in embryonic endothelial cells by antisense oligonucleotides results in inhibition of both TGF-beta-induced Smad 2 and Smad1/5 phosphorylation, an ALk5mutant defective in Smad activation rescues TGF-beta/ALK1-induced signaling in ALK5 null mutant endothelial cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | ALK1 mediates inhibition of the ALK5/Smad2/3 pathway | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Smad1 | Mus musculus | phosphorylation by ALK1 | ADP + phosphorylated Smad1 | - |
? | |
ATP + Smad2 | Mus musculus | phosphorylation by ALK5 | ADP + phosphorylated Smad2 | - |
? | |
ATP + Smad3 | Mus musculus | phosphorylation by ALK5 | ADP + phosphorylated Smad3 | - |
? | |
ATP + Smad5 | Mus musculus | phosphorylation by ALK1 | ADP + phosphorylated Smad5 | - |
? | |
additional information | Mus musculus | TGF-beta regulates the activation state of endothelium via two opposing type I receptor/Smad pathways: ALK1 induces Smad1/5 phosphorylation leading to increased endothelial cell proliferation and migration, while ALK5 promotes Smad2/3 activation and inhibits both processes, regulation overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelium | embryonic cells | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Smad1 | phosphorylation by ALK1 | Mus musculus | ADP + phosphorylated Smad1 | - |
? | |
ATP + Smad2 | phosphorylation by ALK5 | Mus musculus | ADP + phosphorylated Smad2 | - |
? | |
ATP + Smad3 | phosphorylation by ALK5 | Mus musculus | ADP + phosphorylated Smad3 | - |
? | |
ATP + Smad5 | phosphorylation by ALK1 | Mus musculus | ADP + phosphorylated Smad5 | - |
? | |
additional information | TGF-beta regulates the activation state of endothelium via two opposing type I receptor/Smad pathways: ALK1 induces Smad1/5 phosphorylation leading to increased endothelial cell proliferation and migration, while ALK5 promotes Smad2/3 activation and inhibits both processes, regulation overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
activin receptor-like kinase 1 | - |
Mus musculus |
activin receptor-like kinase 5 | - |
Mus musculus |
ALK1 | - |
Mus musculus |
ALK5 | - |
Mus musculus |
TbetaRI | - |
Mus musculus |
TbetaRII | - |
Mus musculus |
TGF-beta receptor | - |
Mus musculus |
transforming growth factor-beta receptor | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |