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Literature summary for 2.7.11.30 extracted from
- Synthesis and biological evaluation of 5-(pyridin-2-yl)thiazoles as transforming growth factor-beta type1 receptor kinase inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 2122-2127.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-(1,3-benzodioxol-5-yl)-2-(6-ethylpyridin-2-yl)ethanone | - |
Rattus norvegicus |  |
| 1-(1,3-benzodioxol-5-yl)-2-(6-methylpyridin-2-yl)ethanone | - |
Rattus norvegicus | |
| 1-(1,3-benzodioxol-5-yl)-2-bromo-2-(6-ethylpyridin-2-yl)ethanone | - |
Rattus norvegicus | |
| 1-(1,3-benzodioxol-5-yl)-2-bromo-2-(6-methylpyridin-2-yl)ethanone | - |
Rattus norvegicus | |
| 1-(1,3-benzodioxol-5-yl)-2-bromo-2-pyridin-2-ylethanone | - |
Rattus norvegicus | |
| 1-(1,3-benzodioxol-5-yl)-2-pyridin-2-ylethanone | - |
Rattus norvegicus | |
| 2,6-lutidine | i.e. 2,6-dimethylpyridine | Rattus norvegicus | |
| 2-(6-ethylpyridin-2-yl)-1-quinoxalin-6-ylethanone | - |
Rattus norvegicus | |
| 2-(6-methylpyridin-2-yl)-1-quinoxalin-6-ylethanone | - |
Rattus norvegicus | |
| 2-bromo-2-(6-ethylpyridin-2-yl)-1-quinoxalin-6-ylethanone | - |
Rattus norvegicus | |
| 2-bromo-2-(6-methylpyridin-2-yl)-1-quinoxalin-6-ylethanone | - |
Rattus norvegicus | |
| 2-bromo-2-pyridin-2-yl-1-quinoxalin-6-ylethanone | - |
Rattus norvegicus | |
| 2-picoline | - |
Rattus norvegicus | |
| 2-pyridin-2-yl-1-quinoxalin-6-ylethanone | - |
Rattus norvegicus | |
| 3-([[4-(1,3-benzodioxol-5-yl)-5-(6-ethylpyridin-2-yl)-1,3-thiazol-2-yl]amino]methyl)benzamide | - |
Rattus norvegicus | |
| 3-([[4-(1,3-benzodioxol-5-yl)-5-(6-ethylpyridin-2-yl)-1,3-thiazol-2-yl]amino]methyl)benzonitrile | - |
Rattus norvegicus | |
| 3-([[4-(1,3-benzodioxol-5-yl)-5-(6-methylpyridin-2-yl)-1,3-thiazol-2-yl]amino]methyl)benzamide | - |
Rattus norvegicus | |
| 3-([[4-(1,3-benzodioxol-5-yl)-5-(6-methylpyridin-2-yl)-1,3-thiazol-2-yl]amino]methyl)benzonitrile | - |
Rattus norvegicus | |
| 3-([[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1,3-thiazol-2-yl]amino]methyl)benzamide | - |
Rattus norvegicus | |
| 3-([[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1,3-thiazol-2-yl]amino]methyl)benzonitrile | - |
Rattus norvegicus | |
| 3-([[5-(6-ethylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-yl]amino]methyl)benzonitrile | - |
Rattus norvegicus | |
| 3-([[5-(6-methylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-yl]amino]methyl)benzonitrile | - |
Rattus norvegicus | |
| 3-[[(5-pyridin-2-yl-4-quinoxalin-6-yl-1,3-thiazol-2-yl)amino]methyl]benzamide | - |
Rattus norvegicus | |
| 3-[[(5-pyridin-2-yl-4-quinoxalin-6-yl-1,3-thiazol-2-yl)amino]methyl]benzonitrile | - |
Rattus norvegicus | |
| 3-[[5-(6-ethylpyridin-2-yl)-4-(quinoxalin-6-yl)thiazol-2-ylamino]methyl]benzamide | - |
Rattus norvegicus | |
| 3-[[5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)thiazol-2-ylamino]methyl]benzamide | - |
Rattus norvegicus | |
| 4-(1,3-benzodioxol-5-yl)-5-(6-ethylpyridin-2-yl)-1,3-thiazol-2-amine | - |
Rattus norvegicus | |
| 4-(1,3-benzodioxol-5-yl)-5-(6-methylpyridin-2-yl)-1,3-thiazol-2-amine | - |
Rattus norvegicus | |
| 4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1,3-thiazol-2-amine | - |
Rattus norvegicus | |
| 4-([[4-(1,3-benzodioxol-5-yl)-5-(6-ethylpyridin-2-yl)-1,3-thiazol-2-yl]amino]methyl)benzonitrile | - |
Rattus norvegicus | |
| 4-([[4-(1,3-benzodioxol-5-yl)-5-(6-methylpyridin-2-yl)-1,3-thiazol-2-yl]amino]methyl)benzonitrile | - |
Rattus norvegicus | |
| 4-([[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1,3-thiazol-2-yl]amino]methyl)benzonitrile | - |
Rattus norvegicus | |
| 4-([[5-(6-ethylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-yl]amino]methyl)benzamide | - |
Rattus norvegicus | |
| 4-([[5-(6-ethylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-yl]amino]methyl)benzonitrile | - |
Rattus norvegicus | |
| 4-([[5-(6-methylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-yl]amino]methyl)benzamide | - |
Rattus norvegicus | |
| 4-([[5-(6-methylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-yl]amino]methyl)benzonitrile | - |
Rattus norvegicus | |
| 4-[[(5-pyridin-2-yl-4-quinoxalin-6-yl-1,3-thiazol-2-yl)amino]methyl]benzamide | - |
Rattus norvegicus | |
| 4-[[(5-pyridin-2-yl-4-quinoxalin-6-yl-1,3-thiazol-2-yl)amino]methyl]benzonitrile | - |
Rattus norvegicus | |
| 5-(6-ethylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-amine | - |
Rattus norvegicus | |
| 5-(6-methylpyridin-2-yl)-4-quinoxalin-6-yl-1,3-thiazol-2-amine | - |
Rattus norvegicus | |
| 5-pyridin-2-yl-4-quinoxalin-6-yl-1,3-thiazol-2-amine | - |
Rattus norvegicus | |
| 6-ethyl-2-methylpyridine | i.e. 2-ethyl-6-methylpyridine | Rattus norvegicus | |
| A-83-01 | - |
Rattus norvegicus | |
| GW6604 | - |
Rattus norvegicus | |
| IN-1130 | - |
Rattus norvegicus | |
| IN-1166 | - |
Rattus norvegicus | |
| LY580276 | - |
Rattus norvegicus | |
| additional information | inhibitory potency of 5-(pyridin-2-yl)thiazole inhibitors, overview | Rattus norvegicus | |
| SB-431542 | - |
Rattus norvegicus | |
| SB-505124 | - |
Rattus norvegicus | |
| SB-525334 | - |
Rattus norvegicus | |
| SD-208 | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ALK5 | - |
Rattus norvegicus |
| TGF-beta type I receptor kinase | - |
Rattus norvegicus |
| transforming growth factor-beta type1 receptor kinase | - |
Rattus norvegicus |
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