Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | exposure to apoptotic cells induces a time-dependent increase in association of scavenger receptor A with Mertk in a direct or indirect manner | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | during apoptotic cell uptake by murine macrophages, scavenger receptor A is essential for optimal phosphorylation of Mertk and subsequent signaling is required for apoptotic cell ingestion. The Mertk/SR-A complex may be a potential target to manipulate apoptotic cell clearance and hence, resolution of inflammation and infections | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | soluble anti-scavenger receptor A substantially inhibits apoptotic cell-induced phosphorylation of Mertk and of phospholipase Cgamma2, essential steps in apoptotic cell ingestion. Relative to macrophage tissue of wild-type mice, apoptotic cell-induced Mertk phosphorylation is reduced and delayed in macrophage tissue of SR-A-/- mice, as is in vitro apoptotic cell ingestion at early time-points | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q60805 | wild-type 129/P3J mice and 129/SvJ SR-A-/- mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
J-774A.1 cell | in resting J774, scavenger receptor A is associated minimally with unphosphorylated (monomeric) Mertk | Mus musculus | - |
additional information | thymocytes lack Mertk and scavenger receptor A | Mus musculus | - |
peritoneal macrophage | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Mer receptor tyrosine kinase | - |
Mus musculus |
Mertk | - |
Mus musculus |