Activating Compound | Comment | Organism | Structure |
---|---|---|---|
macrophage-stimulating protein | the ligand for RON, inhibits IFN-gamma-induced STAT1 phosphorylation and CIITA expression, resulting in reduced surface levels of MHC class II | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | RON receptor regulates both the production of and response to IFN-gamma, resulting in enhanced susceptibility to endotoxin challenge | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | RON(-/-) mice harbor significantly increased systemic levels of IFN-gamma and IL-12p70 and increased levels of IL-12p40 transcript in their spleen. Enhanced susceptibility of RON(-/-) mice to endotoxin challenge is dependent on IFN-gamma-mediated signals | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q62190 | CD-1 mice, BALB/cJ mice and C57BL/6 mice | - |
Synonyms | Comment | Organism |
---|---|---|
RON receptor | - |
Mus musculus |
RON receptor tyrosine kinase | - |
Mus musculus |