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5-fluoroorotate + 5-phospho-alpha-D-ribose 1-diphosphate
?
-
-
-
?
5-fluoroorotate + phosphoribose diphosphate
5-fluoroorotidine 5'-phosphate + diphosphate
-
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
orotate + 5-alpha-D-phosphorylribose 1-diphosphate
diphosphate + orotidine 5'-phosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
orotate methylester + phosphoribose diphosphate
diphosphate + orotidine 4-methylester
-
-
-
-
?
orotidine + diphosphate
orotate + alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + phosphonoacetic acid
?
orotidine 5-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
uracil + phosphoribose diphosphate
diphosphate + uridine
-
-
-
-
?
additional information
?
-
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
-
-
672923, 673097, 673120, 674045, 674056, 676267, 676270, 676296, 677169, 689294, 706023, 735748 -
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
-
essential enzyme for activation of 5-fluorouracil and its derivatives
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
-
the activating OPRT and its antagonist the catabolizing dihydropyrimidine dehydrogenase play important roles in 5-fluorouracil metabolism, overview
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
-
the enzyme is involved in degradation of 5-fluorouracil being the key enzyme related to the first-step activation process of 5-fluorouracil, and possibly predicts chemosensitivity to 5-fluorouracil, overview
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
-
the enzyme is involved in the de novo biosynthesis of pyrimidine nucleotides, main enzyme involved in phosphoribosylation of 5-fluorouracil, an essential step that leads to tumor growth inhibition
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
-
the enzyme is involved in the metabolism of 5-fluorouracil, a chemotherapeutic drug in treatment of solid cancers, major pathways of 5-fluorouracil metabolism, overview
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
reverse reaction: tri-, tetrapoly- or trimetaphosphate can replace diphosphate with 29%, 70% or 78% efficiency
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
involved in de novo synthesis of pyrimidine nucleotides
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
final steps in biosynthesis of UMP
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
i.e. orotidylate or OMP
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
final steps in biosynthesis of UMP
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
final steps in biosynthesis of UMP
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
catalyzes stereospecific formation of beta-glycosidic bond between orotate and ribose 5'-phosphate portion of phospho-ribose diphosphate
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
predominant species of phosphoribose diphosphate: metal ion complex
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
high specificity for orotate
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
nucleotide-forming step in pyrimidine biosynthesis
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
involved in de novo synthesis of pyrimidine nucleotides
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotidine + diphosphate
orotate + alpha-D-ribose 1-diphosphate
-
-
-
-
?
orotidine + diphosphate
orotate + alpha-D-ribose 1-diphosphate
-
-
-
-
r
orotidine + diphosphate
orotate + alpha-D-ribose 1-diphosphate
-
-
-
-
?
orotidine + diphosphate
orotate + alpha-D-ribose 1-diphosphate
-
-
-
-
r
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
r
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
r
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
r
orotidine 5'-phosphate + phosphonoacetic acid
?
-
-
-
-
?
orotidine 5'-phosphate + phosphonoacetic acid
?
-
-
-
-
?
orotidine 5-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
orotidine 5-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
the compounds bind very tightly to the enzyme in a Mg2+-dependent manner, overview
the compounds bind very tightly to the enzyme in a Mg2+-dependent manner, overview
-
?
additional information
?
-
-
enzyme from mammals is a bifunctional polypeptide, it also catalyzes the reaction listed as EC 4.1.1.23
-
-
?
additional information
?
-
-
relationship between OPRT, antagonizing dihydropyrimidine dehydrogenase, and clinicopathologic features in cancer and treatment with 5-fluorouracil, relation of patients survival and enzyme activities after surgery, detailed overview
-
-
?
additional information
?
-
-
the enzyme expression is weakly correlated to 5-fluorouracil sensitivity and apoptotic cell rate, overview
-
-
?
additional information
?
-
-
the enzyme is associated with thymidylate synthase and dihydropyrimidine dehydrogenase in resectable colorectal cancer, overview, prognostic impact of the enzyme among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy, overview
-
-
?
additional information
?
-
-
enzyme from mammals is a bifunctional polypeptide, it also catalyzes the reaction listed as EC 4.1.1.23
-
-
?
additional information
?
-
-
enzyme from mammals is a bifunctional polypeptide, it also catalyzes the reaction listed as EC 4.1.1.23
-
-
?
additional information
?
-
-
half-of-sites binding of orotidine 5-phosphate and alpha-D-5-phosphorylribose 1-diphosphate to the enzyme supports an alternative variant of the Theorell-Chance mechanism with alternating site catalysis, overview
-
-
?
additional information
?
-
-
enzyme from mammals is a bifunctional polypeptide, it also catalyzes the reaction listed as EC 4.1.1.23
-
-
?
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(1R,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[(4-nitrophenyl)methyl]pyrrolidin-1-ium
(1S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[2-(4-nitrophenyl)ethyl]pyrrolidin-1-ium
(2R,3R,4S)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium
(2R,3R,4S)-1-[2-(6-carboxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium
(2R,3S)-3-hydroxy-2-(hydroxymethyl)-5-(4-nitrophenyl)pyrrolidin-1-ium
(2S,3S,4R,5R)-2-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium
(2S,3S,4R,5R)-2-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium
(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium
(3R,4R)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium
(7R,8R,9S,9aS)-8,9-dihydroxy-7-(hydroxymethyl)-8,9,9a,10-tetrahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidine-1,3,5(2H)-trione
1,3-dihydroxy-N-[(4-nitrophenyl)methyl]propan-2-aminium
1,3-dihydroxy-N-[2-(4-nitrophenyl)ethyl]propan-2-aminium
1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]pyrrolidin-1-ium
2,6-dihydroxypyridine-4-carboxylic acid
-
competitive to orotate, uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate
3-(2-hydroxybenzylidene)-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid
-
competitive to orotate, uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate
3-benzylidene-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid
-
competitive to orotate, uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate
4-nitrophenyl beta-D-ribose
4-nitrophenyl beta-D-ribose 5'-phosphate
5-aminoorotate
50% inhibition at 0.01 mM
5-fluorouracil
50% inhibition at 0.005-0.01 mM
5-Methylorotate
50% inhibition at 0.001 mM
5-phospho-alpha-D-ribose 1-diphosphate
6-hydroxy-5-((2-hydroxyethylamino)methyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid
-
competitive to orotate, uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate
arabinose 5-phosphate
-
at higher concentrations
Co2+
-
inhibits Mg2+-activation
erythrose 4-phosphate
-
at higher concentrations
fructose 1-phosphate
-
at higher concentrations
fructose 6-phosphate
-
at higher concentrations
HgCl2
-
slight inhibition of mutant, not wild-type
iodoacetamide
-
slight inhibition of mutant, not wild-type
NEM
-
slight inhibition of mutant, not wild-type
Orotic acid
-
when grown on glucose as carbon source, supplementation with orotic acid significantly decreases orotate phosphoribosyltransferase and orotidine 5'-monophoshate decarboxylase activities. In a strain deficient for dihydroorotase activity, orotic acid induces both phosphoribosyltransferase and orotidine 5'-monophoshate decarboxylase activites
p-nitrophenyl beta-D-ribose
p-nitrophenyl beta-D-ribose 5'-phosphate
pyrazofurin
50% inhibition at 0.006-0.024 mM
xanthosine-5'-phosphate
-
-
[(2R,3R,4S,5S)-5-(4-carboxypyridin-3-yl)-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
[(2R,3R,4S,5S)-5-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
[(2R,3R,4S,5S)-5-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
[(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-4-hydroxypyrrolidin-1-ium-3-yl]methyl hydrogen phosphate
[(7R,8R,9S,9aS)-8,9-dihydroxy-1,3,5-trioxo-1,2,3,5,8,9,9a,10-octahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidin-7-yl]methyl hydrogen phosphate
(1R,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[(4-nitrophenyl)methyl]pyrrolidin-1-ium
-
-
(1R,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[(4-nitrophenyl)methyl]pyrrolidin-1-ium
-
-
(1S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[2-(4-nitrophenyl)ethyl]pyrrolidin-1-ium
-
-
(1S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[2-(4-nitrophenyl)ethyl]pyrrolidin-1-ium
-
-
(2R,3R,4S)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium
-
-
(2R,3R,4S)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium
-
-
(2R,3R,4S)-1-[2-(6-carboxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium
-
-
(2R,3R,4S)-1-[2-(6-carboxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium
-
-
(2R,3S)-3-hydroxy-2-(hydroxymethyl)-5-(4-nitrophenyl)pyrrolidin-1-ium
-
-
(2R,3S)-3-hydroxy-2-(hydroxymethyl)-5-(4-nitrophenyl)pyrrolidin-1-ium
-
-
(2S,3S,4R,5R)-2-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium
-
-
(2S,3S,4R,5R)-2-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium
-
-
(2S,3S,4R,5R)-2-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium
-
-
(2S,3S,4R,5R)-2-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium
-
-
(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium
-
-
(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium
-
-
(3R,4R)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium
-
-
(3R,4R)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium
-
-
(7R,8R,9S,9aS)-8,9-dihydroxy-7-(hydroxymethyl)-8,9,9a,10-tetrahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidine-1,3,5(2H)-trione
-
-
(7R,8R,9S,9aS)-8,9-dihydroxy-7-(hydroxymethyl)-8,9,9a,10-tetrahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidine-1,3,5(2H)-trione
-
-
1,3-dihydroxy-N-[(4-nitrophenyl)methyl]propan-2-aminium
-
-
1,3-dihydroxy-N-[(4-nitrophenyl)methyl]propan-2-aminium
-
-
1,3-dihydroxy-N-[2-(4-nitrophenyl)ethyl]propan-2-aminium
-
-
1,3-dihydroxy-N-[2-(4-nitrophenyl)ethyl]propan-2-aminium
-
-
1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]pyrrolidin-1-ium
-
-
1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]pyrrolidin-1-ium
-
-
4-nitrophenyl beta-D-ribose
-
-
4-nitrophenyl beta-D-ribose
-
-
4-nitrophenyl beta-D-ribose 5'-phosphate
-
-
4-nitrophenyl beta-D-ribose 5'-phosphate
-
-
5-Fluoroorotate
-
at 0.05 M
5-Fluoroorotate
50% inhibition at 2-10 nM
5-phospho-alpha-D-ribose 1-diphosphate
product inhibition, competitive to diphosphate, competitive to orotidine 5'-phosphate
5-phospho-alpha-D-ribose 1-diphosphate
-
phosphorolysis, product inhibition, kinetics
5-phospho-alpha-D-ribose 1-diphosphate
-
phosphorolysis, product inhibition, kinetics
adenine
-
not inhibitory
adenosine
-
not inhibitory
ADP
-
not inhibitory
AMP
-
not inhibitory
ATP
-
not inhibitory
diphosphate
-
-
diphosphate
product inhibition
diphosphate
product inhibition, noncompetitive to orotate, competitive to 5-phospho-alpha-D-ribose 1-diphosphate
diphosphate
noncompetitive inhibition versus orotate, and noncompetitive versus 5-phospho-alpha-D-ribose 1-diphosphate with the bifunctional enzyme form, while competitive with the monofunctional and multienzyme form
diphosphate
-
product inhibition, kinetics
diphosphate
-
product inhibition, kinetics
EDTA
-
5 mM, complete inhibition
Orotate
product inhibition, noncompetitive to diphosphate, competitive to orotidine 5'-phosphate
Orotate
-
phosphorolysis, product inhibition, kinetics
Orotate
-
phosphorolysis, product inhibition, kinetics
orotidine 5'-phosphate
product inhibition
orotidine 5'-phosphate
product inhibition, competitive to 5-phospho-alpha-D-ribose 1-diphosphate, competitive to orotate
orotidylate
-
-
orotidylate
-
product inhibition, kinetics
orotidylate
-
product inhibition, kinetics
p-nitrophenyl beta-D-ribose
-
-
p-nitrophenyl beta-D-ribose
-
-
p-nitrophenyl beta-D-ribose 5'-phosphate
-
competitive inhibitor against orotidine 5'-phosphate
p-nitrophenyl beta-D-ribose 5'-phosphate
-
competitive inhibitor against orotidine 5'-phosphate
PCMB
-
reversible by DTT
PCMB
-
0.01 mM, complete inhibition
phosphate
-
-
phosphate
-
at higher concentrations
ribose 5-phosphate
-
not inhibitory
ribose 5-phosphate
-
at higher concentrations
sulfate
-
competitive to diphosphate
sulfate
-
competitive to diphosphate
UDP
-
-
UMP
-
1 mM, not 0.1 mM
Uracil
-
-
UTP
-
not inhibitory
[(2R,3R,4S,5S)-5-(4-carboxypyridin-3-yl)-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
-
-
[(2R,3R,4S,5S)-5-(4-carboxypyridin-3-yl)-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
-
-
[(2R,3R,4S,5S)-5-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
-
-
[(2R,3R,4S,5S)-5-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
-
-
[(2R,3R,4S,5S)-5-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
-
-
[(2R,3R,4S,5S)-5-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
-
-
[(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-4-hydroxypyrrolidin-1-ium-3-yl]methyl hydrogen phosphate
-
-
[(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-4-hydroxypyrrolidin-1-ium-3-yl]methyl hydrogen phosphate
-
-
[(7R,8R,9S,9aS)-8,9-dihydroxy-1,3,5-trioxo-1,2,3,5,8,9,9a,10-octahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidin-7-yl]methyl hydrogen phosphate
-
-
[(7R,8R,9S,9aS)-8,9-dihydroxy-1,3,5-trioxo-1,2,3,5,8,9,9a,10-octahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidin-7-yl]methyl hydrogen phosphate
-
-
additional information
-
no inhibition by SH-group reagents
-
additional information
-
not inhibitory: CMP, TMP, 6-aza-UMP or 5-bromo-UMP
-
additional information
-
no inhibition by SH-group reagents
-
additional information
-
structural features of pyrimidine nucleobase inhibitors
-
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0.2 - 0.75
(1R,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[(4-nitrophenyl)methyl]pyrrolidin-1-ium
0.23 - 0.57
(1S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[2-(4-nitrophenyl)ethyl]pyrrolidin-1-ium
0.08 - 0.27
(2R,3R,4S)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium
0.29 - 0.69
(2R,3R,4S)-1-[2-(6-carboxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium
0.23 - 0.48
(2R,3S)-3-hydroxy-2-(hydroxymethyl)-5-(4-nitrophenyl)pyrrolidin-1-ium
0.35 - 0.53
(2S,3S,4R,5R)-2-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium
0.3 - 0.36
(2S,3S,4R,5R)-2-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium
0.083 - 0.22
(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium
0.52 - 1.3
(3R,4R)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium
0.11 - 0.27
(7R,8R,9S,9aS)-8,9-dihydroxy-7-(hydroxymethyl)-8,9,9a,10-tetrahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidine-1,3,5(2H)-trione
0.15 - 0.5
1,3-dihydroxy-N-[(4-nitrophenyl)methyl]propan-2-aminium
0.12 - 0.51
1,3-dihydroxy-N-[2-(4-nitrophenyl)ethyl]propan-2-aminium
0.00047
1-deazaorotic acid
-
-
0.25 - 0.47
1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]pyrrolidin-1-ium
0.00025 - 0.0082
2,6-dihydroxypyridine-4-carboxylic acid
0.0074 - 0.014
3-(2-hydroxybenzylidene)-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid
0.00019 - 0.0065
3-benzylidene-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid
0.00012 - 0.00019
4-nitrophenyl beta-D-ribose
0.00004 - 0.000041
4-nitrophenyl beta-D-ribose 5'-phosphate
0.0021
5-azaorotic acid
-
-
0.0482
5-bromoorotate
pH 8.0, 37°C
0.0954
5-Fluoroorotate
pH 8.0, 37°C
0.0561
5-fluorouracil
pH 8.0, 37°C
0.0153
5-iodoorotate
pH 8.0, 37°C
0.0214
5-Methylorotate
pH 8.0, 37°C
0.042 - 0.1501
5-phospho-alpha-D-ribose 1-diphosphate
0.0062 - 0.0135
6-hydroxy-5-((2-hydroxyethylamino)methyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid
0.001 - 1.077
diphosphate
0.00044 - 0.035
orotidine 5'-phosphate
0.0063 - 0.01
orotydilate
0.000121 - 0.000188
p-nitrophenyl beta-D-ribose
0.00004 - 0.000041
p-nitrophenyl beta-D-ribose 5'-phosphate
0.0705
pyrazofurin
pH 8.0, 37°C
0.1212
Uracil
pH 8.0, 37°C
4.3 - 15.5
[(2R,3R,4S,5S)-5-(4-carboxypyridin-3-yl)-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
0.2 - 0.37
[(2R,3R,4S,5S)-5-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
0.14 - 0.35
[(2R,3R,4S,5S)-5-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
0.24 - 0.5
[(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-4-hydroxypyrrolidin-1-ium-3-yl]methyl hydrogen phosphate
0.09 - 0.17
[(7R,8R,9S,9aS)-8,9-dihydroxy-1,3,5-trioxo-1,2,3,5,8,9,9a,10-octahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidin-7-yl]methyl hydrogen phosphate
0.2
(1R,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[(4-nitrophenyl)methyl]pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.75
(1R,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[(4-nitrophenyl)methyl]pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.23
(1S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[2-(4-nitrophenyl)ethyl]pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.57
(1S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-1-[2-(4-nitrophenyl)ethyl]pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.08
(2R,3R,4S)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.27
(2R,3R,4S)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.29
(2R,3R,4S)-1-[2-(6-carboxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.69
(2R,3R,4S)-1-[2-(6-carboxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.23
(2R,3S)-3-hydroxy-2-(hydroxymethyl)-5-(4-nitrophenyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.48
(2R,3S)-3-hydroxy-2-(hydroxymethyl)-5-(4-nitrophenyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.35
(2S,3S,4R,5R)-2-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.53
(2S,3S,4R,5R)-2-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.3
(2S,3S,4R,5R)-2-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.36
(2S,3S,4R,5R)-2-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.083
(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.22
(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.52
(3R,4R)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
1.3
(3R,4R)-1-[2-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl]-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.11
(7R,8R,9S,9aS)-8,9-dihydroxy-7-(hydroxymethyl)-8,9,9a,10-tetrahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidine-1,3,5(2H)-trione
-
at pH 8.0 and 25°C
0.27
(7R,8R,9S,9aS)-8,9-dihydroxy-7-(hydroxymethyl)-8,9,9a,10-tetrahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidine-1,3,5(2H)-trione
-
at pH 8.0 and 25°C
0.15
1,3-dihydroxy-N-[(4-nitrophenyl)methyl]propan-2-aminium
-
at pH 8.0 and 25°C
0.5
1,3-dihydroxy-N-[(4-nitrophenyl)methyl]propan-2-aminium
-
at pH 8.0 and 25°C
0.12
1,3-dihydroxy-N-[2-(4-nitrophenyl)ethyl]propan-2-aminium
-
at pH 8.0 and 25°C
0.51
1,3-dihydroxy-N-[2-(4-nitrophenyl)ethyl]propan-2-aminium
-
at pH 8.0 and 25°C
0.25
1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.47
1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]pyrrolidin-1-ium
-
at pH 8.0 and 25°C
0.00025
2,6-dihydroxypyridine-4-carboxylic acid
-
competitive to orotate, pH 8.0, 25°C
0.0082
2,6-dihydroxypyridine-4-carboxylic acid
-
uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate, pH 8.0, 25°C
0.0074
3-(2-hydroxybenzylidene)-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid
-
competitive to orotate, pH 8.0, 25°C
0.014
3-(2-hydroxybenzylidene)-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid
-
uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate, pH 8.0, 25°C
0.00019
3-benzylidene-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid
-
competitive to orotate, pH 8.0, 25°C
0.0065
3-benzylidene-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid
-
uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate, pH 8.0, 25°C
0.00012
4-nitrophenyl beta-D-ribose
-
at pH 8.0 and 25°C
0.00019
4-nitrophenyl beta-D-ribose
-
at pH 8.0 and 25°C
0.00004
4-nitrophenyl beta-D-ribose 5'-phosphate
-
at pH 8.0 and 25°C
0.000041
4-nitrophenyl beta-D-ribose 5'-phosphate
-
at pH 8.0 and 25°C
0.042
5-phospho-alpha-D-ribose 1-diphosphate
-
-
0.0423
5-phospho-alpha-D-ribose 1-diphosphate
pH 8.0, 37°C, cosubstrate diphosphate
0.1501
5-phospho-alpha-D-ribose 1-diphosphate
pH 8.0, 37°C, cosubstrate orotidine 5'-phosphate
0.0062
6-hydroxy-5-((2-hydroxyethylamino)methyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid
-
competitive to orotate, pH 8.0, 25°C
0.0135
6-hydroxy-5-((2-hydroxyethylamino)methyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid
-
uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate, pH 8.0, 25°C
0.001
diphosphate
pH and temperature not specified in the publication, recombinant multienzyme complex, versus OPRT activity and substrate 5-phospho-alpha-D-ribose 1-diphosphate
0.007
diphosphate
pH and temperature not specified in the publication, recombinant multienzyme complex, versus OPRT activity and substrate orotate
0.026
diphosphate
mixed type inhibition, 5-phospho-alpha-D-ribose 1-diphosphate varied substrate, orotate unsaturated, pH 8.0, 25°C
0.029
diphosphate
mixed type inhibition, orotate varied substrate, 5-phospho-alpha-D-ribose 1-diphosphate unsaturated, pH 8.0, 25°C
0.0797
diphosphate
pH 8.0, 37°C, cosubstrate orotate
0.08
diphosphate
pH and temperature not specified in the publication, recombinant monofunctional enzyme, versus OPRT activity and substrate orotate
0.108
diphosphate
noncompetitive, 5-phospho-alpha-D-ribose 1-diphosphate varied substrate, orotate saturated, pH 8.0, 25°C
0.125
diphosphate
pH 8.0, 37°C, cosubstrate 5-phospho-alpha-D-ribose 1-diphosphate
0.125
diphosphate
pH and temperature not specified in the publication, recombinant monofunctional enzyme, versus OPRT activity and substrate 5-phospho-alpha-D-ribose 1-diphosphate
0.209
diphosphate
mixed type inhibition, orotate varied substrate, 5-phospho-alpha-D-ribose 1-diphosphate saturated, pH 8.0, 25°C
1.006
diphosphate
pH and temperature not specified in the publication, recombinant bifunctional enzyme, versus OPRT activity and substrate 5-phospho-alpha-D-ribose 1-diphosphate
1.077
diphosphate
pH and temperature not specified in the publication, recombinant bifunctional enzyme, versus OPRT activity and substrate orotate
0.0075
Orotate
pH 8.0, 37°C, cosubstrate orotidine 5'-phosphate
0.0213
Orotate
pH 8.0, 37°C, cosubstrate diphosphate
0.00044
orotidine 5'-phosphate
mixed type inhibition, 5-phospho-alpha-D-ribose 1-diphosphate varied substrate, orotate unsaturated, pH 8.0, 25°C
0.001
orotidine 5'-phosphate
mixed type inhibition, 5-phospho-alpha-D-ribose 1-diphosphate varied substrate, orotate saturated, pH 8.0, 25°C
0.0074
orotidine 5'-phosphate
mixed type inhibition, orotate varied substrate, 5-phospho-alpha-D-ribose 1-diphosphate unsaturated, pH 8.0, 25°C
0.0157
orotidine 5'-phosphate
pH 8.0, 37°C, cosubstrate 5-phospho-alpha-D-ribose 1-diphosphate
0.0241
orotidine 5'-phosphate
pH 8.0, 37°C, cosubstrate orotate
0.035
orotidine 5'-phosphate
noncompetitive, orotate varied substrate, 5-phospho-alpha-D-ribose 1-diphosphate saturated, pH 8.0, 25°C
0.0063
orotydilate
-
plus 5-phospho-alpha-D-ribose 1-diphosphate
0.0083
orotydilate
-
plus orotate
0.000121
p-nitrophenyl beta-D-ribose
-
in the presence of orotidine 5'-phosphate, at 25°C, 50 mM Tris-HCl, pH 8.0, 5 mM MgCl2
0.000188
p-nitrophenyl beta-D-ribose
-
in the presence of orotidine 5'-phosphate, at 25°C, 50 mM Tris-HCl, pH 8.0, 5 mM MgCl2
0.00004
p-nitrophenyl beta-D-ribose 5'-phosphate
-
in the presence of orotidine 5'-phosphate, at 25°C, 50 mM Tris-HCl, pH 8.0, 5 mM MgCl2
0.000041
p-nitrophenyl beta-D-ribose 5'-phosphate
-
in the presence of orotidine 5'-phosphate, at 25°C, 50 mM Tris-HCl, pH 8.0, 5 mM MgCl2
2.7
sulfate
-
orotidine 5'-phosphate as substrate, pH not specified in the publication, temperature not specified in the publication
3.1
sulfate
-
orotidine 5'-phosphate as substrate, pH not specified in the publication, temperature not specified in the publication
10.8
sulfate
-
orotidine 5'-phosphate as substrate, pH not specified in the publication, temperature not specified in the publication
17.6
sulfate
-
orotidine 5'-phosphate as substrate, pH not specified in the publication, temperature not specified in the publication
4.3
[(2R,3R,4S,5S)-5-(4-carboxypyridin-3-yl)-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
-
at pH 8.0 and 25°C
15.5
[(2R,3R,4S,5S)-5-(4-carboxypyridin-3-yl)-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
-
at pH 8.0 and 25°C
0.2
[(2R,3R,4S,5S)-5-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
-
at pH 8.0 and 25°C
0.37
[(2R,3R,4S,5S)-5-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
-
at pH 8.0 and 25°C
0.14
[(2R,3R,4S,5S)-5-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
-
at pH 8.0 and 25°C
0.35
[(2R,3R,4S,5S)-5-[(6-cyano-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-3,4-dihydroxypyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
-
at pH 8.0 and 25°C
0.24
[(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-4-hydroxypyrrolidin-1-ium-3-yl]methyl hydrogen phosphate
-
at pH 8.0 and 25°C
0.5
[(3R,4R)-1-[(6-carboxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-4-hydroxypyrrolidin-1-ium-3-yl]methyl hydrogen phosphate
-
at pH 8.0 and 25°C
0.09
[(7R,8R,9S,9aS)-8,9-dihydroxy-1,3,5-trioxo-1,2,3,5,8,9,9a,10-octahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidin-7-yl]methyl hydrogen phosphate
-
at pH 8.0 and 25°C
0.17
[(7R,8R,9S,9aS)-8,9-dihydroxy-1,3,5-trioxo-1,2,3,5,8,9,9a,10-octahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2-c]pyrimidin-7-yl]methyl hydrogen phosphate
-
at pH 8.0 and 25°C
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The relationship between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase, excision repair cross-complementation group 1 and class III beta-tubulin, and the therapeutic effect of S-1 or carboplatin plus paclitaxel in nonx1esmallx1ecell lung cancer
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2018
Homo sapiens
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