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Literature summary for 2.4.2.10 extracted from

  • Rathod, P.K.; Reyes, P.
    Orotidylate-metabolizing enzymes of the human malarial parasite, Plasmodium falciparum, differ from host cell enzymes (1983), J. Biol. Chem., 258, 2852-2855.
    View publication on PubMed
Search for more literature for 2.4.2.10

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by SH-group reagents Homo sapiens
additional information no inhibition by SH-group reagents Plasmodium falciparum
PCMB 0.01 mM, complete inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-
soluble
-
 Plasmodium falciparum
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
orotate + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens final steps in biosynthesis of UMP orotidine 5'-phosphate + diphosphate
-
 ?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate Plasmodium falciparum final steps in biosynthesis of UMP orotidine 5'-phosphate + diphosphate
-
 ?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate Plasmodium falciparum FCB final steps in biosynthesis of UMP orotidine 5'-phosphate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Plasmodium falciparum
-
 FCB strain
-
Plasmodium falciparum FCB
-
 FCB strain
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Storage Stability

Storage Stability Organism
4°C, t1/2: 1.5 days Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme from mammals is a bifunctional polypeptide, it also catalyzes the reaction listed as EC 4.1.1.23 Homo sapiens ?
-
 ?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Plasmodium falciparum orotidine 5'-phosphate + diphosphate
-
 ?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate final steps in biosynthesis of UMP Homo sapiens orotidine 5'-phosphate + diphosphate
-
 ?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate final steps in biosynthesis of UMP Plasmodium falciparum orotidine 5'-phosphate + diphosphate
-
 ?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Plasmodium falciparum FCB orotidine 5'-phosphate + diphosphate
-
 ?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate final steps in biosynthesis of UMP Plasmodium falciparum FCB orotidine 5'-phosphate + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
More
-
 Plasmodium falciparum
More enzyme from mammals is a bifunctional polypeptide, it also catalyzes the reaction listed as EC 4.1.1.23 Homo sapiens