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Literature summary for 2.7.10.1 extracted from
- Role of protein tyrosine kinase and Erk1/2 activities in the Toll-like receptor 2-induced cellular activation of murine B cells by neisserial porin (2008), Clin. Vaccine Immunol., 15, 630-637.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| PorB | PorB from Neisseria meningitidis is able to induce protein tyrosine kinase activity | Mus musculus |
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | B-cell proliferation and the induction of increased surface expression of costimulatory ligand CD86 by PorB are dependent on PTK activity and not Erk1/2 activation | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| genistein | - |
Mus musculus |  |
| Herbimycin | - |
Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
strains C3H/HeJ and C57BL/6 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| spleen | in B-cells of LPS-hyporesponsive strains C3H/HeJ, C57BL/6, and TLR2-deficient mice | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Protein tyrosine kinase | - |
Mus musculus |
| PTK | - |
Mus musculus |
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