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Literature summary for 2.7.10.1 extracted from

  • Zhu, D.; Yang, Z.; Luo, Z.; Luo, S.; Xiong, W.C.; Mei, L.
    Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin (2008), J. Neurosci., 28, 1688-1696.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.1

Activating Compound

Activating Compound Comment Organism Structure
agrin MuSK becomes rapidly internalized in response to agrin, which appears to be required for induced acetylcholine receptor clustering Mus musculus
N-ethylmaleimide sensitive factor an appropriate level of N-ethylmaleimide sensitive factor and its ATPase activity may be required for MuSK endocytosis and subsequent activation Mus musculus

Application

Application Comment Organism
additional information role of N-ethylmaleimide sensitive factor in regulating MuSK endocytosis and subsequent signaling in response to agrin stimulation Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
coexpression of HA-tagged MuSK with Myc-tagged N-ethylmaleimide sensitive factor wild-type or mutant constructs in HEK-293 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information only MuSK deletion mutants containing the intact kinase domain can bind to N-ethylmaleimide sensitive factor. Deletion of the C terminus (13 amino acids) has no effect on MuSK binding to N-ethylmaleimide sensitive factor. Deletion of the middle 30 amino acids in the juxtamembrane, including Y556, a tyrosine implicated in agrin signaling, has no apparent effect on binding to N-ethylmaleimide sensitive factor. Deletion of any 30 amino acids in the kinase domain or in the region linking the juxtamembrane and kinase domains abolishes the binding activity, with the exception of one deletion mutant, DELTA739-768 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
dynamin K44A inhibits agrin-induced MuSK endocytosis Mus musculus
additional information suppression of N-ethylmaleimide sensitive factor expression or N-ethylmaleimide sensitive factor mutation attenuate MuSK downstream signaling Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Mus musculus 9986
-
cytoplasm cytoplasmic domain Mus musculus 5737
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q61006
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
-
 Mus musculus
-
muscle
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
muscle-specific receptor tyrosine kinase
-
 Mus musculus
MuSK
-
 Mus musculus