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Literature summary for 2.4.2.10 extracted from

  • Imprasittichail, W.; Roytrakul, S.; Krungkrai, S.R.; Krungkrail, J.
    A unique insertion of low complexity amino acid sequence underlies protein-protein interaction in human malaria parasite orotate phosphoribosyltransferase and orotidine 5-monophosphate decarboxylase (2014), Asian Pac. J. Trop. Med., 7, 184-192.
    View publication on PubMed
Search for more literature for 2.4.2.10

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli M15[pREP4]cells Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
 2 * 33000, SDS-PAGE. Orotate phosphoribosyltransferase and orotidine 5-monophosphate decarboxylase exist physically as a heterotetrameric enzyme complex containing two subunits of each enzyme Plasmodium falciparum
67000
-
 gel filtration Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
orotate + 5-phospho-alpha-D-ribose 1-diphosphate Plasmodium falciparum
-
 orotidine 5'-phosphate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q8N0R1
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Plasmodium falciparum orotidine 5'-phosphate + diphosphate
-
 ?

Subunits

Subunits Comment Organism
homodimer 2 * 33000, SDS-PAGE. Orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase exist physically as a heterotetrameric enzyme complex containing two subunits of each enzyme Plasmodium falciparum

Synonyms

Synonyms Comment Organism
OPRT
-
 Plasmodium falciparum