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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Mus musculus and UniProt Accession P05532

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EC Tree
IUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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This record set is specific for:
Mus musculus
UNIPROT: P05532
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
mast/stem cell growth factor receptor
-
receptor tyrosine kinase c-Kit
-
Adhesion-related kinase
ALK receptor tyrosine kinase
-
-
ALK tyrosine kinase receptor
-
alpha platelet-derived growth factor receptor
-
Anaplastic lymphoma kinase
angiopoietin 1 receptor
-
AXL oncogene
-
-
-
-
basic fibroblast growth factor receptor 1
-
BDNF/NT-3 growth factors receptor
-
BEK/FGFR-2 receptor
-
beta platelet-derived growth factor receptor
-
brain specific kinase
-
Brain-specific kinase
-
-
-
-
Breathless protein
-
-
-
-
c-erbB3
-
-
-
-
c-fgr
-
-
-
-
c-fms
-
-
-
-
c-kit
c-kit receptor
-
-
c-Kit receptor tyrosine kinase
-
-
c-Kit tyrosine kinase
-
-
-
-
C-mer
-
-
-
-
c-met
-
-
-
-
C-ret
-
-
-
-
C14
-
-
-
-
Cadherin 96Ca
-
-
-
-
Cak I receptor
-
CD115 antigen
-
-
-
-
CD117 antigen
-
-
-
-
CD135 antigen
-
-
-
-
CD136 antigen
-
-
-
-
CD140a antigen
-
-
-
-
CD140b antigen
-
-
-
-
CD167a antigen
-
-
-
-
CD202b antigen
-
-
-
-
CD220 antigen
-
-
-
-
CD221 antigen
-
-
-
-
CD246 antigen
-
-
-
-
CDW136
-
-
-
-
CEK4
-
-
-
-
Cell adhesion kinase
-
-
-
-
Derailed protein
-
-
-
-
DFGF-R1
-
-
-
-
discoidin domain receptor 2
-
Discoidin receptor tyrosine kinase
-
-
-
-
Doughnut protein
-
-
-
-
Dror
-
-
-
-
Drosophila relative of ERBB
-
-
-
-
DRT
-
-
-
-
Eek receptor
-
EGF receptor tyrosine kinase
-
-
-
-
EGFr TK
-
-
-
-
Egg laying defective protein 15
-
-
-
-
ELK
-
-
-
-
embryo brain kinase
-
Embryonic brain kinase
-
-
-
-
Endothelial kinase receptor EK1
-
-
-
-
EPH-and ELK-related kinase
-
-
-
-
ephrin type-A receptor 2
-
ephrin type-A receptor 3
-
ephrin type-A receptor 4
-
ephrin type-A receptor 5
-
ephrin type-A receptor 6
-
ephrin type-A receptor 7
-
ephrin type-A receptor 8
-
ephrin type-B receptor 3
-
ephrin type-B receptor 4
-
epidermal growth factor receptor
Epidermal growth factor receptor-related protein
-
-
-
-
Epithelial cell kinase
-
-
-
-
epithelial discoidin domain receptor 1
-
erbB tyrosine kinase
-
-
-
-
ErbB2 kinase
-
-
-
-
erbB2 receptor tyrosine kinase
-
-
ErbB3 receptor tyrosine kinase
-
ERK
-
-
-
-
ETK
-
-
-
-
fetal liver kinase 1
-
FGFR
-
-
fibroblast growth factor receptor
-
-
fibroblast growth factor receptor 2
fibroblast growth factor receptor 3
-
fibroblast growth factor receptor 4
-
FL cytokine receptor
-
FLT3/FLK2 receptor tyrosine kinase
-
Fms proto-oncogene
-
-
-
-
GCTK
-
-
-
-
GP145-TrkB
-
-
-
-
GP145-TrkB/GP95-TrkB
-
-
-
-
GP145-TrkC
-
-
-
-
Gurken receptor
-
-
-
-
Heartless protein
-
-
-
-
HEK
-
-
-
-
HEK3
-
-
-
-
HEK4
-
-
-
-
HEK6
-
-
-
-
Heparin-binding growth factor receptor
-
-
-
-
hepatocyte growth factor receptor
HGF receptor
-
-
-
-
HGF-SF receptor
-
-
-
-
hydroxyaryl-protein kinase
-
-
-
-
IGF-1R tyrosine kinase
-
-
ILP receptor
-
-
-
-
insulin receptor
insulin receptor protein-tyrosine kinase
-
-
-
-
insulin receptor-related protein
-
insulin-like growth factor I receptor
-
IR-related receptor
-
-
-
-
IRK
-
-
-
-
IRR
-
-
-
-
IRR-protein tyrosine kinase
-
Keratinocyte growth factor receptor
KGF receptor
-
Kinase insert domain receptor
-
-
-
-
Kinase NYK
-
-
-
-
Kinase VIK
-
-
-
-
Kit protein-tyrosine kinase
-
-
leptin receptor
-
-
leukocyte tyrosine kinase receptor
-
Linotte protein
-
-
-
-
ltk receptor tyrosine kinase
-
macrophage colony stimulating factor I receptor
-
macrophage colony-stimulating factor receptor
-
macrophage-stimulating protein receptor
-
MEK4
-
-
-
-
Mer receptor tyrosine kinase
-
Met proto-oncogene tyrosine kinase
-
-
-
-
Met receptor-tyrosine kinase
-
-
Met RTK
-
-
Met-related kinase
-
-
-
-
MFR
-
-
-
-
MIR
-
-
-
-
MLN 19
-
-
-
-
mouse developmental kinase 1
-
mROR1
-
-
-
-
mROR2
-
-
-
-
MSP receptor
-
-
-
-
muscle-specific receptor tyrosine kinase
NET
-
-
-
-
NEU proto-oncogene
-
-
-
-
Neurospecific receptor tyrosine kinase
-
-
-
-
NRTK
-
-
-
-
NUK
-
-
-
-
NYK/FLK-1
-
P140 TEK
-
-
-
-
p140-TrkA
-
-
-
-
p180erbB4
-
-
-
-
p185-Ron
-
-
-
-
p185erbB2
-
-
-
-
p72ITK/EMT
-
Pagliaccio
-
-
-
-
PDGF receptor tyrosine kinase
-
-
PDGF-R-alpha
-
-
-
-
PDGF-R-beta
-
-
-
-
PDGFR
-
-
PDGFR kinase
-
-
-
-
PDGFR-beta
-
-
PKCdelta
-
-
platelet-derived growth factor receptor
-
-
protein kinase Cdelta
-
-
Protein tyrosine kinase
-
-
Protein-tyrosine kinase byk
-
-
-
-
protein-tyrosine kinase ITK/EMT
-
Protein-tyrosine kinase receptor MPK-11
-
-
-
-
Proto-oncogene tyrosine-protein kinase Kit
-
-
-
-
proto-oncogene tyrosine-protein kinase MER
-
proto-oncogene tyrosine-protein kinase receptor ret
-
recepteur d'origine nantais receptor tyrosine kinase
-
-
Receptor protein-tyrosine kinase HEK11
-
-
-
-
Receptor protein-tyrosine kinase HEK5
-
-
-
-
Receptor protein-tyrosine kinase HEK7
-
-
-
-
Receptor protein-tyrosine kinase HEK8
-
-
-
-
Receptor protein-tyrosine kinase TKT
-
-
-
-
receptor tyrosine kinase
-
-
receptor tyrosine kinase EphA2
-
receptor tyrosine kinase Mer
-
Receptor tyrosine kinase MerTK
-
-
-
-
receptor tyrosine kinase Ror2
-
-
receptor tyrosine kinase Sek
-
Receptor-activated Janus kinase
-
-
-
-
receptor-like protein tyrosine kinase bsk
-
RON receptor
-
RON receptor tyrosine kinase
Ron/Stk receptor tyrosine kinase
-
RTKs
-
-
sam3 protein
-
SCFR
-
-
-
-
Slow nerve growth factor receptor
-
-
-
-
stem cell derived tyrosine kinase
-
-
Stem cell-derived tyrosine kinase
-
-
-
-
T-cell-specific kinase
-
Tec family kinase EMT/ITK/TSK
-
Tek receptor tyrosine kinase
-
Torpedo protein
-
-
-
-
TRK1 transforming tyrosine kinase protein
-
-
-
-
TrkB tyrosine kinase
-
-
-
-
TrkC tyrosine kinase
-
-
-
-
Tunica interna endothelial cell kinase
-
-
-
-
Tyro 10 receptor tyrosine kinase
-
Tyrosine kinase CEK6 receptor
-
-
-
-
Tyrosine kinase DDR
-
-
-
-
tyrosine kinase Emt/Itk
-
Tyrosine kinase receptor HD-14
-
-
-
-
tyrosine kinase receptor HER2
-
Tyrosine kinase-type cell surface receptor HER2
-
-
-
-
Tyrosine kinase-type cell surface receptor HER3
-
-
-
-
Tyrosine kinase-type cell surface receptor HER4
-
-
-
-
Tyrosine-protein kinase CAK
-
-
-
-
Tyrosine-protein kinase CEK9
-
-
-
-
Tyrosine-protein kinase DTK
-
-
-
-
Tyrosine-protein kinase FLT3
-
-
-
-
Tyrosine-protein kinase FRT
-
-
-
-
tyrosine-protein kinase ITK/TSK
-
Tyrosine-protein kinase receptor CEK10
-
-
-
-
Tyrosine-protein kinase receptor CEK11
-
-
-
-
Tyrosine-protein kinase receptor CEK5
-
-
-
-
Tyrosine-protein kinase receptor CEK7
-
-
-
-
Tyrosine-protein kinase receptor CEK8
-
-
-
-
Tyrosine-protein kinase receptor CEPHA7
-
-
-
-
Tyrosine-protein kinase receptor ECK
-
-
-
-
Tyrosine-protein kinase receptor EEK
-
-
-
-
Tyrosine-protein kinase receptor EPH
-
-
-
-
Tyrosine-protein kinase receptor ESK
-
-
-
-
Tyrosine-protein kinase receptor ETK1
-
-
-
-
Tyrosine-protein kinase receptor FLT
-
-
-
-
Tyrosine-protein kinase receptor FLT3
-
-
-
-
Tyrosine-protein kinase receptor FLT4
-
-
-
-
Tyrosine-protein kinase receptor HTK
-
-
-
-
Tyrosine-protein kinase receptor PAG
-
-
-
-
Tyrosine-protein kinase receptor QEK5
-
-
-
-
Tyrosine-protein kinase receptor REK4
-
-
-
-
Tyrosine-protein kinase receptor SEK
-
-
-
-
Tyrosine-protein kinase receptor TCK
-
-
-
-
Tyrosine-protein kinase receptor TEK
-
-
-
-
tyrosine-protein kinase receptor Tie-1
-
tyrosine-protein kinase receptor TYRO3
-
tyrosine-protein kinase receptor UFO
-
Tyrosine-protein kinase receptor XEK
-
-
-
-
Tyrosine-protein kinase receptor XELK
-
-
-
-
Tyrosine-protein kinase receptor ZEK1
-
-
-
-
Tyrosine-protein kinase receptor ZEK2
-
-
-
-
Tyrosine-protein kinase receptor ZEK3
-
-
-
-
Tyrosine-protein kinase RSE
-
-
-
-
tyrosine-protein kinase RYK
-
Tyrosine-protein kinase SKY
-
-
-
-
tyrosine-protein kinase transmembrane receptor ROR1
-
tyrosine-protein kinase transmembrane receptor ROR2
-
vascular endothelial growth factor receptor
vascular endothelial growth factor receptor 2
-
vascular endothelial growth factor receptor 3
-
Vascular permeability factor receptor
-
-
-
-
VEGF receptor
-
VEGF receptor tyrosine kinase
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
ATP + cortactin-L-tyrosine
ADP + cortactin-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + insulin receptor substrate 1-L-tyrosine
ADP + insulin receptor substrate 1-L-tyrosine phosphate
show the reaction diagram
-
-
tyrosine phosphorylation of insulin receptor substrate-1 by insulin receptor is decreased when insulin receptor substrate-1 is contained in high-molecular mass complexes prepared from 3T3-L1 adipocytes treated with tumor necrosis factor-alpha. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases
-
?
ATP + p130Cas-L-tyrosine
ADP + p130Cas-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + paxillin-L-tyrosine
ADP + paxillin-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + phospholipase C gamma-L-tyrosine
ADP + phospholipase C gamma-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
ATP + cortactin-L-tyrosine
ADP + cortactin-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + p130Cas-L-tyrosine
ADP + p130Cas-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + paxillin-L-tyrosine
ADP + paxillin-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + phospholipase C gamma-L-tyrosine
ADP + phospholipase C gamma-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-(2-aminoquinazolin-6-yl)-4-methyl-1-(3-(trifluoromethyl)phenyl)pyridin-2(1H)-one
-
(R)-2-(2-[[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]methyl]pyrrolidin-1-yl)-2-oxoethanol
(R)-N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]-1-methylethyl]-2-hydroxyacetamide
(R)-N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]propyl]-2-hydroxyacetamide
(S)-2-(2-[[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]methyl]pyrrolidin-1-yl)-2-oxoethanol
(S)-N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]-1-methylethyl]-2-hydroxyacetamide
(S)-N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]propyl]-2-hydroxyacetamide
dynamin K44A
inhibits agrin-induced MuSK endocytosis
-
genistein
-
-
Herbimycin
-
-
herceptin
-
-
-
humanized monoclonal antibody
-
significantly decreases tumor growth of murine xenografts from subcutaneously injected lung, colon, and pancreatic cancer cell lines in nude mice
-
N-(4-chlorophenyl)-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide
dose dependent inhibition of Flk-1 phosphorylation
N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]ethyl]-2-hydroxyacetamide
PD153035
inhibits tyrosine kinase activity of EGFR and whereby blocks cellular responses of activated ErbB3. It inhibits heregulin-induced VEGFA expression
PKI-166
-
-
protein tyrosine phosphatase 1B
-
PTP1B, negative regulator of Met. Loss of protein tyrosine phosphatase 1B enhances heregulin-mediated phosphorylation of Met. Interaction with Met requires phosphorylation of twin tyrosines (Y1234/35) in the activation loop of the Met kinase domain
-
rottlerin
-
specific inhibitor of PKCdelta
shRNA
sh-ErbB3 cells normally metastasize to the lung, but the heregulin-induced increase in metastasis is completely abrogated. Inactivation of ErbB3 by shRNA does not directly influence the formation of metastatic colonies in the experimental metastasis model, although heregulin-induced enhancement is completely dependent on ErbB3. However, spontaneous metastasis by inoculating the cells without heregulin stimulation into the foot pad is significantly decreased
-
siRNA
-
sorafenib
-
oral multikinase inhibitor, inhibits receptor tyrosine kinase autophosphorylation
Spry protein
-
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
12-O-tetradecanoylphorbol-13-acetate
-
upregulates Ron protein expression
agrin
MuSK becomes rapidly internalized in response to agrin, which appears to be required for induced acetylcholine receptor clustering
-
capsaicin
-
c-kit receptor expression is significantly up-regulated in medium-sized dorsal root ganglia neurons after neonatal capsaicin treatment
fibroblast growth factor
-
activation occurs by phosphorylation on residues 653 and 654
-
heregulin
-
macrophage-stimulating protein
the ligand for RON, inhibits IFN-gamma-induced STAT1 phosphorylation and CIITA expression, resulting in reduced surface levels of MHC class II
-
N-ethylmaleimide sensitive factor
an appropriate level of N-ethylmaleimide sensitive factor and its ATPase activity may be required for MuSK endocytosis and subsequent activation
-
PorB
-
PorB from Neisseria meningitidis is able to induce protein tyrosine kinase activity
-
stem cell factor
-
soluble and membrane-bound glycoprotein, activating ligand of the stem cell receptor i.e. the Kit protein-tyrosine kinase
-
tumor necrosis factor-alpha
-
tyrosine phosphorylation of insulin receptor substrate-1 by insulin receptor is decreased when insulin receptor substrate-1 is contained in high-molecular mass complexes prepared from 3T3-L1 adipocytes treated with tumor necrosis factor-alpha.Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases
-
additional information
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000002 - 0.000097
(R)-2-(2-[[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]methyl]pyrrolidin-1-yl)-2-oxoethanol
0.000002 - 0.000003
(R)-N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]-1-methylethyl]-2-hydroxyacetamide
0.000002
(R)-N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]propyl]-2-hydroxyacetamide
0.000002 - 0.000327
(S)-2-(2-[[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]methyl]pyrrolidin-1-yl)-2-oxoethanol
0.000019 - 0.00258
(S)-N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]-1-methylethyl]-2-hydroxyacetamide
0.000022 - 0.000191
(S)-N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]propyl]-2-hydroxyacetamide
0.000004 - 0.000035
N-[2-[(4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl)oxy]ethyl]-2-hydroxyacetamide
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
postmeiotic male germ cells
Manually annotated by BRENDA team
only one out of seven mature B cell lines expressed ltk and the in vitro maturation of pre-B into B cells is in one case accompanied by the inactivation of ltk expression
Manually annotated by BRENDA team
overexpression of functional ErbB3
Manually annotated by BRENDA team
endothelium of blood vessel
Manually annotated by BRENDA team
-
ossification centers of developing bone
Manually annotated by BRENDA team
3LL carcinoma and T10 sarcoma, overexpression of PDGF-alpha receptor in high-metastatic clones
Manually annotated by BRENDA team
inner ear, expressed in the developing and adult cochlea
Manually annotated by BRENDA team
-
in tissue surrounding the esophagus
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
expressed in definitive endoderm of the developing gut and extraembryonic endoderm of the yolk-sac from 8.5 to 14.5 days p.c.
Manually annotated by BRENDA team
predominantly expressed on glomerular endothelial cells
Manually annotated by BRENDA team
in resting J774, scavenger receptor A is associated minimally with unphosphorylated (monomeric) Mertk
Manually annotated by BRENDA team
expressed at high levels in the hippocampus, tenia tecta, indusium griseum, and the piriform cortex, major components of the limbic system
Manually annotated by BRENDA team
BAC1.2F5 macrophage cell line
Manually annotated by BRENDA team
expression is induced during the proliferation of the mammary gland and down-regulated by its differentiation
Manually annotated by BRENDA team
which surrounds the developing neuroepithelium
Manually annotated by BRENDA team
of the neural tube of 10-day-old embryos
Manually annotated by BRENDA team
the c-fms protooncogene, is selectively expressed in immature and mature mononuclear phagocytes and trophoblasts
Manually annotated by BRENDA team
lymphoid ltk uses a CUG translational start codon and has a 110 amino acid putative extracellular domain. The predominant ltk mRNA in brain is alternatively spliced and predicts a protein with a substantially larger extracellular part
Manually annotated by BRENDA team
3LL carcinoma and T10 sarcoma, overexpression of PDGF-alpha receptor in high-metastatic clones
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
exclusively expressed in T lymphocytes
Manually annotated by BRENDA team
the c-fms protooncogene, is selectively expressed in immature and mature mononuclear phagocytes and trophoblasts
Manually annotated by BRENDA team
paravertebral trunk of the sympathetic nervous system
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
cell membrane-associated expression of HER2 significantly augments during the differentiation of preadipocytes
Manually annotated by BRENDA team
additional information
two alternatively spliced mouse lymphocyte and brain ltk cDNAs predict small transmembrane tyrosine kinases that use CUG translational start codons and that differ upstream of their transmembrane segment. A human neuroblastoma ltk cDNA, includes a regular AUG start codon and predicts a more conventional receptor kinase with a larger N-terminal segment
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
Mer deficiency is associated with increased renal inflammation when mice are challenged with nephrotoxic serum
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KIT_MOUSE
979
2
109343
Swiss-Prot
Secretory Pathway (Reliability: 2)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
109001
x * 109001, calculation from nucleotide sequence
120000
-
SDS-PAGE
130000
150000
-
1 * 150000 + 1 * 35000
35000
-
1 * 150000 + 1 * 35000
66000
-
SDS-PAGE
80000
-
full-length enzyme, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 109001, calculation from nucleotide sequence
heterodimer
-
1 * 150000 + 1 * 35000
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
phosphoprotein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D1232V
-
is more active than the wild-type, produces tumors in nude mice and is highly metastatic
D314N
-
no activity
DELTA(T573-H579)
-
c-Kit mutant, juxtamembrane mutation
M1231T
-
equivalent tumor latency and 100% tumor formation as the wild-type
M1254T
-
is more active than the wild-type, produces tumors in nude mice and is highly metastatic
R318A
-
no activity
Y719F
-
c-Kit mutant, knock-in mouse, which does not show an apparent abnormality in hematopoiesis
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
conotoxin IMI Sepharose affinity chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning of a c-kit mRNA of 3.2 kb expressed in postmeiotic male germ cells
determination of the primary structure of murine c-kit from a DNA clone isolated from a brain cDNA library
a chimeric receptor consisting of the extracellular domain of insulin receptor and the intracellular domain of IRR is expressed in Chinese hamster ovary cells
application of the polymerase chain reaction to cloning
bacterially expressed gst-Sek kinase domain fusion protein autophosphorylated exclusively on tyrosine residues
bek cDNA expression in receptor-negative Chinese hamster ovary cells and in 32D myeloid cells
cDNA introduced into COS cells
cloning and sequencing of the extracellular ligand binding domain of murine EGF-R
coexpression of HA-tagged MuSK with Myc-tagged N-ethylmaleimide sensitive factor wild-type or mutant constructs in HEK-293 cells
DTK gene maps to mouse chromosome 2, band F
endothelial-specific gene expression directed by the tie gene promoter in vivo
expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop
expression in CHO cells
expression in Cos-1 cells
expression in NIH3T3 cells
fibroblast growth factor receptor 1 gene generates multiple messenger RNAs containing two open reading frames via alternative splicing
gene is located on chromosome 6
identification of the gene
isolation of a full-length cDNA, encoding the mouse homologue of a previous by partially characterized Eek protein
isolation of cDNA
isolation of mouse cDNA clones encoding Tyro 3
leucine-rich motifs in TrkB are essential for ligand binding and signaling
localized to chromosome 9
maps to chromosome 4
stable expression of wild-type and constitutively active murine Ron mutants in NIH3T3 mouse fibrobalst cells
-
tek, which maps to mouse chromosome 4 between the brown and pmv-23 loci
the c-fms clone is inserted into a retroviral vector containing a neomycin resistance gene and cell lines resistant to G418 are isolated, that express the protein
translation of Jak2 mRNA in rabbit reticulocytes
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
high levels of epidermal growth factor receptor are expressed in response to exogenous epidermal growth factor
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
aminoquinazoline pyridones are potent, selective, and orally efficacious c-Kit inhibitors for the treatment of fibrotic diseases. Compounds show greater than 200fold selectivity against KDR, p38, Lck, and Src
drug development
synthesis of a series of naphthyl-based compounds, which are potential inhibitors of vascular endothelial growth factor receptors
medicine
additional information
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Park, S.; Sanchez, M.P.
The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands
Oncogene
14
533-542
1997
Mus musculus (O09127), Mus musculus
Manually annotated by BRENDA team
Nocka, K.; Buck, J.; Levi, E.; Besmer, P.
Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors
EMBO J.
9
3287-3294
1990
Mus musculus (P05532), Mus musculus
Manually annotated by BRENDA team
Nocka, K.; Tan, J.C.; Chiu, E.; Chu, T.Y.; Ray, P.; Traktman, P.; Besmer, P.
Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W
EMBO J.
9
1805-1813
1990
Mus musculus (P05532), Mus musculus
Manually annotated by BRENDA team
Qiu, F.H.; Ray, P.; Brown, K.; Barker, P.E.; Jhanwar, S.; Ruddle, F.H.; Besmer, P.
Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus
EMBO J.
7
1003-1011
1988
Mus musculus (P05532), Mus musculus
Manually annotated by BRENDA team
Rossi, P.; Marziali, G.; Albanesi, C.; Charlesworth, A.; Geremia, R.; Sorrentino, V.
A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids
Dev. Biol.
152
203-207
1992
Mus musculus (P05532), Mus musculus
Manually annotated by BRENDA team
Tan, J.C.; Nocka, K.; Ray, P.; Traktman, P.; Besmer, P.
The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase
Science
247
209-212
1990
Mus musculus (P05532), Mus musculus
Manually annotated by BRENDA team
Yarden, Y.; Escobedo, J.A.; Kuang, W.J.; Yang-Feng, T.L.; Daniel, T.O.; Tremble, P.M.; Chen, E.Y.; Ando, M.E.; Harkins, R.N.; Francke, U.; et al.
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors
Nature
323
226-232
1986
Mus musculus (P05622), Mus musculus
Manually annotated by BRENDA team
Ben-Neriah, Y.; Bauskin, A.R.
Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain
Nature
333
672-676
1988
Mus musculus (P08923), Mus musculus
Manually annotated by BRENDA team
Bernards, A.; de la Monte, S.M.
The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator
EMBO J.
9
2279-2287
1990
Mus musculus (P08923), Mus musculus
Manually annotated by BRENDA team
Haase, V.H.; Snijders, A.J.; Cooke, S.M.; Teng, M.N.; Kaul, D.; Le Beau, M.M.; Bruns, G.A.; Bernards, A.
Alternatively spliced ltk mRNA in neurons predicts a receptor with a larger putative extracellular domain
Oncogene
6
2319-2325
1991
Mus musculus (P08923)
Manually annotated by BRENDA team
Snijders, A.J.; Haase, V.H.; Bernards, A.
Four tissue-specific mouse ltk mRNAs predict tyrosine kinases that differ upstream of their transmembrane segment
Oncogene
8
27-35
1993
Mus musculus (P08923)
Manually annotated by BRENDA team
Snijders, A.J.; Ho, S.C.; Haase, V.H.; Pillai, S.; Bernards, A.
A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin
J. Biol. Chem.
272
1297-1301
1997
Mus musculus (P08923), Mus musculus
Manually annotated by BRENDA team
De Parseval, N.; Bordereaux, D.; Gisselbrecht, S.; Sola, B.
Reassessment of the murine c-fms proto-oncogene sequence
Nucleic Acids Res.
21
750
1993
Mus musculus (P09581), Mus musculus
Manually annotated by BRENDA team
Rothwell, V.M.; Rohrschneider, L.R.
Murine c-fms cDNA: cloning, sequence analysis and retroviral expression
Oncogene Res.
1
311-324
1987
Mus musculus (P09581), Mus musculus
Manually annotated by BRENDA team
Van der Geer, P.; Hunter, T.
Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line
Mol. Cell. Biol.
10
2991-3002
1990
Mus musculus (P09581), Mus musculus
Manually annotated by BRENDA team
Yue, X.; Favot, P.; Dunn, T.L.; Cassady, A.I.; Hume, D.A.
Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation
Mol. Cell. Biol.
13
3191-3201
1993
Mus musculus (P09581), Mus musculus
Manually annotated by BRENDA team
Flores-Riveros, J.R.; Sibley, E.; Kastelic, T.; Lane, M.D.
Substrate phosphorylation catalyzed by the insulin receptor tyrosine kinase. Kinetic correlation to autophosphorylation of specific sites in the beta subunit
J. Biol. Chem.
264
21557-21572
1989
Mus musculus (P15208), Mus musculus
Manually annotated by BRENDA team
Sibley, E.; Kastelic, T.; Kelly, T.J.; Lane, M.D.
Characterization of the mouse insulin receptor gene promoter
Proc. Natl. Acad. Sci. USA
86
9732-9736
1989
Mus musculus (P15208), Mus musculus
Manually annotated by BRENDA team
Klein, R.; Conway, D.; Parada, L.F.; Barbacid, M.
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
Cell
61
647-656
1990
Mus musculus (P15209)
Manually annotated by BRENDA team
Klein, R.; Parada, L.F.; Coulier, F.; Barbacid, M.
trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development
EMBO J.
8
3701-3709
1989
Mus musculus (P15209), Mus musculus
Manually annotated by BRENDA team
Ninkina, N.; Grashchuck, M.; Buchman, V.L.; Davies, A.M.
TrkB variants with deletions in the leucine-rich motifs of the extracellular domain
J. Biol. Chem.
272
13019-13025
1997
Mus musculus (P15209)
Manually annotated by BRENDA team
Soppet, D.; Escandon, E.; Maragos, J.; Middlemas, D.S.; Reid, S.W.; Blair, J.; Burton, L.E.; Stanton, B.R.; Kaplan, D.R.; Hunter, T.; et al.
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
Cell
65
895-903
1991
Mus musculus (P15209)
Manually annotated by BRENDA team
Chan, A.M.; King, H.W.; Deakin, E.A.; Tempest, P.R.; Hilkens, J.; Kroezen, V.; Edwards, D.R.; Wills, A.J.; Brookes, P.; Cooper, C.S.
Characterization of the mouse met proto-oncogene
Oncogene
2
593-599
1988
Mus musculus (P16056), Mus musculus
Manually annotated by BRENDA team
Wilks, A.F.; Kurban, R.R.; Hovens, C.M.; Ralph, S.J.
The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family
Gene
85
67-74
1989
Mus musculus (P16056), Mus musculus (Q60751), Mus musculus
Manually annotated by BRENDA team
Harada, T.; Saito, H.; Kouhara, H.; Kurebayashi, S.; Kasayama, S.; Terakawa, N.; Kishimoto, T.; Sato, B.
Murine fibroblast growth factor receptor 1 gene generates multiple messenger RNAs containing two open reading frames via alternative splicing
Biochem. Biophys. Res. Commun.
205
1057-1063
1994
Mus musculus (P16092), Mus musculus
Manually annotated by BRENDA team
Kouhara, H.; Kasayama, S.; Saito, H.; Matsumoto, K.; Sato, B.
Expression cDNA cloning of fibroblast growth factor (FGF) receptor in mouse breast cancer cells: a variant form in FGF-responsive transformed cells
Biochem. Biophys. Res. Commun.
176
31-37
1991
Mus musculus (P16092), Mus musculus
Manually annotated by BRENDA team
Mansukhani, A.; Moscatelli, D.; Talarico, D.; Levytska, V.; Basilico, C.
A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF
Proc. Natl. Acad. Sci. USA
87
4378-4382
1990
Mus musculus (P16092), Mus musculus
Manually annotated by BRENDA team
Reid, H.H.; Wilks, A.F.; Bernard, O.
Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain
Proc. Natl. Acad. Sci. USA
87
1596-1600
1990
Mus musculus (P16092), Mus musculus
Manually annotated by BRENDA team
Safran, A.; Avivi, A.; Orr-Urtereger, A.; Neufeld, G.; Lonai, P.; Givol, D.; Yarden, Y.
The murine flg gene encodes a receptor for fibroblast growth factor
Oncogene
5
635-643
1990
Mus musculus (P16092), Mus musculus
Manually annotated by BRENDA team
Kornbluth, S.; Paulson, K.E.; Hanafusa, H.
Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries
Mol. Cell. Biol.
8
5541-5544
1988
Mus musculus (P21803), Mus musculus
Manually annotated by BRENDA team
Mansukhani, A.; Dell'Era, P.; Moscatelli, D.; Kornbluth, S.; Hanafusa, H.; Basilico, C.
Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin
Proc. Natl. Acad. Sci. USA
89
3305-3309
1992
Mus musculus (P21803), Mus musculus
Manually annotated by BRENDA team
Miki, T.; Fleming, T.P.; Bottaro, D.P.; Rubin, J.S.; Ron, D.; Aaronson, S.A.
Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop
Science
251
72-75
1991
Mus musculus (P21803)
Manually annotated by BRENDA team
Raz, V.; Kelman, Z.; Avivi, A.; Neufeld, G.; Givol, D.; Yarden, Y.
PCR-based identification of new receptors: molecular cloning of a receptor for fibroblast growth factors
Oncogene
6
753-760
1991
Mus musculus (P21803), Mus musculus
Manually annotated by BRENDA team
Twigg, S.R.; Burns, H.D.; Oldridge, M.; Heath, J.K.; Wilkie, A.O.
Conserved use of a non-canonical 5' splice site (/GA) in alternative splicing by fibroblast growth factor receptors 1, 2 and 3
Hum. Mol. Genet.
7
685-691
1998
Mus musculus (P21803), Mus musculus
Manually annotated by BRENDA team
Do, M.S.; Fitzer-Attas, C.; Gubbay, J.; Greenfeld, L.; Feldman, M.; Eisenbach, L.
Mouse platelet-derived growth factor alpha receptor: sequence, tissue-specific expression and correlation with metastatic phenotype
Oncogene
7
1567-1575
1992
Mus musculus (P26618), Mus musculus
Manually annotated by BRENDA team
Wang, C.; Kelly, J.; Bowen-Pope, D.F.; Stiles, C.D.
Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene
Mol. Cell. Biol.
10
6781-6784
1990
Mus musculus (P26618)
Manually annotated by BRENDA team
Sajjadi, F.G.; Pasquale, E.B.; Subramani, S.
Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor
New Biol.
3
769-778
1991
Gallus gallus (P29318), Gallus gallus, Mus musculus (P29319), Mus musculus
Manually annotated by BRENDA team
Iwamoto, T.; Taniguchi, M.; Asai, N.; Ohkusu, K.; Nakashima, I.; Takahashi, M.
cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily
Oncogene
8
1087-1091
1993
Mus musculus (P35546), Mus musculus
Manually annotated by BRENDA team
Finnerty, H.; Kelleher, K.; Morris, G.E.; Bean, K.; Merberg, D.M.; Kriz, R.; Morris, J.C.; Sookdeo, H.; Turner, K.J.; Wood, C.R.
Molecular cloning of murine FLT and FLT4
Oncogene
8
2293-2298
1993
Mus musculus (P35917), Mus musculus, Homo sapiens (P35968)
Manually annotated by BRENDA team
Matthews, W.; Jordan, C.T.; Gavin, M.; Jenkins, N.A.; Copeland, N.G.; Lemischka, I.R.
A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit
Proc. Natl. Acad. Sci. USA
88
9026-9030
1991
Mus musculus (P35918), Mus musculus
Manually annotated by BRENDA team
Millauer, B.; Wizigmann-Voos, S.; Schnurch, H.; Martinez, R.; Moller, N.P.; Risau, W.; Ullrich, A.
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
Cell
72
835-846
1993
Mus musculus (P35918), Mus musculus
Manually annotated by BRENDA team
Oelrichs, R.B.; Reid, H.H.; Bernard, O.; Ziemiecki, A.; Wilks, A.F.
NYK/FLK-1: a putative receptor protein tyrosine kinase isolated from E10 embryonic neuroepithelium is expressed in endothelial cells of the developing embryo
Oncogene
8
11-18
1993
Mus musculus (P35918), Mus musculus
Manually annotated by BRENDA team
Patterson, C.; Perrella, M.A.; Hsieh, C.M.; Yoshizumi, M.; Lee, M.E.; Haber, E.
Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor
J. Biol. Chem.
270
23111-23118
1995
Mus musculus (P35918), Homo sapiens (P35968), Homo sapiens
Manually annotated by BRENDA team
Quinn, T.P.; Peters, K.G.; De Vries, C.; Ferrara, N.; Williams, L.T.
Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium
Proc. Natl. Acad. Sci. USA
90
7533-7537
1993
Mus musculus (P35918), Mus musculus
Manually annotated by BRENDA team
Kondo, K.; Hiratsuka, S.; Subbalakshmi, E.; Matsushime, H.; Shibuya, M.
Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors
Gene
208
297-305
1998
Mus musculus (P35969), Mus musculus
Manually annotated by BRENDA team
Gilardi-Hebenstreit, P.; Nieto, M.A.; Frain, M.; Mattei, M.G.; Chestier, A.; Wilkinson, D.G.; Charnay, P.
An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain
Oncogene
7
2499-2506
1992
Mus musculus (Q03137), Mus musculus (Q03142), Mus musculus (Q03146), Mus musculus
Manually annotated by BRENDA team
Becker, N.; Seitanidou, T.; Murphy, P.; Mattei, M.G.; Topilko, P.; Nieto, M.A.; Wilkinson, D.G.; Charnay, P.; Gilardi-Hebenstreit, P.
Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain
Mech. Dev.
47
3-17
1994
Mus musculus (P54754), Mus musculus (Q03145), Mus musculus
Manually annotated by BRENDA team
Ciossek, T.; Lerch, M.M.; Ullrich, A.
Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family
Oncogene
11
2085-2095
1995
Mus musculus (P54754), Mus musculus (P54761), Mus musculus
Manually annotated by BRENDA team
Imondi, R.; Wideman, C.; Kaprielian, Z.
Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons
Development
127
1397-1410
2000
Mus musculus (P54754)
Manually annotated by BRENDA team
Andres, A.C.; Reid, H.H.; Zurcher, G.; Blaschke, R.J.; Albrecht, D.; Ziemiecki, A.
Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis
Oncogene
9
1461-1467
1994
Mus musculus (P54761)
Manually annotated by BRENDA team
Crosier, P.S.; Lewis, P.M.; Hall, L.R.; Vitas, M.R.; Morris, C.M.; Beier, D.R.; Wood, C.R.; Crosier, K.E.
Isolation of a receptor tyrosine kinase (DTK) from embryonic stem cells: structure, genetic mapping and analysis of expression
Growth Factors
11
125-136
1994
Mus musculus (P55144), Mus musculus
Manually annotated by BRENDA team
Lai, C.; Gore, M.; Lemke, G.
Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase
Oncogene
9
2567-2578
1994
Mus musculus (P55144), Mus musculus
Manually annotated by BRENDA team
Mark, M.R.; Scadden, D.T.; Wang, Z.; Gu, Q.; Goddard, A.; Godowski, P.J.
Rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain
J. Biol. Chem.
269
10720-10728
1994
Mus musculus (P55144), Mus musculus, Homo sapiens (Q06418), Homo sapiens
Manually annotated by BRENDA team
Schulz, N.T.; Paulhiac, C.I.; Lee, L.; Zhou, R.
Isolation and expression analysis of tyro3, a murine growth factor receptor tyrosine kinase preferentially expressed in adult brain
Brain Res. Mol. Brain Res.
28
273-280
1995
Mus musculus (P55144), Mus musculus
Manually annotated by BRENDA team
Iwahara, T.; Fujimoto, J.; Wen, D.; Cupples, R.; Bucay, N.; Arakawa, T.; Mori, S.; Ratzkin, B.; Yamamoto, T.
Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system
Oncogene
14
439-449
1997
Mus musculus (P97793), Mus musculus
Manually annotated by BRENDA team
Maroc, N.; Rottapel, R.; Rosnet, O.; Marchetto, S.; Lavezzi, C.; Mannoni, P.; Birnbaum, D.; Dubreuil, P.
Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase
Oncogene
8
909-918
1993
Mus musculus (Q00342), Mus musculus
Manually annotated by BRENDA team
Matthews, W.; Jordan, C.T.; Wiegand, G.W.; Pardoll, D.; Lemischka, I.R.
A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
Cell
65
1143-1152
1991
Mus musculus (Q00342), Mus musculus
Manually annotated by BRENDA team
Rosnet, O.; Marchetto, S.; deLapeyriere, O.; Birnbaum, D.
Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family
Oncogene
6
1641-1650
1991
Mus musculus (Q00342), Mus musculus
Manually annotated by BRENDA team
Faust, M.; Ebensperger, C.; Schulz, A.S.; Schleithoff, L.; Hameister, H.; Bartram, C.R.; Janssen, J.W.
The murine ufo receptor: molecular cloning, chromosomal localization and in situ expression analysis
Oncogene
7
1287-1293
1992
Mus musculus (Q00993), Mus musculus
Manually annotated by BRENDA team
Rescigno, J.; Mansukhani, A.; Basilico, C.
A putative receptor tyrosine kinase with unique structural topology
Oncogene
6
1909-1913
1991
Mus musculus (Q00993), Mus musculus
Manually annotated by BRENDA team
Avivi, A.; Lax, I.; Ullrich, A.; Schlessinger, J.; Givol, D.; Morse, B.
Comparison of EGF receptor sequences as a guide to study the ligand binding site
Oncogene
6
673-676
1991
Mus musculus (Q01279), Mus musculus
Manually annotated by BRENDA team
Avivi, A.; Skorecki, K.; Yayon, A.; Givol, D.
Promoter region of the murine fibroblast growth factor receptor 2 (bek/KGFR) gene
Oncogene
7
1957-1962
1992
Mus musculus (Q01279), Mus musculus
Manually annotated by BRENDA team
Luetteke, N.C.; Phillips, H.K.; Qiu, T.H.; Copeland, N.G.; Earp, H.S.; Jenkins, N.A.; Lee, D.C.
The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase
Genes Dev.
8
399-413
1994
Mus musculus (Q01279), Mus musculus
Manually annotated by BRENDA team
Paria, B.C.; Das, S.K.; Andrews, G.K.; Dey, S.K.
Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation
Proc. Natl. Acad. Sci. USA
90
55-59
1993
Mus musculus (Q01279), Mus musculus
Manually annotated by BRENDA team
Hovens, C.M.; Stacker, S.A.; Andres, A.C.; Harpur, A.G.; Ziemiecki, A.; Wilks, A.F.
RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs
Proc. Natl. Acad. Sci. USA
89
11818-11822
1992
Mus musculus (Q01887), Mus musculus
Manually annotated by BRENDA team
Kelman, Z.; Simon-Chazottes, D.; Guenet, J.L.; Yarden, Y.
The murine vik gene (chromosome 9) encodes a putative receptor with unique protein kinase motifs
Oncogene
8
37-44
1993
Mus musculus (Q01887), Mus musculus
Manually annotated by BRENDA team
Paul, S.R.; Merberg, D.; Finnerty, H.; Morris, G.E.; Morris, J.C.; Jones, S.S.; Kriz, R.; Turner, K.J.; Wood, C.R.
Molecular cloning of the cDNA encoding a receptor tyrosine kinase-related molecule with a catalytic region homologous to c-met
Int. J. Cell Cloning
10
309-314
1992
Mus musculus (Q01887)
Manually annotated by BRENDA team
Simoneaux, D.K.; Fletcher, F.A.; Jurecic, R.; Shilling, H.G.; Van, N.T.; Patel, P.; Belmont, J.W.
The receptor tyrosine kinase-related gene (ryk) demonstrates lineage and stage-specific expression in hematopoietic cells
J. Immunol.
154
1157-1166
1995
Mus musculus (Q01887), Mus musculus
Manually annotated by BRENDA team
Yee, K.; Bishop, T.R.; Mather, C.; Zon, L.I.
Isolation of a novel receptor tyrosine kinase cDNA expressed by developing erythroid progenitors
Blood
82
1335-1343
1993
Mus musculus (Q01887)
Manually annotated by BRENDA team
Dumont, D.J.; Gradwohl, G.J.; Fong, G.H.; Auerbach, R.; Breitman, M.L.
The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors
Oncogene
8
1293-1301
1993
Mus musculus (Q02858), Mus musculus
Manually annotated by BRENDA team
Dumont, D.J.; Yamaguchi, T.P.; Conlon, R.A.; Rossant, J.; Breitman, M.L.
Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors
Oncogene
7
1471-1480
1992
Mus musculus (Q02858), Mus musculus
Manually annotated by BRENDA team
Horita, K.; Yagi, T.; Kohmura, N.; Tomooka, Y.; Ikawa, Y.; Aizawa, S.
A novel tyrosine kinase, hyk, expressed in murine embryonic stem cells
Biochem. Biophys. Res. Commun.
189
1747-1753
1992
Mus musculus (Q02858), Mus musculus
Manually annotated by BRENDA team
Runting, A.S.; Stacker, S.A.; Wilks, A.F.
Tie2, a putative protein tyrosine kinase from a new class of cell surface receptor
Growth Factors
9
99-105
1993
Mus musculus (Q02858), Mus musculus
Manually annotated by BRENDA team
Sato, T.N.; Qin, Y.; Kozak, C.A.; Audus, K.L.
Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system
Proc. Natl. Acad. Sci. USA
90
9355-9358
1993
Mus musculus (Q02858), Mus musculus (Q06806), Mus musculus, Bos taurus (Q06807)
Manually annotated by BRENDA team
Schnurch, H.; Risau, W.
Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage
Development
119
957-968
1993
Mus musculus (Q02858), Mus musculus, Bos taurus (Q06805)
Manually annotated by BRENDA team
Ellis, C.; Kasmi, F.; Ganju, P.; Walls, E.; Panayotou, G.; Reith, A.D.
A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn
Oncogene
12
1727-1736
1996
Mus musculus (Q03137)
Manually annotated by BRENDA team
Gilardi-Hebenstreit, P.; Nieto, M.A.; Frain, M.; Mattei, M.G.; Chestier, A.; Wilkinson, D.G.; Charnay, P.
An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain
Oncogene
8
1103
1993
Mus musculus (Q03137)
Manually annotated by BRENDA team
Stark, K.L.; McMahon, J.A.; McMahon, A.P.
FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse
Development
113
641-651
1991
Mus musculus (Q03142), Mus musculus
Manually annotated by BRENDA team
Ganju, P.; Shigemoto, K.; Brennan, J.; Entwistle, A.; Reith, A.D.
The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development
Oncogene
9
1613-1624
1994
Mus musculus (Q03145), Mus musculus
Manually annotated by BRENDA team
Perez, J.L.; Jing, S.Q.; Wong, T.W.
Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines
Oncogene
12
1469-1477
1996
Mus musculus (Q03146), Mus musculus, Homo sapiens (Q08345)
Manually annotated by BRENDA team
August, A.; Gibson, S.; Kawakami, Y.; Kawakami, T.; Mills, G.B.; Dupont, B.
CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line
Proc. Natl. Acad. Sci. USA
91
9347-9351
1994
Mus musculus (Q03526)
Manually annotated by BRENDA team
Ching, K.A.; Kawakami, Y.; Kawakami, T.; Tsoukas, C.D.
Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain
J. Immunol.
163
6006-6013
1999
Mus musculus (Q03526)
Manually annotated by BRENDA team
Heyeck, S.D.; Berg, L.J.
Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk
Proc. Natl. Acad. Sci. USA
90
669-673
1993
Mus musculus (Q03526), Mus musculus
Manually annotated by BRENDA team
King, P.D.; Sadra, A.; Han, A.; Liu, X.R.; Sunder-Plassmann, R.; Reinherz, E.L.; Dupont, B.
CD2 signaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK
Int. Immunol.
8
1707-1714
1996
Mus musculus (Q03526)
Manually annotated by BRENDA team
Siliciano, J.D.; Morrow, T.A.; Desiderio, S.V.
Itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2
Proc. Natl. Acad. Sci. USA
89
11194-11198
1992
Mus musculus (Q03526), Mus musculus
Manually annotated by BRENDA team
Iwama, A.; Hamaguchi, I.; Hashiyama, M.; Murayama, Y.; Yasunaga, K.; Suda, T.
Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells
Biochem. Biophys. Res. Commun.
195
301-309
1993
Mus musculus (Q06806), Mus musculus
Manually annotated by BRENDA team
Korhonen, J.; Lahtinen, I.; Halmekyto, M.; Alhonen, L.; Janne, J.; Dumont, D.; Alitalo, K.
Endothelial-specific gene expression directed by the tie gene promoter in vivo
Blood
86
1828-1835
1995
Mus musculus (Q06806), Mus musculus
Manually annotated by BRENDA team
Karn, T.; Holtrich, U.; Brauninger, A.; Bohme, B.; Wolf, G.; Rubsamen-Waigmann, H.; Strebhardt, K.
Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain
Oncogene
8
3433-3440
1993
Homo sapiens (Q16832), Homo sapiens, Mus musculus (Q62371), Mus musculus
Manually annotated by BRENDA team
Zhou, R.; Copeland, T.D.; Kromer, L.F.; Schulz, N.T.
Isolation and characterization of Bsk, a growth factor receptor-like tyrosine kinase associated with the limbic system
J. Neurosci. Res.
37
129-143
1994
Mus musculus (Q60629), Mus musculus
Manually annotated by BRENDA team
Graham, D.K.; Bowman, G.W.; Dawson, T.L.; Stanford, W.L.; Earp, H.S.; Snodgrass, H.R.
Cloning and developmental expression analysis of the murine c-mer tyrosine kinase
Oncogene
10
2349-2359
1995
Mus musculus (Q60805), Mus musculus
Manually annotated by BRENDA team
Ciossek, T.; Millauer, B.; Ullrich, A.
Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system
Oncogene
10
97-108
1995
Mus musculus (Q61772), Mus musculus
Manually annotated by BRENDA team
Ellis, J.; Liu, Q.; Breitman, M.; Jenkins, N.A.; Gilbert, D.J.; Copeland, N.G.; Tempest, H.V.; Warren, S.; Muir, E.; Schilling, H.; et al.
Embryo brain kinase: a novel gene of the eph/elk receptor tyrosine kinase family
Mech. Dev.
52
319-341
1995
Mus musculus (Q61772), Mus musculus
Manually annotated by BRENDA team
Chellaiah, A.T.; McEwen, D.G.; Werner, S.; Xu, J.; Ornitz, D.M.
Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1
J. Biol. Chem.
269
11620-11627
1994
Mus musculus (Q61851)
Manually annotated by BRENDA team
Katoh, O.; Hattori, Y.; Sasaki, H.; Sakamoto, H.; Fujimoto, K.; Fujii, T.; Sugimura, T.; Terada, M.
Isolation of the complementary DNA encoding a mouse heparin-binding growth factor receptor with the use of a unique kinase insert sequence
Cancer Res.
53
1136-1141
1993
Mus musculus (Q61851), Mus musculus
Manually annotated by BRENDA team
Ornitz, D.M.; Leder, P.
Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3
J. Biol. Chem.
267
16305-16311
1992
Mus musculus (Q61851), Mus musculus
Manually annotated by BRENDA team
Iwama, A.; Okano, K.; Sudo, T.; Matsuda, Y.; Suda, T.
Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells
Blood
83
3160-3169
1994
Mus musculus (Q62190), Mus musculus
Manually annotated by BRENDA team
Waltz, S.E.; Toms, C.L.; McDowell, S.A.; Clay, L.A.; Muraoka, R.S.; Air, E.L.; Sun, W.Y.; Thomas, M.B.; Degen, S.J.
Characterization of the mouse Ron/Stk receptor tyrosine kinase gene
Oncogene
16
27-42
1998
Mus musculus (Q62190), Mus musculus
Manually annotated by BRENDA team
Lai, C.; Lemke, G.
Structure and expression of the Tyro 10 receptor tyrosine kinase
Oncogene
9
877-883
1994
Mus musculus (Q62371)
Manually annotated by BRENDA team
Olaso, E.; Labrador, J.P.; Wang, L.; Ikeda, K.; Eng, F.J.; Klein, R.; Lovett, D.H.; Lin, H.C.; Friedman, S.L.
Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2
J. Biol. Chem.
277
3606-3613
2002
Mus musculus (Q62371)
Manually annotated by BRENDA team
Lee, A.M.; Navaratnam, D.; Ichimiya, S.; Greene, M.I.; Davis, J.G.
Cloning of m-ehk2 from the murine inner ear, an eph family receptor tyrosine kinase expressed in the developing and adult cochlea
DNA Cell Biol.
15
817-825
1996
Mus musculus (Q62413), Mus musculus
Manually annotated by BRENDA team
Hirayama, I.; Tamemoto, H.; Yokota, H.; Kubo, S.K.; Wang, J.; Kuwano, H.; Nagamachi, Y.; Takeuchi, T.; Izumi, T.
Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2
Diabetes
48
1237-1244
1999
Mus musculus (Q9wtl4), Mus musculus
Manually annotated by BRENDA team
DeChiara, T.M.; Kimble, R.B.; Poueymirou, W.T.; Rojas, J.; Masiakowski, P.; Valenzuela, D.M.; Yancopoulos, G.D.
Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development
Nat. Genet.
24
271-274
2000
Mus musculus (Q9z138), Mus musculus
Manually annotated by BRENDA team
Oishi, I.; Takeuchi, S.; Hashimoto, R.; Nagabukuro, A.; Ueda, T.; Liu, Z.J.; Hatta, T.; Akira, S.; Matsuda, Y.; Yamamura, H.; Otani, H.; Minami, Y.
Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system
Genes Cells
4
41-56
1999
Mus musculus (Q9z138), Mus musculus (Q9z139), Mus musculus
Manually annotated by BRENDA team
Kawai, J.; Shinagawa, A.; Shibata, K.; Yoshino, M.; Itoh, M.; et al.
Functional annotation of a full-length mouse cDNA collection
Nature
409
685-690
2001
Mus musculus (P09581)
Manually annotated by BRENDA team
Roskoski, R.Jr.
Signaling by Kit protein-tyrosine kinase - the stem cell factor receptor
Biochem. Biophys. Res. Commun.
337
1-13
2005
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Haj, F.G.; Markova, B.; Klaman, L.D.; Bohmer, F.D.; Neel, B.G.
Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B
J. Biol. Chem.
278
739-744
2003
Mus musculus
Manually annotated by BRENDA team
Hupfeld, C.J.; Olefsky, J.M.
Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins
Annu. Rev. Physiol.
69
561-577
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Kumar, P.; Ferns, M.J.; Meizel, S.
Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) [corrected] in sperm
Biochem. Biophys. Res. Commun.
342
522-528
2006
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Ballard, P.; Barlaam, B.C.; Bradbury, R.H.; Dishington, A.; Hennequin, L.F.; Hickinson, D.M.; Hollingsworth, I.M.; Kettle, J.G.; Klinowska, T.; Ogilvie, D.J.; Pearson, S.E.; Scott, J.S.; Suleman, A.; Whittaker, R.; Williams, E.J.; Wood, R.; Wright, L.
Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase
Bioorg. Med. Chem. Lett.
17
6326-6329
2007
Mus musculus
Manually annotated by BRENDA team
Thomas, R.M.; Toney, K.; Fenoglio-Preiser, C.; Revelo-Penafiel, M.P.; Hingorani, S.R.; Tuveson, D.A.; Waltz, S.E.; Lowy, A.M.
The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression
Cancer Res.
67
6075-6082
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Vernersson, E.; Khoo, N.K.; Henriksson, M.L.; Roos, G.; Palmer, R.H.; Hallberg, B.
Characterization of the expression of the ALK receptor tyrosine kinase in mice
Gene Expr. Patterns
6
448-461
2006
Mus musculus
Manually annotated by BRENDA team
McGarrigle, D.; Shan, D.; Yang, S.; Huang, X.Y.
Role of tyrosine kinase Csk in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration
J. Biol. Chem.
281
10583-10588
2006
Mus musculus
Manually annotated by BRENDA team
Tapinos, N.; Ohnishi, M.; Rambukkana, A.
ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli
Nat. Med.
12
961-966
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Lentsch, A.B.; Pathrose, P.; Kader, S.; Kuboki, S.; Collins, M.H.; Waltz, S.E.
The Ron receptor tyrosine kinase regulates acute lung injury and suppresses nuclear factor kappaB activation
Shock
27
274-280
2007
Mus musculus
Manually annotated by BRENDA team
Mason, J.M.; Morrison, D.J.; Basson, M.A.; Licht, J.D.
Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling
Trends Cell Biol.
16
45-54
2006
Drosophila melanogaster, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Wagh, P.K.; Peace, B.E.; Waltz, S.E.
Met-related receptor tyrosine kinase Ron in tumor growth and metastasis
Adv. Cancer Res.
100
1-33
2008
Bos taurus, Canis lupus, Gallus gallus, Equus caballus, Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus, Strongylocentrotus purpuratus, Takifugu rubripes
Manually annotated by BRENDA team
Matsumura, I.; Mizuki, M.; Kanakura, Y.
Roles for deregulated receptor tyrosine kinases and their downstream signaling molecules in hematologic malignancies
Cancer Sci.
99
479-485
2008
Homo sapiens, Mus musculus, Canis lupus familiaris (O97799)
Manually annotated by BRENDA team
MacLeod, H.; Bhasin, N.; Wetzler, L.M.
Role of protein tyrosine kinase and Erk1/2 activities in the Toll-like receptor 2-induced cellular activation of murine B cells by neisserial porin
Clin. Vaccine Immunol.
15
630-637
2008
Mus musculus
Manually annotated by BRENDA team
Caldwell, C.C.; Martignoni, A.; Leonis, M.A.; Ondiveeran, H.K.; Fox-Robichaud, A.E.; Waltz, S.E.
Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival benefit in a murine model of bacterial peritonitis
Crit. Care Med.
36
1585-1593
2008
Mus musculus (Q62190), Mus musculus
Manually annotated by BRENDA team
Ueno, Y.; Sakurai, H.; Tsunoda, S.; Choo, M.K.; Matsuo, M.; Koizumi, K.; Saiki, I.
Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells
Int. J. Cancer
123
340-347
2008
Mus musculus (Q01279), Mus musculus (Q61526)
Manually annotated by BRENDA team
Nomachi, A.; Nishita, M.; Inaba, D.; Enomoto, M.; Hamasaki, M.; Minami, Y.
Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A
J. Biol. Chem.
283
27973-27981
2008
Mus musculus, Homo sapiens (Q01974)
Manually annotated by BRENDA team
Sangwan, V.; Paliouras, G.N.; Abella, J.V.; Dube, N.; Monast, A.; Tremblay, M.L.; Park, M.
Regulation of the Met receptor tyrosine kinase by the protein tyrosine phosphatases PTP1B and TCPTP
J. Biol. Chem.
283
34374-34383
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Vazquez-Martin, A.; Ortega-Delgado, F.J.; Fernandez-Real, J.M.; Menendez, J.A.
The tyrosine kinase receptor HER2 (erbB-2): From oncogenesis to adipogenesis
J. Cell. Biochem.
105
1147-1152
2008
Mus musculus (P70424)
Manually annotated by BRENDA team
Brantley-Sieders, D.M.; Zhuang, G.; Hicks, D.; Fang, W.B.; Hwang, Y.; Cates, J.M.; Coffman, K.; Jackson, D.; Bruckheimer, E.; Muraoka-Cook, R.S.; Chen, J.
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling
J. Clin. Invest.
118
64-78
2008
Homo sapiens (P29317), Homo sapiens, Mus musculus (Q03145), Mus musculus
Manually annotated by BRENDA team
Wilson, C.B.; Ray, M.; Lutz, M.; Sharda, D.; Xu, J.; Hankey, P.A.
The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity
J. Immunol.
181
2303-2310
2008
Mus musculus (Q62190)
Manually annotated by BRENDA team
Todt, J.C.; Hu, B.; Curtis, J.L.
The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages
J. Leukoc. Biol.
84
510-518
2008
Mus musculus (Q60805), Mus musculus
Manually annotated by BRENDA team
Harmange, J.C.; Weiss, M.M.; Germain, J.; Polverino, A.J.; Borg, G.; Bready, J.; Chen, D.; Choquette, D.; Coxon, A.; DeMelfi, T.; DiPietro, L.; Doerr, N.; Estrada, J.; Flynn, J.; Graceffa, R.F.; Harriman, S.P.; Kaufman, S.; La, D.S.; Long, A.; Martin, M.W.; Neervannan, S.; Patel, V.F.; Potashman, M.; Regal, K.
Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation
J. Med. Chem.
51
1649-1667
2008
Rattus norvegicus (O08775), Mus musculus (P35918), Homo sapiens (P35968), Homo sapiens
Manually annotated by BRENDA team
Hu, E.; Tasker, A.; White, R.D.; Kunz, R.K.; Human, J.; Chen, N.; Buerli, R.; Hungate, R.; Novak, P.; Itano, A.; Zhang, X.; Yu, V.; Nguyen, Y.; Tudor, Y.; Plant, M.; Flynn, S.; Xu, Y.; Meagher, K.L.; Whittington, D.A.; Ng, G.Y.
Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit
J. Med. Chem.
51
3065-3068
2008
Mus musculus (P05532), Homo sapiens (P35968), Mus musculus C57BL/6 (P05532)
Manually annotated by BRENDA team
Zhu, D.; Yang, Z.; Luo, Z.; Luo, S.; Xiong, W.C.; Mei, L.
Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin
J. Neurosci.
28
1688-1696
2008
Mus musculus (Q61006)
Manually annotated by BRENDA team
Wilhelm, S.M.; Adnane, L.; Newell, P.; Villanueva, A.; Llovet, J.M.; Lynch, M.
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
Mol. Cancer Ther.
7
3129-3140
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Takagi, K.; Okuda-Ashitaka, E.; Mabuchi, T.; Katano, T.; Ohnishi, T.; Matsumura, S.; Ohnaka, M.; Kaneko, S.; Abe, T.; Hirata, T.; Fujiwara, S.; Minami, T.; Ito, S.
Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation
Neuroscience
153
1278-1288
2008
Mus musculus
Manually annotated by BRENDA team
Arisaka, M.; Nakamura, T.; Yamada, A.; Negishi, Y.; Aramaki, Y.
Involvement of protein kinase Cdelta in induction of apoptosis by cationic liposomes in macrophage-like RAW264.7 cells
FEBS Lett.
584
1016-1020
2010
Mus musculus
Manually annotated by BRENDA team
Cunningham, D.L.; Sweet, S.M.; Cooper, H.J.; Heath, J.K.
Differential phosphoproteomics of fibroblast growth factor signaling: identification of Src family kinase-mediated phosphorylation events
J. Proteome Res.
9
2317-2328
2010
Mus musculus
Manually annotated by BRENDA team
Carrillo-Garcia, C.; Suh, Y.; Obernier, K.; Mandl, G.H.; Ciccolini, F.
Multipotent precursors in the anterior and hippocampal subventricular zone display similar transcription factor signatures but their proliferation and maintenance are differentially regulated
Mol. Cell. Neurosci.
44
318-329
2010
Mus musculus
Manually annotated by BRENDA team
Fukushima, T.; Arai, T.; Ariga-Nedachi, M.; Okajima, H.; Ooi, Y.; Iijima, Y.; Sone, M.; Cho, Y.; Ando, Y.; Kasahara, K.; Ozoe, A.; Yoshihara, H.; Chida, K.; Okada, S.; Kopchick, J.; Asano, T.; Hakuno, F.; Takahashi, S.
Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases
Biochem. Biophys. Res. Commun.
404
767-773
2011
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Miyamoto, T.; Kim, D.; Knox, J.; Johnson, E.; Mucke, L.
Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-?-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
J. Biol. Chem.
291
1719-1734
2016
Mus musculus (P54763)
Manually annotated by BRENDA team
Zhen, Y.; Finkelman, F.; Shao, W.
Mechanism of Mer receptor tyrosine kinase inhibition of glomerular endothelial cell inflammation
J. Leukoc. Biol.
103
709-717
2018
Mus musculus (Q60805)
Manually annotated by BRENDA team