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Literature summary for 2.7.10.1 extracted from

  • Todt, J.C.; Hu, B.; Curtis, J.L.
    The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages (2008), J. Leukoc. Biol., 84, 510-518.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information exposure to apoptotic cells induces a time-dependent increase in association of scavenger receptor A with Mertk in a direct or indirect manner Mus musculus

Application

Application Comment Organism
medicine during apoptotic cell uptake by murine macrophages, scavenger receptor A is essential for optimal phosphorylation of Mertk and subsequent signaling is required for apoptotic cell ingestion. The Mertk/SR-A complex may be a potential target to manipulate apoptotic cell clearance and hence, resolution of inflammation and infections Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information soluble anti-scavenger receptor A substantially inhibits apoptotic cell-induced phosphorylation of Mertk and of phospholipase Cgamma2, essential steps in apoptotic cell ingestion. Relative to macrophage tissue of wild-type mice, apoptotic cell-induced Mertk phosphorylation is reduced and delayed in macrophage tissue of SR-A-/- mice, as is in vitro apoptotic cell ingestion at early time-points Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q60805 wild-type 129/P3J mice and 129/SvJ SR-A-/- mice
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Source Tissue

Source Tissue Comment Organism Textmining
J-774A.1 cell in resting J774, scavenger receptor A is associated minimally with unphosphorylated (monomeric) Mertk Mus musculus
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additional information thymocytes lack Mertk and scavenger receptor A Mus musculus
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peritoneal macrophage
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Mus musculus
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Synonyms

Synonyms Comment Organism
Mer receptor tyrosine kinase
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Mus musculus
Mertk
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Mus musculus