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ATP + parkin
ADP + phosphorylated parkin
parkin has four putative Cdk5 phosphorylation sites according to the motif (S/T)PX(K/R)
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
ATP + dopamine
ADP + phosphorylated dopamine
-
phosphorylation by cdk5
-
-
?
ATP + dopamine and cAMP-regulated phosphoprotein
ADP + phosphorylated dopamine and cAMP-regulated phosphoprotein
-
i.e. DARPP-32, phosphorylation by cdk5 at Thr75 and Thr34
-
-
?
ATP + glucocorticoid receptor
ADP + dephosphorylated glucocorticoid receptor
-
CDK5 phosphorylates glucocorticoid receptor at multiple serines, including Ser203 and Ser211 of its N-terminal domain, and suppresses the transcriptional activity of this receptor on glucocorticoid-responsive promoters by attenuating attraction of transcriptional cofactors to DNA
-
-
?
ATP + glucocorticoid receptor
ADP + phosphorylated glucocorticoid receptor
-
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
-
-
-
?
ATP + huntingtin
ADP + phosphorylated huntingtin
-
huntingtin is phosphorylated by Cdk5 at Ser1181 and Ser1201
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
ATP + neuregulin receptor ErbB3
ADP + phosphorylated neuregulin receptor ErbB3
-
phosphorylation at Thr871 and Ser1120 by Cdk5
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
ATP + NF-H peptide
ADP + phosphorylated NF-H peptide
ATP + NF-M
ADP + phosphorylated NF-M
ATP + parkin
ADP + phosphorylated parkin
-
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
ATP + protein
ADP + phosphoprotein
Ser/Thr kinase
-
-
?
ATP + protein tau
ADP + protein tau phosphate
-
-
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
ATP + septine 5
ADP + phosphorylated septine 5
-
Ser327 is the major phosphorylation site for Cdk5 in presence of activator p35
-
-
?
ATP + syntaxin-1
ADP + phosphorylated syntaxin-1
-
-
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
ATP + [tau protein]
ADP + O-phospho-[tau-protein]
-
Cdk5-p25 or Cdk5-p35, see also EC 2.7.11.26, phosphorylation at Ser202 and Thr205
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
additional information
?
-
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation at Thr131
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
-
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + NF-H peptide
ADP + phosphorylated NF-H peptide
-
-
-
-
?
ATP + NF-H peptide
ADP + phosphorylated NF-H peptide
-
i.e. RREAKSPAKAKSPAKE
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
-
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
tau is microtubule-associated, phopshorylation at T231 by CDK5 causes its release into the cytoplasm
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
phosphorylation at T231, no activity with tau mutant T231A
-
-
?
additional information
?
-
enzyme is required for mitosis
-
-
?
additional information
?
-
enzyme plays an important role in spermatogenesis
-
-
?
additional information
?
-
Cdk2 protein might be required for entry into the S phase of the cell cycle in FRTL-Tc cells
-
-
?
additional information
?
-
-
CDK5-dependent clustering of endoplasmic reticulum ER and mitochondria during ceramide-mediated neuronal death: neurotoxic calcium transfer from ER to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau, inhibition of the process leads to cell death
-
-
?
additional information
?
-
-
CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview
-
-
?
additional information
?
-
-
Cdk5 regulates Akt activation and cell survival through the neuregulin-mediated PI 3-kinase signaling pathway, null mutants show lower phosphatidylinositol 3-kinase activity, Cdk5-p35 mediates neuroprotection
-
-
?
additional information
?
-
-
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
-
-
?
additional information
?
-
-
Cdk5-p35 is negatively regulated by interaction with membranes in brain and liver, mechanism
-
-
?
additional information
?
-
-
cyclin-dependent kinase activity is required for apoptotic death involving the retinoblastoma protein but not inclusion formation in cortical neurons after proteasomal inhibition, Cdk2, Cdk4, and Cdk6 promote the apoptosis induced by lactacystin and other proteasome inhibitors, expression of a defective retinoblastoma protein is neuroprotective
-
-
?
additional information
?
-
-
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
-
-
?
additional information
?
-
-
the phosphatidylinositol-linked dopamine receptor is involved in regulation of cdk5 enzyme activity in the brain
-
-
?
additional information
?
-
-
CDK5 induces caspase-independent mitochondrial fission
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + c-Jun N-terminal kinase 3
ADP + phosphorylated c-Jun N-terminal kinase 3
-
i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis
-
-
?
ATP + dopamine
ADP + phosphorylated dopamine
-
phosphorylation by cdk5
-
-
?
ATP + dopamine and cAMP-regulated phosphoprotein
ADP + phosphorylated dopamine and cAMP-regulated phosphoprotein
-
i.e. DARPP-32, phosphorylation by cdk5 at Thr75 and Thr34
-
-
?
ATP + MEK1
ADP + phosphorylated MEK1
-
Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview
-
-
?
ATP + neuregulin receptor ErbB3
ADP + phosphorylated neuregulin receptor ErbB3
-
phosphorylation at Thr871 and Ser1120 by Cdk5
-
-
?
ATP + NF-H
ADP + phosphorylated NF-H
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + NF-M
ADP + phosphorylated NF-M
-
neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein
-
-
?
ATP + pocket protein p107
ADP + phosphorylated pocket protein 107
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + pocket protein p130
ADP + phosphorylated pocket protein 130
-
hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
ATP + tau protein
ADP + phosphorylated tau protein
-
cdk5 substrate in brain, Cdk5-p25 or Cdk5-p35
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
tau is microtubule-associated, phopshorylation at T231 by CDK5 causes its release into the cytoplasm
-
-
?
additional information
?
-
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein
-
-
?
ATP + retinoblastoma protein
ADP + phosphorylated retinoblastoma protein
-
i.e. Rb protein, hyperphosphorylation by CDK/cyclin contributes to the transactivation of genes with functional E2F-binding sites, including growth and cell-cycle regulators, i.e. c-myc, Rb protein, cdc2, cyclin E, and cyclin A, and genes encoding proteins required for nucleotide and DNA biosynthesis
-
-
?
additional information
?
-
enzyme is required for mitosis
-
-
?
additional information
?
-
enzyme plays an important role in spermatogenesis
-
-
?
additional information
?
-
Cdk2 protein might be required for entry into the S phase of the cell cycle in FRTL-Tc cells
-
-
?
additional information
?
-
-
CDK5-dependent clustering of endoplasmic reticulum ER and mitochondria during ceramide-mediated neuronal death: neurotoxic calcium transfer from ER to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau, inhibition of the process leads to cell death
-
-
?
additional information
?
-
-
CDK-cyclins and CDK inhibitory proteins are involved in the cell cycle regulation and of vascular cell proliferation and migration, as well as in the control of neointimal thickening, modeling, overview
-
-
?
additional information
?
-
-
Cdk5 regulates Akt activation and cell survival through the neuregulin-mediated PI 3-kinase signaling pathway, null mutants show lower phosphatidylinositol 3-kinase activity, Cdk5-p35 mediates neuroprotection
-
-
?
additional information
?
-
-
Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration
-
-
?
additional information
?
-
-
Cdk5-p35 is negatively regulated by interaction with membranes in brain and liver, mechanism
-
-
?
additional information
?
-
-
cyclin-dependent kinase activity is required for apoptotic death involving the retinoblastoma protein but not inclusion formation in cortical neurons after proteasomal inhibition, Cdk2, Cdk4, and Cdk6 promote the apoptosis induced by lactacystin and other proteasome inhibitors, expression of a defective retinoblastoma protein is neuroprotective
-
-
?
additional information
?
-
-
the CDKs are involved in regulation of cell cycle and neuronal differentiation, cleavage of p35 to p25 occurs in neurons undergoing induced cell death and in brains exposed to ischaemia
-
-
?
additional information
?
-
-
the phosphatidylinositol-linked dopamine receptor is involved in regulation of cdk5 enzyme activity in the brain
-
-
?
additional information
?
-
-
CDK5 induces caspase-independent mitochondrial fission
-
-
?
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2,5-hexanedione
-
CDK5 contents and activities in sciatic nerve of rats treated with 200 or 400 mg/kg 2,5-hexanedione are significantly increased in both the cytosolic and membrane fractions, increase of CDK5 content in both the cytosolic and membrane fractions of spinal cord in 200 and 400 mg/kg 2,5-hexanedione-treated rats are observed
beta-amyloid peptide25-35
-
-
-
CHAPS
-
the detergent increases Cdk5-p35 activity with histone H1 and the autophosphorylation at p35
ginsenoside Rb1
-
attenuates beta-amyloid peptide25-35-induced CDK5 activation
N-acetylcysteine
-
10 mM, increases cyclin-dependent kinase 5 phosphorylation, phosphorylation of Cdk5 on tyrosine 15 by c-Abl increases kinase activity of the p35/Cdk5 complex
NP-40
-
the detergent increases Cdk5-p35 activity with histone H1 and the autophosphorylation at p35
Triton X-100
-
the detergent increases Cdk5-p35 activity with histone H1 and the autophosphorylation at p35
Tween 20
-
the detergent increases Cdk5-p35 activity with histone H1 and the autophosphorylation at p35
p25
-
activator required for CDK5 activity, activation of CDK5 by p25 which is activated by cleavage of p35 to p25
-
p25
-
increased calpain activity in sensory neurons after inflammation results in the cleavage of p35 to p25, which forms a more stable complex with Cdk5 and, consequently, leads to elevation of Cdk5 activity
-
p25
-
physically interacts with ligand-bound glucocorticoid receptor in vitro through the C-terminal portion enclosed by amino acids 190 and 262, p25 with a much stronger effect than p35 on suppression of glucocorticoid receptor transcriptional activity
-
p35
-
-
-
p35
-
activation subunit, required, interacts with and activates Cdk5, laminin induces upregulation of p35, regulation of p35 expression, overview
-
p35
-
regulatory activating cofactor of cdk5
-
p35
-
regulatory subunit and activator of Cdk5
-
p35
-
regulatory subunit of Cdk5
-
p35
-
the cyclin is the regulatory subunit, dependent on
-
p35
-
physically interacts with ligand-bound glucocorticoid receptor in vitro through the C-terminal portion enclosed by amino acids 190 and 262
-
p35
-
Cdk5 activity is dysregulated by cleavage of activator p35 to p25 by calpain
-
p35
-
monomeric Cdk5 has no enzymatic activity and requires association with a regulatory binding partner p35 for its activation
-
p39
-
-
-
p39
-
activation subunit, can substitute for p35, interacts with and activates Cdk5
-
p39
-
regulatory activating cofactor of cdk5
-
p39
-
regulatory subunit and activator of Cdk5
-
additional information
-
6-chloro-7,8-dihydroxy-3-methyl-1-(3-methyl-phenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine, i.e. SKF83959, induces transctivation of cdk5 via the brain phosphatidylinositol-linked dopamine receptor, which is inhibited by SCH23390 or U-73122
-
additional information
-
CDKs are activated by phosphorylation
-
additional information
-
the proteasomal inhibitor lactacystin induces the Cdk-dependent phosphorylation of the retinoblastoma protein
-
additional information
-
inflammation increases Cdk5 activity
-
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Hirose, T.; Tamaru, T.; Okumura, N.; Nagai, K.; Okada, M.
PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons
Eur. J. Biochem.
249
481-488
1997
Rattus norvegicus (O35831), Rattus norvegicus (O35832)
brenda
Matsushime, H.; Jinno, A.; Takagi, N.; Shibuya, M.
A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis
Mol. Cell. Biol.
10
2261-2268
1990
Rattus norvegicus (P20793), Homo sapiens (P20794)
brenda
Cho, F.S.; Phillips, K.S.; Khan, S.A.; Weaver, T.E.
Cloning of the rat cyclin-dependent kinase 4 cDNA: implication in proliferation-dependent expression in rat tissues
Biochem. Biophys. Res. Commun.
191
860-865
1993
Rattus norvegicus (P35426)
brenda
Riabowol, K.; Draetta, G.; Brizuela, L.; Vandre, D.; Beach, D.
The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells
Cell
57
393-401
1989
Rattus norvegicus (P39951)
brenda
Kerr, M.; Fischer, J.E.; Purushotham, K.R.; Gao, D.; Nakagawa, Y.; Maeda, N.; Ghanta, V.; Hiramoto, R.; Chegini, N.; Humphreys-Beher, M.G.
Characterization of the synthesis and expression of the GTA-kinase from transformed and normal rodent cells
Biochim. Biophys. Acta
1218
375-387
1994
Rattus norvegicus (P46892)
brenda
Xiong, Y.; Zhang, H.; Beach, D.
D Type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
Cell
71
505-514
1992
Rattus norvegicus (Q03114)
brenda
Hellmich, M.R.; Pant, H.C.; Wada, E.; Battey, J.F.
Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression
Proc. Natl. Acad. Sci. USA
89
10867-10871
1992
Rattus norvegicus (Q03114)
brenda
Kotani, S.; Endo, T.; Kitagawa, M.; Higashi, H.; Onaya, T.
A variant form of cyclin-dependent kinase 2 (Cdk2) in a malignantly transformed rat thyroid (FRTL-Tc) cell line
Oncogene
10
663-669
1995
Rattus norvegicus (Q63699)
brenda
Hosokawa, Y.; Yang, M.; Kaneko, S.; Tanaka, M.; Nakashima, K.
Synergistic gene expressions of cyclin E, cdk2, cdk5 and E2F-1 during the prolactin-induced G1/S transition in rat Nb2 pre-T lymphoma cells
Biochem. Mol. Biol. Int.
37
393-399
1995
Rattus norvegicus (Q63699)
brenda
Darios, F.; Muriel, M.P.; Khondiker, M.E.; Brice, A.; Ruberg, M.
Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau
J. Neurosci.
25
4159-4168
2005
Rattus norvegicus
brenda
Kesavapany, S.; Li, B.S.; Amin, N.; Zheng, Y.L.; Grant, P.; Pant, H.C.
Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide
Biochim. Biophys. Acta
1697
143-153
2004
Danio rerio, Saccharomyces cerevisiae, Caenorhabditis elegans, Canis lupus familiaris, Drosophila melanogaster, Homo sapiens, Doryteuthis pealeii, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Andres, V.
Control of vascular cell proliferation and migration by cyclin-dependent kinase signalling: new perspectives and therapeutic potential
Cardiovasc. Res.
63
11-21
2004
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Li, B.S.; Ma, W.; Jaffe, H.; Zheng, Y.; Takahashi, S.; Zhang, L.; Kulkarni, A.B.; Pant, H.C.
Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival
J. Biol. Chem.
278
35702-35709
2003
Mus musculus, Rattus norvegicus
brenda
Zhu, Y.S.; Saito, T.; Asada, A.; Maekawa, S.; Hisanaga, S.
Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation
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94
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2005
Rattus norvegicus
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Rideout, H.J.; Wang, Q.; Park, D.S.; Stefanis, L.
Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition
J. Neurosci.
23
1237-1245
2003
Rattus norvegicus
brenda
Zhen, X.; Goswami, S.; Abdali, S.A.; Gil, M.; Bakshi, K.; Friedman, E.
Regulation of cyclin-dependent kinase 5 and calcium/calmodulin-dependent protein kinase II by phosphatidylinositol-linked dopamine receptor in rat brain
Mol. Pharmacol.
66
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2004
Rattus norvegicus
brenda
Hisanaga, S.; Saito, T.
The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator
Neurosignals
12
221-229
2003
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Li, T.; Hawkes, C.; Qureshi, H.Y.; Kar, S.; Paudel, H.K.
Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta
Biochemistry
45
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2006
Bos taurus, Homo sapiens, Rattus norvegicus
brenda
Avraham, E.; Rott, R.; Liani, E.; Szargel, R.; Engelender, S.
Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation
J. Biol. Chem.
282
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2007
Homo sapiens, Rattus norvegicus, Rattus norvegicus (Q03114)
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Kino, T.; Ichijo, T.; Amin, N.D.; Kesavapany, S.; Wang, Y.; Kim, N.; Rao, S.; Player, A.; Zheng, Y.L.; Garabedian, M.J.; Kawasaki, E.; Pant, H.C.; Chrousos, G.P.
Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress
Mol. Endocrinol.
21
1552-1568
2007
Rattus norvegicus
brenda
Pareek, T.K.; Keller, J.; Kesavapany, S.; Pant, H.C.; Iadarola, M.J.; Brady, R.O.; Kulkarni, A.B.
Cyclin-dependent kinase 5 activity regulates pain signaling
Proc. Natl. Acad. Sci. USA
103
791-796
2006
Mus musculus, Rattus norvegicus
brenda
Moore, N.L.; Narayanan, R.; Weigel, N.L.
Cyclin dependent kinase 2 and the regulation of human progesterone receptor activity
Steroids
72
202-209
2007
Homo sapiens, Rattus norvegicus
brenda
Chen, X.; Huang, T.; Zhang, J.; Song, J.; Chen, L.; Zhu, Y.
Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1s attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons
Brain Res.
1200
99-106
2008
Rattus norvegicus
brenda
Meuer, K.; Suppanz, I.E.; Lingor, P.; Planchamp, V.; Goericke, B.; Fichtner, L.; Braus, G.H.; Dietz, G.P.; Jakobs, S.; Baehr, M.; Weishaupt, J.H.
Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis
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14
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2007
Rattus norvegicus
brenda
Saito, T.; Konno, T.; Hosokawa, T.; Asada, A.; Ishiguro, K.; Hisanaga, S.
p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons
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102
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2007
Rattus norvegicus
brenda
Anne, S.L.; Saudou, F.; Humbert, S.
Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons
J. Neurosci.
27
7318-7328
2007
Mus musculus, Rattus norvegicus
brenda
Amin, N.D.; Zheng, Y.L.; Kesavapany, S.; Kanungo, J.; Guszczynski, T.; Sihag, R.K.; Rudrabhatla, P.; Albers, W.; Grant, P.; Pant, H.C.
Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis
J. Neurosci.
28
3631-3643
2008
Mus musculus, Rattus norvegicus
brenda
Hsiao, Y.H.; Chen, P.S.; Yeh, S.H.; Lin, C.H.; Gean, P.W.
N-acetylcysteine prevents beta-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neurons
J. Neurosci. Res.
86
2685-2695
2008
Rattus norvegicus
brenda
Wang, Q.S.; Zhang, C.L.; Hou, L.Y.; Zhao, X.L.; Yang, X.W.; Xie, K.Q.
Involvement of cyclin-dependent kinase 5 in 2,5-hexanedione-induced neuropathy
Toxicology
248
1-7
2008
Rattus norvegicus
brenda
Chan, K.C.; Ho, H.H.; Peng, C.H.; Lan, K.P.; Lin, M.C.; Chen, H.M.; Wang, C.J.
Polyphenol-rich extract from mulberry leaf inhibits vascular smooth muscle cell proliferation involving upregulation of p53 and inhibition of cyclin-dependent kinase
J. Agric. Food Chem.
58
2536-2542
2010
Rattus norvegicus
brenda
Mairet-Coello, G.; Tury, A.; DiCicco-Bloom, E.
Insulin-like growth factor-1 promotes G1/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developing rat cerebral cortex
J. Neurosci.
29
775-788
2009
Rattus norvegicus
brenda
Ivanov, A.; Tyzio, R.; Zilberter, Y.; Ben-Ari, Y.
(R)-roscovitine, a cyclin-dependent kinase inhibitor, enhances tonic GABA inhibition in rat hippocampus
Neuroscience
156
277-288
2008
Rattus norvegicus
brenda