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Literature summary for 2.4.2.10 extracted from
- Pyrophosphate interactions at the transition states of plasmodium falciparum and human orotate phosphoribosyltransferases (2010), J. Am. Chem. Soc., 132, 8787-8794.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Homo sapiens |
| expressed in Escherichia coli | Plasmodium falciparum |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0015 | - |
orotidine 5'-phosphate | pH 8.0, 25°C | Homo sapiens |  |
| 0.0037 | - |
orotidine 5'-phosphate | pH 8.0, 25°C | Plasmodium falciparum | |
| 0.091 | - |
Orotidine | pH 8.0, 25°C | Homo sapiens | |
| 0.096 | - |
Orotidine | pH 8.0, 25°C | Plasmodium falciparum | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | - |
Plasmodium falciparum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Plasmodium falciparum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Plasmodium falciparum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| orotidine + diphosphate | - |
Homo sapiens | orotate + alpha-D-ribose 1-diphosphate | - |
? | |
| orotidine + diphosphate | - |
Plasmodium falciparum | orotate + alpha-D-ribose 1-diphosphate | - |
? | |
| orotidine 5'-phosphate + diphosphate | - |
Homo sapiens | orotate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
? | |
| orotidine 5'-phosphate + diphosphate | - |
Plasmodium falciparum | orotate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| orotate phosphoribosyltransferase | - |
Homo sapiens |
| orotate phosphoribosyltransferase | - |
Plasmodium falciparum |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.024 | - |
Orotidine | pH 8.0, 25°C | Homo sapiens | |
| 0.042 | - |
Orotidine | pH 8.0, 25°C | Plasmodium falciparum | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.26 | - |
Orotidine | pH 8.0, 25°C | Homo sapiens | |
| 0.44 | - |
Orotidine | pH 8.0, 25°C | Plasmodium falciparum | |
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