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Literature summary for 2.7.10.1 extracted from

  • Nomachi, A.; Nishita, M.; Inaba, D.; Enomoto, M.; Hamasaki, M.; Minami, Y.
    Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A (2008), J. Biol. Chem., 283, 27973-27981.
    View publication on PubMed

Application

Application Comment Organism
medicine in wound-healing, Ror2 plays critical roles in Wnt5a-induced cell migration by regulating formation of lamellipodia and reorientation of microtubule-organizing center. Wnt5a/Ror2 activates c-Jun N-terminal kinase JNK, through a process involving filamin A and PKCsigma, to regulate polarized cell migration Mus musculus
medicine in wound-healing, Ror2 plays critical roles in Wnt5a-induced cell migration by regulating formation of lamellipodia and reorientation of microtubule-organizing center. Wnt5a/Ror2 activates c-Jun N-terminal kinase JNK, through a process involving filamin A and PKCsigma, to regulate polarized cell migration Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information differences in Wnt5a-induced wound closure and microtubule-organizing center reorientation are not detectable in immortalized mouse embryonic fibroblasts from wild-type and Ror2-/- embryos Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
siRNA suppressed expression of Ror2, which results in impaired microtubule-organizing center reorientation following Wnt5a stimulation Homo sapiens
siRNA knocks down Ror2 expression, results in a drastic inhibition of Wnt5a CM- or purified Wnt5a-induced wound closure and no lamellipodia formation following Wnt5a stimulation. Wnt5a-induced microtubule-organizing center reorientation is also impaired in Ror2-depleted cells Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens Q01974
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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NIH-3T3 cell
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Mus musculus
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Synonyms

Synonyms Comment Organism
receptor tyrosine kinase Ror2
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Mus musculus
receptor tyrosine kinase Ror2
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Homo sapiens