Reference on EC 2.5.1.18 - glutathione transferase and Organism(s) Homo sapiens and UniProt Accession O15217
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Radulovic, L.L.; Kulkarni, A.P.
A rapid, novel high performance liquid chromatography method for the purification of glutathione S-transferase: an application to the human placental enzyme
Biochem. Biophys. Res. Commun.
128
75-81
1985
Homo sapiens
Jakoby, W.B.
Glutathione transferases: an overview
Methods Enzymol.
113
495-499
1985
Ovis aries, Homo sapiens, Mus musculus, Rattus norvegicus
Habig, W.H.; Jakoby, W.B.
Glutathione S-transferases (rat and human)
Methods Enzymol.
77
218-231
1981
Homo sapiens, Rattus norvegicus
Rogerson, K.S.; Mitchell, A.L.; Ibbotson, R.; Cotton, W.; Strange, R.C.
Studies on the glutathione S-transferase of human platelets and erythrocytes
Biochem. Soc. Trans.
13
200-201
1985
Homo sapiens
-
Jakoby, W.B.; Keen, J.H.
A triple-threat in detoxification: the glutathione S-transferases
Trends Biochem. Sci.
2
229-231
1977
Homo sapiens, Pisum sativum, Rattus norvegicus, Zea mays
-
Mannervik, B.; Guthenberg, C.
Glutathione transferase (human placenta)
Methods Enzymol.
77
231-235
1981
Homo sapiens
Guthenberg, C.; Warholm, M.; Rane, A.; Mannervik, B.
Two distinct forms of glutathione transferase from human foetal liver. Purification and comparison with isoenzymes isolated from adult liver and placenta
Biochem. J.
235
741-745
1986
Homo sapiens
Stockman, P.K.; McLellan, L.I.; Hayes, J.D.
Characterization of the basic glutathione S-transferase B1 and B2 subunits from human liver
Biochem. J.
244
55-61
1987
Homo sapiens
Vander Jagt, D.L.; Hunsaker, L.A.; Garcia, K.B.; Royer, R.E.
Isolation and characterization of the multiple glutathione S-transferases from human liver. Evidence for unique heme-binding sites
J. Biol. Chem.
260
11603-11610
1985
Homo sapiens
Warholm, M.; Guthenberg, C.; van Bahr, C.; Mannervik, B.
Glutathione transferases from human liver
Methods Enzymol.
113
499-504
1985
Homo sapiens
Rogerson, K.S.; Mitchell, D.; Lawton, A.; Ibbotson, R.; Cotton, W.; Strange, R.C.
Studies on the glutathione S-transferase of human platelets
Biochem. Biophys. Res. Commun.
122
407-412
1984
Homo sapiens
Awasthi, Y.C.; Singh, S.V.
Purification and characterization of a new form of glutathione S-transferase from human erythrocytes
Biochem. Biophys. Res. Commun.
125
1053-1060
1984
Homo sapiens
Habig, W.H.; Jakoby, W.B.
Assays for differentiation of glutathione S-transferases
Methods Enzymol.
77
398-405
1981
Homo sapiens, Rattus norvegicus
Simons, P.C.; Vander Jagt, D.L.
Purification of glutathione S-transferases by glutathione-affinity chromatography
Methods Enzymol.
77
235-237
1981
Homo sapiens
Simons, P.C.; Vander Jagt, D.L.
Purification of glutathione S-transferases from human liver by glutathione-affinity chromatography
Anal. Biochem.
82
334-341
1977
Homo sapiens
Vander Jagt, D.L.; Wilson, S.P.; Heidrich, J.E.
Purification and bilirubin binding properties of glutathione S-transferase from human placenta
FEBS Lett.
136
319-321
1981
Homo sapiens
Caccuri, A.M.; Ascenzi, P.; Antonini, G.; Parker, M.W.; Oakley, A.J.; Chiessi, E.; Nuccetelli, M.; Battistoni, A.; Bellizia, A.; Ricci, G.
Structural flexibility modulates the activity of human glutathione transferase P1-1. Influence of a poor co-substrate on dynamics and kinetics of human glutathione transferase
J. Biol. Chem.
271
16193-16198
1996
Homo sapiens
Berhane, K.; Widersten, M.; Engstroem, A.; Kozarich, J.W.; Mannervik, B.
Detoxication of base propenals and other alpha,beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases
Proc. Natl. Acad. Sci. USA
91
1480-1484
1994
Homo sapiens
Ricci, G.; Caccuri, A.M.; Lo Bello, M.; Rosato, N.; Mei, G.; Nicotra, M.; Chiessi, E.; Mazzetti, A.P.; Federici, G.
Structural flexibility modulates the activity of human glutathione transferase P1-1. Role of helix 2 flexibility in the catalytic mechanism
J. Biol. Chem.
271
16187-16192
1996
Homo sapiens
Whalen, R.; Kempner, E.S.; Boyer, T.D.
Structural studies of a human pi class glutathione S-transferase. Photoaffinity labeling of the active site and target size analysis
Biochem. Pharmacol.
52
281-288
1996
Homo sapiens
Board, P.G.; Taylor, M.C.; Coggan, M.; Parker, M.W.; Lantum, H.B.; Anders, M.W.
Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique
Biochem. J.
374
731-737
2003
Homo sapiens
Prabhu, K.S.; Reddy, P.V.; Liken, A.D.; Jones, E.C.; Yennawar, H.P.; Reddy, C.C.
Identification, characterization, and properties of a class alpha microsomal glutathione S-transferase
Adv. Exp. Med. Biol.
525
189-192
2003
Ovis aries, Homo sapiens
Prabhu, K.S.; Reddy, P.V.; Jones, E.C.; Liken, A.D.; Reddy, C.C.
Characterization of a class alpha glutathione-S-transferase with glutathione peroxidase activity in human liver microsomes
Arch. Biochem. Biophys.
424
72-80
2004
Homo sapiens
Gu, Y.; Guo, J.; Pal, A.; Pan, S.S.; Zimniak, P.; Singh, S.V.; Ji, X.
Crystal structure of human glutathione S-transferase A3-3 and mechanistic implications for its high steroid isomerase activity
Biochemistry
43
15673-15679
2004
Homo sapiens
Park, H.J.; Koh, J.U.; Ahn, S.Y.; Kong, K.H.
Functional studies of tyrosine 108 residue in the active site of human glutathione S-transferase P1-1
Bull. Korean Chem. Soc.
26
433-439
2005
Homo sapiens
-
Grahn, E.; Novotny, M.; Jakobsson, E.; Gustafsson, A.; Grehn, L.; Olin, B.; Madsen, D.; Wahlberg, M.; Mannervik, B.; Kleywegt, G.J.
New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix
Acta crystallogr. Sect. D
62
197-207
2006
Homo sapiens
Sanchez-Gomez, F.J.; Gayarre, J.; Avellano, M.I.; Perez-Sala, D.
Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival
Arch. Biochem. Biophys.
457
150-159
2007
Homo sapiens
Shokeer, A.; Larsson, A.K.; Mannervik, B.
Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates
Biochem. J.
388
387-392
2005
Homo sapiens
Hayeshi, R.; Mutingwende, I.; Mavengere, W.; Masiyanise, V.; Mukanganyama, S.
The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin
Food Chem. Toxicol.
45
286-295
2007
Homo sapiens
Wang, L.; Xu, J.; Ji, C.; Gu, S.; Lv, Y.; Li, S.; Xu, Y.; Xie, Y.; Mao, Y.
Cloning, expression and characterization of human glutathione S-transferase Omega 2
Int. J. Mol. Med.
16
19-27
2005
Homo sapiens (Q9H4Y5), Homo sapiens
Ricci, G.; De Maria, F.; Antonini, G.; Turella, P.; Bullo, A.; Stella, L.; Filomeni, G.; Federici, G.; Caccuri, A.M.
7-Nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione S-transferases. Mechanism of action of potential anticancer drugs
J. Biol. Chem.
280
26397-26405
2005
Homo sapiens
Tars, K.; Larsson, A.K.; Shokeer, A.; Olin, B.; Mannervik, B.; Kleywegt, G.J.
Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant
J. Mol. Biol.
355
96-105
2006
Homo sapiens
Griswold, K.E.; Aiyappan, N.S.; Iverson, B.L.; Georgiou, G.
The evolution of catalytic efficiency and substrate promiscuity in human theta class 1-1 glutathione transferase
J. Mol. Biol.
364
400-410
2006
Rattus norvegicus, Homo sapiens (P30711), Homo sapiens
Zhao, X.; Fan, Y.; Shen, J.; Wu, Y.; Yin, Z.
Human glutathione S-transferase P1 suppresses MEKK1-mediated apoptosis by regulating MEKK1 kinase activity in HEK293 cells
Mol. Cells
21
395-400
2006
Homo sapiens
Cannady, E.A.; Chien, C.; Jones, T.M.; Borel, A.G.
In vitro metabolism of the epoxide substructure of cryptophycins by cytosolic glutathione S-transferase: species differences and stereoselectivity
Xenobiotica
36
659-670
2006
Canis lupus familiaris, Macaca fascicularis, Homo sapiens, Mus musculus, Rattus norvegicus, Mus musculus CD1
Torres-Rivera, A.; Landa, A.
Glutathione transferases from parasites: a biochemical view
Acta Trop.
105
99-112
2008
Homo sapiens, Echinococcus granulosus (O16058), Rattus norvegicus (P04905), Schistosoma mansoni (P15964), Mus musculus (P24472), Schistosoma japonicum (P26624), Onchocerca volvulus (P46427), Ascaris suum (P46436), Fasciola hepatica (P56598), Sus scrofa (P80031), Clonorchis sinensis (Q1L2C7), Taenia solium (Q3ZJN3), Ancylostoma caninum (Q6J1M5), Plasmodium yoelii (Q7REH6), Wuchereria bancrofti (Q86LL8), Plasmodium falciparum (Q8MU52)
Kurtovic, S.; Grehn, L.; Karlsson, A.; Hellman, U.; Mannervik, B.
Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine
Anal. Biochem.
375
339-344
2008
Bos taurus, Homo sapiens, Homo sapiens (P08263), Homo sapiens (Q16772), Rattus norvegicus (P04903), Rattus norvegicus (P04904)
Eklund, B.I.; Gunnarsdottir, S.; Elfarra, A.A.; Mannervik, B.
Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs
Biochem. Pharmacol.
73
1829-1841
2007
Homo sapiens (O15217), Homo sapiens (O43708), Homo sapiens (P08263), Homo sapiens (P09210), Homo sapiens (P09211), Homo sapiens (P09488), Homo sapiens (P28161), Homo sapiens (P30711), Homo sapiens (P46439), Homo sapiens (P78417), Homo sapiens (Q03013), Homo sapiens (Q16772), Homo sapiens
Ivarsson, Y.; Norrgard, M.A.; Hellman, U.; Mannervik, B.
Engineering the enantioselectivity of glutathione transferase by combined active-site mutations and chemical modifications
Biochim. Biophys. Acta
1770
1374-1381
2007
Homo sapiens
Cho, H.Y.; Kong, K.H.
Study on the biochemical characterization of herbicide detoxification enzyme, glutathione S-transferase
Biofactors
30
281-287
2007
Homo sapiens, Oryza sativa
Zheng, K.; Board, P.G.; Fei, X.; Sun, Y.; Lv, S.; Yan, G.; Liu, J.; Shen, J.; Luo, G.
A novel selenium-containing glutathione transferase zeta1-1, the activity of which surpasses the level of some native glutathione peroxidases
Int. J. Biochem. Cell Biol.
40
2090-2097
2008
Homo sapiens (O43708)
Fujikawa, Y.; Urano, Y.; Komatsu, T.; Hanaoka, K.; Kojima, H.; Terai, T.; Inoue, H.; Nagano, T.
Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells
J. Am. Chem. Soc.
130
14533-14543
2008
Homo sapiens (P09211)
Huang, Y.C.; Misquitta, S.; Blond, S.Y.; Adams, E.; Colman, R.F.
Catalytically active monomer of glutathione S-transferase pi and key residues involved in the electrostatic interaction between subunits
J. Biol. Chem.
283
32880-32888
2008
Homo sapiens (P09211), Homo sapiens
Parker, L.J.; Ciccone, S.; Italiano, L.C.; Primavera, A.; Oakley, A.J.; Morton, C.J.; Hancock, N.C.; Bello, M.L.; Parker, M.W.
The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants
J. Mol. Biol.
380
131-144
2008
Homo sapiens (P09211), Homo sapiens
Kurtovic, S.; Shokeer, A.; Mannervik, B.
Diverging catalytic capacities and selectivity profiles with haloalkane substrates of chimeric alpha class glutathione transferases
Protein Eng. Des. Sel.
21
329-341
2008
Rattus norvegicus (P04903), Rattus norvegicus (P04904), Homo sapiens (P08263), Homo sapiens (P09210), Homo sapiens (Q16772), Homo sapiens, Bos taurus (Q28035), Bos taurus
Wu, Y.; Shen, J.; Yin, Z.
Expression, purification and functional analysis of hexahistidine-tagged human glutathione S-transferase P1-1 and its cysteinyl mutants
Protein J.
26
359-370
2007
Homo sapiens (P09211), Homo sapiens
Jenkins, R.E.; Kitteringham, N.R.; Goldring, C.E.; Dowdall, S.M.; Hamlett, J.; Lane, C.S.; Boerma, J.S.; Vermeulen, N.P.; Park, B.K.
Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites
Proteomics
8
301-315
2008
Homo sapiens (P09211), Homo sapiens
Josephy, P.D.; Kent, M.; Mannervik, B.
Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties
Arch. Biochem. Biophys.
490
24-29
2009
Homo sapiens (P30711), Homo sapiens
Larsson, A.K.; Shokeer, A.; Mannervik, B.
Molecular evolution of theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents
Arch. Biochem. Biophys.
497
28-34
2010
Homo sapiens, Mus musculus
Balogh, L.M.; Le Trong, I.; Kripps, K.A.; Shireman, L.M.; Stenkamp, R.E.; Zhang, W.; Mannervik, B.; Atkins, W.M.
Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal
Biochemistry
49
1541-1548
2010
Homo sapiens
Pezzola, S.; Antonini, G.; Geroni, C.; Beria, I.; Colombo, M.; Broggini, M.; Mongelli, N.; Leboffe, L.; MacArthur, R.; Mozzi, A.F.; Federici, G.; Caccuri, A.M.
Role of glutathione transferases in the mechanism of brostallicin activation
Biochemistry
49
226-235
2010
Homo sapiens
Blikstad, C.; Shokeer, A.; Kurtovic, S.; Mannervik, B.
Emergence of a novel highly specific and catalytically efficient enzyme from a naturally promiscuous glutathione transferase
Biochim. Biophys. Acta
1780
1458-1463
2008
Homo sapiens
Shokeer, A.; Mannervik, B.
Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1
Biochim. Biophys. Acta
1800
466-473
2010
Mus musculus, Rattus norvegicus, Homo sapiens (P30711), Homo sapiens
Gildenhuys, S.; Dobreva, M.; Kinsley, N.; Sayed, Y.; Burke, J.; Pelly, S.; Gordon, G.P.; Sayed, M.; Sewell, T.; Dirr, H.W.
Arginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1
Biophys. Chem.
146
118-125
2010
Homo sapiens (P08263), Homo sapiens
Wang, J.; Wang, S.; Song, D.; Zhao, D.; Sha, Y.; Jiang, Y.; Jing, Y.; Cheng, M.
Chalcone derivatives inhibit glutathione S-transferase P1-1 activity: insights into the interaction mode of alpha, beta-unsaturated carbonyl compounds
Chem. Biol. Drug Des.
73
511-514
2009
Homo sapiens
Yang, X.; Liu, G.; Li, H.; Zhang, Y.; Song, D.; Li, C.; Wang, R.; Liu, B.; Liang, W.; Jing, Y.; Zhao, G.
Novel oxadiazole analogues derived from ethacrynic acid: design, synthesis, and structure-activity relationships in inhibiting the activity of glutathione S-transferase P1-1 and cancer cell proliferation
J. Med. Chem.
53
1015-1022
2010
Homo sapiens
Appiah-Opong, R.; Commandeur, J.N.; Istyastono, E.; Bogaards, J.J.; Vermeulen, N.P.
Inhibition of human glutathione S-transferases by curcumin and analogues
Xenobiotica
39
302-311
2009
Homo sapiens, Rattus norvegicus
Achilonu, I.; Gildenhuys, S.; Fisher, L.; Burke, J.; Fanucchi, S.; Sewell, B.T.; Fernandes, M.; Dirr, H.W.
The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function
Acta Crystallogr. Sect. F
66
776-780
2010
Homo sapiens (P08263), Homo sapiens
Wang, B.; Peng, Y.; Zhang, T.; Ding, J.
Crystal structures and kinetic studies of human Kappa class glutathione transferase provide insights into the catalytic mechanism
Biochem. J.
439
215-225
2011
Homo sapiens
Board, P.; Menon, D.
Glutathione transferases, regulators of cellular metabolism and physiology
Biochim. Biophys. Acta
1830
3267-3288
2013
Homo sapiens (O15217), Homo sapiens (O43708), Homo sapiens (O60760), Homo sapiens (P08263), Homo sapiens (P09210), Homo sapiens (P09211), Homo sapiens (P09488), Homo sapiens (P0CG30), Homo sapiens (P21266), Homo sapiens (P28161), Homo sapiens (P46439), Homo sapiens (P78417), Homo sapiens (Q03013), Homo sapiens (Q16772), Homo sapiens (Q7RTV2), Homo sapiens (Q9H4Y5)
Norrgard, M.A.; Hellman, U.; Mannervik, B.
Cys-X scanning for expansion of active-site residues and modulation of catalytic functions in a glutathione transferase
J. Biol. Chem.
286
16871-16878
2011
Homo sapiens
Mukanganyama, S.; Bezabih, M.; Robert, M.; Ngadjui, B.T.; Kapche, G.F.; Ngandeu, F.; Abegaz, B.
The evaluation of novel natural products as inhibitors of human glutathione transferase P1-1
J. Enzyme Inhib. Med. Chem.
26
460-467
2011
Homo sapiens
Koutsoumpli, G.E.; Dimaki, V.D.; Thireou, T.N.; Eliopoulos, E.E.; Labrou, N.E.; Varvounis, G.I.; Clonis, Y.D.
Synthesis and study of 2-(pyrrolesulfonylmethyl)-N-arylimines: a new class of inhibitors for human glutathione transferase A1-1
J. Med. Chem.
55
6802-6813
2012
Homo sapiens
Chronopoulou, E.; Papageorgiou, A.; Markoglou, A.; Labrou, N.
Inhibition of human glutathione transferases by pesticides: development of a simple analytical assay for the quantification of pesticides in water
J. Mol. Catal. B
81
43-51
2012
Homo sapiens
-
Yin, L.; Song, J.; Board, P.G.; Yu, Y.; Han, X.; Wei, J.
Characterization of selenium-containing glutathione transferase zeta1-1 with high GPX activity prepared in eukaryotic cells
J. Mol. Recognit.
26
38-45
2013
Homo sapiens
Dourado, D.F.; Fernandes, P.A.; Ramos, M.J.
Glutathione transferase classes alpha, pi, and mu: GSH activation mechanism
J. Phys. Chem. B
114
12972-12980
2010
Homo sapiens
Ahmad, S.; Niegowski, D.; Wetterholm, A.; Haeggstroem, J.Z.; Morgenstern, R.; Rinaldo-Matthis, A.
Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps
Biochemistry
52
1755-1764
2013
Homo sapiens
Shroads, A.L.; Coats, B.S.; Langaee, T.; Shuster, J.J.; Stacpoole, P.W.
Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans
Drug Metab. Pers. Ther.
30
49-55
2015
Homo sapiens (O43708), Homo sapiens
Zompra, A.; Georgakis, N.; Pappa, E.; Thireou, T.; Eliopoulos, E.; Labrou, N.; Cordopatis, P.; Clonis, Y.
Glutathione analogues as substrates or inhibitors that discriminate between allozymes of the MDR-involved human glutathione transferase P1-1
Biopolymers
106
330-344
2016
Homo sapiens (P09211), Homo sapiens
Dai, W.; Samanta, S.; Xue, D.; Petrunak, E.M.; Stuckey, J.A.; Han, Y.; Sun, D.; Wu, Y.; Neamati, N.
Structure-based design of N-(5-phenylthiazol-2-yl)acrylamides as novel and potent glutathione S-transferase omega 1 inhibitors
J. Med. Chem.
62
3068-3087
2019
Homo sapiens (P78417)
Xie, Y.; Tummala, P.; Oakley, A.J.; Deora, G.S.; Nakano, Y.; Rooke, M.; Cuellar, M.E.; Strasser, J.M.; Dahlin, J.L.; Walters, M.A.; Casarotto, M.G.; Board, P.G.; Baell, J.B.
Development of benzenesulfonamide derivatives as potent glutathione transferase omega-1 inhibitors
J. Med. Chem.
63
2894-2914
2020
Homo sapiens
