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Literature summary for 2.7.10.1 extracted from
- Met-related receptor tyrosine kinase Ron in tumor growth and metastasis (2008), Adv. Cancer Res., 100, 1-33.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 12-O-tetradecanoylphorbol-13-acetate | upregulates Ron protein expression | Mus musculus |  |
| chicken macrophage stimulating-protein | MSP, activates | Gallus gallus | |
| hepatocyte growth factor-like protein | stimulates | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | Ron is a critical factor in tumorigenesis | Mus musculus |
| medicine | Ron is a critical factor in tumorigenesis and its inhibition, alone or in combination with current therapies, may prove beneficial in the treatment of cancer patients | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| stable expression of wild-type and constitutively active murine Ron mutants in NIH3T3 mouse fibrobalst cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D1232V | is more active than the wild-type, produces tumors in nude mice and is highly metastatic | Mus musculus |
| M1231T | equivalent tumor latency and 100% tumor formation as the wild-type | Mus musculus |
| M1254T | is more active than the wild-type, produces tumors in nude mice and is highly metastatic | Mus musculus |
| additional information | mouse model with total loss of Ron protein, mice are lethal at an early stage of embryo development, mice hemizygous for the deletion of Ron are viable and fertile, but display an enhanced response to inflammation, are more susceptible to endotoxic shock and display an impaired ability to regulate nitric oxide. Mouse model in which the extracellular and transmembrane domains of Ron are preserved, along with eight amino acids of the intracellular domain, while ablation of the cytoplasmic domain results in complete loss of Ron intracellular signaling, homozygous mice with this germline deletion are viable, fertile and display no gross phenotypic abnormalities, but show an enhanced response to both acute and cell-mediated inflammatory stimuli. Mutant with insertion of beta-galactosidase gene into exon 1 of the mouse Ron gene, so that transcription of the reporter arises from the endogenous reporter and translates from its own start site. Homozygous mice with this mutation are viable and phenotypic normal, but show ablation of activity of Ron | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| geldanamycin | - |
Homo sapiens | |
| gemcitabine | - |
Homo sapiens | |
| humanized monoclonal antibody | blocks the interaction of Ron with hepatocyte growth factor-like protein and diminishes Ron phosphorylation and its downstream signaling | Homo sapiens | |
| humanized monoclonal antibody | significantly decreases tumor growth of murine xenografts from subcutaneously injected lung, colon, and pancreatic cancer cell lines in nude mice | Mus musculus | |
| mouse monoclonal blocking antibody | increases apoptosis by 32% as compared to gemcitabine alone | Homo sapiens | |
| siRNA | significantly reduces cancer cell proliferation, motility, and increases apoptotic susceptibility of colorectal carcinoma cells | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
1 * 150000 + 1 * 35000 | Homo sapiens |
| 150000 | - |
1 * 150000 + 1 * 35000 | Homo sapiens |
| 185000 | - |
- |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Canis lupus | - |
- |
- |
| Equus caballus | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Macaca mulatta | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Strongylocentrotus purpuratus | - |
- |
- |
| Takifugu rubripes | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Mus musculus | - |
| bone | ossification centers of developing bone | Mus musculus | - |
| breast cancer cell | - |
Mus musculus | - |
| breast cancer cell | overexpression of Ron | Homo sapiens | - |
| BxPC-3 cell | Ron is highly expressed | Homo sapiens | - |
| central nervous system | - |
Mus musculus | - |
| CFPAC-1 cell | Ron is highly expressed | Homo sapiens | - |
| colon | - |
Mus musculus | - |
| colon | - |
Homo sapiens | - |
| colonic cancer cell | - |
Mus musculus | - |
| colonic cancer cell | - |
Homo sapiens | - |
| DU-145 cell | Ron is highly expressed | Homo sapiens | - |
| embryo | expression during the process of implantation and placentation | Mus musculus | - |
| epididymis | - |
Mus musculus | - |
| epithelium | - |
Mus musculus | - |
| esophagus | - |
Homo sapiens | - |
| gastric cancer cell | - |
Mus musculus | - |
| gastrointestinal tract | - |
Mus musculus | - |
| hematopoietic stem cell | - |
Mus musculus | - |
| hepatocyte | - |
Homo sapiens | - |
| keratinocyte | foreskin | Homo sapiens | - |
| kidney | - |
Mus musculus | - |
| kidney cancer cell | - |
Mus musculus | - |
| Kupffer cell | - |
Homo sapiens | - |
| L3.6pl cell | Ron is highly expressed | Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| liver | epression of Ron from day 12.5 | Mus musculus | - |
| liver cancer cell | - |
Mus musculus | - |
| liver cancer cell | - |
Homo sapiens | - |
| LNCaP cell | Ron is highly expressed | Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| lung cancer cell | - |
Mus musculus | - |
| lung cancer cell | - |
Homo sapiens | - |
| macrophage | Ron is expressed on alveolar and peritoneal and monocyte-derived macrophages | Homo sapiens | - |
| additional information | present in ductal breast carcinoma cells, epithelial tumor cells, stomach cancer cells, NSCLC cell line and SCLC cell line. Ron is highly expressed in FG cells. Ron is not expressed on circulating human monocytes and is absent from gall bladder | Homo sapiens | - |
| additional information | present in hematopoietic cancer cells. Ron is highly expressed in 4964-PDA cells, 4964-LM cells, 5143-PDA cells and 5143-LM cells | Mus musculus | - |
| ovary | - |
Mus musculus | - |
| ovary cancer cell | Ron and Met are significantly coexpressed. Also another short form Ron is present | Homo sapiens | - |
| pancreas | Ron is highly expressed in fetal pancreas as compared to adults. Also another short form Ron is present | Homo sapiens | - |
| pancreatic cancer cell | - |
Mus musculus | - |
| pancreatic cancer cell | - |
Homo sapiens | - |
| PC-3 cell | Ron is highly expressed | Homo sapiens | - |
| peripheral nervous system | - |
Mus musculus | - |
| placenta | - |
Mus musculus | - |
| prostate cancer cell | - |
Homo sapiens | - |
| small intestine | - |
Homo sapiens | - |
| stomach | - |
Mus musculus | - |
| stomach | Ron is highly expressed in fetal stomach as compared to adults | Homo sapiens | - |
| T-47D cell | Ron is highly expressed | Homo sapiens | - |
| testis | - |
Mus musculus | - |
| uterus | - |
Mus musculus | - |
| ZR-75-1 cell | Ron is highly expressed | Homo sapiens | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 150000 + 1 * 35000 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| macrophage stimulating 1-receptor | - |
Homo sapiens |
| MST1R | - |
Homo sapiens |
| Ron | - |
Mus musculus |
| Ron | - |
Homo sapiens |
| Ron | - |
Rattus norvegicus |
| Ron | - |
Bos taurus |
| Ron | - |
Equus caballus |
| Ron | - |
Macaca mulatta |
| Ron | - |
Canis lupus |
| Ron | - |
Strongylocentrotus purpuratus |
| Ron | - |
Takifugu rubripes |
| RON receptor tyrosine kinase | - |
Mus musculus |
| RON receptor tyrosine kinase | - |
Homo sapiens |
| RON receptor tyrosine kinase | - |
Rattus norvegicus |
| RON receptor tyrosine kinase | - |
Bos taurus |
| RON receptor tyrosine kinase | - |
Equus caballus |
| RON receptor tyrosine kinase | - |
Macaca mulatta |
| RON receptor tyrosine kinase | - |
Canis lupus |
| RON receptor tyrosine kinase | - |
Strongylocentrotus purpuratus |
| RON receptor tyrosine kinase | - |
Takifugu rubripes |
| sea receptor | - |
Gallus gallus |
| stem cell derived tyrosine kinase | - |
Mus musculus |
| STK | - |
Mus musculus |
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Release 2023.1 (January 2023)
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